Analytical Methods
·
2024
·
IF 2.7
Kang Shen,Caili Bi,Haifan Yang,Miaowen Xu,Lili Huang,Youwei Wang
Based on the coordination principle of Lewis acid, the 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorods (4-MPBA@DS Au-AgNRs) substrate has been developed, which could be combined with the surface-enhanced Raman scattering (SERS) technique to detect SO42- with high sensitivity and specificity. DS Au-AgNRs synthesized in this paper with dumbbell particular structure have been verified by finite-difference time domain (FDTD) simulation to be capable of stimulating strong localized electromagnetic enhancement (EM) at nano-edge, gap, generating a large number of “hot spots” exhibiting excellent SERS performance. The 4-MPBA modified on its surface could specifically recognize SO42-, producing a change in the spectral peak at 1382 cm-1, thus realizing highly sensitive and specific sensing of SO42-. Under optimized conditions, this SERS sensor responded rapidly to SO42- within 2 minutes and demonstrated uncommon immunity. Ratio calculation by the ratio of the characteristic peaks at 1382 and 1070 cm-1 (I1382/I1070) enabled quantitative detection of SO42- in the range of 1 × 10-8-1 × 10-3 M, and the detection threshold was as low as 1 nM, which was superior to that of similar detection methods. Importantly, the utility and reliability of this SERS substrate for the determination of SO42- in actual samples were evaluated using ion chromatography as the gold standard, and there was no significant difference between the two protocols (P > 0.05), and the RSD was less than 6% with a satisfactory recovery rate (97.6-102.3%). Therefore, the present protocol has the advantages of simplicity and rapidity, high sensitivity, specificity, stability, and practicability in the determination of SO42- in aqueous solution, providing a reliable solution for tracing SO42- in the field of food safety and environmental testing.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Jiaxin Liu,Jia Zheng,Yunshu Lu,Zhongmin Feng,Siqi Zhang,Ting Sun
17β-E 2 is used in animal growth regulation and agricultural fertilizer, and even ng L −1 mass concentration levels can show biological effects. In this work, Ag NPs was used as surface-enhanced Raman spectroscopy (SERS) source and WS 2 was synthesized by a simple method to provide a uniform distribution platform for Ag NPs. The MIP was the shell, which can selectively enrich the target molecule, pull the distance between the target molecule and SERS source, and protect Ag NPs. A cyclable SERS substrate with high sensitivity for detecting 17β-E 2 in food was constructed. The optimized WS 2 /Ag@MIP as SERS substrate has the advantages of high Enhanced Factor (EF = 2.78 × 10 9 ), low detection limit (LOD = 0. 0958 pM), strong anti-interference ability, and good recycling performance. Moreover, the detection of 17β-E 2 in real samples still has good accuracy. This work provides a new possibility for the trace detection of 17β-E 2 in food.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Shengmao Chao,Xueqing Wang,Fan Li,Hong Shao,Changyu Tang,Meikun Fan
Phthalate esters (PAEs), prevalent plasticizers used extensively in packaging materials, pose significant environmental and health risks. Addressing the challenge of their trace detection, we introduce a dual-functional superhydrophobic sponge (Ag NPs@rGO/PU) that seamlessly integrates sample enrichment and ultrasensitive surface-enhanced Raman scattering (SERS) analysis. This platform (Ag NPs@rGO/PU) combines superhydrophobicity, strong adsorption capacity, and high SERS sensitivity for rapid quantification of trace PAEs in plastic bottled water. The composite was fabricated by photochemical reduction of Ag NPs@GO anchored on polyurethane (PU) foam, enabling efficient reduction of GO and formation of densely distributed plasmonic hotspots. The resulting material exhibited excellent superhydrophobicity (>150°), rapid adsorption kinetics (<80 s), and robust cyclic adsorption capability (>100 cycles). Furthermore, combining SERS with principal component analysis (PCA) enables accurate classification and quantitative analysis of six structurally similar PAEs even in complex mixtures with ultralow detection limits down to 1 × 10–10 M and linear response (R2 ≥ 0.98). Practical applicability was demonstrated by successfully identifying and quantifying trace PAEs in commercial bottled water, uncovering significant migration under high-temperature storage conditions. This platform not only advances the analytical performance for trace contaminant detection but also offers a versatile tool with substantial implications for environmental safety monitoring and protection of public health.
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Food Analytical Methods
·
2024
·Vol. 17
·期 4
·585-593
·
IF 2.6
Wang Haoyu,Zhang Li,Chen Chen,Waterhouse Geoffrey I. N.,Sun Yufeng,Xu Zhixiang
In this study, a sensitive surface-enhanced Raman scattering (SERS) sensor based on core–shell-structured Au@Ag nanoparticles (NPs) was successfully developed for the detection of acrylamide (AA) in foods. Coating Au NPs with a shell of silver gave the Au@Ag NPs outstanding SERS performance for AA detection. Under the optimal experimental conditions, a good linear relationship was established SERS intensity at 1272 cm −1 and the logarithm of the AA concentration (over the concentration range 10 −8 ‒10 −3 mol L −1 ). The limit of detection (LOD) of the SERS method was 1.27 × 10 −9 mol L −1 . The recoveries of AA in spiked cookie samples were in the range of 85.68–102.50%. In addition, the SERS sensor was used to determine the content of AA in three food samples (potato chips, fried dough twist, and instant coffee), with the results obtained being consistent with those determined by high-performance liquid chromatography (HPLC), demonstrating that the SERS sensor was suitable for the detection of AA in real food samples.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2020
·Vol. 25
·期 2
·683-688
·
IF 2.646
Yu Qizhi,Kong Xiangfa,Chen Chaoshu,Kang Caiyan,Meng Mianwu,Huang Siyu
An Ag nanoparticles (NPs) layer was synthesized on Ag sheet by alloying/electrochemical dealloying method: X-ray diffraction confirmed that the new Ag phase appeared after removing Ga from Ag-Ga alloy, and scanning electron microscopy examination showed that the prepared Ag layer had a NPS structure. The fine microstructure of silver resulted in significant SERS enhancement effect, while the NPs layer was used as the SERS substrate: when the prepared NPs layer was used as a SERS substrate to detect p-phenylenediamine (PPD), it exhibited a strong SERS peak at 1590 cm −1 . The result revealed that the intensity of SERS peaks was linear to the logarithm of PPD concentration in the range from 10 −16 mol L −1 to 10 −12 mol L −1 and the detection limit was 1.0 × 10 −17 mol L −1 .
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2018
·
IF 2.88
Anxin Jiao,Xuejian Dong,Hua Zhang,Linlin Xu,Yue Tian,Xiangdong Liu,Ming Chen
Ultrasensitive detection of pesticide residues on agricultural products using surface-enhanced Raman spectroscopy (SERS) is of significant interest in food security. Herein, worm-like AuAg nanochains with highly interconnected ultrafine (~6.2 nm) bimetallic particles were developed as an excellent SERS nanosensor via laser-assisted strategy. The SERS detection limit of thiram molecules on apple surfaces is about 10 −7 M (0.03 ppm), which is about 200 times lower than the maximal residue limit (MRL, 7 ppm) in fruit prescribed by the U.S. Environmental Protection Agency (EPA). Importantly, the established excellent linear relationships between the SERS intensities and thiram concentrations can sensitively monitor the slight variation of pesticide residues in agriculture.
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Photonics and Nanostructures-Fundamentals and Applications
·
2026
·
IF 3.5
Litong Dong,Xuanyi Dong,Yue Wang,Mengnan Liu,Wenmin Zhang,Lu Wang,Dayou Li,Wilhelm Pfleging,Zuobin Wang
LIL enables straightforward, low-cost fabrication of large-area SERS chips. • Periodic nano-stripe Ag/SiO 2 /Au structures strengthen local electromagnetic fields. • SERS substrate with periodic stripe MIM structures achieves an EF exceeding 10 10 . • Integrating MIM substrates with microfluidics enables real-time, in situ detection. Large-area, low-cost, good-reliability, and high-sensitivity surface-enhanced Raman scattering (SERS) substrate is a prerequisite for such devices to enter the market. In this work, we present a SERS substrate consisting of a vertical metal-insulator-metal (MIM) nano-stripe pattern fabricated by laser interference lithography (LIL). The proposed SERS substrate exhibits high sensitivity, reproducibility, and stability, with the characteristic Raman signals of rhodamine 6 G (R6G) experimentally detected at concentrations down to 10 -8 M and an enhancement factor (EF) exceeding 10 10 . Furthermore, by integrating the SERS substrate with a microfluidic chip enabled the construction of a real-time, in situ and non-destructive detection device, whose SERS performance was validated via Raman spectra tests of melamine and malachite green. Overall, this work comes up with an efficient strategy for fabricating sensitive and reproducible SERS substrates that hold considerable promise for advancing biochemical sensors equipped with SERS functionality.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2015
·Vol. 17
·期 33
·21261-21267
·
IF 4.493
Guannan Zhang,Junrong Li,Aiguo Shen,Jiming Hu
Anisotropic metallic nanoparticles (NPs) possess unique optical properties, which lend them to applications such as surface-enhanced Raman scattering (SERS). However, their preparation by an efficient, biocompatible and high yield synthetic method is still challenging. In this work, we demonstrate a simple and reproducible way to produce chitosan (CS) encapsulated gold–silver nanoflowers by sequentially adding chitosan, chloroauric acid, silver nitrate, and ascorbic acid to water at room temperature. This is a one-pot, seed- and surfactant-free synthetic method, which is simple and credible. CS is used to modulate the size of NPs, while AgNO3 is introduced to improve the monodispersity and homogeneity of NPs. Highly sensitive, spectrally and physically stable SERS tags are developed in virtue of the cooperative effect of CS and Ag+. Cresyl violet (CV) is applied as a Raman reporter to test the SERS property of NPs, and the results demonstrated that the nanoflowers exhibited stronger and more stable SERS signals than those of spherical gold nanoparticles. Importantly, after being modified by tumor cell-specific targeting ligands (folic acid), the sensitive and stable labeled nanoflowers are applied for cancer cell targeting and SERS imaging.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·561
·
IF 5.4
Wang Xiaoxi,Wang Haitong,Feng Bin,Liu Yu,Zhao Xinyuan,Chen Wenwen,Wei Haiyan,Zhang Wei,Wang Mengjie,Liu Chuanxi,Shang Ming,Wang Cuijuan
We developed an on-site surface-enhanced Raman scattering (SERS) sensor for rapid detection of difenoconazole (DIF) and flusilazole (FLU) in environmental water. The substrate combines gold nanostars (AuNSs) with covalent organic frameworks (COF) and is implemented on a portable round 20-well quartz plate, enabling in situ testing. After a simple filtration process, environmental water can be directly dripped onto the SERS-active AuNSs/COF composite, thereby simultaneously achieving the adsorption of the target compound and SERS detection. There is a good linear relationship between the SERS intensity of the characteristic peak and the logarithmic concentration of the analyte, with correlation coefficients (R 2 ) from 0.923 to 0.986, meeting the monitoring needs of non-laboratory scenarios. The entire workflow completes within 9 min, offering a faster alternative to conventional methods while maintaining high sensitivity and reproducibility. Detection limits reach 0.88–1.17 ppb for DIF and FLU. Distinct SERS fingerprints enable reliable discrimination of mixed pesticides across environmental water, supporting rapid on-site monitoring and cost-effective pesticide surveillance. Graphical
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Boran Zhang,Qinyi Li,Yun Qin,Li Zhang,Ranran Zhou,Xinling Liu,Yiping Wu,Ying Wen,Haifeng Yang,Xiaoyu Guo
Surface-enhanced Raman scattering (SERS) based on semiconductor substrates offers advantages of low cost and high stability over noble metals, but its practical application is hindered by intrinsically weak signal enhancement. Herein, we report a simple molecular engineering strategy to dramatically boost the SERS performance of TiO2 microspheres through phytic acid (PA) modification. The PA molecules anchor onto TiO2 surfaces via Ti–O–P bonds, forming PA/TiO2 composites in a single-step postsynthesis process. The optimized PA/TiO2 substrate achieves an enhancement factor (EF) of 1.2 × 107─comparable to typical noble metal substrates─and enables detection of the probe molecule 4-mercaptobenzoic acid at concentrations as low as 1 × 10–9 mol/L. Comprehensive mechanistic investigation reveals a synergistic effect: (i) PA-induced coffee-ring aggregation for analyte enrichment, (ii) Mie resonance from the TiO2 microspheres (∼253 nm) for electromagnetic field enhancement, and (iii) charge transfer (CT) resonance at the PA/TiO2 interface for additional chemical contribution, supported by density functional theory calculations and finite-difference time-domain simulations. Leveraging this high-performance platform, we construct an SERS sensor for the endocrine disruptor bisphenol A (BPA), a common contaminant in thermal paper products. The sensor exhibits excellent analytical performance: a limit of detection (LOD) of 4.7 × 10–7 mol/L, a wide linear range from 5.0 × 10–6 to 1.0 × 10–3 mol/L (R2 = 0.9971), and satisfactory spike-recovery results (97.8–103.0%) in real thermal paper samples. This work demonstrates that molecular-level surface engineering offers a scalable and cost-effective route to high-performance semiconductor SERS substrates for environmental monitoring applications.
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ACS Omega
·
2026
·
IF 5.2
You Bian,Binbin Zeng,Kun Huang,Jingwen Zhu,Tong Yang,Yuxuan Wu,Jianing Zhu,Jialu Li,Zhong Zhao
Liver fibrosis represents the earliest and most critical pathological stage in the progression of various liver diseases. Its accurate detection is paramount for preventing transformation into cirrhosis and hepatocellular carcinoma. Here, we report an aptamer-driven nanozyme-catalyzed surface-enhanced Raman scattering (SERS) dual-functionality sensor. By integrating magnetic enrichment and separation effects, we achieve multiple signal amplification, enabling the ultrasensitive detection of fibrosis-associated miR-34a. In this study, we synthesized gold–platinum nanoparticles (Au@Pt NPs) exhibiting high peroxidase activity and intrinsic surface-enhanced Raman scattering (SERS) properties. These were surface-modified with the complementary strand (H1) of an aptamer to serve as nanozyme probes. Fe3O4 modified with an aptamer (cDNA) was employed as the capture substrate. The assembly and dissociation of Au@Pt NPs with Fe3O4 are driven by the competitive binding of the target and H1 to the cDNA. The degree of aggregation of Au@Pt NPs on Fe3O4 directly enhances the catalytic oxidation of oxTMB. Moreover, the synergistic interaction between the local surface plasmon resonance effect of nanozyme probes and capture substrates with external magnetic enrichment achieves exponential amplification of oxTMB signals. Based on this strategy, the dual-functional sensor demonstrates robust detection performance, with a limit of detection (LOD) as low as 0.27 fM and a detection time of merely 12 min. Moreover, this nanozyme-SERS dual-functional sensor exhibits strong specificity and resistance to interference, with detection results demonstrating high concordance with qRT-PCR. This research provides a robust method for detecting serum miRNAs in liver fibrosis and paves new pathways for the clinical translation of the SERS-nanozyme combined technology.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Xiaoyu Zhang,Zhi Yang,Mingyue Li,Min Li,Chengju Guo,Muhammad Saleem,Muhammad Zahid,Jianbao Liu,Shuai Qiu,Mei Liu
The application of surface-enhanced Raman spectroscopy (SERS) into gas sensing, particularly for breath-based diagnostics, is hindered by the challenge of simultaneously achieving high sensitivity, selectivity, and stability. This work introduces a synergistic enhancementarchitecture based on porous molybdenum oxide (MoO x ) nanobowl arrays to overcome this trilemma. This architecture is designed to couple electromagnetic field enhancement, efficient gas adsorption/concentration, and specific molecular recognition within a single unit cell. Finite element simulations confirm that the concave geometry creates densely packed electromagnetic hotspots, while the mesoporous structure induces gas vortices that prolong analyte residence time precisely within these enhancement zones. Functionalized with 4-aminothiophenol (4-ATP), the substrate achieves a detection limit of 0.95 ppb for 4-ethylbenzaldehyde (EBA), maintains high selectivity in complex simulated breath matrices, and exhibits remarkable long-term stability. This study proposes a potential design principle for next-generation, non-metal SERS platforms, supporting their potential in non-invasive early disease diagnosis.
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