ACS Omega
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2023
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IF 4.1
Ning Shi,Tianlang Zhu,Hongyan Zhang,Hongsheng Huang,Liang Zhou,Ying Liu,Riyang Shu
Catalytic conversion of cellulose into the novel platform molecule 2,5-hexanedione (HXD) is regarded as one feasible approach for high-value utilization of biomass resources. Here, we reported one efficient way of one-pot conversion of cellulose into HXD with high yield of 80.3% in H2O and tetrahydrofuran (THF) mixture within Al2(SO4)3 combined with Pd/C as a catalyst. In the catalytic reaction system, Al2(SO4)3 could catalyze the conversion of cellulose into 5-hydroxymethylfurfural (HMF), and Pd/C combined with Al2(SO4)3 could catalyze the hydrogenolysis of HMF into furanic intermediates such as 5-methylfurfuryl alcohol and 2,5-dimethylfuran (DMF) without causing over-hydrogenation of these furanic intermediates. These furanic intermediates were finally transformed into HXD catalyzed by Al2(SO4)3. Besides, the H2O/THF ratio could significantly influence the reactivity of the hydrolytic furanic ring-opening of the furanic intermediates. The catalytic system also showed excellent performance on the conversion of other carbohydrates (glucose and sucrose) into HXD.
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2023
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IF 3.6
Yujia Liu,Jun Qian,Xiufen Zhao,Tianyu Lan,Yongjun Luo,Qianqian Guo,Xiangchun Shen
Globally, due to the rapid development of bacterial resistance, bacterial infections lead to significant mortality and morbidity which require efficient strategies to eradicate these infections. Herein, we prepared a dual-responsive synergistic drug delivery nanoparticle carrier (NPS@Bai/Cip), which responds to sub-acid bacterial microenvironments and targets phosphatase or phospholipase at infection sites. Nanoparticles surfaces were positively (10.0 mV) charged under acidic conditions, leading to good bacterial adhesion and enhanced drug accumulation. NPS@Bai/Cip showed good antibacterial and anti-biofilm activity against drug-resistant Pseudomonas aeruginosa. NPS@Bai/Cip could inhibit the biofilm formation via affecting the swimming, swarming, and twitching motilities of P. aeruginosa. NPS@Bai/Cip was used to treat drug-resistance P. aeruginosa-induced infection in rats by improving wound healing and reducing inflammatory responses. Thus, NPS@Bai/Cip functioned as an antibacterial and antibiofilm agent with good potential for treating bacteria-induced infections.
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Applied Sciences-Basel
·
2023
·Vol. 13
·期 5
·3182
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IF 2.7
Chuning Zhang,Huaqiang Chu,Qian Ma,Yanyan Chen,Jianwei Fan
It is important to further enhance the performance of green and efficient non-homogeneous catalysts for advanced oxidation process of Peroxymonosulfate (PMS-AOP) for green treatment of industrial wastewater. In this paper, nitrogen–sulfur co-doped MOFs-derived carbon material (CoSN@C) was prepared by one-pot synthesis followed by carbonization, and its morphological structure was characterized by XRD and SEM. After pyrolysis, the CoSN@C still maintained the dodecahedral morphology and structure of ZIF-67. The synergistic effects of S and N significantly elevated the activation of PMS. The results show that the CoSN@C + PMS system can effectively activate PMS to degrade Rhodamine B (RhB), with a rate constant (1.85 min−1) four times higher than that of the CoN@C + PMS system (0.44 min−1). The optimal catalytic process parameters of material dosage, PMS concentration, temperature, pH, and other parameters were also investigated for the activation of PMS to remove Rhodamine B. The cyclic experiment shows that the CoSN@C has excellent recyclability and the degradation rate of RhB still reached 88.9% after four cycles. Radical capture experiments and EPR tests showed that the CoSN@C + PMS system generated a large amount of SO4·−and ·OH radicals adsorbed on the catalyst surface and a certain amount of singlet oxygen, and the free radical pathway and non-radical pathway worked together to degrade RhB efficiently and rapidly. While non-radical pathway with singlet oxygen as main reactive oxygen species played a key role in the CoN@C + PMS system. This work provides a new idea for the rational design of non-homogeneous catalysts for PMS-AOP system.Keywords:advanced oxidation process;peroxymonosulfate (PMS);non-homogeneous catalyst;MOFs
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JOURNAL OF LUMINESCENCE
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2023
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IF 3.6
Yuxuan Luo,Danyu Zhang,Shujun Xu,Lianjie Li,Liping Chen,Hai Guo
Herein, YNbO 4 (YNO):Bi 3+ ,Ln 3+ (Ln = Dy, Eu) phosphors were manufactured though high-temperature solid-phase reaction. Their structural properties, optical characteristics and energy transfer mechanisms (Bi 3+ →Ln 3+ ) were analyzed in detail, and their potential application in optical thermometry was explored. Under 312 nm excitation, YNO:Bi 3+ ,Ln 3+ phosphors show broad emission from Bi 3+ ions ( 3 P 1 → 1 S 0 ) and sharp peaks from 4f-4f transitions of Ln 3+ ions. YNO:Bi 3+ ,Ln 3+ samples exhibit high sensitivity and superior thermochromic properties in temperature sensing. For YNO:Bi 3+ ,Dy 3+ phosphor, the maximum absolute sensitivity ( S a ) and relative sensitivity ( S r ) reach 14.25 %K −1 (573 K) and 1.48 %K −1 (444 K), respectively. For YNO:Bi 3+ ,Eu 3+ phosphor, the maximum S a and S r reach 38.21 %K −1 (573 K) and 1.58 %K −1 (445 K), respectively. And the chromaticity shift of emission from YNO:Bi 3+ ,Eu 3+ phosphor is 0.38 for temperature from 303 to 573 K. Such results suggest that YNO:Bi 3+ ,Ln 3+ phosphors can be candidate for visual and highly sensitive optical thermometry.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·Vol. 30
·期 18
·53355-53369
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IF 5.8
Ding Chunsheng,Lei Jia,Cai Zhiyue,Gao Mengying,Zou Zhaozheng,Li Yuanfeng,Deng Jing
In this research, FeCo 2 O 4 nanomaterial was successfully synthesized by a typical sol–gel method and conducted as an effective agent for peroxymonosulfate (PMS) activation to eliminate antibiotics flurbiprofen (FLU), a strong nonsteroidal drug. FeCo 2 O 4 nanomaterial was characterized by XRD, TEM, SEM, and XPS. Various characterization results proved that FeCo 2 O 4 held stable spinel structure. The interfering factors including initial pH, PMS concentration, catalyst dosage, inorganic anions, and humic acid on FLU removal were also discussed. The conclusion was that the removal efficiency of FLU reached 98.2% within 120 min after adding FeCo 2 O 4 (0.4 g L −1 ) and PMS (3 mM). The optimal pH for FLU degradation was the initial pH of 6.5; too acidic or alkaline was not conductive to the degradation. The existence of HA and Cl − restrained the degradation of FLU, and HCO 3 − promoted the removal, while the influence of NO 3 − and SO 4 2− could not be considered. The radical scavenging experiment confirmed that • OH, O 2 •− , and SO 4 •− participated in FLU removal and SO 4 •− functioned a leading role. FeCo 2 O 4 showed high efficiency for PMS activation in pH range of 3.0 to 10.0. After the fourth cycle operation, the FLU removal rate exceeded 76.9%, and the Co leaching rate was low during the catalytic reaction. This study shows that FeCo 2 O 4 nanomaterial is an efficient and environment-friendly catalyst, which can be applied for PMS activation to remove organic pollutants in water.
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JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 12
·1171-1182
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IF 3.4
Yue Meng,Hong Zhai,Ziting Zhou,Xiaoying Wang,Jiandong Han,WenJuan Feng,Yuxin Huang,Yuan Wang,Ying Bai,Jing Zhou,Daping Quan
The development of artificial organs and implants demands new materials with both processability and functionality. A series of star like poly(CL- co -TOSUO) copolymers with different molecular weights are synthesized via ring-opening polymerization. The polymers are modified with norbornene end groups for rapid photo-crosslinking. Due to the random insertion of 1,4,8-trioxaspiro-[4,6]-9-undecanone and well-constructed permanent chemical network, the photo-crosslinked elastomers are more flexible and resilient than conventional poly(ε-caprolactone), with 84% resilience above the melting point. Their thermal and mechanical properties can be fine-tuned by varying the molecular weights of the precursors. The polymer can be fabricated into complex shapes by digital light processing 3D printing. Combined with good cytocompatibility and degradability, the highly flexible elastomers show great potential for tissue engineering. Graphical
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JOURNAL OF CONTROLLED RELEASE
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2023
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IF 10.8
Chen Xu,Shiyou Li,Jitang Chen,Huimin Wang,Zheng Li,Qingyuan Deng,Jiayuan Li,Xing Wang,Yuxuan Xiong,Zhijie Zhang,Xiangliang Yang,Zifu Li
Cancer stem cells (CSCs), enabled to self-renew, differentiate, and initiate the bulk tumor, are recognized as the culprit of treatment resistance, metastasis, and recurrence. Simultaneously eradicating CSCs and bulk cancer cells is crucial for successful cancer therapy. Herein, we reported that doxorubicin (Dox) and erastin co -loaded hydroxyethyl starch-polycaprolactone nanoparticles (DEPH NPs) eliminated CSCs and cancer cells by regulating redox status. We found that an excellently synergistic effect existed when Dox and erastin were co-delivered by DEPH NPs. Specifically, erastin could deplete intracellular glutathione (GSH), thereby inhibiting the efflux of intracellular Dox and boosting Dox-induced reactive oxygen species (ROS) to amplify redox imbalance and oxidative stress. The high ROS levels restrained CSCs self-renewal via downregulating Hedgehog pathways, promoted CSCs differentiation, and rendered differentiated cancer cells vulnerable to apoptosis . As such, DEPH NPs significantly eliminated not only cancer cells but more importantly CSCs, contributing to suppressed tumor growth, tumor-initiating capacity, and metastasis, in various tumor models of triple negative breast cancer . This study demonstrates that the combination of Dox and erastin is potent in elimination of both cancer cells and CSCs, and that DEPH NPs represent a promising treatment against CSCs-rich solid tumors .
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JOURNAL OF MEMBRANE SCIENCE
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2023
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IF 9.5
Yanrui Wang,Hailin Chang,Shu Jiang,Jialong Chen,Jinlong Wang,Heng Liang,Guibai Li,Xiaobin Tang
The interfacial polymerization (IP) plays a fundamental role in the fabrication of polyamide (PA) nanofiltration (NF) membranes with high ion selectivity and water permeability, which has enormous value for the increasing permeate quality and production in desalination. Herein, this study adopted a weak-polar organic solvent of ethyl formate (EF) to effectively regulate the IP process between piperazine (PIP) and trimesoyl chloride (TMC). The engineered PA separate layer conferred a uniform and ultrafine pore size (∼0.195 nm), exhibited a precise solute separation, and maintained a desirable permeability (18.4 ± 0.9 L m −2 h −1 bar −1 ). Molecular dynamics (MD) simulation indicated that EF involvement would significantly reduce the interfacial tension to motivate a fast and abundant diffusion of amine monomers from the aqueous phase into organic phase during the IP reaction, contributing to engineering a PA film with higher crosslinking degree. The optimized PA NF membranes conferred a more efficient rejection for divalent anions and cations (e.g., 99.5% for Na 2 SO 4 and 98.8% for MgCl 2 ). Remarkably, the membrane endowed a fairly high mono/divalent ion selectivity at sub-angstrom size, such as 145 for Cl − /SO 4 2− and 61 for Na + /Mg 2+ . The outstanding NF performance successfully broke the "trade-off" bound of perm-selectivity and was superior to the most "state-of-the-art" NF membranes. Overall, the co-solvent based IP strategy was beneficial to developing high-performance NF membranes without any significant changes to the existing fabrication process, and its facile and cost-effective merits were full of significance to the membrane manufacture.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Jie Zhu,Qixing Du,Muhammad Arif Khan,Hongbin Zhao,Jianhui Fang,Daixin Ye,Jiujun Zhang
A significant issue in the overall water splitting process is the development of bifunctional non-precious metal catalysts with high performance. Herein, we designed and synthesized heterogeneous structure of Co 5.47 N/MoN (Co-Mo-N) porous nanosheets in situ grown on nickel foam substrates by thermal ammonolysis of CoMoO 4 precursors. The special heterogeneous and porous nanosheet structure of Co-Mo-N not only provides abundance of active sites, but also accelerates the charge transfer due to the interaction between Co 5.47 N and MoN. Additionally, the differing energy band configurations of the various phases in heterostructure will cause charge transport at the interface, which would be advantageous for the surface electron modification of heterojunctions and further enhances the electrocatalytic performance. As a result, the Co-Mo-N heterostructure exhibited excellent OER and HER catalytic activity, with over potentials of 288 and 82 mV at 10 mA cm −2 , respectively. When using Co-Mo-N heterostructures as cathodes and anodes to achieve overall water splitting, a low voltage of 1.59 V is required to achieve a current density of 10 mA cm −2 . This research presents a novel approach to designing bifunctional non-precious metal catalysts for overall water splitting.
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International Journal of Nanomedicine
·
2023
·
IF 8
Shaoyin Wei,Sijie Zhou,Wenjuan Huang,Xingjie Zan,Wujun Geng
Purpose There has been a substantial global market for antibodies, which are based on extracellular targets. Binding intracellular targets by antibodies will bring new chances in antibody therapeutics and a huge market increase. We aim to evaluate the efficiency of a novel delivery system of His6-metal assembly (HmA) in delivering intracellular antibodies and biofunctions of delivered antibodies.Methods In this study, the physicochemical properties of HmA@Antibodies generated through co-assembling with antibodies and HmA were well characterized by dynamic light scatter. The cytotoxicity of HmA@Antibodies was investigated by Cell Counting Kit-8 (CCK-8). The endocytic kinetics and lysosome escape process of HmA@Antibodies were studied by flow cytometry and fluorescent staining imaging, respectively. Compared to the commercialized positive control, the intracellular delivery efficiency by HmA@Antibodies and biofunctions of delivered antibodies were evaluated by fluorescent imaging and CCK-8.Results Various antibodies (IgG, anti-β-tubulin and anti-NPC) could co-assemble with HmA under a gentle condition, producing nano-sized (~150 nm) and positively charged (~+30 eV) HmA@Antibodies particles with narrow size distribution (PDI ~ 0.15). HmA displayed very low cytotoxicity to divers cells (DCs, HeLa, HCECs, and HRPE) even after 96 h for the feeding concentration ≤100 μg mL−1, and fast escape from endosomes. In the case of delivery IgG, the delivery efficiency into alive cells of HmA was better than a commercial protein delivery reagent (PULSin). For cases of the anti-β-tubulin and anti-NPC, HmA showed comparable delivery efficiency to their positive controls, but HmA with ability to deliver these antibodies into alive cells was still superior to positive controls delivering antibodies into dead cells through punching holes.Conclusion Our results indicate that this strategy is a feasible way to deliver various antibodies intracellularly while preserving their functions, which has great potential in various applications and treating many refractory diseases by intracellular antibody delivery.
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高影响因子
SOLID STATE SCIENCES
·
2023
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IF 3.5
Yijun Yin,Xiaoyi Huang,Wang Wang,Xia Liu
Carbon and oxygen co-doped phosphotungstate were successfully prepared by one-pot thermal treatment with phosphotungstic acid (HPW) and melamine-cyanuric acid supramolecule (MCA) as precursors. Based on the results of X-ray photoelectron spectra (XPS), UV–visible diffuse reflectance spectroscopy (UV–vis DRS), and Photoluminescence (PL) measurements, the existence of C O in CNPW-8-420 has been confirmed. Carbon and oxygen which are co-doped as C O in the Keggin structure of phosphotungstate are contributed to the separation of charge carriers and can increase the amount of the photocatalysis active sites. With the amount of HPW increasing, MCA decomposed in CNPW-8-420 and CNPW-20-420 without synthesizing g-C 3 N 4 , leading to in-situ doped of C O. Furthermore, the increase of treatment temperature can cause the supramolecular structure of MCA to overbreak, leading to carbon and nitrogen elements doped in CNPW-8-500. The photocatalytic degradation efficiency rate constant of CNPW-8-420 is 0.40 h −1 and it can be reused 3 times with no obvious change. LC−MS/MS revealed the most likely photocatalytic degradation pathway and intermediates of imidacloprid including imidacloprid olefin, guanidine-type imidacloprid, imidacloprid urea, 6-chloronicotinic acid, 5-hydroxy-imidacloprid, and 4,5-dihydroxy-imidacloprid. This study provides a promising strategy for the construction of co-doped POMs photocatalysts using different supramolecule precursors.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Mingzhi Li,Xiaojun Huang,Jiajia Wen,Shikang Chen,Xincheng Wu,Wanning Ma,Steve W. Cui,Mingyong Xie,Shaoping Nie
The law and mechanism of the interaction between polysaccharides and pattern recognition receptors (PRRs) has been unclear. Herein, three glucomannans with different structures were selected to explore the universal mechanism for PRRs to recognize glucomannans. Screening results showed that the silence of TLR4 but not TLR2 severely blocked the production of inflammatory cytokines and the transduction of signal pathways. In-depth results revealed that the participation of myeloid differentiation protein 2 (MD2) and CD14 and the dimerization of the TLR4-MD2 complex were required for glucomannan-activated TLR4 signal transduction . Mannose receptor (MR) was also engaged in glucomannan-induced respiratory burst, endocytosis , and inflammatory signaling pathways in a spleen tyrosine kinase-dependent manner. The internalization of glucomannans into the cytoplasm by MR directly initiated complex intracellular signaling cascades. Finally, molecular docking characterized the binding energy and binding sites between glucomannans and multiple receptors from other perspectives. The essence of glucomannans recognized by PRRs was the non-covalent interaction of multiple receptors and the subsequent transmission of the signal cascade was triggered in a multi-channel and cooperative manner. As a result, the hypothesis that “Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response” was proposed to outline these meaningful phenomena.
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危险品化学品经营许可证（带存储）