ACS Applied Electronic Materials
·
2022
·
IF 4.494
Cheng Han,Lirong He,Qi Wang,Chuhong Zhang
Three-dimensional (3D) printing technologies possess incomparable advantages in fabricating 3D piezoelectric devices, enhancing the mechanical-to-electrical conversion efficiency. Among them, direct ink writing (DIW) holds great promise in constructing piezoelectric polymer devices as it enables self-polarization benefiting from the alignment of dipoles induced by the high pressure during the printing process. Besides, the electroactive phase of piezoelectric polymers is retained due to the operation is under ambient conditions. However, for the generally applied solvent-evaporation-assisted DIW technique, the architected structure suffers from drastic shrinkage and warpage in the final parts, which ultimately leads to a significant deviation from the programmed measure. In this work, for the first time, we develop a solvent-exchange-assisted DIW printing strategy to architect accurate and stable 3D PVDF PEH. This solvent exchange process in water not only enables the complete retaining of filament measure and generation of micropores to amplify the stain but also promotes the PVDF crystallization and formation of the β-phase. Moreover, trace vitamin B2 is formulated into the ink, affording self-polarized high β-phase content (95%) PVDF with good printability and optimal storage modulus to hold the 3D shapes. As a result, the 3D printed PVDF delivers an output voltage of 17.8 V, increased by 304% compared with device fabricated by solvent-evaporation-assisted DIW technique, and an impressive area output voltage density (11.04 V cm–2) which is twice that of the reported DIW printed PVDF PEH. This facile approach demonstrates a potential roadmap to high performance PEH through exploring complex 3D geometries enabled by the solvent-exchange-assisted 3D printing technique.
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International Journal of Applied Ceramic Technology
·
2022
·Vol. 19
·期 5
·2533-2544
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IF 2.328
Changxi Jiang,Yinghua Zhuang,Jianjun Wang,Shengjun Liao,Lijuan Zhou,Shuang Li,Yunxia Zhao
Si 3 N 4 ceramics with high thermal conductivity and outstanding mechanical properties were prepared by adding β-Si 3 N 4 seeds and nanophase α-Si 3 N 4 powders as modifiers. The introduction of β-Si 3 N 4 seeds enhanced the growth of β-Si 3 N 4 grains. Owing to the interlocked structure induced by the β-Si 3 N 4 grains, the fracture toughness of Si 3 N 4 ceramics reached a high value of 7.6 MPa·m 1/2 ; also, the large-sized grains increased the contact possibility of Si 3 N 4 grains, improving the thermal conductivity of Si 3 N 4 ceramics (64 W/(m·K)). Because of the introduction of nanophase α-Si 3 N 4 , the flexural strength, fracture toughness, and thermal conductivity of the Si 3 N 4 ceramics increased to 754 MPa, 7.2 MPa·m 1/2 , and 54 W/(m·K), respectively. According to the analysis of the growth kinetics of Si 3 N 4 grains, the rapid growth of Si 3 N 4 grains was ascribed to the reduction in the activation energy resulting from the introduction of β-Si 3 N 4 seeds and nanophase α-Si 3 N 4 .
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2022
·Vol. 37
·期 3
·393-398
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IF 1.271
Hou Huayu,Gan Lin,Wang Youfa,Wang Wei
Nd 3+ -doped NaGdF 4 : Yb, Tm nanocrystals were synthesized by an improved high-temperature thermal decomposition method, and the effects of doping concentrations on the crystal structure, phase composition, and upconverted fluorescence intensity were also investigated. The results reveal that the introduction of Nd 3+ ions does not cause the transformation of the crystal phase, but induce the change of the unit cell parameters. Meanwhile, the fluorescence intensity of the synthesized nanocrystals when co-doped with 3 mol% Nd 3+ is the strongest under the excitation of 980 nm laser, which is 3.9 times that of the Nd 3+ -free doped nanoparticles, and the average size is 62.9 nm. And it is located in the blue area of the CIE coordinate diagram, and the corresponding color purity is 91.81% under the same experimental conditions. The resulting nanocrystals show the potential as excellent fluorescence labeling and in vivo imaging probes.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Cuiping Wang,Chen Chao,Jinglin Yu,Les Copeland,Yongchun Huang,Shujun Wang
The aim of the present study was to reveal the mechanisms underlying the formation of ternary complexes with a model system of amylose (AM), lauric acid (LA), and β-lactoglobulin (βLG) using experimental studies and molecular dynamics (MD) simulations. Experimental analyses showed that hydrophobic interactions and hydrogen bonds contributed more than electrostatic forces to the formation of the AM−LA–βLG complex. MD simulations indicated that interactions between AM and βLG through electrostatic forces and hydrogen bonds, and to a less extent van der Waals forces, and interactions between AM and LA through van der Waals forces, were mostly responsible for complex formation. The combination of experimental results and MD simulations has provided new mechanistic insights and led us to conclude that hydrophobic interactions, van der Waals forces between AM and LA, and van der Waals forces and hydrogen bonds between AM and βLG were the main driving forces for the formation of the AM–LA−βLG complex.
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PubMed
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Frontiers in Genetics
·
2022
·
IF 4.772
Tang Han,Du Han,Kuang Xielan,Huang Hao,Zeng Jingshu,Long Chongde,Zhu Binbin,Fu Licheng,Wang Hua,Zhang Qingjiong,Lin Shuibin,Yan Jianhua,Shen Huangxuan
Age-related macular degeneration (AMD), which is the leading cause of blindness among the elderly in western societies, is majorly accompanied by retinal pigment epithelium (RPE) degeneration. Because of the irreversible RPE cell loss among oxidative stress, it is crucial to search for available drugs for atrophic (dry) AMD. RNA-Seq analysis revealed that genes related to aging and mitochondrial health were differentially expressed under Arbutin treatment, whereas compared to oxidative injury, our study demonstrated that Arbutin substantially abrogated oxidative stress-induced cell senescence and apoptosis linked to intracellular antioxidant enzyme system homeostasis maintenance, restored mitochondrial membrane potential (MMP), and reduced the SA-β-GAL accumulation in RPE. Furthermore, Arbutin alleviated oxidative stress-mediated cell apoptosis and senescence via activation of SIRT1, as evidenced by the increase of the downstream FoxO3a and PGC-1α/β that are related to mitochondrial biogenesis, and the suppression of NF-κB p65 inflammasome, whereas rehabilitation of oxidative stress by SIRT1 inhibitor attenuated the protective effect of Arbutin. In conclusion, we validated the results in an in vivo model constructed by NAIO3-injured mice. OCT and HE staining showed that Arbutin sustained retinal integrity in the case of oxidative damage in vivo, and the disorder of RPE cytochrome was alleviated through fundus observation. In summary, our findings identified that oxidative stress-induced mitochondrial malfunction and the subsequent senescence acceleration in RPE cells, whereas Arbutin inhibited TBHP-induced RPE degeneration via regulating the SIRT1/Foxo3a/PGC-1α/β signaling pathway. These findings suggested that Arbutin is a new agent with potential applications in the development of AMD diseases.
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PHARMACEUTICAL BIOLOGY
·
2022
·
IF 3.889
Hui Wang,Qingtao Jiang,Lizhu Zhang
Context Baicalin, a flavonoid extracted from radix scutellariae, possesses various pharmacological effects, including protective effects on renal interstitial fibrosis (RIF), but its possible role and mechanisms have not been fully elucidated.Objective This study explores the protective effects and mechanisms of baicalin on RIF.Materials and methods C57BL/6 male mice were divided into six groups: sham, model, low baicalin, middle baicalin, high baicalin and positive drug groups. The unilateral ureteral obstruction (UUO) model of RIF was constructed and treated with baicalin doses (10, 20 and 40 mg/kg) and a positive control drug (valsartan, 8 mg/kg). H&E staining was used to observe the pathological changes in renal tissues, Masson staining was performed to evaluate collagen deposition in renal tissues, and immunohistochemical examination was adopted to determine α-SMA and extracellular matrix (ECM) expression. Primary mouse fibroblasts were isolated, extracted and treated with baicalin and/or TGF-β. qRT-PCR and enzyme-linked immunosorbent assay (ELISA) were applied to detect the inflammatory responses. Moreover, ECM and TGF-β/Smad expression levels were evaluated by western blot assay.Results Baicalin ameliorated RIF in UUO mice by inhibiting fibrosis and inflammatory responses. The TGF-β/Smad pathway was significantly suppressed in the UUO mouse model. Additionally, baicalin significantly inhibited ECM expression and inflammatory factors in fibroblasts treated with TGF-β. TGF-β/Smad pathway activation was significantly decreased in fibroblasts.Discussion and conclusions These findings support the use of baicalin as a potential therapeutic option for the treatment of RIF by possibly inhibiting the TGF-β/Smad signalling pathway.
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CHROMATOGRAPHIA
·
2022
·Vol. 85
·期 7
·589-603
·
IF 2.213
Zhong Hui,Zeng Qingli,Huang Zhiqin,Li Laisheng
Ferrocene is a stable metallocene complex with aromatic high-electron π-conjugated system and sandwich structures. We first prepared and characterized a novel ferrocenediamide bridged bis (β-cyclodextrin) chiral stationary phase (FeCDP) to explore its chiral separation function. Its HPLC performance was systematically evaluated by basic, acidic, amphoteric and neutral chiral probes, including triazoles, profens, flavanones, amino acids and β-blocker drugs in reversed-phase and polar organic modes, respectively. The results showed that FeCDP successfully resolved 44 kinds of tested analytes ( R s = 0.66–4.38), of which 36 were completely separated ( R s ≥ 1.5). The best resolutions of different types, such as hexaconazole, ketoprofen, 3'-hydroxyflavanone, phenylalanine and arotinolol on FeCDP were reached at 3.06, 1.90, 4.38, 1.89 and 2.12 in a short time, respectively. Especially, FeCDP could completely resolve imazalil ( R s = 1.97), ketoprofen ( R s = 1.90), dansylated arginine (Dns-Arg, R s = 1.50), pindolol ( R s = 1.42), bevantolol ( R s = 1.41), which were very difficult to be resolved on the conventional CDCSPs. However, under optimal condition, the ordinary CDCSP could only separate 19 analytes with low resolutions ( R s = 0.29–1.27). Compared with the reported similar stationary phases, the HPLC performance of FeCDP was also further improved. Based on the above comparison results, the satisfactory enantioselectivity of FeCDP may be mainly due to the fact that the “ pseudo -cavity” composed of two CDs and a ferrocene diamide, could provide cooperative inclusion for analytes. Meanwhile, the large π-conjugated ferrocenediamide bridging group could also provide hydrogen bonding, π–π stacking, dipole–dipole and hydrophobic interactions, which may promote the chiral recognition effect of FeCDP. Bridge CD-CSP was a versatile chiral separation material in drugs analysis. Graphical Abstract
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ANALYTICA CHIMICA ACTA
·
2022
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IF 6.911
Shengmei Tai,Zhijuan Qian,Hongxin Ren,Alberta Osei Barimah,Chifang Peng,Xinlin Wei
A colorimetric assay based on an enzyme-inhibition strategy is promising for the on-site detection of pesticide residues . However, very few works of pesticide detection were reported based on the inhibition toward nanozymes although nanozymes have demonstrated many advantages in sensing various targets. Herein, a facile colorimetric detection for Glyp was developed based on β [email protected] enzyme mimics. The β [email protected] with high peroxidase-like activity was synthesized using random DNA double strands as template and β -CD as surface ligand. β [email protected] could catalyze the H 2 O 2 -3,3′,5,5′-tetramethylbenzidine (TMB) system. The oxidation product OxTMB with a blue color and presented a large absorption signal at 652 nm. However, Glyp could destroy the synergic effect between redox doublet (Cu 2+ /Cu + ) on the β [email protected] A-CuNCs surface, resulting in the inhibition of the peroxidase-like activity. Colorimetric detection for Glyp could be established by detecting the changes of absorption signal at 652 nm. The linear range was 0.02–2 μ g/mL and the detection limit was 0.85 ng/mL (3δ/s). The method was applied in measuring Glyp spiked in lake water and various food samples. This method had rapidness, high sensitivity, and selectivity advantages, indicating the high application potential in monitoring Glyp residue in food.
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Foods
·
2022
·Vol. 11
·期 7
·936
·
IF 5.561
Xue-Mei Tang,Pan-Dao Liu,Zhi-Jian Chen,Xin-Yong Li,Rui Huang,Guo-Dao Liu,Rong-Shu Dong,Jian Chen
Owing to their excellent characteristics, Pickering emulsions have been widely used in the development and the application of new carriers for embedding and for delivering active compounds. In this study, β-carotene was successfully encapsulated in a Pickering emulsion stabilized usingDesmodium intortumprotein isolate (DIPI). The results showed that the encapsulation efficiencies of β-carotene in the control group Tween 20 emulsion (TE) and the DIPI Pickering emulsion (DIPIPE) were 46.7 ± 2.5% and 97.3 ± 0.8%, respectively. After storage for 30 days at 25 °C and 37 °C in a dark environment, approximately 79.4% and 72.1% of β-carotene in DIPIPE were retained. Compared with TE, DIPIPE can improve the stability of β-carotene during storage. In vitro digestion experiments showed that the bioaccessibility rate of β-carotene in DIPIPE was less than that in TE. Cytotoxicity experiments showed that DIPI and β-carotene micelles within a specific concentration range exerted no toxic effects on 3T3 cells. These results indicate that DIPIPE can be used as a good food-grade carrier for embedding and transporting active substances to broaden the application of the protein-based Pickering emulsion system in the development of functional foods.Keywords:Pickering emulsion;β-carotene;simulated in vitro digestion;bioaccessibility;cytotoxicity
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Shanying Zhang,Xiaolei Li,Lili Zheng,Xiaoyan Zheng,Yang Yang,Dao Xiao,Binling Ai,Zhanwu Sheng
β-Lactoglobulin (β-LG) is a whey protein with multiple binding sites for bioactive phenolics. Encapsulation of bioactive components in β-LG could enhance their activity and stability. In this study, vanillic acid (VA), ferulic acid (FA), and quercetin (QT) were encapsulated in β-LG. The resulting complex was studied by fluorescence spectroscopy, isothermal titration calorimetry, molecular docking, and molecular dynamics simulations. The β-LG–tri-ligand complex was successfully formed via an exothermic binding process when the ligands were added in the sequence of FA, QT, and VA, or QT, FA, and VA. The stabilities of the bioactive components in the complex were greatly improved by encapsulation. Molecular dynamics simulations confirmed that the binding of ligand molecules could increase the stability of the β-LG structure and made it more rigid/inflexible. The antioxidant activity and inhibition activity of the β-LG–tri-ligand complex against advanced glycation end products were higher than those of a mixture of FA, QT, and VA. The β-LG–tri-ligand complex shows great potential in functional food applications.
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Nutrients
·
2022
·Vol. 14
·期 8
·1564
·
IF 6.706
Hongbo Jiang,Pei Ma,Zhiguang Duan,Yannan Liu,Shihong Shen,Yu Mi,Daidi Fan
Gastric cancer (GC) is the leading causes of cancer-related death worldwide. Surgery remains the cornerstone of gastric cancer treatment, and new strategies with adjuvant chemotherapy are currently gaining more and more acceptance. Ginsenoside Rh4 has excellent antitumor activity. Conversely, the mechanisms involved in treatment of GC are not completely understood. In this study, we certified that Rh4 showed strong anti-GC efficiency in vitro and in vivo. MTT and colony formation assays were performed to exhibit that Rh4 significantly inhibited cellular proliferation and colony formation. Results from the wound healing assay, transwell assays, and Western blotting indicated that Rh4 restrained GC cell migration and invasion by reversing epithelial–mesenchymal transition (EMT). Further validation by proteomic screening, co-treatment with disitertide, and SIX1 signal silencing revealed that SIX1, a target of Rh4, induced EMT by activating the TGF-β/Smad2/3 signaling pathway. In summary, our discoveries demonstrated the essential basis of the anti-GC metastatic effects of Rh4 via suppressing the SIX1–TGF-β/Smad2/3 signaling axis, which delivers a new idea for the clinical treatment of GC.Keywords:ginsenoside Rh4;SIX1;TGF-β/Smad2/3 pathway;gastric cancer
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yangyang Zhou,Chen Chen,Qiling Li,Yanbo Liu,Ting Wei,Youzhen Liu,Zebing Zeng,Darren Bradshaw,Bing Zhang,Jia Huo
Hydrogenation of unsaturated biomass in a control manner is highly desirable but challenging, especially under mild conditions. We here report selective hydrogenation of α,β-unsaturated aldehydes (UALs), featuring a precise control of all potential products by adjustment of the role of ammonia borane (AB) in transfer and/or catalytic hydrogenation. The hydrogenation can be readily operated in neat water without using any external H 2 -source, because AB as the H 2 -source is favorable in aqueous solution. Impressively, unsaturated alcohols are prepared in 100% conversion by the room-temperature transfer hydrogenation of UALs with AB, while saturated aldehydes are obtained in 100% conversion and > 90% selectivity with high activity ( i.e ., turnover frequency = 0.98 s −1 for cinnamaldehyde), by the catalytic hydrogenation with H 2 released from AB and Pd immobilized on two-dimensional metal organic layer. On the other hand, UALs can be completely converted into the saturated alcohols through a combination of transfer and catalytic hydrogenation in one pot. This strategy can be extended to more than 8 types of UALs, and provides a facile way to fine-control the selective hydrogenation of unsaturated compounds with competing bonds.
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