COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Yuxin Tang,Xinyi Yang,Lingyu Zeng,Bili Tan,Fei Qi,Bo Feng,Liang Wang,Guangbo Che
Precise atomic-scale interface engineering across the entire pH range remains a formidable challenge for photocatalytic H 2 evolution. Herein, hexamethylenetetramine (HMT) is introduced as a bifunctional surface modifier that spontaneously constructs Pd-N coordination bridges on g-C 3 N 4 . The interfacial Pd-N bonds collectively down-shift the N-p-band center away from the Fermi level, break intrinsic surface charge symmetry of C/N atoms, and fully expose the originally buried N active sites, thereby steering the hydrogen adsorption free energy (|ΔG H* |) toward thermoneutral. Simultaneously, the Pd-N bond confines Pd cluster growth to ∼5 nm, doubling specific surface area and enriching edge active sites that serve as primary proton reduction centers. Transient photoelectric voltage results reveal that the Pd-N electron transfer channel shortens the carrier transfer path and prolongs photoelectron lifetime, enabling quantitative electron delivery under acidic, neutral, and alkaline environments. As a result, the Pd-CN-HMT sample presents an efficient H 2 evolution rate across the entire pH window. This work advances the field by providing a versatile ligand-based strategy to precisely tailor the interfacial electronic structure via strong chemical bonding, offering a distinct and scalable solution for constructing high-performance pH-universal photocatalysts.
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Food Bioscience
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2026
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IF 6.2
Mingsha Jie,Xingang Lang,Bingxue Liu,Shengkai Lan,Xiaoyue Yue,Junguang Li,Yanhong Bai,Dianbo Zhao
The rapid and accurate detection of pork freshness is critical for food safety and public health supervision, while conventional detection methods suffer from complicated pretreatment and reliance on large laboratory equipment. To overcome these drawbacks, a microneedle array chip (MAC) was successfully constructed through the composite assembly of a microneedle array (MA) and a pH-responsive red fluorescent carbon dots (R-CDs) electrospun membrane. Endowed with excellent tissue penetration capability and rapid interstitial fluid adsorption capacity, the MAC enables a sensitive fluorescence response to pH elevation within 10 min during pork spoilage, accompanied by a distinct fluorescence color transition from purple to pink and finally to red. Coupled with smartphone-based RGB analysis, a linear regression model was established to correlate R values with pH, showing a wide linear range of = 1144. Real-time monitoring of pork freshness at 4 °C and 25 °C confirmed that the MAC enables visual and efficient detection of pork freshness. The developed MAC holds great potential as a portable and point-of-care testing platform for on-site food quality control.
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Catalysts
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2026
·Vol. 16
·期 8
·679
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IF 4.5
Xiangxu Du,Lei Wang,Yuxiang Yang,Zihao Ma
In this study, we introduce a rational, surfactant-free synthetic strategy for the scalable preparation of relatively uniform spherical mesoporous silica with moderate-to-high surface area particles (MSPs), engineered specifically as advanced heterogeneous catalytic supports. Leveraging Ostwald ripening as the core morphogenetic driver—rather than conventional organic structure-directing agents—our approach improves process simplicity and reduces reliance on organic templates. Precise pH modulation to 8.0 using biocompatible organic acids enables controlled silica dissolution–reprecipitation kinetics, yielding MSPs with good spherical morphology, a relatively narrow particle-size distribution, a specific surface area of up to 484 m2/g, and uniform mesopores centered at approximately 3.02 nm. A systematic pH-screening study reveals a distinct structural transition: at pH < 7.5, incomplete condensation and suppressed ripening yield polydisperse aggregates with disordered worm-like porosity; at pH > 8.5, accelerated silicate dissolution induces particle coalescence and partial mesostructural degradation. Critically, pore ordering, channel dimensionality, surface area, and particle morphology are all systematically influenced by pH, establishing it as a key synthetic parameter for hierarchical textural programming. This study compares the methoxychlor (MXC) removal efficiency of polyhedral Bi2WO6and Bi2WO6/MSP under identical irradiation conditions to assess MSPs’ catalytic impact. The enhanced photocatalytic performance is mainly associated with the improved dispersion of Bi2WO6and enhanced interfacial contact between Bi2WO6and the silica support. Considering the substantial decrease in surface area and pore volume after Bi2WO6loading, the role of MSP is discussed primarily as an interfacial support rather than as a fully open mesoporous transport network in the final composite.
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POLYMER
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2026
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IF 5.1
Silu Wang,Yinan Zeng,Ammara Aslam,Haofei Yang,Yu Wang,Runsha Zhai,Yangyang Hu,Jianhua Zhang
The fast sol-gel transition of ABA triblock copolymers in aqueous solution has demonstrated excellent promise for various applications. However, the occurrence of gelation behaviors often needs precise temperature control or concentration regulation. Considering the advantages of precisely spatiotemporal control and noninvasive manner, the photo-controlled gelation behaviors are desirable but still remain a significant challenge, especially for ABA triblock copolymers. Herein, we reported a facile strategy for spatiotemporal photo-modulation of reversible gelation of ABA triblock copolymers. The pH-responsive ABA triblock copolymers [poly( N,N - diethylaminoethyl methacrylate)- b -polyethylene glycol- b -poly( N,N -diethylaminoethyl methacrylate), PDEAEMA-PEG-PDEAEMA] were synthesized and used for preparing photobase generator (Malachite green carbinol base, MGOH)-containing micellar solution. Under ultraviolet irradiation, the MGOH in PDEAEMA-PEG-PDEAEMA micelles could rapidly generate OH − , resulting in deprotonation and hydrophobization of PDEAEMA chain, finally achieving micellar reconstruction and in situ gelation transition. This study demonstrated not only a photo-controlled reversible sol-gel transition of ABA triblock copolymers without the limitations associated with conventional photosensitive reagents, but also a low-cost and fast system for intelligent monitoring, early warning, and rapid shielding of ultraviolet rays. Considering the easily available agents, simple preparation process and high flexibility in tuning hydrogel properties, this strategy opens up a promising avenue to develop photo-controlled hydrogels for various applications without involving complex synthesis of photosensitive polymers.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Zhihao Guo,Linyun Xiu,Yumei Li,Cailing Wei,Ji-Liang Li
Intravitreal chemotherapy is a widely employed therapeutic strategy for retinoblastoma. However, its clinical efficacy and safety are considerably compromised by rapid drug clearance from the vitreous cavity and off-target toxicity. To address these limitations, we developed a pH-responsive, hyaluronic acid-based dual drug-loaded nanoplatform (HDLNs) for intravitreal co-delivery of doxorubicin and lapatinib. The nanoscale dimensions and negative surface charge of HDLNs facilitate efficient diffusion within the vitreous gel network while enhancing cellular uptake by Y79 cells. Upon exposure to the acidic intracellular microenvironment, HDLNs rapidly disassemble and trigger the synchronized release of both payloads, thereby synergistically inhibiting tumor cell proliferation and migration. In vivo investigations demonstrated that intravitreal administration of HDLNs significantly prolonged intraocular drug retention and effectively suppressed tumor progression in an intraocular Y79 retinoblastoma mouse model. Importantly, HDLNs substantially mitigated ocular and systemic toxicities associated with intravitreal chemotherapy, exhibiting a favorable in vivo safety profile. Collectively, this tailored drug delivery nanoplatform represents a promising and feasible strategy for safe and effective intravitreal chemotherapy against retinoblastoma.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Muhammad Arif,Min He,N.A. Samreen,Hasi Hays,Ling Wang,Xiyuan Zhang,Bingqiang Zhang,Guotai Li,Tengbo Yu,Qihui Zhou
The increasing prevalence of antibiotic-resistant Helicobacter pylori (R- H. pylori ) poses a significant clinical challenge, contributing to persistent gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic therapies are increasingly limited by resistance, incomplete eradication, and disruption of the gut microbiota. To address these challenges, we developed pH-responsive iron-doped ammonium citrate carbon dots (Fe-CDs), a nanozyme with intrinsic specificity for targeting and eradicating R- H. pylori within the acidic gastric microenvironment. Fe-CDs exhibit dual oxidase (OXD)- and peroxidase (POD)-like catalytic activities that are selectively activated under acidic conditions, driving the localized generation of reactive oxygen species (ROS) via Fenton and Fenton-like reactions involving Fe(II) and endogenous hydrogen peroxide (H₂O₂). The nanozyme shows strong binding affinity for H. pylori through ammonium (NH 4 + )-mediated interactions and specifically targets Urel, thereby inhibiting urease activity and disrupting bacterial acid resistance. This dual mechanism—acid-enhanced ROS production combined with urease suppression—confers potent bactericidal effects against R- H. pylori while preserving commensal microbiota and minimizing off-target damage. Transcriptomic analysis of infected gastric tissue revealed that Fe-CDs induce ROS-mediated stress pathways and metabolic disruption in H. pylori . In vivo studies confirmed that Fe-CDs significantly reduce bacterial load in R- H. pylori -infected mice with negligible toxicity. These findings highlight Fe-CDs as a targeted, antibiotic-free therapeutic strategy for resistant gastric infections and offer a promising alternative to conventional treatments.
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PubMed
高影响因子
Gels
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2026
·Vol. 12
·期 4
·284
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IF 6.4
Chubin He,Xiuru Xu
A dual-mode electrical–optical nanocomposite hydrogel is developed by integrating carboxyl-modified upconversion nanoparticles (UCNPs-COOH) and quaternized chitosan (CQAS) into a polyacrylamide (PAAm) covalent network. The hydrogel exhibits high optical transparency (>90% in the visible region), excellent mechanical properties (fracture strain of 1742%, tensile strength of 0.85 MPa, toughness of 6.57 MJ/m3), and robust adhesion to various substrates. The synergistic covalent–noncovalent hybrid network enables efficient energy dissipation, while CQAS-enhanced dispersion of UCNPs significantly improves upconversion luminescence intensity and stability, as evidenced by prolonged fluorescence lifetime from 0.564 ms to 0.691 ms at 539 nm. Leveraging distinct electrical and optical signal transduction pathways, the hydrogel functions as a highly sensitive resistive strain sensor with multistage gauge factors up to 13.85 and excellent cyclic stability over 1200 loading–unloading cycles at 100% strain for human motion monitoring. It also serves as a ratiometric optical pH sensor over a broad range (pH 1–13) based on phenolphthalein-sensitized upconversion luminescence, with excellent repeatability. By integrating real-time resistance responses with optical readouts within a single soft material, this work demonstrates a reliable dual-mode sensing strategy for simultaneous mechanical and chemical monitoring, holding promise for wearable electronics, smart healthcare, and environment-responsive sensing systems.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Qingchen Cui,Linrong Yu,Jiahe Miao,Yanjun Wei,ShanShan Du,Xianggen Wu
Curdlan (CUR)-based hydrogels have shown promise for wound healing but suffer from poor flexibility, high brittleness, and limited drug-loading capacity. To overcome these limitations, a curdlan-based complementary hydrogel (CM Gel) was developed by integrating CUR with mangiferin (MF), a polyphenol capable of self-assembly. Non-covalent interactions between CUR and MF led to a stable and flexible network with improved mechanical properties and gelation under mildly acidic pH conditions (pH ∼6.5), which aligns with skin wound conditions. Furthermore, the hydrogel was loaded with dihydromyricetin (DMY), a natural antibacterial agent, using a solvent-free one-pot pH/heating-driven process to fabricate the enhanced comprehensive hydrogel properties D@CM Gel. Multispectral analysis suggested that MF, CUR, and DMY were transformed from the crystalline state to the amorphous state. In vitro studies confirmed its potent antibacterial activity against S. aureus and E. coli , strong antioxidant capacity, and effective biofilm inhibition capacity. In an S. aureus -infected full-thickness wound model, D@CM Gel significantly accelerated wound closure, reduced inflammation (TNF-α, IL-6), promoted collagen deposition and angiogenesis (VEGF, CD31, α-SMA), and outperformed commercial hydrogel dressings with excellent biocompatibility. These findings suggest that D@CM Gel is a promising and easily fabricated wound dressing with synergistic therapeutic functions for treating infected skin wounds.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Dongyan Hu,Jiao Guan,Jiaming Luo,Liushuang Zhang,Zhijuan Bao
RGB probe monitors lysosomal pH in real time. • Biocompatible design suits live-cell imaging. • High sensitivity tracks subtle pH fluctuations. • Enables visualization of lysosome-related pathological processes. Lysosomal pH is tightly linked to diverse cellular physiological and pathological processes, and real-time monitoring of its dynamic shifts is critical for uncovering underlying disease mechanisms. Herein, we developed a new lysosome-targeted pH fluorescent probe RGB with facile synthesis, low cytotoxicity, favorable biocompatibility and efficient cell membrane permeability. Its fluorescence emission intensity exhibits a well-defined linear correlation with environmental pH, enabling rapid, sensitive and quantitative detection of subtle pH changes at the single-lysosome level. RGB functions via a pH-triggered spirolactam ring-opening ICT fluorescence turn-on mechanism, with a measured pKa value of 4.12. Confocal fluorescence imaging results verify that RGB can evaluate oxidative stress-induced cellular damage and dynamically visualize autophagy in live tumor cells. As a robust molecular imaging reagent, RGB holds great promise for subcellular pH detection and basic mechanistic exploration of lysosome-associated disorders. The RGB fluorescent probe provides a simple, biocompatible tool for sensitive real-time monitoring of lysosomal pH. It allows visualization of key cellular events and offers valuable insights for biomedical research on lysosome-related processes. Download: Download high-res image (154KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Rui Cheng,Hongan Zhang,Ziqi He,Xueting Luo,Wanju Zhang,Ziqiang Xu,Minsong Lin
Myricetin-derived carbon dots enable ratio-metric pH sensing with pH from 7.2 to 9.6. • Hydrazone structures confer highly sensitive and selective Al 3+ recognition. • Confocal imaging validates dual-function intracellular pH and Al 3+ monitoring. Sensitive analysis of intracellular pH and Al 3+ is essential for biological and environmental accessment. And traditional fluorescent nanomaterials often contain heavy metal components, whereas carbon dots (CDs) are metal-free with excellent biocompatibility, making them attractive candidates for probe construction. However, most CDs-based fluorescent probes have been developed empirically, with rational design strategies remaining relatively limited. Therefore, hydrazone functionalized carbon dots (N 2 H 4 @CDs) are fabricated by combining natural myricetin precursor with hydrazine-assisted post-functionalization strategy, establishing a structure-guided design that enables both ratio-metric pH sensing and selective Al 3+ analysis. Notably, N 2 H 4 @CDs showed dual emissions at 495 and 570 nm, with the peak at 570 nm increasing under higher pH. This ratio-metric response enabled accurate self-calibrated analyzing, showing a great linear correlation between the ratio I 495 / I 570 and pH from 7.2 to 9.6. As for Al 3+ analysis, fluorescence spectra show a pronounced enhancement of the emission intensity at 495 nm upon addition of Al 3+ , reflecting specific coordination with surface functional groups. The N 2 H 4 @CDs platform enable sensitive analysis of Al 3+ , with a linear range of 2–18 μmol/L and a detection limit of 0.125 μmol/L (3.37 μg/L). The spiked recovery experiments in lake water yielded satisfactory results, indicating its potential application in environmental exposure analysis. Confocal imaging in L929 fibroblasts confirmed that N 2 H 4 @CDs enable imaging of intracellular pH and Al 3+ . This strategy propses a rational hydrazone engineering strategy to realize ratiometric pH imaging as well as selective Al 3+ sensing. Download: Download high-res image (100KB) Download: Download full-size image
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Journal of Materials Chemistry B
·
2025
·
IF 5.7
Jia-yin You,Jia-rong Wang,Zhao-yang Chen,Yi-xian Mu,Yi-jing Yin,Xing-wang Wang,Ke-feng Ren,Jian Ji
Medical catheters often fail due to bacterial infections during clinical use. An antibacterial coating offers an effective material solution to this issue. Herein, we prepared a polyelectrolyte hydrogel coating with tunable antibiotic loading. The crosslinked poly(2-acrylamido-2-methylpropanesulfonic acid sodium salt) (pAN) hydrogel coating was prepared by initiator pre-entrapment and in situ UV initiation. The sulfonate groups in pAN enable efficient hydrophobic rifampicin (RIF) loading via electrostatic interactions with the antibiotic's positively charged groups. RIF loading could reach 119.3 ± 10.8 μg cm−2 at pH 2.0 and remain tunable (the range >100 μg cm−2) across a pH range of 2.0–9.5 due to pH-dependent charge modulation. Additionally, the sulfonated polyelectrolyte simultaneously offered excellent hydrophilic lubricity with a coefficient of friction <0.03 and anticoagulant properties. Such a multifunctional hydrogel coating with antibacterial, lubricating, and anticoagulant properties provides a promising approach to reducing catheter-associated infections, equipping medical polymer-based catheters with better practical performance.
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DYES AND PIGMENTS
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2025
·
IF 4.2
Yanzheng Zhao,Tao Zhang,Hao Huang,Zhiguang Xu,Tieling Xing,Yan Zhao
Although pH indicator-based, chromic fabrics are advantageous for monitoring the pH of aqueous solutions, they usually require a long time to respond to acidic or alkaline gases. Endowing hygroscopicity to such fabrics could significantly shorten the response time to gas, but moisture-absorption-driven color changes tend to decrease their reliability. Herein, we report the fabrication of hydrophobic-hygroscopic, pH indicator-based chromic fabric coatings with humidity tolerance for rapid colorimetric NH 3 sensing. The fabric coatings were fabricated by grafting a polymerizable pH indicator (cresol red), hygroscopic monomer, and hydrophobic monomer onto cotton fabrics. The resulting fabrics exhibited opposing hygroscopicity and hydrophobicity. Hydrophobicity, reflected by high water contact angles up to 139.4°, prevented color change induced by various aqueous solutions, and hygroscopicity, with moisture absorption capacity up to 11.3 %, did not have an influence on color change, with color preserved in all relative humidity ranges. After moisture absorption, the fabrics possessed a remarkable color change from yellow to purple upon exposure to alkaline gases (such as NH 3 ), and the color change could be realized within 5 s. The color change was reversible, and a reusability over 10 cycles was confirmed without obvious deterioration in color change. The simple fabrication, hydrophobicity-hygroscopicity, and rapid response to NH 3 via visual color change make the fabrics an excellent candidate for rapid NH 3 sensing and food spoilage monitoring via changes in color.
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危险品化学品经营许可证（带存储）