ELECTROANALYSIS
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2026
·Vol. 38
·期 7
·e70190
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IF 2.6
Hao Liang,Xuening Jin,Hebing Pei,Zunli Mo
The enantioselective recognition of biomolecules such as amino acids has significant value in medicine, life sciences, agriculture, and other fields. In this study, a novel electrochemical chiral sensor, CS@Cu-β-CD/GCE, was successfully prepared by self-assembling Cu 2+ modified β-cyclodextrin (β-CD) with chitosan (CS) and coating it onto a glassy carbon electrode (GCE). This method effectively addresses the agglomeration issues associated with CS while significantly enhancing the conductive properties of the material and increasing the number of chiral recognition sites. Experimental testing and structural analysis revealed that differentiated hydrogen bonding provides the driving force for molecular binding, while the confinement of the Cu-β-CD cavity and steric hindrance enable structure selection. At optimized testing conditions (30 s incubation, 25°C, pH = 6.0, 5.0 mM), it exhibited the peak current ratio (I D /I L ) of up to 2.25 for phenylalanine (Phe) isomers, outperforming most previously reported electrochemical sensors. Meanwhile, the CS@Cu-β-CD/GCE exhibits excellent stability (98.6% signal retention after 16 days of storage at 5°C), high enantiomeric selectivity for Phe, and good resistance to interference, can be developed for distinguishing racemic phenylalanine. This strategy provides a simple and efficient approach for electrochemical chiral identification of Phe enantiomers and holds wide-ranging application prospects in chiral sensing and drug analysis.
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高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2026
·
IF 5.1
Jun Liu,Qiao Zhou,Xueming Shi,Shuying Hu,Fang Zhou,Shuangshuang Ren,Changao Xue,Leiying Miao
A soft-chitosan interface was developed for composite flexible electrodes. • The interface bridged SEBS and PEDOT:PSS through multiple interactions. • The fabricated electrode remained stable under extreme and cyclic tensile strain. Flexible conductive electrodes used for wearable electrophysiological sensing are frequently limited by interfacial instability arising from insufficient intercomponent interaction and elastic mismatch under repeated mechanical deformation. In this study, a soft-chitosan interfacial system was introduced into styrene-ethylene-butylene-styrene (SEBS)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) composite electrodes to enhance structural integrity and electrical stability during tensile loading. Glycerol and Tween 80 were employed to maintain chitosan chains in a soft and deformable state, allowing the interfacial layer to penetrate the porous SEBS substrate through capillary action and form rivet-like anchoring structures. Simultaneously, hydrogen bonding and electrostatic attraction between the interfacial layer and the PEDOT conductive layer established effective interfacial coupling. Benefiting from this cooperative interface design, the resulting composite electrode exhibited stable conductivity retention under large tensile strain and cyclic stretching conditions. In addition, the electrode enabled reliable electromyographic (EMG) signal monitoring of the forearm and masseter muscles with stable waveform acquisition during motion. These results demonstrate the potential of the developed electrode for wearable electrophysiological sensing applications. This work provides an interfacial engineering strategy for stretchable conductive electrodes requiring stable electrical performance under mechanical deformation. Download: Download high-res image (296KB) Download: Download full-size image
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Yueru Fang,Lan Zhang,Kuok Ho Daniel Tang,Ronghua Li
3D macroporous chitosan-bentonite foam composite was fabricated via ice-templating. • Bisphenol capture is governed by hydrogen bonding and polar interactions. • BPS preferentially engages –NH sites via its –SO 2 – group revealed by FTIR. • Efficient bisphenol removal was achieved across diverse real water matrices. • Preliminary capture of heavy metals and microplastics was also demonstrated. Bisphenols (BPA, BPF and BPS) are emerging contaminants with well-documented endocrine-disrupting effects, and their environmental occurrence often coincides with heavy metals and microplastics. In this study, a three-dimensional chitosan/bentonite composite foam (CBF) was fabricated via directional ice-templating and systematically evaluated as a recoverable adsorbent for bisphenols. The CBF exhibited stable adsorption performance, with kinetics following the pseudo-second-order model and isotherms well described by the Langmuir model, achieving moderate maximum capacities of 13.69 to 16.27 mg/g under a monolithic, manually recoverable design. High removal efficiencies were maintained over a wide pH range (2.0–10.0) and under varying ionic strength conditions. Spectroscopic and thermodynamic analyses indicate that bisphenol adsorption is governed by hydrogen bonding, polar interactions, and pore confinement effects, with selectivity among analogues modulated by their analogue-specific interaction pathways with the functional groups of CBF. The positive enthalpy change and increasingly negative Gibbs free energy further support a spontaneous and endothermic adsorption process. Preliminary tests further indicated that the macroporous framework was capable of capturing heavy metal ions (Pb(II), Cd(II)) and physically entrapping representative microplastics (PLA, PS, PE), suggesting potential applicability beyond bisphenols. Within its intended design scope of prioritizing operational simplicity over maximum capacity, CBF offers a monolithic platform with facile manual separation and minimal secondary turbidity. This combination of low-cost raw materials, monolithic recoverability, and multi-class pollutant applicability distinguishes CBF from conventional powdered adsorbents and is relevant to the practical treatment of bisphenol contaminated water under complex matrix conditions. Download: Download high-res image (83KB) Download: Download full-size image
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PubMed
高影响因子
Bioengineering-Basel
·
2026
·Vol. 13
·期 7
·792
·
IF 4.4
Xiaohui Zhang,Gaopeng Wang,Shuwen Ding,Chenyang Luo,Jing Wang
Diabetic oral mucosal wounds exhibit impaired healing and require biomaterials with strong wet adhesion, favorable biocompatibility, and adequate mechanical stability. In this study, an in situ photocurable adhesive hydrogel (ATDS) based on sulfonated chitosan was developed for diabetic oral mucosal wound repair. ATDS exhibited a tensile strength of 50 kPa, an elongation at break of 320%, and an adhesive strength of 0.605 MPa, while also displaying a porous microstructure without obvious cytotoxicity. Compared with hyaluronic acid (HA) gel, which was completely lost by day 3, ATDS provided more durable wound coverage in the oral environment. In a diabetic rat model of oral mucosal defect, ATDS significantly accelerated wound closure, with wounds nearly completely healed by day 6, promoted re-epithelialization as early as day 3, and increased epidermis thickness by approximately 50% compared with the control group. In addition, ATDS enhanced angiogenesis and reduced the expression of the inflammatory cytokines TNF-α and IL-1β. Collectively, these findings demonstrate that ATDS effectively promotes diabetic oral mucosal wound healing through its barrier-protective, pro-angiogenic, and anti-inflammatory effects, highlighting its potential as a promising biomaterial for oral tissue engineering and regenerative applications.
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高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Yang Yu,Liuchun Zheng,Bing Wang,Guangmou Cao,Xue Ding,Youzhi Ming,Jing Wang
Chitosan cryogels, characterized by highly porous and lightweight architectures, offer the advantages of renewability and excellent biocompatibility, but their inherent brittleness, poor moisture resistance, and limited thermal stability severely restrict practical applications. Herein, a “silicon armor” strategy was developed by employing hyperbranched epoxy silicone resin (HESR) as a chemical bridge to construct a covalently bonded silicon-containing hybrid shell on the chitosan framework through epoxy-amine ring-opening reactions. Benefiting from the abundant reactive epoxy groups, the hybrid shell further enabled the multiscale integration of functional components. An inner-outer dual‑phosphorus flame-retardant architecture was established by incorporating melamine polyphosphate (MPP) and diethyl phosphoramidate (DEPA), while the Si-O-Si network simultaneously contributed to structural reinforcement and thermal stability. In addition, polyetheramine flexible segments introduced entropy elasticity into the hybrid network, effectively alleviating the intrinsic brittleness of the rigid silicon framework and improving its deformation recovery capability. Subsequent hydrophobic modification further reduced the surface energy and significantly enhanced the moisture resistance and environmental stability of the cryogel. As a result, the obtained CS-Si cryogel integrates efficient flame retardancy, excellent elasticity, mechanical robustness, thermal insulation, and hydrophobic protection into a single biomass-derived system, providing a simple, efficient, and versatile strategy for the design of multifunctional sustainable cryogel materials.
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Biomimetics
·
2026
·Vol. 11
·期 9
·639
·
IF 4.2
Lei Nie,Yingying Liang,Yiran Lin,Wei Guo
Rapid hemostasis, oxidative stress resistance, and minimally invasive administration are crucial performance requirements for high-performance wound covering. Inspired by the dynamic remodeling properties of the native extracellular matrix, we fabricated a multifunctional injectable hydrogel through dynamic Schiff-base crosslinking between oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS), combined with magnesium ion (Mg2+) coordination. The effects of Mg2+content on hydrogel properties were systematically investigated. The hydrogels gelled rapidly under physiological conditions and showed good injectability, self-healing behavior, and favorable adhesion to moist tissues. Notably, Mg2+incorporation significantly enhanced hemostatic performance in a mouse tail amputation model, reducing blood loss from 391.7 mg to approximately 75 mg and shortening hemostasis time from 151.7 s to 50.3 s. The 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging efficiency reached approximately 80%, and the hydrogel effectively scavenged intracellular reactive oxygen species (ROS) without compromising cytocompatibility or fibroblast activity. This study presents a biomimetic and easily prepared hydrogel platform that integrates pro-coagulant activity, redox regulation, and on-demand injectability, showing translational potential as bioactive wound covering for bleeding control and oxidative microenvironment regulation.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
·
IF 5.2
Chao Hao,Keke Xie,Jie He,Guangrui Liu,Anqi Zhu,Xiao Han,Yimeng Yang,Linshan Fan,Guisen Zhang,Jian Zhang
A long-acting Taphalgin-loaded thermoresponsive chitosan hydrogel (TAP-CS/β-GP) depot was developed. • TAP-CS/β-GP rapidly undergoes sol-gel transition within 3 min at 37 °C. • TAP-CS/β-GP showed a first-order release profile with 72 h cumulative release ratio of 93.96%. • TAP-CS/β-GP extended the analgesic duration by 36-fold compared to free TAP. • Subcutaneous TAP-CS/β-GP depot showed a degradation ratio of > 85% within 14 days. The clinical application of Taphalgin (TAP), a tetrapeptide analgesic targeting μ 1 -opioid receptor, was greatly limited owing to fast systemic clearance. In this study, a TAP-loaded in situ injectable thermoresponsive chitosan (CS) hydrogel via β-glycerophosphate (β-GP) crosslinking (TAP-CS/β-GP) was prepared for long-term postoperative analgesia management. The porous microstructure of TAP-CS/β-GP was characterized by scanning electron microscopy (SEM). Rheological analysis further revealed that TAP-CS/β-GP precursor solution showed favorable injectability and shear-thinning behavior, which rapidly approached the solution to gel (sol-gel) transition within 3 min at 37 °C. Furthermore, TAP-CS/β-GP showed a first-order drug release profile with 72 h cumulative TAP release ratio of 93.96 ± 3.18%. The analgesic efficacy of TAP-CS/β-GP was thoroughly evaluated using the rat incisional pain model, mouse acetic acid-induced writhing test and mouse hot-plate test. TAP-CS/β-GP demonstrated fast, potent and sustained analgesia with paw withdrawal threshold (PWT) increase by 3.49-fold at 1 h and effectively prolonged the analgesic efficacy to 144 h for incisional pain. In addition, CS/β-GP demonstrated a degradation ratio of > 85% within 14 days. This TAP-CS/β-GP system provides a prolonged TAP release profile with potent analgesia and favorable safety profile, presenting an alternative strategy for postoperative analgesia. Download: Download high-res image (359KB) Download: Download full-size image
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Polymers
·
2026
·Vol. 18
·期 10
·1237
·
IF 5.8
Danyun Lei,Weiyi She,Xiaoyu Chen,Lei You,Ying Zheng,Byoung-Suhk Kim
Chitosan (CS) was employed to modify coconut shell activated carbon (CAC) to fabricate a composite adsorbent for wastewater treatment. By integrating the functional groups of CS with the high specific surface area of CAC through chemical modification, the resulting CS-AC composite exhibited significantly enhanced adsorption performance toward hexavalent chromium (Cr(VI)) in aqueous solutions. The effects of key parameters, including adsorbent dosage, initial Cr(VI) concentration, contact time, temperature, and solution pH on the adsorption efficiency were systematically investigated. Under optimal conditions, the CS-AC composite achieved a Cr(VI) removal efficiency of up to 99.04%. Kinetic and isotherm modeling revealed that the adsorption process followed the pseudo-second-order kinetic model and was well described by the Langmuir isotherm. Regeneration studies conducted over five consecutive adsorption-desorption cycles demonstrated that the composite retained a high removal efficiency of 98.10%, indicating excellent reusability. These findings suggest that the CS-AC composite is a promising and effective adsorbent for the removal of Cr(VI) from contaminated water.
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高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2026
·
IF 2.4
Jiajie Li,Huanyu Zhong,Danyang Li,Na Peng
Post-traumatic wound management is a critical issue that needs to be addressed. Chitosan (CS) with inherent biocompatibility and biodegradability is widely applied in wound healing, but the products of CS often suffer from poor water solubility and mechanical strength. Herein, we developed new double-crosslinked CS-based cryogels. Firstly, glycidyl methacrylate (GMA) was used to modify CS for the crosslinking of double bonds, followed by further crosslinking with 1,4-butanediol diglycidyl ether (BDDE). A series of CS-based cryogels were prepared by adjusting the concentration of CS from 2wt% to 4wt% and the content of BDDE from 0.1vol% to 0.4vol%. The CS-based cryogels demonstrated enhanced mechanical properties as the concentration of CS increased, higher swelling capacity as the content of BDDE increased and potent antioxidant activity around 80%. The CS-based cryogels exhibited broad-spectrum antibacterial performance, with antibacterial rates over 90% against both S. aureus and E. coli. Cytotoxicity and hemolysis assays confirmed the biocompatibility and hemocompatibility of the cryogels. The CS-based cryogels reduced blood loss in mice tail amputation models and accelerated tissue regeneration in full-thickness wound models demonstrating potential for clinical application. Among them, the CS3-GB3 cryogel demonstrated the most effective promotion of wound healing.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Haofeng Qiu,Jingfang Zheng,Zheyu Yao,Ximing Cai,Gaoke Pan,Xufeng Mao,Xin Zhao,Lei Shao,Dangsheng Xiong,Rong Wang,Yi Zhang
Cartilage degradation after joint injury often leads to post-traumatic osteoarthritis, a process accompanied by a drop in synovial pH. Traditional dynamically crosslinked hydrogels overlook how their mechanical and tribological properties change in such acidic, inflammatory environments. Here, we report an arthritis-responsive, injectable hydrogel designed to both regenerate articular cartilage and inhibit its further degradation. The hydrogel is formed via Schiff base chemistry between aldehyde groups of oxidized hyaluronic acid (OHA) and amino groups of adipic acid dihydrazide-grafted chondroitin sulfate (Chs-ADH) and carboxyethyl chitosan (CEC). Under neutral pH, the imine bonds remain stable, allowing precise defect filling and minimizing stress-induced debris; under acidic conditions, their reversible nature enhances lubrication and resists wear. The hydrogel formulation was optimized using molecular dynamics simulations to achieve excellent injectability, shear-thinning behavior, and low friction without impeding normal joint motion. In vitro , the hydrogel exhibited outstanding biocompatibility and stimulated cell migration. In vivo , it accelerated cartilage repair, prevented cartilage degradation, and restored the lubrication of newly formed tissue to levels comparable with healthy cartilage. Together, these findings demonstrate that the pH-sensitive hydrogel is a promising candidate for effective cartilage repair and prevention of cartilage degradation.
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PubMed
高影响因子
FOOD CONTROL
·
2026
·
IF 7
Chaojie Yu,Yuxin Sang,Xuanyi Guo,Qinxing Sun,Haihong Huang,Zuwei Song,Gaoyuan Kong,Weina Li
Rapid screening of tetracycline (TC) residues in milk is important for dairy quality control and regulatory compliance. In this study, portable multicolor molecularly imprinted chitosan gel beads embedded with europium-doped carbon dots (Eu-CDs@MIP) were developed as a visual and smartphone-assisted screening platform for TC in pretreated milk samples. The beads produced a concentration-dependent fluorescence color transition from blue to red under 365 nm UV light, enabling both ratiometric fluorescence quantification and RGB-based image analysis. The method showed linear responses in the range of 0-200 nM, with limits of detection (LOD) of 7.0 ± 0.12 nM for F 620 /F 486 and 9.9 ± 0.09 nM for the R/B ratio. In spiked commercial milk samples with different fat contents, recoveries ranged from 92.3% to 106.65% with satisfactory reproducibility. Agreement with liquid chromatography-mass spectrometry (LC-MS) was confirmed by Passing-Bablok regression and Bland-Altman analysis. The visual color output, short assay time, and smartphone compatibility support the use of this method as a screening and triage tool with portable readout for laboratory-pretreated milk samples.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Tianyi Hu,Wanqin Xu,Qun Liu,Nan Zhou,Wuyin Weng,Yucang Zhang
Food spoilage calls for sustainable packaging solutions. In this study, a green strategy was developed by incorporating tea processing wastewater (TPW) into chitosan (CS) films, thereby enabling the valorization of agro-industrial by-products. Owing to its high polyphenol content, TPW markedly improved the functional properties of the composite films. The results showed that TPW incorporation provided excellent UV-blocking ability (UVT ≈ 0%), strong antioxidant activity (DPPH radical scavenging rate of 80.86%), and high antibacterial efficiency (>90%), despite a slight decrease in mechanical strength. Practical application tests further confirmed that the films effectively extended the shelf life of strawberries and beef. Overall, this work provides a cost-effective approach for developing multifunctional active packaging by combining the film-forming capacity of CS with the bioactivity of TPW, thus contributing to the circular bioeconomy.
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高影响因子
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