Journal of Physical Chemistry Letters
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2024
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IF 4.8
Wenfeng Sun,Shaolong Liu,Caizheng Wang,Xiaotao Zu,Sean Li,Xia Xiang
Lead-free perovskites are considered to be candidates for next-generation photodetectors, because of their excellent charge carrier transport properties and low toxicity. However, their application in integrated circuits is hindered by their inadequate performance and size restrictions. To aim at the development of lead-free perovskite-integrated optoelectronic devices, a CsAg2I3/silicon (CAI/Si) heterojunction is presented in this work by using a spatial confinement growth method, where the in-plane growth of CAI microbelts with high-quality single-crystal characteristics is primarily dependent on the concentration of surrounding precursor solution. The fabricated photodetectors based on the CAI/Si heterojunctions exhibit a broad-spectrum detection capability in the ultraviolet–visible–near-infrared (UV-vis-NIR) range. In addition, the photodetectors show good photoelectric detection performance, including a maximum responsivity of 48.5 mA/W and detectivity of 1.13 × 1011 Jones, respectively. Besides, the photodetectors have a rapid response of 6.5/224 μs and good air stability for over 2 months. This work contributes a new idea to design next-generation optoelectronic devices with high integration density.
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PROGRESS IN SOLID STATE CHEMISTRY
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2026
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IF 9.7
Yutong Wang,Hang Zhao,Jiayin Niu,Anurak Weahayee,Wanwisa Limphirat,Theeranun Siritanon,Jingyi Ren,Peng Jiang,Yanfei Sun,Tingting Lu
The development of high-performance narrowband near-infrared second window (NIR-II) phosphors remains a critical challenge in the fields of advanced bioimaging and optical thermometry. Herein, a series of Mn 5+ -doped ABaPO 4 (A = Li, Na, K) phosphors are synthesized via conventional solid-state method, and the effect of A-site alkali metal cations on their crystal structure and luminescence properties is comparatively investigated. Mn K -edge X-ray absorption near-edge structure (XANES) spectroscopy unambiguously confirms that Mn ions are predominantly stabilized in the +5 oxidation state and exclusively occupy tetrahedral [PO 4 ] sites in all three hosts. All samples exhibit characteristic narrowband NIR-II emission in the 1160-1200 nm range originating from the 1 E → 3 A 2 spin-forbidden transition of Mn 5+ . The lattice distortion induced by different A-site cations significantly modulates the doping limit, crystal field strength, thermal stability and temperature sensing performance of Mn 5+ ions. All three Mn 5+ -doped hosts exhibit good thermal stability. The fluorescence decay lifetime of LiBaPO 4 : Mn 5+ reaches 772.436 μs NaBaPO 4 : Mn 5+ shows unique energy level splitting and achieves a maximum relative temperature sensitivity of 2.43% K −1 based on the fluorescence intensity ratio technique. KBaPO 4 : Mn 5+ possesses a highly symmetric crystal lattice and a higher doping limit, with a thermal quenching activation energy ( ΔE ) of 0.414 eV. This work not only provides three promising NIR-II phosphors for bioimaging and optical thermometry, but also offers new insights into the research of Mn 5+ -activated phosphate systems.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Wen-Zhen Li,Dongyang Li,Huanhuan Wang,Hongli Zhang,Xipeng Li,Xiaoling Yang,Jiamei Wang,Anning Yang,Qin Zeng,Judun Zheng,Yideng Jiang,Yuhui Liao
Green-Synthesized Scaffolds for Smart Hydrogels. Green-synthesized quaternized chitosan (QCS) represents an ideal macromolecular backbone for constructing functional hydrogels, driven by its structural tunability, excellent aqueous solubility, and intrinsic cationic nature. Unlike native chitosan, the targeted introduction of quaternary ammonium groups endows QCS with a permanent positive charge. This modification not only enhances its degradation but also confers superior antibacterial efficacy and mucoid hesiveness. By leveraging QCS as a versatile scaffold to rationally design polysaccharide-based hydrogels with tailored physicochemical and biological profiles, this work provides a sustainable and highly effective platform for advancing next-generation bioactive materials. • Sol-Gel transition and enhanced antibacterial performance. Macrocyclic host TEBox markedly improves EGCG’s (guest) water solubility and antibacterial effect via host-guest interactions. It also effectively drives the Sol-Gel transition of QCS-EC Sol, finally enabling the preparation of bacteria-responsive multifunctional injectable hydrogel (MQCEC-TEB Gel). This gel has excellent skin adhesion and promotes cell proliferation and tissue regeneration. • Real-Time, Visual Infection Monitoring. Key innovation: a chaotropic effect-based bacteria-responsive agent (TEBox-B 12 ). When exposed to bacteria, TEBox-B 12 undergoes in situ reduction to generate stable organic radicals, causing rapid visible color change (pale yellow to deep purple). This provides a revolutionary tool for early, non-invasive, real-time infection diagnosis. • Synergistic Anti-infection Therapy for Deep Tissue. Radicals from the above reaction not only enable color development but also have strong NIR-II absorption, allowing the hydrogel to achieve deep-tissue photothermal (PTT) and photodynamic (PDT) antibacterial therapy. NIR-II light penetrates deeper into tissue, overcoming traditional phototherapy limitations. This study presents a new smart dressing and "diagnosis-and-therapy integration" strategy, offering a new paradigm for managing invasive infection wounds. Smart hydrogel dressings with sustained wound-healing promotion and infection-monitoring capabilities demonstrate significant potential for invasive infection wound repair. Inspired by mussels, a highly adhesive and multifunctional injectable antibacterial hydrogel dressing (MQCEC-TEB Gel) was developed for wound repair and real-time infection monitoring, comprising a viscous hydrogel scaffold (QCS-EC) and a bacteria-responsive agent (TEBox-B 12 ) crosslinked via host-guest interaction. The epigallocatechin gallate (EGCG) was incorporated into quaternized chitosan (QCS) enhancing the viscosity of QCS and forming the QCS-EC scaffold by hydrogen bonding, providing sustained antibacterial activity and promoting wound-healing. Meanwhile, the bacteria-responsive agent TEBox-B 12 self-assembles via a chaotropic effect between box-shaped quaternized pyridinium salt (TEBox) and the superchaotropic anion B 12 H 12 2− . Upon bacterial exposure, TEBox-B 12 underwent in situ reduction, generating stable organic radicals that trigger a rapid visible color change from pale yellow to deep purple for real-time infection monitoring. The resulting radicals also exhibit strong NIR-II absorption, enabling deep-tissue photothermal (PTT) and photodynamic (PDT) antibacterial therapy. The host-guest interactions between TEBox of TEBox-B 12 and EGCG on QCS-EC improves the water solubility and antibacterial efficiency of EGCG, facilitating Sol-Gel transition to form the injectable MQCEC-TEB Gel platform. This system synergistically integrates host-guest interaction, NIR-II PDT, and PTT to efficiently eradicate deep-tissue bacteria and promote wound healing, offering a novel multimodal strategy for early diagnosis, non-invasive monitoring and treatment of invasive infection wounds.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yumei Li,Xingjun Zhao,Linna Chang,Yanan Hu,Shibo Xu,Xiuli Ren,Xifan Mei,Zhenhua Chen
Antimicrobial hydrogels with NIR and enhanced mechanics benefit diabetic wound healing. • Au/MXene modifies gel network intermolecular interactions, regulating hydrogel mechanics. • NIR-triggered hyperthermia promotes wound healing via ROS/EGCG release. Biological hydrogels are ideal wound dressings due to their moisturizing, biocompatible, and drug delivery properties. Polyvinyl alcohol (PVA) and sodium alginate (Alg)-based injectable hydrogels show great potential in wound repair; however, simple hydrogels lack antimicrobial properties and cannot effectively prevent and control infections. Herein, Au@Ti 3 C 2 -E composites were obtained by anchoring gold nanoclusters on the surface of ultrathin Ti 3 C 2 nanosheets (1.5 nm) and modifying them by grafting epi gallocatechin gallate (EGCG). Under 808 nm laser irradiation, Au@Ti 3 C 2 -E@H exhibited good photothermal effects. Interestingly, elevated temperature can act as a “switch” that significantly enhances the Fenton-like catalytic activity of gold nanoclusters (3–5 nm) and promotes the release of EGCG grafted on the surface. The inhibition results showed that Au@Ti 3 C 2 -E@H achieved 94.5% and 93.0% kill rates of Methicillin-Resistant Staphylococcus Aureus (MRSA) and Ampr Escherichia coli ( E.coli ) through higher Reactive Oxygen Species (ROS) generation efficiency and disruption of bacterial biofilms. Molecular biology results showed that Au@Ti 3 C 2 -E@H significantly upregulated Vascular Endothelial Growth Factor (VEGF), Basic Fibroblast Growth Factor (bFGF), Epidermal Growth Factor (EGF) and Platelet Endothelial Cell Adhesion Molecule-1 (CD31) nearly threefold and downregulated Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), and Matrix Metalloproteinase-9 (MMP-9) nearly fourfold, which could promote angiogenesis and epithelial repair. After 21 days of the treatment cycle, the diabetic rats achieved a wound healing rate of 99.2%. Au@Ti 3 C 2 -E enhances the mechanical properties and antibacterial effects of hydrogels, synergizing photothermal and nanozyme activities to provide a promising solution for the repair of diabetic wounds infected with drug-resistant bacteria. Download: Download high-res image (168KB) Download: Download full-size image
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Materials Today Bio
·
2026
·
IF 11
Zhangwei Qiu,Danyan Wang,Zijun Jin,Jiaping Han,Xueli Wang,Xiaojun He,Liqin Wu
Managing pneumonia caused by multidrug-resistant (MDR) bacteria presents significant clinical challenges. The near-infrared II (NIR-II) laser irradiance exhibits strong photothermal conversion capabilities, making it a promising candidate for photothermal and chemodynamic therapies as non-antibiotic strategies. However, traditional methods are often hindered by issues such as the uncontrollable production of reactive oxygen species and the low efficiency associated with NIR-II photothermal therapy. This underscores the necessity for precisely regulated and highly effective synergistic therapies. To address these limitations, we have innovatively developed a defect/interface dual-engineered nanozyme (PtPb@SbO 3-x ) and comprehensively characterized its atomic-scale structure and catalytic mechanisms using density functional theory calculations and synchrotron radiation techniques. In vitro experiments demonstrated that PtPb@SbO 3-x could efficiently eliminate drug-resistant bacteria and disrupt biofilm structures under low-concentration hydrogen peroxide and NIR-II irradiation while exhibiting excellent biocompatibility. In pneumonia models, the nanozyme enabled rapid infection clearance and significantly reduced inflammatory responses via synergistic photothermal and chemodynamic therapy effects. Furthermore, integrated multi-omics analyses-including metabolomics, transcriptomics, and proteomics-systematically uncovered the molecular mechanisms driving its therapeutic efficacy. This study successfully establishes a non-antibiotic nanozyme-based therapeutic strategy that is efficient, low in toxicity, and non-invasive for treating MDR bacterial infections. It also provides a solid theoretical basis and technical framework for the rational design of defect/interface dual-engineered nanoplatforms.
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LANGMUIR
·
2025
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IF 3.9
Mi Liu,Weidan Zhao,Denghao Li,Dingyu Cui,Jiali Liu,Qingao Chen,Yan Zhou,Li Jiang,Huaibin Zhou
Infected wound healing remains a significant clinical challenge due to bacterial resistance and excessive inflammation. Herein, a multifunctional hydrogel dressing (Nb2C-Arg/Gel) is developed that integrates two-dimensional Nb2C nanosheets (photothermal agent) and arginine [nitric oxide (NO) donor] into a calcium ion cross-linked sodium alginate matrix. The hydrogel has a relatively high swelling capacity and good ability to scavenge reactive oxygen species (ROS), which are beneficial for absorbing wound exudate and reducing the inflammatory response of wounds. Under irradiation with a low-power NIR-II laser (1064 nm, 1 W cm–2), Nb2C-Arg/Gel achieves rapid photothermal heating (48.6 °C in 1 min), while thermally enhances arginine decomposition-triggered on-demand NO release. This synergistic mechanism provides superior antimicrobial efficacy against Staphylococcus aureus (97.65%) and methicillin-resistant S. aureus (90.05%). In vivo studies on MRSA-infected murine wounds demonstrate that the residual area on day 10 was 2.9%, which accelerated healing compared to that of the control group (17.8%), accompanied by reduced inflammation and enhanced angiogenesis. The excellent biocompatibility of hydrogel is validated by low hemolysis (<5%) and promoted fibroblast proliferation (125% cell viability). Combining with photothermal, NO-mediated antibacterial action, and ROS scavenging to alleviate oxidative stress, this antibiotic-free hydrogel dressing has great potential for clinical application for the treatment of refractory-infected wounds.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Yuhang Li,Wei He,Hanwen Zhang,Yue'e Li,Xiaomeng Li,Guokan Ge,Yawei Huang,De Ji
The accurate botanical origin identification of Chebulae Fructus (CF) is crucial for ensuring their quality and therapeutic efficacy. To address this, this study established, for the first time, a comprehensive quality assessment strategy integrating multiple modern analytical techniques. Initially, DNA barcoding was employed to verify the botanical source of the samples. Subsequently, electronic eyes (E-eye) and electronic noses (E-nose) were employed to objectively quantify and differentiate the colour characteristics and flavour profiles of the fruit. Untargeted metabolomic analysis identified 9037 metabolites, comprehensively revealing distinct chemical profiles between the two subspecies. Antioxidant activity assays indicate that Terminalia chebula Retz. demonstrates superior performance in both the ABTS and FRAP tests. To achieve rapid quality evaluation, machine learning models based on fourier transform near-infrared (FT-NIR) spectroscopy were developed. A classification model integrating linear discriminant analysis (LDA) achieved perfect discrimination between the two origins. Furthermore, partial least squares (PLS) regression models constructed using optimised spectral variables selected via algorithms such as competitive adaptive reweighted sampling (CARS) can accurately predict the content of five key active components and three antioxidant activity indices (R 2 c, R 2 p > 0.92). This approach provides an efficient and reliable analytical tool for the quality control of CF, meeting the industry's demand for rapid, on-site analysis.
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Advanced Optical Materials
·
2023
·Vol. 12
·期 10
·2302300
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IF 9
Xibao Zhang,Xiudi Wu,Yonghui Xu,Shuwen Yin,Chuansheng Zhong,Liang Zhou,Hongpeng You
For near-infrared (NIR) luminescent materials, it is a challenge to develop the next generation materials with high external quantum efficiency (EQE), low toxicity, and adjustable spectrum. The transition metal ion Fe 3+ can act as a good activator and emit NIR light in oxide host lattice, but there is limited research on this topic. Herein, authors have developed a series of Fe 3+ activated A 2 BSbO 6 :yFe 3+ (A = Ca, Sr, Ba; B = Sc, Y, Ga) phosphors with a double perovskite structure, which can efficiently convert the exciting light into NIR emission in the range of 750–1200 nm with a full-width half-maximum (FWHM) of 1372−1525 cm −1 . The NIR luminescence originates from the 4 T 1 (4G)→ 6 A 1 (6S) transition of the Fe 3+ ions situated in the octahedral sites. By employing crystal field engineering, the emission spectra peak can be adjusted within the range of 842–944 nm, and the excitation spectra can be tuned from 334 to 374 nm. These spectral adjustments enable a good match between the phosphors and commercially ultraviolet chips. When excited at 334 nm, the Sr 2 ScSbO 6 :0.1%Fe 3+ phosphor demonstrates a remarkably high EQE of 54.2% and high luminescent thermostability. These characteristics make it suitable for applications in NIR spectral detection.
研究领域:
材料科学
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光学材料
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固态化学
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发光学
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光子学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yu Chen,Danqi Li,Yaping Zhong,Zhentan Lu,Dong Wang
Developing a hydrogel dressing with excellent antibacterial efficacy for accelerating wound healing is high desirable in clinical applications. In this work, NIR regulated metal-organic framework composite hydrogel dressing was constructed for enhanced antibacterial efficacy and accelerated wound healing via the compounding between hydrogel and UCNPs@ZrMOF-Pt nanoparticles. The visible light emitted from upconvertion nanoparticles (UCNPs) activated porphyrin based metal-organic framework (MOF) in composite hydrogel to generate 1 O 2 for photodynamic antibacterial therapy under NIR laser irradiation. Moreover, the UCNPs@ZrMOF-Pt in composite hydrogel with catalase-like performance could effectively convert the high concentration H 2 O 2 in wound to abundant O 2 , which relieved the hypoxic in infected wound. Thus, the photodynamic antibacterial efficacy was remarkably enhanced, leading to accelerate the wound healing. This work presented a novel strategy for high efficient antibacterial therapy and accelerated wound healing.
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Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 17
·3657-3667
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IF 7
Lirong Wang,Ji Qi,Ke Zhang,Zeyan Zhuang,Keke Ding,Xu Chen,Hong Shan,Dan Ding,Anjun Qin,Ben Zhong Tang
Fluorescence and magnetic resonance imaging (FL/MRI) has received much attention due to their complementary characteristics. However, the simultaneous enhancement of fluorescence and MR signals plus the efficacy of the treatment is still a major challenge. To tackle this difficulty, we put forward a strategy of aggregation and de-aggregation based on luminogens with aggregation-induced emission (AIE) features. NIR II photosensitizer 4,4′-(6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(N,N-diphenylaniline) (TQ-TPA) with type I reactive oxygen species (ROS) generation ability and amphiphilic 2TPE-Gd were synthesized, and both of them showed the AIE feature. During the construction of nanomicelles, hydrophobic TQ-TPA spontaneously aggregated into the core of the nanomicelles formed by 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-methoxy(polyethylene glycol)-2000 (DSPE-PEG). Meanwhile, aggregates of 2TPE (tetraphenylethylene)-Gd in aqueous solution could be de-aggregated and inserted into the interface, and formed TGdTT nanomicelles (NMs). Based on this strategy and the AIE feature, the TGdTT NMs exhibited strong NIR II fluorescence and type I ROS generation ability, and enhanced T1 relaxivity (r1). Moreover, in vitro, in vivo, and pharmacokinetics results demonstrated that these nanomicelles have good biosafety and a long blood circulation time. Finally, they allowed successful realization of complementary MR/NIR II fluorescence dual-modal imaging-guided photodynamic therapy (PDT) to inhibit tumor growth. This work demonstrated that the aggregation and de-aggregation strategy of AIEgens in core–shell nanomicelles is very attractive for constructing multifunctional theranostic probes.
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Journal of Materials Chemistry B
·
2023
·
IF 7
Qi Long,Yuliang Yang,Fangling Liao,Haoting Chen,Dongyue He,Shengliang Li,Li Pengcheng,Weisheng Guo,Yafang Xiao
Photothermal immunotherapy has shown great potential for efficient cancer treatment. However, the immunosuppressive tumor microenvironment forms a heavy barrier for photothermal-induced anti-tumor immunity by inhibiting dendritic cells (DCs) maturation and cytotoxic T cell response. Moreover, the lack of reliable spatiotemporal imaging modalities makes photothermal immunotherapy difficult to guide tumor ablation and monitor the therapeutic outcomes in real time. Herein, we designed a theranostic thermosensitive liposome (PLDD) as a versatile nanoplatform to boost adaptive anti-tumor immunity of photothermal immunotherapy and achieve multiple bioimaging modalities in a real-time manner. The PLDD contains two major functional components: a multifunctional photothermal agent (DTTB) and an immune potentiator STING pathway agonist (DMXAA). Upon irradiation, the heat generated by DTTB induced the immunogenic cell death (ICD) of the tumor and dissociated the structure of thermosensitive liposome to release DMXAA, which ultimately activated the STING pathway and promoted the ICD-induced immune response by increasing DC cells maturation and T cell recruitment. Meanwhile, the DTTB in PLDD displayed excellent second near-infrared (NIR-II) fluorescence and photoacoustic (PA) dual-modal imaging, which provided omnibearing information on the tumor and guided the subsequent therapeutic operation. Therefore, this versatile PLDD with light-triggered promotion of anti-tumor immunity and multiple spatiotemporal imaging profiles holds great potential for the future development of cancer immunotherapy.
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NEW JOURNAL OF CHEMISTRY
·
2023
·
IF 3.3
Qingyuan Cheng,Liman Li,Mingxia Yu
Silver chalcogenide (Ag2X; X = S, Se, Te) quantum dots (QDs) have facilitated the biomedical applications of QDs due to their low toxicity and tunable emission reaching the second near-infrared window (NIR-II window, 1000–1700 nm). The photoluminescence intensity of Ag2S QDs and Ag2Se QDs is considerably enhanced via Pb doping. However, the developed Pb-doped Ag2S QDs lacked in vivo verification, and the toxicity of the Pb-doped Ag2X QDs was only preliminarily assessed. Although QDs containing Pb have been widely introduced into the field of biomedicine, there are still concerns regarding toxicity associated with Pb. In the present study, we prepared polyethylene glycol (PEG)-modified Pb-doped Ag2S QDs with better biocompatibility and tested their in vivo bioimaging and toxicity in comparison with Ag2S QDs modified with the same PEG under identical concentrations. Results indicated that the PEG-modified Pb-doped Ag2S QDs significantly enhanced the brightness of in vivo bioimaging and spatial resolution for vessels inside the tumor without increasing toxicity, assessed based on cell viability post incubation for 96 h, intracellular ROS level, DNA damage, early apoptosis and mitochondrial injury. Our study demonstrated that the PEG-modified Pb-doped Ag2S QDs could serve as an advanced fluorescent probe for various biomedical applications.
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