TALANTA
·
2023
·
IF 6.1
Mengjiao Li,Yu Wu,Chenxi Ke,Zichen Song,Meie Zheng,Qingjie Yu,Hongda Zhu,Huiling Guo,Hongmei Sun,Mingxing Liu
In this study, an ultrasensitive unlabeled electrochemical immunosensor for the detection of cardiac troponin I (cTnI) was developed based on Pt/Au modified B,S,N co-doped reduced graphene oxide (Pt/Au–B,S,N-rGO) as a signal amplification platform. First-principles calculations were employed to analyze the electron density of states of Pt/Au–B,S,N-rGO, revealing an increase in the electron density of the graphene oxide (GO) states. Furthermore, scanning electron microscopy (SEM), X-ray photoelectron diffraction spectroscopy (XPS), and electrochemical detection were used to successfully construct and analyze Pt/Au–B,S,N-rGO. The results showed that B,S,N-rGO exhibited good electrochemical activity, and the Au/Pt NPs demonstrated excellent catalytic properties, which provided a strong foundation for achieving high-sensitivity detection. Moreover, the constructed unlabeled electrochemical immunosensor had an ideal linear range (0.1 pg/mL∼50 ng/mL) and detection limit (0.082 pg/mL). In human serum detection, the results of this immunosensor were essentially similar to the ELISA results for the same samples, which suggested that the immunosensor had a promising clinical application prospect for the detection of cTnI.
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CHEMISTRY OF MATERIALS
·
2021
·
IF 9.811
Da Chen,Shiqiang Hao,Liubing Fan,Yangwu Guo,Jiyong Yao,Christopher Wolverton,Mercouri G. Kanatzidis,Jing Zhao,Quanlin Liu
Recent discoveries in organic−inorganic metal halides reveal superior semiconducting and polarization properties. Herein, we report three organic–inorganic metal halides, (PBA)4BiBr7·H2O, (PBA)4BiI7·H2O, and (PBA)4InBr7·H2O [(PBA)+ = C6H5(CH2)4NH3+], with band gaps of ∼3.52, ∼2.29, and ∼4.05 eV, respectively. They possess zero-dimensional structures containing the inorganic octahedra [MX6]3– (M = Bi, In, X = Br, I) and unbound X– ions and crystallize in the C2 space group. (PBA)4BiI7·H2O shows a second-harmonic-generation (SHG) response in the infrared region, approximately 1.3 times that of AgGaS2; (PBA)4BiBr7·H2O and (PBA)4InBr7·H2O show SHG responses in the ultraviolet region, approximately 0.4 and 0.6 times that of KH2PO4, respectively. The large SHG responses are attributed to the synergistic contribution of the octahedral distortion of [MX6]3– (M = Bi, In, X = Br, I) and the ordered arrangement of the benzene ring-containing organic cation PBA+. Upon ultraviolet and visible-light excitations at room temperature, (PBA)4BiBr7·H2O, (PBA)4BiI7·H2O, and (PBA)4InBr7·H2O exhibit broad red-light luminescence with large Stokes shifts of 290, 237, and 360 nm, respectively, due to self-trapped exciton emission. All of these properties demonstrate that this series of metal halides are potential multifunctional optoelectronic materials.
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ANALYTICAL CHEMISTRY
·
2019
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IF 6.35
Shanshan Wang,Yangyang Zhao,Minmin Wang,Haijuan Li,Muhammad Saqib,Chunhua Ge,Xiangdong Zhang,Yongdong Jin
Electrochemiluminescence (ECL) has emerged as one of the most important methods for in vitro diagnosis and detection, but it is still limited in sensitivity for ultrasensitive biodetections. Fast and ultrasensitive detection of biomolecules is critical, especially for the clinical detection of cardiac troponin I (cTnI) for cardiac infarction diagnosis. In this study, an effective tactic was developed to enhance ECL efficiency of the luminol system, by combined use of Co2+-based metal organic frameworks (MOF), zeolitic imidazolate frameworks (ZIF-67), and luminol-capped Ag nanoparticles (luminol-AgNPs). The integration leads to a pronounced ∼115-fold enhancement in luminol ECL. On the basis of this fascinating sensing platform, a robust label-free ECL immunosensor was constructed for ultrasensitive detection of cTnI, the main marker of myocardial infarction, with good stability and a detection limit as low as 0.58 fg mL–1 (S/N = 3).
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 51
·期 2
·340-346
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IF 3.919
Delong Liu,Hou Chen,Naiyi Ji,Zhi Tan
In this study, we reported the synthesis of polyacrylonitrile (PAN) via living radical polymerization in N, N -dimethylformamide using carbon tetrachloride as initiator, copper(II) chloride (CuCl 2 )/hexamethylenetetramine as catalyst system, and 2,2-azobisisobutyronitrile as a high concentration of thermal radical initiator. The polymerization proceeded in controlled/living manner as indicated by first-order kinetics of the polymerization with respect to the monomer concentration, linear increase of the molecular weight with monomer conversion and narrow polydispersity. Higher polymerization rate and narrower molecular weight distributions were observed with CuCl 2 less than 50 ppm. The rate of polymerization showed a trend of increase along with temperature. The modified PAN containing amidoxime group was used for extraction of Ag(I) ions from aqueous solutions. The adsorption kinetics data indicated that the adsorption process followed pseudo-second-order rate model. The isotherm adsorption process could be described by the Freundlich isotherm model. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
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RSC Advances
·
2016
·Vol. 6
·期 73
·69370-69380
·
IF 3.289
Juncai Zhang,Youning Chen
With chloromethylated polystyrene resin being the base material, a new type of salicylic acid-type chelating resin with high capacity was prepared by grafting glycidyl methacrylate (GMA) on the surface of the resin via surface-initiated atom transfer radical polymerization and followed by the derivatization with 5-aminosalicylic acid. Fourier-transform infrared spectrometry and X-ray photoelectron spectroscopy were used to characterize the surface composition of the resin. It was found that the grafting degree of GMA increased linearly with the extension of ATRP time and GMA concentration. The maximum adsorption capacities of the resin were up to 4.23 mmol g−1 for Fe(III), 4.02 mmol g−1 for Ag(I), 2.36 mmol g−1 for Ni(II) and 1.75 mmol g−1 for Cu(II) at pH 4.0, respectively. The adsorption kinetics of the four metal ions conform to the model of pseudo second-order kinetics, and adsorption equilibria were better characterized by the Langmuir equation. Thermodynamic parameters were calculated to understand the nature of the adsorption process. The resin possesses excellent desorption rate and reusability. All these results indicate that the resin could be potentially applied to the efficient removal of heavy metal ions from waste water.
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Molecular Medicine Reports
·
2016
·Vol. 14
·期 4
·3871-3877
·
IF 1.559
Jing Qin,Yongmei Hua
Periodontal ligament cells (PDLCs) are important in homeostasis and remodeling in the mechanically‑stimulated periodontium. The aim of the present study was to investigate the effects of hydrogen sulfide (H2S) on periodontal tissue remodeling by examining the mRNA and protein expression levels of alkaline phosphatase (ALP), osteocalcin (OCN) and collagen type I (COL‑1) in human (h)PDLCs induced by tension force application. Cultured hPDLCs were treated with H2S for 24 h, followed by application of a tension force for 1, 3 and 6 h. Cell proliferation and apoptosis were determined using a Cell Counting Kit 8 assay and flow cytometric analysis, respectively. The mRNA expression levels of ALP, OCN and COL‑1 were quantified using reverse transcription‑quantitative polymerase chain reaction analysis, and western blot analysis was used to detect the protein levels of ALP, OCN and COL‑1. The results demonstrated that the mRNA and protein expression levels of ALP, OCN and COL‑1 increased with H2S treatment in a concentration‑dependent manner, which was enhanced by the application of tension force in a relatively short period of time. These findings suggested that H2S may be important in periodontal tissue remodeling during orthodontic tooth movement via increasing hPDLC differentiation, tissue mineralization, bone formation and collagen synthesis.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2024
·Vol. 26
·期 24
·17155-17170
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IF 2.9
Dongsheng Chen,Keqian Gong,Xiangyang Xu,Chenyu Huang,Pengtao Lei
Metal-ion doping and halogen substitution have been largely applied to tune the bandgap of bismuth oxybromide (BiOBr) to upgrade its photodegradation capacity. In this work, the adsorption capacity and photocatalytic behavior of solvothermally synthesized BiOBr photocatalysts can be optimized via the synergistic effect of Y3+- and I−-doping. After an adsorption reaction in the dark and exposure for another 80 min to visible light, pure BiOBr can remove 46.5% of Congo red (CR) from water with an initial CR concentration of 50 mg L−1. Meanwhile, Bi0.8Y0.20OBr0.97I0.03, the co-doped catalyst, displays total degradation rates exceeding 98% and 92% with CR dosages of 50 and 100 mg L−1, respectively, demonstrating a doubled degradation capacity. With the co-doping solution, the negative charges on the catalysts reduce, more oxygen vacancies are generated, the bandgap remarkably narrows, and the photoabsorption range broadens for derivation of photoinduced electron–hole pairs. The mechanism for optimized photodegradation behavior and dramatically increased adsorption capacity are discussed based on analyses of the structural evolution, surface properties including the chemical state and surface charge, electrochemical performance and the yield/type of photogenerated species. Density functional theory (DFT) simulations were conducted to investigate the structural state, density of states (DOS) and electrostatic potential.
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Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 20
·7098-7109
·
IF 6.1
Fengmei Zhu,Yuan Gao,Jianbei Qiu
Presently, there is a need to expand the near-infrared (NIR) emission range, especially in the bio-transparent window, to improve the internal quantum efficiency and external quantum efficiency, and to minimize the shortcomings of luminescence properties. In this work, an ultra-broadband NIR emission Cr3+-doped Cs2NaLuCl6 all-inorganic metal halide perovskite phosphor was synthesized by a grinding–sintering method. Under 300 nm excitation, Cs2NaLuCl6:Cr3+ phosphors exhibited ultra-broadband NIR emission of 800–1400 nm, which covers nearly the entire NIR-I (700–1000 nm) and NIR-II (1000–1400 nm) regions; the emission peaked at around 960 nm, with a full width at half maximum of ∼182 nm. Noticeably, the internal- and external-quantum efficiencies of the optimized Cs2NaLuCl6:Cr3+ phosphor were as high as ∼92.9% and ∼60.75%, respectively. We showed through analysis and simulation that the weak crystal field strength is conducive to increasing the odd term of the crystal field, and therefore it partially released the restriction imposed by the parity prohibition law and improved the energy absorption efficiency of Cr3+. As the size of the phosphor approaches the wavelength of NIR luminescence, the apparent Mie scattering effect starts to take effect, which enhances the light extraction of NIR luminescence in the radial direction.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·Vol. 416
·期 29
·7043-7062
·
IF 3.8
Liu Wen-Ya,Xu Di,Meng Hui-Hui,Wang Cheng-Yao,Feng Xin,Wang Jun-Song
Cucurbitacin B (CuB) is a natural triterpenoid with diverse pharmacological effects including potent anticancer activity. However, its oral bioavailability is hampered by limited metabolism in vivo. We characterized CuB’s in vivo metabolism in rats to uncover bioactive metabolites retaining therapeutic potential, using a robust UHPLC-Q-TOF–MS/MS workflow. This workflow combined molecular networking, fragmentation filtering, and mass defect filtering to identify CuB metabolites in rat urine, plasma, and feces following oral administration. Thirteen metabolites were identified and seven were confirmed. Major phase I transformations involved hydrolysis, reduction, epoxidation, and amination. Phase II conjugation included cysteine, glutathione, glucuronide, and gluconic acid conjugates. Notably, one of the main metabolites formed was the cysteine conjugate CuB-Cys. CuB-Cys maintained similar in vitro antiproliferative activity to CuB on HepG2, MCF-7, and PANC-1 cancer cell lines. However, it demonstrated lower cytotoxicity towards non-cancerous L02 cells, highlighting improved therapeutic selectivity. Mechanistically, CuB-Cys induced greater apoptotic signaling in HepG2 cells than CuB via enhanced caspase activation and disrupted BAX-Bcl-2 balance. This represents the first systematic characterization of CuB’s in vivo metabolic pathway. The identification and confirmation of CuB-Cys provide insight for drug development efforts aiming to maintain therapeutic efficacy while reducing toxicity, via metabolite-based approaches. Our findings shed light on strategies for improving CuB’s clinical potential. Graphical Abstract
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CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 24
·6458-6463
·
IF 5.16
Xinyue Song,Zihong Yue,Jiayu Zhang,Yanxialei Jiang,Zonghua Wang,Shusheng Zhang
Graphical By taking advantage of a lack of spectral overlapping and single NIR excitation wavelengths, sandwich-structured multicolor upconversion nanoparticles (SWUCNPs) were used to establish a dual luminescence resonance energy transfer (LRET) nanoprobe with special recognition ligands. The quenched fluorescence would be recovered after the detachment and/or absorbance change of the attached ligands (see scheme) to investigate the interplaying roles of [Ca 2+ ] i and pH i . Intracellular [Ca 2+ ] i and pH i have a close relationship, and their abnormal levels can result in cell dysfunction and accompanying diseases. Thus, simultaneous determination of [Ca 2+ ] i and pH i can more accurately investigate complex biological processes in an integrated platform. Herein, multicolor upconversion nanoparticles (UCNPs) were prepared with the advantages of no spectral overlapping, single NIR excitation wavelengths, and greater tissue penetration depth. The upconversion nanoprobes were easily prepared by the attachment of two fluorescent dyes, Fluo-4 and SNARF-4F. Based on the dual luminescence resonance energy transfer (LRET) process, the blue and green fluorescence of the UCNPs were specially quenched and selectively recovered after the detachment and/or absorbance change of the attached fluorescent dyes, enabling dual detection. Importantly, the developed nanoprobe could successfully be applied for the detection of [Ca 2+ ] i and pH i change in adenosine triphosphate (ATP) and ethylene glycol tetraacetic acid (EGTA) stimulation in living cells.
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Redox Biology
·
2025
·
IF 11.9
Dongsheng Ji,Jiahui Zhang,Jihai Liang,Zhi-Shu Huang,Bing Shu,Ding Li
Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by abnormal metabolism of β-amyloid (Aβ) precursor proteins and neuronal apoptosis, ultimately leading to cognitive dysfunction. The pathogenesis of AD is complex, and current single-target therapies are not effective in preventing the rapid progression of AD, which highlights the urgent need for developing multi-target drugs. In this study, a series of compounds were synthesized through a multi-targeting ligand strategy. After extensive screening and evaluation, we found a lead compound B14 , which showed excellent dual targeting ability for effectively alleviating neuronal apoptosis and oxidative stress damage of AD. In our molecular and cellular level experiments, B14 could target and stabilize the i-motif structure formed on the BCL-2 promoter to upregulate BCL-2 expression, which could also bind to Aβ and inhibit its deposition. In the Aβ 1-42 -induced cell model, B14 could maintain mitochondrial function and number, regulate intracellular reactive oxygen species (ROS) and Ca 2+ metabolism disorders, and effectively reduce Aβ 1-42 -induced apoptosis. Further studies showed that B14 also exhibited good ability to cross the blood-brain barrier (BBB), which significantly improved learning memory and cognitive deficits, reduced brain Aβ plaques, alleviated inflammation and restored oxidative stress markers in APP/PS1 mice. Our findings provide an innovative strategy of dual targeting BCL-2 promoter i-motif for transcriptional regulation and Aβ aggregation synergistically for mitigating AD pathologies. B14 represents a promising multi-target lead compound with a good potential for further development for AD treatment.
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LANGMUIR
·
2025
·
IF 3.9
Meiting Li,Bingxin Yuan,Chi Zhang,Jia Li,Xuejiao Wang
Hierarchical BiOCl/BiOI and BiO(Cl,I) photocatalysts were obtained via a solution-phase reaction for visible-light-driven elimination of aqueous pollutants, where the phase/morphology evolution, relationship between energy band/microstructure structure and photocatalytic properties, and photoreaction mechanism can be deciphered in detail. It was well-documented that the R = 8:1 BiOCl/BiOI heterojunctions with a coherent interface of Bi and O atoms showed a relatively strong redox capacity owing to their rapid Z-scheme charge transfer and large interfacial contact and eventually degraded ∼92.52% and 96.57% of rhodamine B (RhB) and tetracycline (TC) molecules under 10 min of visible light irradiation, which was larger than those of bare BiOCl and BiOI. However, their poor photocatalytic stability was proved to be unfavorable to practical applications. The best BiOCl0.88I0.12 solid solutions separately elucidated the optimal RhB and TC removal efficiency of ∼99.97% and 97.54% after 10 and 6 min of illumination, and it still maintained a high photodegradation efficiency toward RhB after five consecutive runs. The exceptional photocatalytic performance is cogoverned by the characteristics of in situ generated oxygen vacancies and defect energy levels.
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