SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Lihan Liu,Yuhan Guo,Yuxin Wang,Senjian Han,Lina Xu,Zengyu Ma,Shiqiang Wang,Tianlong Deng,Zhenyu Liao
Zinc ferrocyanide (ZnFC) composites exhibit high selectivity for cesium, but conventional bulk forms suffer from slow mass transfer. In this work, ZnFC was anchored onto exfoliated α-phosphazene ( E -ZrP) nanosheets via an in-situ growth method to construct ZnFC@ E -ZrP composites, which were further fabricated into ZnFC@E-ZrP/PSf adsorption membranes. The two-dimensional E-ZrP support inhibited ZnFC agglomeration and enhanced Cs + mass transfer through shortened diffusion paths and a surface P–OH-induced electronegative field. Experimental results indicated that ZnFC@ E -ZrP exhibited Cs + adsorption properties significantly surpassing that of the α-ZrP support, along with good acid-base stability and recyclability. The corresponding membrane combined rapid transport from E -ZrP with precise capture from ZnFC, achieving adsorption equilibrium within 5 min in filtration and maintaining >98% Cs + recovery from geothermal brine under high ionic competition. The strategy demonstrated in this work enables the design of efficient materials for rapid cesium separation.
✓ 已验证
产品关联
DOI
高影响因子
Biochar
·
2026
·Vol. 8
·期 1
·113
·
IF 15.1
Zhang Jian,Xie Jiafang,Zhu Shuhui,Yang Jiacheng E.,Weng Bo,Zheng Yuming
Biochar optimized with oxygen-containing functional groups is believed to be beneficial for peroxymonosulfate (PMS) activation, and biochar-loaded Co 3 O 4 -based catalysts are expected to be one of the most promising PMS activators for the efficient removal of organic pollutants. Nevertheless, the real active sites on Co 3 O 4 catalysts are still in debate due to insufficient experimental evidence. Herein, Co 3 O 4 growing on the oxygen-containing functional groups optimized rice husk biochar (RHBA) was synthesized (RHBA@Co 3 O 4 ), and RHBA800@25Co 3 O 4 + PMS system achieved complete degradation (100%) of refractory levofloxacin (LFX) within 4 min. The superior catalytic performance was suggested to be attributed not only to the uniform dispersion of Co 3 O 4 , but also to the transformation of lattice oxygen in Co 3 O 4 , which was found to play an important role in the catalytic process by inducing the formation of Co 3 O 4−α –OH. Meanwhile, density functional theory (DFT) calculations indicated that the adsorption energy ( E ads ) of PMS on Co 3 O 4−α –OH was far lower than that on Co 3 O 4 . Moreover, both radical and non-radical pathways were indicated to be involved during the degradation process. Additionally, the practical application of RHBA@Co 3 O 4 was investigated using various antibiotics, actual water environments, and fixed-bed reactors. The results showed that it possessed good practical degradation performance and significantly reduced the toxicity of intermediate products. This work provides a fresh insight into the catalytic mechanism of RHBA800@25Co 3 O 4 for PMS activation and wastewater treatment, offering a new perspective on the catalytic mechanism of Co 3 O 4 -based materials. Highlights
RHBA800@25Co 3 O 4 exhibited ultrafast antibiotics degradation via peroxymonosulfate activation.
Inspired formation of Co 3 O 4−α –OH by lattice oxygen induction was explored.
Ecological safety of levofloxacin degradation products was verified through antibacterial experiments.
Graphical The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Junjie Zhang,Fawei He,Yurui Wang,Peng Jiang,Jiongwen Qin,Meng Liu,Jiawei Yao,Dongting Zhangsun,Meng Li,Sulan Luo,Yong Wu
The surge in multidrug-resistant (MDR) pathogens necessitates novel therapeutic strategies. Here, we report the rational design of C4-VG7, an N-terminal butyrylated lipopeptide engineered from a compact, cationic, helix-compatible segment of the marine conotoxin αO-GeXIVA. Through stepwise structural optimization─from constrained cyclic prototypes to lipidated derivatives─C4-VG7 was identified as a lead candidate with potent, broad-spectrum activity against MDR ESKAPE pathogens, including clinical isolates (MIC ≈1 μM). Mechanistically, C4-VG7 exhibits multimodal bactericidal action: C4-tail-mediated membrane depolarization is consistent with early membrane disruption followed by intracellular DNA association and oxidative stress. In murine models of MRSA and Acinetobacter baumannii infections (skin and peritonitis), C4-VG7 achieved efficacy comparable to polymyxin B with significantly reduced hepatonephrotoxicity. Thus, C4-VG7 represents a systemically viable, well-tolerated candidate for combating MDR ESKAPE infections.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Ziqun Yang,Liangmu Pei,Juan Lei,Caiyun Han,Lijun Cheng,Shuang Wang
Selective regulation of α-MnO 2 (110) facet via doping-masking-alkaline etching. • The (110) facet dominates toluene oxidation over 0.4CMO-AT. • Cu doping masks the (110) facet, impairing O 2 adsorption. • Re-exposure optimizes O 2 adsorption and elongates the O-O bond. • (110) facet and dual vacancies boost lattice oxygen mobility and benzoate ring-opening. Regarding the ambiguity of the advantageous crystal facet of α-MnO 2 in the catalytic oxidation of toluene, this study proposes a “doping–masking–alkali etching–re‑exposure” strategy. Through Cu doping, the (110) facet is selectively masked, followed by alkali etching to selectively re‑expose the (110) facet. The intrinsic activity and regulation mechanism of the (110) facet for low‑temperature catalytic oxidation of toluene were systematically investigated. The results show that the 0.4CMO‑AT catalyst (0.4 mmol Cu‑doped α-MnO 2 after alkali etching) with selectively re‑exposed (110) facets achieves 90% toluene conversion at 209 °C, significantly outperforming 0.4CMO (0.4 mmol Cu‑doped α-MnO 2 , 280 °C) without re‑exposed (110) facets and MO (undoped α-MnO 2 , 229 °C) with unregulated facets. Density functional theory (DFT) calculations and experiments collectively demonstrate that the (110) facet significantly promotes O 2 adsorption and activation, and that the synergistic effect of oxygen vacancies enhances lattice oxygen migration, thereby reducing the reaction energy barrier. In-situ DRIFTS identifies benzoic acid as the rate‑determining intermediate, while DFT calculations further reveal that the re‑exposed (110) facet thermodynamically favors its stabilization and ring‑opening. This work provides fresh insights into how α-MnO 2 facet engineering can be utilized for the catalytic breakdown of volatile organic compounds (VOCs). A “doping-masking-alkali etching” strategy was employed to selectively re-expose the (110) facet of α-MnO 2 . This facet, in synergy with copper/oxygen vacancies, markedly enhances O 2 adsorption and activation while reducing the reaction energy barrier, thereby constructing an efficient redox cycle and boosting catalyst activity. Download: Download high-res image (119KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
Thoracic Cancer
·
2026
·Vol. 17
·期 17
·e70383
·
IF 2.6
Kairui Zhu,Yulong Mu,Zhenguo Su,Zhen Yue,Dongyang Wu,Guiwu Qu,Chenyang Jiang,Qing Li,Youjie Li,Ning Xie
Background Pyroptosis-related signaling contributes to lung adenocarcinoma (LUAD) progression and prognosis. Apigenin (AP) has anti-inflammatory and cytoprotective properties, but its effects on pyroptosis-associated signaling in injured LUAD cells remain unclear. Methods A549 cells were treated with carbonyl cyanide m -chlorophenyl hydrazone (CCCP) and ferrous sulfate (FeSO 4 ) to establish a cellular injury model. Cell morphology, Cell Counting Kit-8 signals, and pyroptosis-associated proteins were assessed after AP treatment. Network pharmacology, molecular docking, molecular dynamics simulations, and analyses of The Cancer Genome Atlas and Gene Expression Omnibus datasets were used to prioritize candidate targets, characterize pyroptosis-related genes, and develop a prognostic signature. Results CCCP/FeSO 4 reduced CCK-8 signals and induced morphological injury, whereas AP partially reversed these changes. AP also reduced alterations in GSDMD-N, caspase-1, IL-1β, TNF-α/NF-κB pathway proteins, AIM2, and ASC. TNF was prioritized as a candidate target, and computational analyses predicted a potentially stable AP–TNF interaction without demonstrating direct binding. Bioinformatic analyses identified distinct pyroptosis-related LUAD subgroups and generated a prognostic signature that stratified survival in training and external validation cohorts. AIM2 was additionally prioritized as a LUAD- and stress-associated candidate. Conclusion AP attenuated CCCP/FeSO 4 -induced injury and pyroptosis-associated molecular changes in A549 cells, potentially through TNF-α/NF-κB and AIM2-related signaling. Further mechanistic validation is required.
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 8
·e71552
·
IF 2.9
Wenyu Li,Yafang Chen,Mingjiang Lu,Juan Zou,Xiang Yu,Kang He
To discover novel potential enzyme inhibitors based on natural products, a series of N ‐acyl pregnane alkaloid ester derivatives were designed, synthesized, and evaluated for their inhibitory activity against acetylcholinesterase (AChE) and α ‐glucosidase. The bioassay test results revealed that the target compounds generally showed more potent inhibition against α ‐glucosidase than against AChE. Notably, compounds 6e and 6i demonstrated significant α ‐glucosidase inhibitory activity, with IC 50 values of 29.85 µM and 38.11 µM (acarbose IC 50 : 16.49 µM), respectively, and exhibited low cytotoxicity toward Thle‐2 cells, with IC 50 values of 112.70 µM and 73.65 µM, respectively. Structure‐activity relationship (SAR) analysis indicated that derivatives bearing an N ‐tigloyl group and nitro or pyridine substituents at the C‐20 position contributed to enhanced α ‐glucosidase inhibition. Enzyme kinetics confirmed that 6e and 6i function as reversible, noncompetitive inhibitors of α ‐glucosidase. Molecular docking studies further illustrated that both compounds bind to the lateral surface of the α ‑glucosidase through hydrogen bonds and hydrophobic interactions, rather than occupying the catalytic active site. These findings highlight that 6e and 6i exhibit certain inhibitory activity, providing a basis for the design of subsequent derivatives. A series of N ‐acyl pregnane alkaloid esters are synthesized and evaluated for enzyme inhibition. Compounds 6e and 6i show preferable α ‐glucosidase inhibitory activity (IC 50 29.85 and 38.11 µ M). Enzyme kinetics and molecular docking studies confirm that 6e and 6i function as reversible, noncompetitive inhibitors of α ‐glucosidase.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science Advances
·
2025
·Vol. 11
·期 24
·
IF 12.5
Jian-Yu Zou,Fang-Li Xing,Quan-Xing Zi,Hai-Wu Du,Meiwan Chen,Wei Shu
α-Chiral phosphorus compounds have broad applications as organic catalysts or ligands in organic chemistry and related areas. Herein, we disclose a Ni-catalyzed enantioselective cross-hydrodimerization of alkenyl phosphine sulfides with unactivated alkenes to access α-chiral phosphine sulfides, representing the first example of asymmetric hydrodimerization of electron-deficient alkenes with electron-rich alkenes. Key to success is the precise recognition between electron-deficient alkenes and electron-rich alkenes and streamlined alkyl-alkyl bond forming with the control of chemo-, regio-, and enantioselectivity. This strategy requires alkenes as sole precursors for asymmetric alkyl-alkyl cross-coupling, circumventing the use of stoichiometric amounts of alkyl electrophiles or alkyl nucleophiles as coupling partners. The mild conditions tolerate a wide range of functional groups, providing direct access to α-chiral phosphines through a carbon-carbon bond-forming process without prefunctionalized coupling precursors.
✓ 已验证
DOI
PubMed
高影响因子
PLoS Pathogens
·
2026
·Vol. 22
·期 2
·e1013954
·
IF 4.9
Gan Luo,Mingzhu Zhao,Qingxia Wang,Yang Zhou,Dan Yao,Jue Zhang,Gang Wang,Junjie Zhang,Chongbing Liao,Wuyuan Lu
Harnessing antimicrobial peptides as bactericidal agents affords an attractive approach to developing new anti-infective therapies. We found that abolishing disulfide bonding in mouse cryptdin 1 (Crp1), a weakly bactericidal α-defensin of 35 residues, turned it into a potent antimicrobial peptide against Gram-negative bacteria. Here we report that Crp1 in its natively folded β-sheet structure forms high-ordered nanonets to cloak, but not kill, Escherichia coli , whereas its disulfide-devoid linear counterpart (L-Crp1) readily disintegrates the bacterial membrane as monomers. L-Crp1 adopts a helix-loop-helix conformation in molecular dynamics simulations, likely conducive to productive peptide-membrane interactions detrimental to bacteria. A truncated peptide spanning the helix-loop-helix, L-Crp1 1-25 , maintains the same conformation as and similar membranolytic and bactericidal activities to L-Crp1. Remarkably, intraperitoneally administered L-Crp1 1-25 rescues E. coli -challenged mice from lethality in a sepsis model by effectively reducing bacterial burden, inflammation and tissue damage. Our studies cultivate additional mechanistic insights into the mode of action of defensins and shed new light on how to harness these host factors for potential therapeutic use.
A recent epidemiological study estimates that antibiotic-resistant bacterial infections directly and indirectly killed 4.71 million patients worldwide in 2021 and will cause 8.22 million annual deaths by 2050. Searching new classes of antibiotics refractory to the existing resistance mechanisms for antibacterial therapy is imperative for global public health and economic growth. Toward this end, cationic antimicrobial peptides are particularly attractive drug candidates as they primarily target the anionic microbial membrane by a mechanism that deters the rise of resistance. However, obstacles abound in their clinical translation, including, but not limited to, subpar bactericidal activity and safety concerns. In studying a weakly bactericidal mouse α-defensin, cryptdin 1 (Crp1), we made a surprising finding that breaking its three structurally stabilizing disulfide bonds through Cys-to-Ala mutations unleashed an antimicrobial peptide against Gram-negative bacteria with an altered conformation but significantly improved potency and selectivity. A further shortened peptide of 25 amino acid residues, L-Crp1 1-25 , was safe and highly efficacious in rescuing E. coli -infected mice from lethality by reducing bacterial burden, inflammation and tissue damage. Our study demonstrates how to harness naturally occurring antimicrobial peptides as novel anti-infective agents to combat increasingly prevalent antibiotic resistance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2026
·
IF 7.4
Zehua Zhuo,Rui Wang,Shaoyun Chen,Jianhong Gao,Cuifang Cai,Yanyu Zheng,Xiaoying Liu,Bo Qu,Qinghui Chen,Dongxian Zhuo
Stereolithography (SLA) is highly valued in high-end manufacturing for its exceptional design flexibility. However, the inherent flammability of photosensitive resins significantly limits their safe application. This study designed and synthesized an intrinsically flame-retardant photosensitive resin (TPH) containing phosphorus and sulfur elements. The TPH resin was blended with a phosphorus-containing reactive diluent and an ionic liquid (TFS) to prepare a photosensitive resin (TPHP) suitable for SLA technology. An innovative approach was employed where macroscopic pore structures were constructed through 3D printing, and due to phase separation between the ionic liquid and the 3D-printed samples, microscopic pores were incorporated within the SLA-printed specimens, a porous framework was formed. These pores served as reaction sites for in-situ growth of a nano-zirconium phosphate (α-ZrP) layer on the surface. Thermogravimetric and flame retardancy tests demonstrated that the incorporation of α-ZrP significantly enhanced the material's thermal stability, flame retardancy, and smoke suppression properties. Compared with unmodified samples, the char residue was increased to 47.3%, the limiting oxygen index reached 29.0%, and the UL-94 rating achieved V-0. Cone calorimetry tests showed reductions in peak heat release rate, total heat release, and total smoke production by 42.1%, 65.4%, and 75.1%, respectively. The results indicate that this work provides a new strategy for flame-retardant 3D printing. It resolves the intrinsic conflict between flame retardancy and printability by combining surface pore engineering with in situ growth to achieve surface functionalization without sacrificing printability.
✓ 已验证
产品关联
DOI
高影响因子
Mycology-An International Journal On Fungal Biology
·
2025
·
IF 4.4
Yue Zhang,Yunxiao Luo,Xiaoyu Liu,Jun Li,Yuxian Xia,Yueqing Cao
In pathogenic fungi, N-glycosylated cell wall proteins serve as initial contact points during interactions with host. In the process of protein N-glycosylation, N-linked glycans are processed by α-glucosidases I (Gls1) and II (Gls2) to trim the final two glucose residues to facilitate glycoprotein maturation. In this study, we identified and characterized MaGls2 by disrupting its catalytic subunit MaGls2α, in the entomopathogenic fungus Metarhizium acridum. MaGls2α was found to localize to the endoplasmic reticulum. Deletion of MaGls2α resulted in earlier conidiation and increased conidial yield, but impaired colony growth and diminished tolerance to various stresses. ∆MaGls2α mutant exhibited disrupted cell wall architecture, characterized by a smoother surface, increased wall thickness, reduced β-1,3-glucan, and elevated chitin content. Bioassays demonstrated that the ∆MaGls2α mutant exhibited significantly attenuated virulence and triggered a stronger immune response from the host. Further analysis of the infection process revealed that reduced cell wall hydrophobicity and impaired appressorium formation in ∆MaGls2α mutant led to its decreased ability to penetrate the insect cuticle. Furthermore, the mutant showed slowed growth in host hemolymph, hindering successful colonization. These results indicate that MaGls2α is essential for maintaining proper cell wall composition and structure, thereby influencing fungal growth, conidiation, stress tolerance, and pathogenicity.
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Yang Zhao,Siming Yan,Yi He,Zhijun Li,Changhua Li,Hongjie Li
As a classical two-dimension nanomaterial , α-zirconium phosphate (α-ZrP) with outstanding barrier property and non-conductivity has great potential application in anticorrosion field. However, the thicker layer thickness and lack of long-term anticorrosion property limit the application of α-ZrP. In this work, α-ZrP with the diameter of about 500 nm was prepared and then exfoliated to enhance the dispersion in waterborne epoxy coatings(WEC). Then polypyrrole (PPy) was used to encapsulate the exfoliated α-ZrP (E-ZrP) to obtain final nanomaterial(PPy-ZrP). XRD , FTIR, EDS mapping, SEM, TEM were employed to characterize the as-prepared nanomaterials. WECs with those as-prepared nanomaterials were fabricated by spray and the anticorrosion performance of WECs were tested by electrochemical impedance spectroscopy(EIS) test and salt spray test. At the end of the EIS test (60 days of immersion in 3.5 wt% NaCl solution), the PPy-ZrP/WEC exhibited the highest value of |Z| 0.01 Hz (4.5 × 10 7 Ω·cm 2 ), which is about two orders of magnitude higher than blank WEC. During the EIS test period, PPy-ZrP/WEC displayed better corrosion resistance than other WECs. As a two-dimension nanosheet with good dispersion in WEC, PPy-ZrP provided outstanding barrier property for WEC. And the passivation effect of PPy further enhanced the corrosion resistance of WEC.
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2014
·
IF 2.269
Jinna Zhang,Dandan Hao,Hui Lu,Wenguang Leng,Jianzhou Gui,Yanan Gao
A surface modification strategy was applied by using 3-aminopropyltriethoxysilane (APTES) covalent linkage between the Schiff-base networks (SNW) polymer layers and porous α-Al 2 O 3 ceramic support. The SNW-1 polymer membrane and powders resulting from the polycondensation reaction between melamine and terephthalaldehyde without the polycondensation catalysts were investigated by SEM and FT-IR. The results show that the discrete and few covered polymer layers were formed on the unmodified porous α-Al 2 O 3 support. In contrast, the uniform and compact SNW-1 polymer membrane was fabricated successfully on the APTES modified α-Al 2 O 3 support by in-situ catalyst-free polycondensation method, indicating that the APTES surface modification facilitates the growth of the novel SNW-1 polymer membrane on the porous α-Al 2 O 3 support.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）