CHINESE JOURNAL OF CATALYSIS
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2026
·
IF 17.2
Run Pan,Abubakar Yusuf,Chengjun Wang,Jianrong Li,Zhiyu Xiao,Shuai Liu,Yidong Zhong,Yong Ren,Zheng Wang,Hainam Do,John L. Zhou,George Zheng Chen,Jun He
Natural gas vehicles (NGVs) offer significant environmental advantages by reducing pollutant emissions, but effective exhaust treatment remains a challenge due to high methane emissions and catalyst deactivation over time. This study introduces a core-shell Pd@CeO 2 /Al 2 O 3 three-way catalyst (TWC) designed to enhance the efficiency and durability of NGV exhaust treatment. The core-shell structure significantly improves catalytic performance. The optimized Pd@Ce/Al (S-500) catalyst demonstrates excellent low-temperature activity, with T 50 values of 336 °C for CH 4 and 397 °C for NO. It also achieves remarkable reductions of 113 and 177 °C in the T 90 for CH 4 and NO conversion, respectively, compared to the non-core-shell counterpart, Pd-Ce/Al (S-500). Characterizations reveal enhanced metal-support interactions, increased oxygen vacancies, and optimized Pd-CeO 2 interfaces as key active sites. Density functional theory calculations further demonstrate that the core-shell structure facilitates electron transfer at Pd-CeO 2 interfaces and lowers energy barriers for three-way reactions, enhancing catalytic efficiency. Notably, the core-shell Pd@Ce/Al (S-500) catalyst maintains high conversion efficiency for CH 4 and NO, with only slight losses (5.5% and 6.6%, respectively) over a 100-h time-on-stream stability test, following 16 h of harsh hydrothermal aging at 800 °C, showcasing its long-term stability. These findings provide a deeper understanding of the role of the core-shell Pd@CeO 2 structure in Pd-based TWCs and offer valuable insights for designing durable and efficient catalysts to meet the stringent emission standards of NGVs.
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ACS Sensors
·
2026
·
IF 10.9
He-Jie Wang,Hao-Nan Chen,Xuan-Yu Yang,Fei-Long Gong,Ke-Feng Xie,Shi-Zhong Wei,Yong-Hui Zhang
The development of highly sensitive and reliable hydrogen detection technology is a critical prerequisite for the safe and large-scale application of green hydrogen energy. Pd-based metal oxide semiconductor sensors exhibit decent sensing performance; however, their development for hydrogen detection is hindered by competitive adsorption of hydrogen and oxygen on the surface and sluggish reaction kinetics due to limited active interfaces. Here, a series of Pd nanoparticle-decorated, K+ interstitial doping WO3 nanosheets (PdNP-K/WO3-x) were synthesized. The optimized PdNP-K/WO3-15 sample exhibited exceptional H2 sensing performance, including a high response (Ra/Rg = 1235.94 to 50 ppm H2) at a low temperature of 130 °C, with fast response/recovery. This enhancement stems from synergistic effects where K+ interstitial doping increases electron density and oxygen vacancies in WO3, improving charge transfer and strengthening the W-O-Pd interface. The resulting electron-rich environment also shifts the d-band center of Pd, enhancing hydrogen desorption and spillover, while reducing competitive oxygen adsorption to free up more Pd active sites. The material also showed promising room-temperature sensing, indicating strong application potential and providing a theoretical basis for designing high-performance alkali metal ion-doped metal oxide materials.
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高影响因子
MOLECULAR THERAPY
·
2026
·
IF 11.4
Yang Yang,Jiannan Wang,Hong Yu,Zhen Quan,Zhujiao Zhang,Jingran Guo,Haoxuan Wu,Shanshan Liu,Xiaoqian Li,Xinxin Hu,Hongyan Zou,Mengyuan Zhu,Tianyi Wang,Zijian Zhou,Jiaying Liu,Jing Wang,Kai Wang,Lili Yang,Zhaoguo Han,Xilin Sun
The costimulatory receptor CD28 is indispensable for regulating T-cell effector function, and the absence of co-stimulation is associated with poor immunotherapy response. However, longitudinal molecular imaging studies targeting CD28 as a costimulatory biomarker using positron emission tomography (PET) have not been reported. Here, we developed the co-stimulation-associated radiotracer [ 89 Zr]Zr-DFO-anti-CD28 to enable early prediction of therapeutic response by identifying recovery of T-cell responsiveness following programmed cell death protein 1 (PD-1) blockade in lung cancer. [ 89 Zr]Zr-DFO-anti-CD28 demonstrated high specificity for CD28 + tumor-infiltrating lymphocytes (TILs) in vitro and in vivo. By monitoring CD28 expression and its loss within the tumor microenvironment, [ 89 Zr]Zr-DFO-anti-CD28 PET identified responses to anti-PD-1 therapy earlier than changes in tumor volume observed at day 5, and increased radiotracer uptake correlated with more favorable treatment responses. Repeated PET imaging was performed to monitor dynamic changes in CD28 + TILs induced by different immunotherapies at day 14, and [ 89 Zr]Zr-DFO-anti-CD28 PET captured the CD28-dependent restoration of T-cell effector function, further supporting its potential for early prediction. Taken together, costimulatory biomarker-specific CD28 PET molecular imaging may enable noninvasive early prediction of responses to multiple immunotherapies and facilitate the application of precision medicine in lung cancer.
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2015
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IF 6.409
Cui Ye,Min-Qiang Wang,Xia Zhong,Shihong Chen,Yaqin Chai,Ruo Yuan
One-dimensional Pd–Au nanowires (Pd–Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. Compared with single-component of Pd or Au, the bimetallic nanocomposite of Pd–Au NWs offers a larger surface area for the immobilization of enzyme, and displays superior electrocatalytic activity and efficient electron transport capacity. In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H 2 O 2 in situ , which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Such dual biomarkers method can achieve credible evaluation for AChE activity via providing AChE activity before and after reactivation. The liner range for AChE activity detection was from 0.025 U L −1 to 25 KU L −1 with a low detection limit down to 0.0083 U L −1 .
研究领域:
分析化学
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生物传感器
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纳米材料
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酶活性检测
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2018
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IF 6.434
Xiaolong Liu,Li Chen,Tingyu Zhu,Ruliang Ning
Catalytic oxidation of chlorobenzene over noble metal catalysts Pd/TiO 2 , Pt/TiO 2 , Ru/TiO 2 , and Rh/TiO 2 was evaluated, and Ru/TiO 2 contributed the highest catalytic activity and CO 2 selectivity. During the oxidation, polychlorinated benzenes PhCl x (x ≥ 2) were observed, and Ru/TiO 2 showed apparently lower PhCl x concentrations than other three samples. With the improvement of temperature, the maximum concentration appeared in the sequence of dichlorobenzene (PhCl 2 ), trichlorobenzene (PhCl 3 ), tetrachlorobenzene (PhCl 4 ), and pentchlorobenzene (PhCl 5 ), whereas the concentration of hexachlorobenzene (PhCl 6 ) was always low and showed no apparent regularity. Besides, the dioxin-like PCBs (dl-PCBs) were collected and analyzed for Pd/TiO 2 and Ru/TiO 2 . The ∑dl-PCBs produced by Pd/TiO 2 (0.0055 ng WHO-TEQ/Nm 3 ) was about 1.5 times that of Ru/TiO 2 (0.0027 ng WHO-TEQ/Nm 3 ). XPS analyses revealed that Ru/TiO 2 -used and Rh/TiO 2 -used gave the lowest and the highest Cl content of 0.61% and 1.87%. Ru/TiO 2 -used afforded the lowest (Cl ad +Cl or )/Cl value (22.1%) and the highest Cl br /Cl value (77.9%), which might be an important reason for its strongest chlorine removal ability and the lowest yields of polychlorinated by-products, whereas other three catalysts showed similarity in the Cl distributions. Additionally, systematic in-situ FTIR studies were conducted, and a reaction mechanism for the catalytic oxidation of chlorobenzene was proposed.
研究领域:
环境化学
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催化
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污染控制
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材料科学
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化学工程
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2026
·
IF 9.2
Zhenzhen Wang,Liujun Wang,Zhuoyan Wu,Huanyu Tian,Bing Lu,Ping Liu,Mingyang He,Junfeng Qian
Formic acid (FA), an essential industrial feedstock and promising liquid organic hydrogen carrier, is currently predominantly produced via fossil fuel-dependent routes. The hydrogenation of CO 2 to FA offers a sustainable alternative, but prevailing catalytic processes typically rely on non-recyclable alkali additives to overcome thermodynamic limitations, complicating product separation and generating waste. Herein, we report a novel amino-functionalized, hierarchical porous carbon-supported Pd catalyst (Pd/HPC-DETA, where DETA denotes diethylenetriamine) for the alkaline additive-free hydrogenation of CO 2 to FA. This design synergistically integrates a hierarchically porous architecture for efficient mass transfer, amine groups for in situ CO 2 activation, and highly dispersed Pd nanoparticles for H 2 dissociation. The catalyst achieves an apparent turnover number (TON) of 266 and an apparent turnover frequency (TOF) of 33 h −1 , comparable to conventional alkali-assisted systems while demonstrating robust stability. This is a state-of-the-art performance achieved by a heterogeneous catalyst without the use of basic additives under the similar conditions. This work provides a sustainable and scalable strategy for green FA production, paving the way for efficient carbon utilization.
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Analytical Methods
·
2022
·Vol. 14
·期 48
·5091-5099
·
IF 3.532
Yue Sun,Zihao Xie,Fubin Pei,Wei Hu,Shasha Feng,Qingli Hao,Bing Liu,Xihui Mu,Wu Lei,Zhaoyang Tong
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seriously threatened global public health. Establishing a rapid and sensitive diagnostic test for early detection of the SARS-CoV-2 nucleocapsid protein is urgently required to defend against the pandemic. Herein, an enhanced lateral flow immunoassay (LFIA) was fabricated by trimetallic Au@Pd@Pt core–shell nanozymes for detection of the SARS-CoV-2 nucleocapsid protein. The Au@Pd@Pt nanozymes (Au@Pd@Pt NZs) synthesized via a one-pot method, with a dendrite morphology and uniform particle size, showed excellent peroxidase-like activity. Due to the perfect enzyme-like catalytic activity toward 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2), the catalytic signal could be generated even by a tiny amount of Au@Pd@Pt NZs accumulated on the test strip. Therefore, rapid detection with higher sensitivity was achieved. The Au@Pd@Pt NZs-based LFIA provided a quantitative range of 0.05–100 ng mL−1 with a limit of detection of 0.037 ng mL−1, which was 17-fold lower than the LFIA without enhancement. The average recoveries from spiked samples were in the range of 92.5–107.9% with relative standard deviations all less than 4%, indicating the reliability and repeatability of the proposed LFIA. Additionally, the proposed LFIA could report results within 30 min using a microplate reader. In conclusion, the Au@Pd@Pt NZs-LFIA is a rapid, simple, and sensitive method for detecting the SARS-CoV-2 nucleocapsid protein.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Mengya Ma,Xiaobin Liu,Chaoqun Ma,Ruyue Guo,Xueling Zhang,Zhenzhong Zhang,Xueling Ren
Improved curative effects with reduced toxicity has always been the ultimate goal of gene delivery vectors for tumor immunotherapy. Panax notoginseng polysaccharide (PNP), a natural plant-derived macromolecule, not only has antitumor immune activity but also has the typical structural characteristics useful for gene delivery. In this work, positively charged polyethyleneimine (PEI) was directly grafted to the backbone of PNP to induced its charge reversal and generate a functional gene vector (PNP-PEI). Moreover, a short hairpin RNA targeting the programmed death-ligand 1 (PD-L1) was loaded into PNP-PEI to generate a potentially therapeutic nanoparticle (PNP-PEI/shPD-L1). In vitro and in vivo experiments demonstrated that PNP-PEI could efficiently carry the therapeutic shPD-L1 into tumor cells and that PNP-PEI/shPD-L1 could significantly inhibit the expression of PD-L1 and growth of B16-F10 cells. Noteworthily, treatment with PNP-PEI reversed the phenotype of macrophages from M2 to M1 subtype and promoted dendritic cell maturation, which encouraged the host immunity and enhanced the therapeutic antitumor effects. In summary, this study describes a PNP-based gene delivery vector and highlights the beneficial immunopotentiating therapeutic outcomes of PNP-PEI for tumor immunotherapy.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
·
IF 7.139
Zuqin Duan,Qian Lei,Wenhui Wu,Honglin Chen
Hydrogen release from formic acid is a significant energy supply route. However, the current catalysts suffer from low catalytic efficiency and stability. Herein, a porous N-doped carbon material with high N content (16.87%) and a large surface area (1544 m 2 ·g −1 ) were designed using a 2-dimensional metal-organic framework and etching agent potassium chloride . Due to its high N content and large surface area, ultrafine Pd particles are uniformly distributed on the porous N-doped carbon support, which effectively enhances excellent reactivity and enables a TOF value of 2365 h −1 under additive-free conditions. The research also revealed that the strong interaction between Pd particles and pyridinic-N species can significantly slow metal agglomeration. Hence, the Pd/NC ZIF-L (KCl) displayed good activity even after 10 cycling experiments, and it is a particularly competitive catalyst for hydrogen release from formic acid.
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BIOMATERIALS
·
2022
·
IF 15.304
Yan Gao,Zilin Song,Li Jia,Yi Tang,Chengcheng Wang,Xiuli Zhao,Haiyang Hu,Dawei Chen,Mingxi Qiao
Despite the important role of reactive oxygen species (ROS) in battling cancer, ROS production with current approaches has been severely limited by the deficiency of oxy-substrates in tumor microenvironment . Herein, an atorvastatin (Ato)-catalytic self-amplified approach was utilized for sustainable ROS production and enhancing anti-tumor efficacy of PD-L1 silencing. A C 18 -pArg 8 -ss-pHis 10 lipopeptide based self-assembled nanoplexes was developed to co-encapsulate AMP-activated protein kinase (AMPK) activator of Ato and PD-L1 siRNA. Efficient delivery of payloads was achieved because of the acidic pH triggered the protonation of pHis 10 , disulfide-bond exposure for cleavage and subsequent cytosolic translocation. Ato was found to activate AMPK, boosting the highly restrained mitochondrial fatty acid oxidation (FAO) in cancer cells for ROS production. The ROS derived from FAO further activated AMPK, creating a positive-feedback mechanism of sustainable ROS production. The self-amplified ROS production from cellular mitochondrial FAO was maintained by the sufficient intracellular fatty acid substrates arising from the dysregulated lipid metabolism and Ato inhibited triglyceride synthesis in cancer cells. The excessive ROS level was found to successfully induce immunogenic cell death effect, boosting the anti-tumor efficacy of PD-L1 silencing. Overall, the Ato catalyzed self-amplified ROS production has been demonstrated as a promising alternative for cancer therapy.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 11
·15337-15346
·
IF 5.19
Yang Zhen-xing,Shang Jie,Yan Guang-xu,Wang Yu-xian,Guo Shao-hui
In this paper, Pd-Sn modified Ru-Ir electrode was prepared by thermal oxidation method, and the effects of doping amount of Pd-Sn and synthesis conditions on Pd-Sn modified Ru-Ir electrode performance were studied. Linear sweep voltammetry(LSV), cyclic voltammetry(CV), and the Tafel curve were used to study the electrochemical performance of the Pd-Sn modified Ru-Ir electrode materials. The effects of the doping amount of Pd-Sn on the microstructure and valence states of Pd-Sn modified Ru-Ir electrode materials were investigated by SEM, TEM, XRD, and XPS. When the mass of Pd-Sn accounted for 1.5% of the total mass of the elements, the molar ratio of Ru-Ir was 2:1, and the molar ratio of Pd-Sn was 3:1; the LSV, CV, and the Tafel curves indicated that Pd-Sn modified Ru-Ir electrode had the lowest chlorine evolution potential (1.0640 V vs. SCE), the best CV curve coincidence, and the smallest corrosion current density (6.5 × 10 −4 A/cm 2 ), showing the best chlorine evolution performance, the best durability, and corrosion resistance; the characterization of SEM, TEM, XRD, and XPS showed that Pd-Sn was successfully doped into Ru-Ir electrode materials; the crystallinity of Pd-Sn modified Ru-Ir electrode was the highest, and the binding energy was the lowest, but the crystal form of Ru-Ir solid solution did not have changed. The optimal synthesis conditions of Pd-Sn modified Ru-Ir electrode material were as follows: Pd-Sn molar ratio was 3:1, calcination temperature was 500 ℃, calcination time was 4 h, and water was used as solvent. Pd-Sn modified Ru-Ir electrode can efficiently treat high chlorine ammonia–nitrogen wastewater, when the reaction volume was 200 mL, the initial concentration of NH 3 -N was 100 mg/L, the concentration of chloride ion was 5000 mg/L, the current was 0.75 A, and the reaction time was 40 min; the removal rate of ammonia nitrogen can reach 100%. Responsible editor: Weiming Zhang.
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FUEL
·
2022
·
IF 8.035
Xing Gao,Yingying Ding,Lilin Peng,Dan Yang,Xiaoyue Wan,Chunmei Zhou,Wen Liu,Yihu Dai,Yanhui Yang
Aqueous phase hydrogenative rearrangement of furfural (FAL) to cyclopentanone (CPO) via furfuryl alcohol (FOL) has been studied over Pd catalysts supported on H–ZSM–5 zeolites. Pd states, zeolite properties and reaction condition parameters were optimized, affording 98% selectivity and 120 h −1 specific reaction rate over 2% Pd/H–ZSM–5(25) catalyst at 160 °C and 3 MPa H 2 . For hydrogenation of FAL–to–FOL, the activity was related to the Si/Al ratio and acid property of zeolite supports. For hydrogenative rearrangement of FOL–to–CPO, pure H–ZSM–5 zeolite could catalyze single–step conversion with relatively low reaction rate, whereas the presence of Pd sites could achieve multi–step transformation with remarkably increased rate, highlighting Pd–zeolite acid sites synergy. Proton and furanylmethoxy–relevant intermediates were captured with spin trapping electron paramagnetic resonance experiments, and 4–hydroxy–2–cyclopentenone and 2–cyclopentenone were also identified as key intermediates in tandem reaction pathway to produce CPO.
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危险品化学品经营许可证（带存储）