NANO
·
2024
·
IF 1
Ying Zhou,Jinai Bian,Min Tian,Tingting Wang,Guomei Zhang,Yan Zhang,Caihong Zhang
Chronic ingestion of food containing clenbuterol (CLB) in the human body can cause acute poisoning. Thus, it is essential to develop a sensitive CLB detection way. Here, a novel electrochemical aptamer sensor based on aptamer/gold nanoparticles/amino magnetic ferric oxide/graphene nanosheets (aptamer/Au NPs/Fe 3 O 4 –NH 2 /GN) nanocomposite has been developed. The Fe 3 O 4 –NH 2 nanoparticles were self-assembled on GN, and then Fe 3 O 4 –NH 2 /GN nanocomposite was coated on the glassy carbon electrode (GCE) surface. Afterward, Au NPs were electrodeposited on Fe 3 O 4 –NH 2 /GN nanocomposite to fix the aptamer by the Au–S bonds. When CLB was added to the solution, the aptamer will specifically recognize CLB, causing current changes. Under the optimized conditions, the sensor shows better electrochemical performance (linear range is 1 × 1 0 − 1 3 M to 1 × 1 0 − 7 M, the detection limit is 1 . 1 6 × 1 0 − 1 4 M ( S / N = 3 )). It has been successfully applied to the detection of CLB in actual samples. The results show that the aptamer sensor has good selectivity, stability and repeatability, which will provide a novel idea for more sensitive and quicker CLB detection.
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高影响因子
RSC Advances
·
2025
·Vol. 15
·期 15
·11893-11901
·
IF 4.6
Xixi Wu,Xiang Feng,Peng Yu,Jing Zhang,Rui Liu
Breast cancer remains a significant global health concern owing to the limitations of conventional therapies, such as side effects, drug resistance, and high costs. Nanocatalytic therapy has emerged as a promising alternative due to its tumor specificity, spatiotemporal controllability, and noninvasiveness. However, its effectiveness is limited by endogenous antioxidants like glutathione (GSH) and the low catalytic activity of nanocatalysts. Herein, an Cu/Au-doped polypyrrole nanocatalyst, Cu-AuPP, with multiple catalytic activities is developed by sequentially polymerizing pyrrole monomers using CuCl2 and HAuCl4, followed by PEGylation. The obtained Cu-AuPP catalyzes the production of hydroxyl radicals (·OH) and facilitates the oxidation of GSH to GSSG via redox reactions mediated by multivalent Cu ions, leading to oxidative damage, mitochondrial dysfunction, and tumor cell apoptosis. Upon 1064 nm laser irradiation, these catalytic activities were enhanced by elevated temperature and electron–hole separation mediated by Au nanoclusters, resulting in more intense oxidative damage to tumor cells. Collectively, the developed Cu-AuPP nanocatalytic medicine capable of simultaneously catalyzing GSH depletion and ·OH production via several improved catalytic mechanisms, has significant promise for the treatment of malignant tumors.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 5
·1-11
·
IF 5.3
Tian Li,Li Huiling,Han Pengfei,Ma Guangping,Wang Wenzhuo,Jiang Hanyue,Lu Juan
An electrochemiluminescence (ECL) sensor was constructed based on Ru(bpy) 3 2+ @Au and GO@CdS for the detection of tartrazine (TTZ). In the presence of the co-reactant TPrA, Ru(bpy) 3 2+ and CdS quantum dots (QDs) were used as dual luminophores to synergistically amplify the ECL signal of the sensor. Gold nanoparticles (Au NPs) enhanced the electron transport capability of the system and thereby amplified the ECL intensity. Graphene oxide (GO), as a carrier, has a special wrinkle-like structure that not only adsorbed a substantial amount of CdS QDs but also prevented their agglomeration. Additionally, a more sensitive detection method was established based on the quenching of the ECL signal, which occurred due to the interaction between Ru(bpy) 3 2+ and TTZ. A low detection limit (1.3 × 10 –13 mol·L −1 , S/N = 3) was obtained for TTZ concentrations ranging from 4.0 × 10 –13 to 4.0 × 10 –8 mol·L −1 . Finally, actual measurement results from three beverage samples demonstrated that the prepared sensors possess excellent practical capabilities for TTZ detection. Graphical
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高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 4
·265
·
IF 3.504
Zhongbo Li,Kexi Sun,Zhaofang Du,Bensong Chen,Xuan He
Here we report a low-cost synthetic approach for the direct fabrication of large-area Au nanourchin arrays on indium tin oxide (ITO) via a facile galvanic-cell-reaction-driven deposition in an aqueous solution of chloroauric acid and poly(vinyl pyrrolidone) (PVP). The homogeneous Au nanourchins are composed of abundant sharp nanotips, which can served as nanoantennas and increase the local electromagnetic field enhancement dramatically. Finite element theoretical calculations confirm the strong electromagnetic field can be created around the sharp nanotips and located in the nanogaps between adjacent tips of the Au nanourchins. In addition, the interparticle nanogaps between the neighboring Au nanourchins may create additional hotspots, which can induce the higher electromagnetic field intensity. By using rhodamine 6G as a test molecule, the large-area Au nanourchin arrays on ITO exhibit active, uniform, and reproducible surface-enhanced Raman scattering (SERS) effect. To trial their practical application, the Au nanourchin arrays are utilized as SERS substrates to detect 3,3’,4,4’-tetrachlorobiphenyl (PCB-77) one congener of polychlorinated biphenyls (PCBs) as a notorious class of persistent organic pollutants. The characteristic Raman peaks can be still identified when the concentration of PCB-77 is down to 5 × 10−6M.Keywords:surface-enhanced Raman scattering;galvanic cell reaction;Au nanourchins;PCBs
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高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2023
·Vol. 93
·期 7
·1912-1919
·
IF 0.9
Shen D. X.,Li H.,Ji G. J.,Zhang Z. W.,Lu X. L.,Shen L.,Dang Y. R.,Song A. J.
Abstract The composite material based on polysulfone (PSF) membrane was synthesized as an adsorbent to treatment of dye wastewater. Here, a gold nanoparticle-functionalized PSF/PDA adsorbent (PSF/PDA-Au) was prepared by a three-step method, the polysulfone membrane was prepared by phase transformation method, then the membrane was immersed in 2 g/L dopamine solution for 24 h to obtain the dopamine-coated material, the product was eventually immersed in a chlorauric acid solution for 3 h. The chemical composition and morphology of the composite were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometry (XPS), and measurement of contact angle. The efficiency of the adsorbent was evaluated by a series of experiments on the adsorption of the RhB dye. The reduced water contact angle of the adsorbent showed the improved hydrophilicity. Adsorption experiments have shown that PSF/PDA-Au effectively removes the RhB dye. At the same time, recirculation experiments showed that after four adsorption-desorption cycles, the removal rate can still reach 92.67%, indicating good stability of PSF/PDA-Au. Recyclability and convenient assembly of adsorbent using PSF flat membranes as support material make it an attractive candidate for removing dyes from wastewater.
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高影响因子
Nanoscience and Nanotechnology Letters
·
2018
·Vol. 10
·期 4
·520-527
·
IF 2.917
Deng Yan,Du Xueting,Ma Yuchan,Zhang Kunlei,Zhang Xi,Li De-Lei,Bai Ruyan,Hu Rong,Yang Yun-Hui
In this paper, an ultrasensitive electrochemical immunoassay based on porous covalent organic framework materials and Au NPs-CoS/graphene oxide (GO) nanocomposite was developed for the detection of C-reactive protein (CRP). Au NPs-CoS/graphene oxide (GO) nanocomposite was synthesized,
and employed as substrate because of their high conductivity to immobilize CRP antibody. A new porous covalent organic framework material (COF-LZU8) was functionalized by gold nanoparticles and doped with thionine (Thi) as the electron transfer mediator to obtain nanocomposite. The reduction
peak signal of Thi/Au NPs-COF-LZU8 at –0.2 V could be directly detected by highly sensitive differential pulse voltammetry (DPV). Due to the high surface area of COF-LZU8, a great quantity of Thi could be adsorbed on the surface of COF, thus, the signal could be greatly amplified. Moreover,
Thi/Au NPs-COF-LZU8 has strong adsorption capacity to the anti-CRP protein macromolecules due to the large specific surface area and good bio-affinity. The concentration of CRP antigen was proportional to the response current, so the quantitative detection of CRP was realized. Under the optimum
conditions, the linear range of CRP was 0.05–150 ng/mL with the detection limit of 0.016 ng/mL (S/N = 3). This immunosensor provides a more effective and sensitive method for detection of CRP.
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高影响因子
ANALYST
·
2021
·Vol. 147
·期 2
·303-311
·
IF 4.616
Chao Chen,Chenxi Wang,Pengcheng Zhao,Jin Zhang,Dechong Ma,Junjie Fei
First, the nanocomposite Au@rGO-MWCNT was synthesized by a hydrothermal method. Next, a temperature-controlled composite sensing film was prepared by composite modification of poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMEO2MA) and Au@rGO-MWCNT on a glassy carbon electrode (GCE). This sensor was shown to exhibit good temperature sensitivity and reversibility to dopamine. When the testing temperature is lower than the lower critical solution temperature (LCST) of the polymer, the PMEO2MA chain is in a stretched state, which increases the distance between the Au@rGO layers and leads to the inability of MWCNTs in one layer to contact another Au@rGO layer and to low conductivity. Therefore, in this state, dopamine cannot detect an electrochemical signal, and it is termed an “off” state. When the temperature is higher than the LCST of the polymer, the PMEO2MA chain shrinks, allowing the MWCNTs to make contact with another layer of Au@rGO; the electron transfer rate of the modified film increases, and the electrochemical behavior of dopamine turns to an “on” state. Moreover, the sensor has a wide detection range (0.1 to 9.0 μM and 9.0 to 239.0 μM), and the limit of detection of dopamine is as low as 30 nM. This method has been successfully applied to the determination of dopamine in human serum samples. The on–off sensor provides a new avenue for the application of temperature-sensitive polymers.
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高影响因子
Crystals
·
2022
·Vol. 12
·期 7
·884
·
IF 2.67
Yuanzhao Wu,Mingjie Chen,Haohao Bai,Binjie Wang,Jiye Wang,Yazhou Qin,Weixuan Yao
Hollow urchin-like Au nanocrystals have been widely studied due to their excellent surface plasmon resonance properties and large specific surface area, but the controllable preparation of hollow urchin-like Au nanocrystals is still a challenge. In this article, we successfully prepared hollow urchin-like Au nanocrystals using HAuCl4·3H2O and AgNO3as precursors and ascorbic acid as the reducing agent. No surface ligands or polymer stabilizers are required in the preparation process. HAuCl4·3H2O and AgNO3will first form AgCl cubes, then the reducing agent, ascorbic acid, will reduce the Au3+in the solution to Au0, and Au0will be deposited on the pre-formed AgCl cubes to form AgCl@Au nanocrystals. We characterized the morphology of the prepared Au nanocrystals by scanning electron microscopy and found that by increasing the amount of HAuCl4·3H2O in the reaction, the surface morphology of the Au nanocrystals would change from a rough spherical shape to an urchin-like shape. By further increasing the amount of the precursor HAuCl4·3H2O, urchin-like Au will convert into flake-like morphology. The AgCl in the interior was removed with ammonia water, and finally, hollow urchin-like Au crystals were formed. In addition, we used R6G molecule to explore the surface-enhanced Raman spectroscopy (SERS) enhancement effect of prepared Au crystals. The results show that the minimum detectable concentration of R6G reaches 10−8M. Moreover, we applied hollow urchin-like Au nanocrystals as catalysts and SERS enhancing materials to detect the photocatalytic reaction of 4-NTP. We used a 785 nm laser as both the SERS light source and the catalytic light source to monitor the photocatalytic effect of the laser on 4-NTP in situ by adjusting the laser power.Keywords:Au nanocrystals;sea urchin-like structure;SERS;photocatalytic reaction
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高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 26
·13086-13094
·
IF 11.301
Xue Zhao,Ziqiong Yang,Artem V. Kuklin,Glib V. Baryshnikov,Hans Ågren,Wenjing Wang,Xiaohai Zhou,Haibo Zhang
The electrochemical way of reducing nitrogen to ammonia presents green and economic advantages to dial down irreversible damage caused by the energy-intensive Haber–Bosch process. Here, we introduce an advanced catalyst CB[7]–K2[B12H12]@Au with highly dispersed and ultrafine nano-gold. The CB[7]–K2[B12H12]@Au electrochemically driven ammonia yield and Faraday efficiency is as high as 41.69 μg h−1 mgcat.−1 and 29.53% (at −0.4 V vs. RHE), respectively, reaching the US Department of Energy (DOE) utility index of ambient ammonia production along with excellent cycle stability and tolerance that indicates a high potential of industrial practical value. Experimental results and theoretical calculations show that the key to an excellent electrochemical nitrogen reduction performance lies in the smart design of the CB[7]–K2[B12H12]@Au catalyst combining the stable substrate anchored Au nanoparticles and K+ ions that effectively prevent the hydrogen evolution reaction and polarize *N2 leading to lowering of the rate determining step. This research will promote the further development of electrochemical ammonia production with low environmental impact.
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高影响因子
Journal of Nanoelectronics and Optoelectronics
·
2021
·Vol. 16
·期 7
·1029-1036
·
IF 0.961
Wang Hongzhu,Chen Mengxun,Song Liping,Huang Youju
A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2
is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo
and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy
system.
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高影响因子
Nanoscale
·
2016
·Vol. 8
·期 45
·19161-19173
·
IF 7.76
Qingchi Xu,Jiaxin Zeng,Haiqing Wang,Xingyun Li,Jun Xu,Jianyang Wu,Guangcan Xiao,Fang-Xing Xiao,Xiangyang Liu
A facile and efficient ligand-triggered electrostatic self-assembly strategy has been developed to fabricate a series of Au/CdS nanosheet (Ns) (Au–CdS Ns) nanocomposites with varied weight addition ratios of Au nanoparticles (NPs) by judiciously utilizing the intrinsic surface charge properties of assembly units, through which uniform dispersion and controllable deposition of Au NPs on the CdS Ns were achieved. Versatile probe reactions including photocatalytic oxidation of an organic dye pollutant, selective photocatalytic reduction of aromatic nitro compounds and photocatalytic hydrogen production reactions under visible light irradiation and ambient conditions were used to systematically evaluate the photoredox performances of the as-assembled well-defined Au–CdS Ns nanocomposites. It was unveiled that the photoactivities of Au–CdS Ns nanocomposites strongly depend on the weight addition ratio of Au NPs and the addition of an excess amount of Au NPs is detrimental to the separation of photogenerated charge carriers from CdS Ns. With the optimum addition amount of Au NPs (1 wt%), it was found that spontaneous assembly of Au NPs on the CdS Ns remarkably prolonged the lifetime of the photogenerated charge carriers from CdS Ns under visible light irradiation, thus resulting in significantly enhanced photocatalytic redox activities of Au–CdS Ns nanocomposites compared with those of CdS Ns. The crucial role of Au NPs in the photoredox reactions as efficient electron traps rather than plasmonic sensitizers was determined. Moreover, predominant active species responsible for the photocatalytic process were unambiguously determined and a possible photocatalytic mechanism was elucidated. It is anticipated that our work could open up a new avenue to rationally prepare various 2D semiconductors–metal nanocomposites by utilizing such a simple and efficient self-assembly strategy for extensive photocatalytic applications in a myriad of fields.
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高影响因子
RSC Advances
·
2019
·Vol. 9
·期 18
·10272-10281
·
IF 3.049
Yide Xia,Ying Liu,Nannan Shi,Xungao Zhang
In this article, the catalyst Au/γ-Fe2O3@hydroxyapatite (Au/γ-Fe2O3@HAP) consisting of Au nanoparticles supported on the core–shell structure γ-Fe2O3@HAP was prepared through a deposition–precipitation method. The catalyst was characterized by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, N2 adsorption–desorption and atomic absorption spectrometry. The as-prepared Au/γ-Fe2O3@HAP exhibited excellent performance for the reduction of 4-nitrophenolate (4-NP) to 4-aminophenolate (4-AP) in the presence of NaBH4 at room temperature. Thermodynamic and kinetic data on the reduction of 4-NP to 4-AP catalyzed by the as-prepared catalyst were studied. The as-prepared catalyst could be easily separated by a magnet and recycled 6 times with over 92% conversion of 4-NP to 4-AP. In addition, the as-prepared catalyst showed excellent catalytic performance on other nitrophenolates. The TOF value of this work on the reduction of 4-NP to 4-AP was 241.3 h−1. Au/γ-Fe2O3@HAP might have a promising potential application on the production of 4-AP and its derivatives.
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高影响因子
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