ELECTROCHIMICA ACTA
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2011
·
IF 3.65
Zhe Sun,Ren-Kai Zhang,Huan-Huan Xie,Mao Liang,Rui-Hong Du,Song Xue
4- N , N -Dimethylaminopyridine (DMAP) was introduced into poly(ethyleneoxide)/oligo(ethylene glycol) (PEO/PEG) electrolytes for dye-sensitized solar cells (DSCs). The improved photovoltaic performance of DMAP-doped DSCs was attributed to the integrated effects of the upward displacement of the TiO 2 band edge and the decrease in the electron recombination rate. Remarkably, the presence of DMAP suppresses electron recombination via two combined pathways involving the dissociation of triiodide to iodide by a complexation reaction and a modification of the surface state distribution in the band gap of TiO 2 . With the addition of DMAP, the open-circuit voltage enhances dramatically. The short-circuit photocurrent density has a small increase at low DMAP concentration and drops afterwards. The power conversion efficiency is 4.07%, which corresponds to a 63% increase over that of the DSC without DMAP.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2015
·
IF 3.368
Ling Yu,Zhuan Zhuan Shi,Chang Ming Li
Poly[glycidyl methacrylate- co -poly (ethylene glycol) methacrylate] microspheres for the first time were successfully synthesized by atom transfer radical polymerization (ATRP) method at room temperature. The co-polymerization approach was investigated to delicately control the microsphere morphology and size-distribution by reaction conditions including solvent percentage, monomer loading and rotation speed. The results show that the average size of the microspheres is ∼5.7 μm with coexistence of epoxy, hydroxyl and ether groups, which provide plentiful functional sites for protein anchoring. The mechanism of the microsphere formation is proposed. The microsphere successfully demonstrates its unique application for affinity purification of proteins, in which the functional epoxy group facilitates a simple and efficient protein covalent immobilization to purify immunoglobulin G on the microspheres, while the hydrophilic poly (ethylene glycol) motif can repulse nonspecific protein adsorption for good specificity. This microspheres can be used in broad protein biosensors due to their abundant functional groups and high surface to volume ratio.
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PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2024
·
IF 4.3
Chen Jiaqi,Yin Min,Yang Chenguang,Wang Kun,Ma Lili,Yu Haiyang,Huang Yue,Liu Feng,Tang Zhaohui
Introduction: The prognosis of advanced renal carcinoma is not ideal, necessitating the exploration of novel treatment strategies. Poly(L-glutamic acid)-g-methoxy poly(ethylene glycol)/Combretastatin A4 (CA4)/BLZ945 nanoparticles (CB-NPs) possess the dual capability of CA4 (targeting blood vessels to induce tumor necrosis) and BLZ945 (inducing M2 macrophage apoptosis), thereby inhibiting tumor growth.Methods: Here, the therapeutic effects and underlying mechanism was explored by CCK-8 cytotoxicity experiment, transwell cell invasion and migration experiment, H&E, western blot analysis, immunohistochemistry, flow cytometry, and other techniques.Results: These results demonstrated that CB-NPs could inhibit the growth of Renca cells and subcutaneous tumors in mice, with an impressive tumor inhibition rate of 88.0%. Results suggested that CB-NPs can induce necrosis in renal carcinoma cells and tissues, downregulate VEGFA expression, promote renal carcinoma cell apoptosis, and reduce the polarization of M2 macrophages.Discussion: These findings offer innovative perspectives for the treatment of advanced renal carcinoma.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2024
·
IF 4.8
Qing-zhu Zhang,Hui-yuan Xu,Chao-yan Feng,Chu-hao Zhang,Kun Ren,Ying-ni Pan,Dong-mei Wang,Shu-meng Ren,Xiao-qiu Liu
Ethnopharmacological relevance The leaves of Quercus dentata Thunb. (QD), a member of the Fagaceae family and genus Quercus , with distributions in China, Japan, Korea, and other regions. As recorded in the Ben Cao Gang Mu (Compendium of Materia Medica) and other classical Chinese medical texts, QD has been traditionally employed in Traditional Chinese Medicine (TCM) for their hemostatic and diuretic effects and has been used to treat urinary stones ( Lin Zheng ). It is also the main ingredient of the Mishitong capsule (MST), a Chinese patent drug, used for kidney stones and ureteral stones. Nonetheless, the specific active ingredients and the mechanisms of QD in treating kidney stones remain to be elucidated, which is crucial for advancing the scientific understanding and clinical application of this traditional medicine. Aim of study This study aimed to identify the active constituents of QD water extract (QDWE), explore its inhibitory effects on kidney stones through in vitro and in vivo studies, and elucidate the underlying mechanisms of the OPN/CD44 axis and the NLRP3 signaling pathway to provide a full understanding of its potential as a novel treatment approach against kidney stones. Materials and methods The micromolecular components in the supernatant of QDWE (QDS) were analyzed by UPLC-Q-Exactive-Orbitrap-MS and the monosaccharide composition of the macromolecular polysaccharide components in the crude polysaccharide (QDP) was determined by pre-column derivatization in HPLC. The effects of QDWE, QDS and QDP on the shape, size, and structure of calcium oxalate (CaOx) crystals in vitro were explored by XRD, FTIR and SEM. The effects of QDWE, QDS and QDP on CaOx kidney stones in SD rats induced by ethylene glycol and VD 3 were compared in vivo . Furthermore, the underlying mechanisms of OPN/CD44 and NLRP3 pathways were investigated by Western blot analysis. Results There were 32 compounds identified in QDS. The monosaccharide composition ratio of QDP was Man: L-Rha: D-GlcA: D-GalA: D-Glc: D-Gal: L - Ara = 1.01: 22.52: 8.27: 38.61: 3.43: 17.80: 6.38, indicating a mixture of pectin-type acidic heteropolysaccharides. QDP had a more significant inhibitory effect on CaOx crystals in vitro than QDWE, which can inhibit the formation of CaOx monohydrate crystals (COM) and convert them into thermodynamically unstable CaOx dihydrate (COD) crystals. The high dose of QDWE exhibited significant in vivo efficacy ( P < 0.05), including anti-calculus, diuretic effects, and kidney protection, marked by decreased calcification and stone formation, alongside improved kidney vitality. Furthermore, the protective effects of QDWE were demonstrated to be associated with the OPN/CD44 and NLRP3 pathways. Conclusion The studies identified and analyzed the active constituents of QDWE. Among these, QDP significantly inhibited CaOx crystal generation in vitro and could be a potential component for the treatment of urinary stones in QDWE. Moreover, the results indicated that QDWE had a remarkable therapeutic effect on CaOx stones by modulating the OPN/CD44 axis to affect stone formation and the NLRP3 signaling pathway to mediate inflammation, providing an experimental basis for the mechanism of anti-urinary stone and deep development of QD.
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International Journal of Nanomedicine
·
2023
·
IF 8
Hongzhi Qiao,Lihua Chen,Tianqi Rui,Jingxian Wang,Ting Chen,Tingming Fu,Junsong Li,Liuqing Di
Andrographolide (ADG) is a diterpenoid isolated from Andrographis paniculata with a wide spectrum of biological activities, including anti-inflammatory, anticancer and hepatoprotective effects. However, its poor water solubility and efflux by P-glycoprotein have resulted in lower bioavailability. In this study, ADG nanosuspensions (ADG-NS) were prepared using a wet media milling technique followed by freeze drying. d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS), a surfactant that inhibits P-glycoprotein function, and sodium lauryl sulfate were used as surface stabilizers. A Box–Behnken design was used to optimize the nanosuspension preparation. The products of these optimal preparation conditions were amorphous and possessed much faster dissolution in vitro than a coarse powder of ADG. The particle size and redispersibility index of the freeze-dried ADG-NS were 244.6±3.0 nm and 113%±1.14% (n=3), respectively. A short-term stability study indicated that the freeze-dried ADG-NS could remain highly stable as nanosuspensions during the testing period. A test of transport across a Caco-2 cell monolayer revealed that the membrane permeability (Papp) of ADG-NS was significantly higher than the permeability of the ADG coarse powder or ADG-NS without TPGS (P<0.01). Compared to the ADG coarse powder, a physical mixture, commercial dripping pills and ADG-NS without TPGS, ADG-NS exhibited significantly higher plasma exposure with significant enhancements in Cmax and area under the curve of plasma concentration versus time from zero to the last sampling time (AUC0−t) (P<0.01). An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide (NO), Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) (P<0.01) and an increase in superoxide dismutase activity (P<0.05) compared to the ADG coarse powder. This study indicated that nanosuspensions could act as an effective delivery device for ADG to enhance its oral bioavailability and biological efficacy.
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高影响因子
Acta Biomaterialia
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2014
·
IF 5.684
Guohui Xu,Xiaolin Wang,Chao Deng,Xiaomei Teng,Erik J. Suuronen,Zhenya Shen,Zhiyuan Zhong
Injectable biodegradable hybrid hydrogels were designed and developed based on thiolated collagen (Col-SH) and multiple acrylate containing oligo(acryloyl carbonate)-b-poly(ethylene glycol)-b-oligo(acryloyl carbonate) (OAC-PEG-OAC) copolymers for functional cardiac regeneration. Hydrogels were readily formed under physiological conditions (37 °C and pH 7.4) from Col-SH and OAC-PEG-OAC via a Michael-type addition reaction, with gelation times ranging from 0.4 to 8.1 min and storage moduli from 11.4 to 55.6 kPa, depending on the polymer concentrations, solution pH and degrees of substitution of Col-SH. The collagen component in the hybrid hydrogels retained its enzymatic degradability against collagenase , and the degradation time of the hydrogels increased with increasing polymer concentration. In vitro studies showed that bone marrow mesenchymal stem cells (BMSCs) exhibited rapid cell spreading and extensive cellular network formation on these hybrid hydrogels. In a rat infarction model, the infarcted left ventricle was injected with PBS, hybrid hydrogels, BMSCs or BMSC-encapsulating hybrid hydrogels. Echocardiography demonstrated that the hybrid hydrogels and BMSC-encapsulating hydrogels could increase the ejection fraction at 28 days compared to the PBS control group, resulting in improved cardiac function. Histology revealed that the injected hybrid hydrogels significantly reduced the infarct size and increased the wall thickness, and these were further improved with the BMSC-encapsulating hybrid hydrogel treatment, probably related to the enhanced engraftment and persistence of the BMSCs when delivered within the hybrid hydrogel. Thus, these injectable hybrid hydrogels combining intrinsic bioactivity of collagen, controlled mechanical properties and enhanced stability provide a versatile platform for functional cardiac regeneration.
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高影响因子
CELLULOSE
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2020
·Vol. 27
·期 8
·4679-4690
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IF 4.21
Du Xiaosheng,Zhou Mi,Deng Sha,Du Zongliang,Cheng Xu,Wang Haibo
The development of organic phase change materials (PCMs) with large energy storage capacity, high thermal conductivity, and satisfactory solar-thermal conversion performance is critical for large-scale solar energy utilization. Here, novel composite PCMs based on poly(ethylene glycol) (PEG), nanofibrillated cellulose (NFC), and graphene were successfully fabricated by impregnating PEG into PEG-grafted NFC/graphene hybrid aerogels (GA/NFC- g -PEG). The GA/NFC- g -PEG with three-dimensional interconnected porous structures well supported the PEG within the nanostructural frameworks and effectively prevented the leakage and diffusion of PEG above its melting point. Grafting of PEG onto NFC was performed to improve the affinity between PEG and NFC/graphene hybrid aerogels, which significantly increased the PEG loading capacity of the CNF- g -PEG/graphene aerogel and prevented the leakage of PEG. Differential scanning calorimetry result showed that the as-prepared composite PCMs possessed extremely high melting enthalpies ranging from 185.5 to 187.4 J/g. The hot stage-digital camera test and thermogravimetric analyses showed that the composite PCMs exhibited excellent form-stability and thermal stability. Moreover, the introduction of graphene significantly increased the thermal conductivity and solar-thermal conversion efficiency of the composite PCMs. In conclusion, the synthesized composite PCMs showed tremendous potential for thermal energy storage applications.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2020
·Vol. 20
·期 4
·2408-2415
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IF 1.134
Lou Jufeng,Chen Feng,Wu Xi-Lin,Lin Hongjun,Chen Jianrong
New synthetic method toward carbon supported catalysts with improved performance is of great importance in direct alcohol fuel cells (DAFCs). Herein, onion-like nanocarbons (OLNCs) were fabricated by using cheap and readily available candle as the raw material. And a facile one-pot
and surfactant-free solvothermal approach was developed for the fabrication of PtSn nanoparticles supported on the OLNCs. Transmission electron microscopy (TEM) images showed the highly crystalline PtSn nanoparticles with size of ~2–5 nm were evenly deposited on the surface of the OLNCs.
The obtained PtSn/OLNCs nanocomposites with Pt loading of about 10.1% exhibited excellent electrocatalytic activity toward both methanol oxidation reactions (MOR) and ethylene glycol oxidation reactions (EGOR). The current density of PtSn/OLNCs is 2.6 and 2.7 times of the commercial 20 wt%
Pt/C toward the MOR and EGOR, respectively, suggesting the great application potential of the PtSn/OLNCs catalyst in DAFCs. The highly electrocatalytic activity of the PtSn/OLNCs may arise from the ultra-small size of the PtSn NPs as well as the large surface area and good electric conductivity
of the OLNCs support. This study not only provides an example of the cost-effective fabrication and application of the OLNCs based catalysts and also sheds a new light on the application of the PtSn/OLNCs catalyst in DAFS.
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高影响因子
POLYMER
·
2016
·
IF 3.586
Qinglai Yang,Changyu He,Zhen Zhang,Lianjiang Tan,Bingya Liu,Zhenggang Zhu,Zhifeng Shao,Bing Gong,Yu-Mei Shen
Redox-responsive micelles self-assembled from triblock copolymers of poly( l -lactic acid)-poly(ethylene glycol)-poly( l -lactic acid) ( PLA-PEG-PLA) with double-disulfide linkage in the backbone were synthesized and characterized by proton nuclear magnetic resonance ( 1 H NMR) and size exclusion chromatography (SEC), in which both PEG ( M n = 1000, 2000 and 4000 g mol −1 ) and PLA ( M n = 1600 g mol −1 ) have different molecular weights respectively. The triblock copolymers PLA 3000 -PEG 2000 -PLA 3000 and PLA 3000 -PEG 4000 -PLA 3000 can self-assemble into flower-like micelles in aqueous media with average diameters 110 nm and 43 nm and lower critical micelle concentrations (CMC) 0.017 and 0.014 mg mL −1 respectively compared with that of diblock copolymers. Moreover, in vitro drug release analyses indicated that reductive environment can result in triggered drug release profiles. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl- 2-H-tetrazolium bromide (MTT) assay in vitro showed no significant cytotoxicity as NIH 3T3 cells incubated in the micelles even when the concentrations up to 1000 μg/mL. Additionally fluorescence microscopy measurements and MTT assay demonstrated that the micelles exhibited a faster drug release and higher cellular proliferation inhibition due to the effect of intracellular reduction responsiveness compared with that of diblock copolymers. The above results suggest that the reduction-responsive, biodegradable and biocompatibility micelles could provide a platform to construct potential drug delivery systems for cancer therapy.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
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2014
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IF 7.261
Haiyang Yu,Zhaohui Tang,Dawei Zhang,Wantong Song,Ying Zhang,Yan Yang,Zaheer Ahmad,Xuesi Chen
Platinum-based polymeric nano-drugs, especially cisplatin-loaded polymeric nanoparticles (CDDP-NPs), have been extensively exploited for the treatment of solid tumors . However, it is still unclear what role the processing procedure and the properties of the polymeric carrier materials may play in influencing the plasma pharmacokinetics , biodistribution and in vivo efficacy of CDDP-NPs. In this study, a series of poly( l -glutamic acid)- g -methoxy poly(ethylene glycol) (PLG- g -mPEG) copolymers were synthesized for the preparation of CDDP-loaded PLG- g -mPEG (CDDP/PLG- g -mPEG) nanoparticles . All of the parameters, including PLG molecular weight, mPEG/PLG weight ratio, mPEG chain length, ultrafiltration purification and cisplatin loading content, were found to have a significant influence on the plasma pharmacokinetics of the CDDP/PLG- g -mPEG nanoparticles . The blood circulation time of the nanoparticles was prolonged with increases in PLG molecular weight, mPEG/PLG weight ratio, mPEG chain length and CDDP loading content. The use of ultrafiltration purification could prolong the blood circulation time of the nanoparticles as well. Experiments to measure the pharmacokinetics and biodistribution demonstrated that the selected CDDP/PLG- g -mPEG nanoparticles, NP10, had a long blood circulation time and could achieve selective and significant accumulation in Lewis lung carcinoma (LLC) tumors. The platinum plasma concentrations in the LLC tumor-bearing mice receiving NP10 remained up to 46-fold higher than that of mice receiving equivalent doses of free CDDP. In addition, the plasma area under the concentration time curve (AUC) of NP10 was 31-fold higher than that of free CDDP in 48 h. The platinum concentration ratio of NP10 to free CDDP in tumors reached as high as 9.4. The tumor AUC ratio of NP10 to CDDP was 6. Using a mouse C26 tumor model, here we demonstrate that NP10 improves the safety and tolerance in vivo when compared to CDDP and effectively inhibits the growth of C26 tumors. Furthermore, increasing the dosage of NP10 by 2 or 3-fold of free CCDP improved its anticancer efficacy to comparable or higher levels. These results indicate that CDDP/PLG- g -mPEG nanoparticles have greater potential for the treatment of solid tumors in clinical application.
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RENEWABLE ENERGY
·
2025
·
IF 9.1
Ruoxuan Zheng,Shuang Liu,Tianlu He,Chaofan Zu,Di Yin,Yufeng Bai,Chunlong Yue,Tai Peng
The development of energy storage technologies has emerged as a crucial initiative to address global energy challenges. However, existing phase change materials (PCMs) such as polyethylene glycol (PEG) suffer from inherent drawbacks including low thermal conductivity and poor shape stability. To tackle these issues, this study developed a carbon-stitching strategy that directs 1D boron nitride nanorod (BNNR) and 2D boron nitride nanosheet (BNNS) to co-assemble into a 3D skeleton inspired by natural abalone shell, thereby establishing an efficient heat transfer network. Experimental results demonstrated that the prepared PEG/BN c -10/UV composite PCM exhibited a thermal conductivity of 1.33 W · m −1 K −1 . Compared with pure PEG, this represented a 441 % increase in thermal conductivity, while the latent heat retention rate remained as high as 89 %. Through an ingenious design, the encapsulation with UV-curable resin not only prevents the leakage of PEG but also imparts waterproof properties to the composite. This expands the application of PCMs in underwater environments. This study provides a new design paradigm for the development of high-efficiency energy storage materials suitable for diverse environmental conditions.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Zhang Wenlong,Zhang Qi,Xia Tianbao,Ji Qiuhan,Liu Jiefan,Liu Xingwen,Wang Lan,Wang Longyao
A viscoelastic surfactant ( VES ) clean fracturing fluid is an excellent alternative to polymer-based fracturing fluids for fracturing low-permeability reservoirs. However, the existing VES either has poor salt resistance or involve complicated preparation steps. Herein, a cationic Gemini VES with high salt tolerance, named neopentanediol di-(erucamide propyl ammonium bromide) ( NEPB ), was synthesized through a one-step reaction to simplify the process, using erucamide propyl dimethylamine and pentaerythritol dibromide dissolved in DMF . The double hydroxyl groups on the spacer imparts NEPB superior salt tolerance to the Gemini VES with a single hydroxyl ( JS-(OH)-JS ). Salinity-sensitive evaluation experiments consisting of salinity cloud point, DLS , and fluorescent probe tests; rheological experiments including apparent viscosity, viscoelasticity, and heat and shear resistance measurement; and comprehensive tests of fracturing fluids such as proppant suspending, gel-breaking, and core damage rate were carried out to study the performance of NEPB used in a fracturing fluid. The apparent viscosity of 3 wt% NEPB solution rises to the peak value at the NaCl concentration of 5 wt%, much higher than that of the JS-(OH)-JS solution. Oscillatory measurements exhibit that the NEPB solution with the peak apparent viscosity exhibits superior viscoelasticity to the JS-(OH)-JS solution, and the relaxation time and the plateau of the storage moduli are 17.69 s and 53.71 Pa. And the NEPB VES fracturing fluids prepared by the simulated seawater of the South China Sea, with NaSal added, exhibits best heat and shear resistance, and the remain viscosity is above 40 mPa·s. Settling velocity proppant in the NEPB VES fracturing fluid with NaSal added is 1.22 mm/s. Ethylene glycol butyl ether exhibits a superior gel-breaking performance to crude oil, and the insoluble residues of the ethylene glycol butyl ether gel-breaking fluids are all below 3 mg/L. The development of NEPB not only simplifies the preparation course of VES but also improve the salt tolerance of cationic Gemini VES , which is meaningful to the development of low-permeability oil and gas reservoirs offshore. Graphical
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