JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2010
·Vol. 48
·期 24
·5643-5651
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IF 3.971
Peng-Fei Gou,Wei-Pu Zhu,Zhi-Quan Shen
Novel calixarene-centered amphiphilic A 2 B 2 miktoarm star copolymers composed of two PCL arms and two PEG arms with calix[4]arene as core moiety were synthesized by the combination of CROP and “click” chemistry. First, a heterotetrafunctional calix[4]arene derivative with two hydroxyl groups and two alkyne groups was designed as a macroinitiator to prepare calixarene-centered PCL homopolymers (C4-PCL) by CROP in the presence of Sn(Oct) 2 as catalyst at 110 °C. Next, azide-terminated PEG (A-PEG) was synthesized by tandem treating methoxy poly(ethylene glycol)s (mPEG) with 4-chlorobutyryl chloride and NaN 3 . Finally, copper(I)-catalyzed cycloaddition reaction between C4-PCL and A-PEG led to A 2 B 2 miktoarm star copolymer [C4S(PCL) 2 -(PEG) 2 ]. 1 H NMR, FT-IR, and SEC analyses confirmed the well-defined miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in water. The calix[4]arene moieties with a cavity <1 nm on the hydrophilic/hydrophobic interface of these aggregates may provide potential opportunities to entrap guest molecules for special applications in supermolecular science. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
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高影响因子
THERMOCHIMICA ACTA
·
2011
·
IF 1.908
Xiaohong Zhao,Xueqiao Xie,Yongsheng Yan
Binodal data of poly(propylene glycol) PPG 400 + salt ((NH 4 ) 2 SO 4 , MgSO 4 , and KCl) + H 2 O systems were determined at T = 298.15 K, and binodal data of PPG 400 + KAc + H 2 O system was determined at T = (298.15, 308.15, and 318.15) K. Moreover, the binodal curves were fitted to Merchuk equation, and the tie-lines were fitted to both the Othmer–Tobias and Bancroft equations. The effects of temperature and salts on the binodals and tie-lines of the investigated ATPSs were also studied. Finally, the salting-out ability of salts on the polymer was obtained by fitting the Setschenow-type equation to the tie-line data to derive a salting-out coefficient ( k S ) for each salt. For potassium salts, the relative effectiveness of the anions in inducing the phase segregation in ATPSs follows the Hofmeister series. The relative salting-out effectiveness of the sulfate salts is influenced by complexation of the cations by PPG.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2015
·Vol. 54
·期 3
·407-417
·
IF 3.113
Cui-Wei Wang,Chao Liu,Xiao-Wei Zhu,Zi-Ying Yang,Hong-Fan Sun,De-Ling Kong,Jing Yang
Well-defined star-shaped hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) amphiphilic conetworks (APCNs) have been synthesized via the combination of ring opening polymerization (ROP) and click chemistry. Alkyne-terminated six arm star-shaped PCL (6-s-PCL x -CCH) and azido-terminated PEG (N 3 -PEG-N 3 ) are characterized by 1 H NMR and FT-IR. The swelling degree of the APCNs is determined both in water and organic solvent. This unique property of the conetworks is dependent on the nanophase separation of hydrophilic and hydrophobic phases. The morphology and thermal behaviors of the APCNs are investigated by SEM and DSC respectively. The biocompatibility is determined by water soluble tetrazolium salt reagents (WST-1) assay, which shows the new polymer networks had good biocompatibility. Through in vitro release of paclitaxel (PTX) and doxorubicin (DOX), the APCNs is confirmed to be promising drug depot materials for sustained hydrophobic and hydrophilic drugs. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 407–417
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2013
·
IF 2.487
Huihui Ma,Wei Feng,Miaomiao Tian,Qiong Jia
A simple, rapid and sensitive method for simultaneous determination of three N -methylcarbamate pesticides (carbaryl, pirimicarb, and isoprocarb) in vegetables was developed by coupling polymer monolith microextraction (PMME) to high-performance liquid chromatography (HPLC). A poly(methacrylic acid- co -ethylene glycol dimethacrylate) monolith was selected as the extraction medium for PMME. To achieve optimum extraction performance, several parameters were investigated, including desorption solvent, desorption flow rate, sample flow rate, sample volume, sample pH values, inorganic salt and organic solvent content of the sample solution. Under the optimum experimental conditions, the method provides an acceptable linearity (5–5000 μg/kg), low limits of detection (0.36–2.6 μg/kg), good precision (intra-day relative standard deviations < 2.53%, inter-day relative standard deviations <6.36%). Finally, the developed method was successfully applied to the determination of N -methylcarbamate pesticides in vegetables, and the trueness was evaluated by recovery experiments. The obtained relative recoveries were in the range of 70.4–98.5%. This PMME method integrates sample extraction, purification, and preconcentration of analytes into one single step and it also has several advantages such as solvent-free extraction, small sample volume, high enrichment, convenience, and flexibility operation.
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高影响因子
KEY ENGINEERING MATERIALS
·
2021
·
IF 0
Yang Yi Chen,Wen Jing Wen,Zhi Qin Su,Qi Huan,Chu Yang Zhang
Thermo-responsive random copolymer poly (2-(2-methoxyethoxy) ethoxyethyl methacrylate-co-poly (ethylene glycol) methyl ether methacrylate), abbreviated as P(MEO2MA-co-OEGMA300) was synthesized by 2-(2-methoxyethoxy) ethoxyethyl methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA300) with a molar ratio of 1:1 via atom transfer radical polymerization (ATRP). The structure of P(MEO2MA-co-OEGMA300) was confirmed by 1H NMR and GPC. The transition behaviors of P(MEO2MA-co-OEGMA300) in aqueous solution were investigated by UV-Vis and DLS. While the transition behaviors of P(MEO2MA-co-OEGMA300) thin films were probed by white light interferometry. Compared to the P(MEO2MA-co-OEGMA300) in solution, it shows a much broader transition region, which is a promising candidate for the slow release of drug in the field of medicine.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2019
·Vol. 92
·期 3
·618-627
·
IF 1.986
Zhu Hongyu,Zhu Meng,Shuai Shirong,Zhao Cong,Liu Yu,Liu Yuan,Li Xiaohong,Rao Zikun,Li Yang,Hao Jianyuan
The delicacy of nature prompted scientists to create functional or responsive biomaterials using existing natural components. Here we reported novel thermo-gelling hydrogels based on methyl poly (ethylene glycol)-poly (L-valine) (mPEG-L-PV) diblock copolymer solutions, which exhibited well-defined sol–gel transition at a temperature range from 10 °C to 40 °C. The β-sheet was the dominant secondary structure for poly(L-PV) block when the molecular weight of the polypeptide ranged from 277 Da to 1138 Da. The formation of mPEG–L-PV clear sol solutions was related to the stable nanostructures that were aggregated clusters of poly(L-PV) β-sheet filaments and stabilized by the hydrophilic PEG segments. The block length of poly(L-PV) significantly affected the secondary structures of polypeptide and the morphology of assembled filaments, which resulted in different thermo-gelling behavior of the copolymer solutions. The occurrence of sol–gel transition with temperature was primarily due to the dehydration effect of PEG block, whereas in the case of the copolymer with a lower molecular weight of poly(L-PV) block, the change of polypeptide secondary structures also contributed to the formation of the gel. This paper provides fundamental information about the strong dependence of polypeptide block length on the nano-assembly morphology as well as thermosensitive behavior of polypeptide-based hydrogels.
The block length of poly(L-PV) significantly affected the secondary structures of polypeptide and the morphology of assembled filaments, which resulted in different thermo-gelling behavior of the copolymer solutions.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Zhiyan Wang,Qingya Guo,Rongrong Jiang,Shungui Deng,Junfeng Ma,Ping Cui,Xiayin Yao
Solid polymer electrolytes (SPEs) are promising candidates for the next-generation all-solid-state batteries due to their good flexibility as well as safety. However, the low ionic conductivity, uncontrolled lithium dendrite growth, poor cyclic performance and high temperature intolerance are still great challenges for their widely applications. In this work, a flexible and dense poly(vinylidene fluoride)/poly(ethylene glycol) (PVDF@PEG) SPE is designed and fabricated via an in-situ thermocuring method, which exhibits a high ionic conductivity of 8.03 × 10 −5 S cm −1 at 30 °C and excellent electrochemical stability window of 5.2 V. More importantly, the Li/PVDF@PEG/Li symmetric cell can be continuously cycled at 0.1 mA cm −2 more than 3200 h without short-circuit at both 60 and 100 °C. Owing to these outstanding merits, the LiFePO 4 /PVDF@PEG/Li pouch cell delivered a high discharge specific capacity of 122.8 mAh g −1 after 1000 cycles at 1C with a capacity retention of 86.36% under 60 °C. Notably, the LiFePO 4 //Li pouch cell also shows excellent cycle stability at 100 °C, exhibiting reversible capacities from 155.5 to 123.1 mAh g −1 under 1C after 1000 cycles.
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高影响因子
DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 3.6
Jiayi Yao,Jiaqi Wang,Peipei Bu,Kexin Liu,Mingyang Zhao,Jingkai Gu,Xiangjun Meng
Fluorescent probes are extensively used for tracking the in vivo behavior of nanocarriers. However, the impact of fluorescent probes on the in vivo fate of nanomedicines remains uncertain. Potential interference from the probes may lead to misleading conclusions. This study investigated the influence of a commonly used fluorescent probe, DiI, on the in vivo fate of paclitaxel (PTX)-loaded polymeric micelles (PMs) in rats. The drug release kinetics of PTX-loaded PMs (PTX-PM) with DiI/PTX co-loaded PMs (DiI/PTX-PM) in rat plasma was quantitatively compared. The results indicate that co-encapsulation with DiI significantly exacerbated drug release and altered the protein binding of PTX through competitive binding, resulting in an increased proportion of free PTX. DiI enhanced diffusion-driven drug leakage without affecting the micelle dissociation kinetics. Notably, DiI inhibited elimination and increased the systemic exposure of both the free micelle material and the nanocarrier. This study provides evidence that DiI can potentially interfere with the in vivo fate of both the therapeutic payload and the nanocarrier, highlighting the necessity for rigorous validation when employing it for nanocarrier tracking.
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高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2026
·
IF 9.9
Rui Liu,Yiming Gou,Chunhua Ge,Kai Jia,Tingli Liu,Xiangdong Zhang
PEG mixture was innovatively added to the EP. • BNNS-OH enhanced mechanical properties and tribological properties. • EP possesses both flexibility and thermal storage simultaneously. • Flexibility, thermal and tribological enhancement mechanism. Commercial epoxy resin (EP) has been restricted in electronic packaging due to intrinsic brittleness and poor tribological performance. Herein, facile strategy for fabricating flexible, excellent thermal properties, mechanical property and tribological performance of EP-based composite film is proposed. Polyethylene glycol (PEG) mixture fabricated by polyethylene glycol 6000 (PEG6K) and low molecular weight PEG (PEG0.8K, 1K, and 1.5K) and high thermal conductivity fillers hydroxylated boron nitride nanosheets (BNNS–OH) were introduced into EP (EPPB). The effects of PEG addition amount and molecular weight of low molecular weight on flexibility, mechanical, thermal and tribological properties have been systematically investigated. Non-covalent crosslinking EP and PEG mixture polymer network structure endows EPP with flexibility, stretching stress attained 21.04 MPa. Surprisingly, latent heat of EPPB can reach 62.28 J/g, few papers have been reported commercial EP that possess both flexibility and thermal storage properties. In addition, the results of tribological experiment indicated that average friction coefficient (COF) of EPPB achieve 0.1854 and ultralow wear rate of 19.79 × 10 −5 mm 3 /(N·m), demonstrating outstanding tribological performance. This work offers fresh method to obtain phase change composite films utilizing commercial EP in thermal management of flexible electronic packaging devices. Download: Download high-res image (336KB) Download: Download full-size image
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2026
·
IF 5
Yijin Deng,Rang Yang,Wenyou Ding,Jinqing Chen,Huijuan Wei,Haoxiang Fan,Yi Wang,Xian Luo,Lina Lan,Hailan Qin,Minjie Jiang,Wenya Ding
A stable and uniform DMY-CD-CS/TPGS nano-delivery system was prepared. • The system markedly enhances DMY uptake in Caco-2 cells and the small intestine. • NPs open tight junctions and improve paracellular permeability. • Pharmacokinetics show a significant increase in the oral bioavailability of DMY. • Offers a new oral delivery strategy for poorly-absorbed and unstable drugs. The low oral bioavailability of Dihydromyricetin(DMY), resulting from its instability and poor absorption in the gastrointestinal tract, limits its pharmaceutical applications. In order to enhance the oral bioavailability of DMY, a DMY@CD-CS/TPGS nano-delivery system was successfully prepared using β-cyclodextrin grafted with chitosan (CD-CS) and Tocopheryl Polyethylene Glycol Succinate(TPGS). The DMY@CD-CS/TPGS-NPs have a uniform particle size distribution and good stability. In vitro release studies demonstrated that the NPs exhibited a sustained-release profile under acidic conditions. In vivo and in vitro tests showed that the NPs could promote drug uptake and internalization in Caco-2 cells through multiple endocytic pathways, and disrupt epithelial tight junctions, thereby increasing paracellular absorption. Additionally, it exhibits excellent mucosal adhesion, thereby prolonging drug retention time. The intestinal segment distribution and unidirectional perfusion experiment further demonstrated that the NPs enhanced drug uptake in the duodenum, jejunum, and ileum, and increased both the absorption rate constants and the apparent permeability coefficients. Pharmacokinetic studies demonstrated that DMY@CD-CS/TPGS-NPs significantly enhanced the oral absorption of DMY, increasing the Cmax, AUC 0-t , and t 1/2 by 7.12-fold, 1.25-fold, and 14.26-fold, respectively. The relative oral bioavailability was 250.39%, representing a 2.50-fold improvement over DMY. Overall, the CD-CS/TPGS nano-delivery system represents a promising strategy for improving the oral delivery of poorly absorbable compounds such as DMY. Download: Download high-res image (149KB) Download: Download full-size image
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yang Cao,Xiaohong Guo,Ting Li,Zihe Wang,Yi Wang,Keyu Zhu,Di Wu,Kunsong Chen
HAMA-EG hydrogel achieved ultra-rapid crosslinking and curing in 1 s under UV light • EG annealing enhanced compressive strength and mechanical durability of the hydrogel • HAMA-EG retained 72.52% cyclic mechanical retention after −20 °C freezing • HAMA-EG had wide-temperature stability, high water retention, and good cushioning • HAMA-EG hydrogel effectively mitigated vibration and drop damage on peach fruit Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed. Through ethylene glycol (EG) annealing, a cushioning material (HAMA-EG) with good low-temperature tolerance and high water retention was fabricated. Systematic characterizations indicated that the hydrogel achieved rapid 1 s UV curing, attributed to approximately 0.69 methacryloyl groups grafted per HA disaccharide unit, which provided sufficient photosensitive crosslinking sites on the HAMA chains. HAMA-EG also exhibited a regular porous structure, good mechanical properties (Young's modulus of 0.28 MPa and compressive strength of 3.85 MPa), and biocompatibility. The incorporation of EG enhanced the material's low-temperature resistance (no freezing at −40 °C) and environmental stability (cumulative weight loss of only 29.41% after 120 h). In addition, HAMA-EG Gel showed enhanced cyclic mechanical stability after environmental pretreatment; after −20 °C freezing, its cyclic mechanical retention remained at 72.52%, compared with 6.43% for HAMA Gel. In simulated vibration and drop transportation tests using peaches as a bruise-sensitive fruit model, HAMA-EG reduced mechanical damage and better maintained fruit quality than commercial cushioning materials. Overall, HAMA-EG enabled rapid curing and forming with good energy dissipation and water-retention properties, thus holding broad application in cushioning protection for fresh produce. Download: Download high-res image (416KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Lan Zhou,Maoliang Xie,Hang Su,RunLin Chen,Yuxia Pang,Hongming Lou,Dongjie Yang,Xueqing Qiu
Papermaking wastewater has large output and high chemical oxygen demand (COD), which seriously affects the water environment. As a by-product of papermaking industry, lignin is the main contaminant that causes excessive COD value. Bismuth oxide is a potential catalyst for photocatalytic degradation of lignin-contained wastewater because of its high charge conduction performance and light corrosion resistance . However, the high electron-hole recombination rate and poor surface chemical state of pure Bi 2 O 3 seriously hinder the degradation efficiency. Herein, we designed an O V -Bi 2 O 3 /BiOCOOH heterojunction with oxygen vacancies and heterojunction coexisting for photocatalytic degradation of lignin. Temperature induced the oxidation of ethylene glycol into formic acid , resulting in the epitaxial growth of Bi 2 O 3 and forming a Bi 2 O 3 /BiOCOOH heterojunction. The heterojunction presents a tight interface by sharing the Bi-O tetrahedron, and provides a highway for the charge transfer. Meanwhile, the oxidation of ethylene glycol induces oxygen vacancies (O V s) on Bi 2 O 3 /BiOCOOH surface, forming charge trapping centers to promote electron transport and surface reactions. The degradation efficiency of O V -Bi 2 O 3 /BiOCOOH is approximately 3 and 16 times that of Bi 2 O 3 and BiOCOOH, respectively. The improvement of photocatalytic performance can be attributed to the synergy of heterojunction and oxygen vacancy, and the stability is attributed to covalent bonds tightly connected.
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高影响因子
危险品化学品经营许可证（带存储）