PROCEEDINGS OF THE COMBUSTION INSTITUTE
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2025
·
IF 5.2
Meng Yang,Chang Liu,Chenglong Tang,Zuohua Huang
Hypergolic ionic liquids have wide range of potential applications in the propulsion field due to their low toxicity, high thermal stability, and safe handling; however, their high costs and unclear hypergolic ignition mechanisms have limited their development to date. In this work, nitromethane (NM), as an additive, was blended with 1-ethyl-3-methylimidazolium dicyanamide ([EMIm][DCA]) to obtain a new fuel with low viscosity and cost. The hypergolic ignition behaviors of [EMIm][DCA]/NM blends reacting with white fuming nitric acid (WFNA) were then investigated through drop tests. Two high speed cameras and a time-resolved infrared camera were used to record the macro and micro hypergolic ignition processes and the reaction region’s temperature evolution. The effects of the Weber number and NM blend ratio ( α ) on the hypergolic probability and ignition delay time (IDT) of the [EMIm][DCA]/NM blends were investigated. The results show that with increasing impact velocity, more smoke-like vapor and tiny droplets were formed, which promotes the hypergolic ignition probability and decreases the IDT. As increasing NM blend ratios, the hypergolic ignition performance is initially similar to pure [EMIm][DCA] ( α ≤ 30 %) and then decreases rapidly ( α > 30 %). This indicates that when α ≤ 30 %, fuels with excellent hypergolic ignition characteristics can be obtained, whose raw materials costs may be up to ∼25 % lower than pure [EMIm][DCA]. Finally, a hypothesized pre-ignition pathway of [EMIm][DCA]/NM was proposed based on the experimental data and physical characteristics of the system.
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Qingqing Zhou,Yajun Yu,Zuorui Xie,Yingying Zhou,Yanan Li,Ping Li,Jiangning Hu,Qing Gu
Salmonella is a prevalent foodborne pathogen that poses a significant threat to public health. Our previous study identified Lactiplantibacillus plantarum ZJ316, a strain known for its production of indole-3-lactic acid (ILA), which exhibits a broad-spectrum bacteriostatic effect. This study aimed to explore the inhibitory mechanism of ILA against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 ( S . Typhimurium) both in vitro and in vivo , as well as to assess its potential to alleviate colitis induced by S . Typhimurium. In vitro experiments revealed that ILA exerts its ant- Salmonella effect by disrupting the transmembrane proton motive force (PMF) and influencing intracellular ATP synthesis. Subsequent experiments conducted in female C57BL/6 mice demonstrated that oral administration of 45.00 mg/L ILA for 21 d effectively reduced S. Typhimurium infection-induced upregulation of pro-inflammatory cytokines (IL-1β and CXCL15; P < 0.01 and P < 0.05, respectively), while promoting the production of anti-inflammatory cytokines (IL-10 and IL-22; P < 0.001). Compared to the control group, the ILA group had a 4.15% increase in the relative abundance of Firmicutes and a 3.95% decrease in Bacteroidota. Furthermore, ILA also effectively countered the reduction of short-chain fatty acids (SCFAs) such as acetic acid and propionic acid caused by S . Typhimurium. These findings indicate that ILA may possess the capability to suppress pathogens, enhance intestinal microecology, and facilitate the repair of intestinal tissue damage.
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高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Junyu Chen,Xuedong Zhang,Feixiang Wu,Long Xie,Feng Li,Nina Wu,Zixuan Cao,Jinwen Zhao,Yuxuan Zhang,Xin He,Hongxia Gu,Jianyu Huang,Qiao Huang
Integrating conversion-type cathodes (such as iron-based fluorides (IBFs)) into sulfide all-solid-state batteries (ASSBs) significantly enhances energy density but faces challenges including unstable cathode/electrolyte interfaces. To mitigate these issues, a near-amorphous Li1.26Mg0.12Zr1.86(PO4)3 (LMZP) coating technology is developed to protect nano-sized FeF2 (n-FeF2) and micro-sized FeF3 (m-FeF3) cathodes from reacting with the sulfide electrolyte for the first time. The LMZP coating approach offers simplicity, low energy consumption and scalability. With the LMZP-coated cathodes and lithium–indium (Li–In) anode, the ASSBs achieve a discharge capacity of 310 mAh g−1 after 600 cycles and a maximum areal capacity of 2 mAh cm−2 for n-FeF2, and 301 mAh g−1 after 700 cycles with a maximum areal capacity of 3.1 mAh cm−2 for m-FeF3. When using a lithium (Li) metal anode, the ASSBs maintain a discharge capacity of 310 mAh g−1 after 300 cycles for n-FeF2 and 300 mAh g−1 after 600 cycles for m-FeF3, demonstrating excellent cycling stability and capacity retention. Notably, a discharge capacity of 280 mAh g−1 is sustained after 200 cycles for n-FeF2 and 301 mAh g−1 after 180 cycles for m-FeF3, with a reduced stack pressure (10 MPa). These results are unprecedented in IBF-based ASSBs, highlighting the potential of advanced coating strategies to enable scalable, high-performance metal fluoride cathodes in ASSBs with higher energy densities.
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高影响因子
Nano Energy
·
2023
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IF 17.6
Jingwen Zhao,Weitao Yan,Shijia Li,Shiyu Li,Wei-Hua Wang,Ying Bai
The Na superionic conductor of (NASICON)-type Na 4 VMn(PO 4 ) 3 (NVMP) with a three-dimensional framework and high operating voltage has been extensively investigated for sodium-ion batteries (SIBs). However, unexpected Jahn-Teller effect and sluggish Na + diffusion kinetics inevitably lead to rapid capacity fade and unfavorable structural distortion. Herein, the double-pinning effect of Al/F co-doping was adopted for the NVMP system to enhance structural stability and facilitate Na + diffusion. The as-synthesized NVMP-Al&F presents a highly reversible capacity of 110 mAh g −1 at 0.1 C, accompanied with a long-term lifespan of 1000 cycles at 5 C (capacity retention of 86.1 %). Moreover, in situ X-ray diffraction affirms the reversible structural evolution and small volume variation (∼4.43 %) during the highly reversible sodiation/desodiation processes. Benefiting from the double-pinning effect, the lowered Na + migration barrier effectively facilitates Na + diffusion and increases to higher reversible capacity by combining theoretical calculation and kinetic analysis . The assembled NVMP-Al&F//hard carbon (HC) full cell manifests a high energy density of 353.9 Wh kg −1 and excellent cycling durability of 91.3 % at 1 C after 100 cycles. This work sheds light on the double-pinning as a novel strategy to boost the cycling stability of high-performance NASICON-type cathodes.
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-20
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IF 14.7
Liu Jinhu,Zhao Huajun,Gao Tong,Huang Xinyan,Liu Shujun,Liu Meichen,Mu Weiwei,Liang Shuang,Fu Shunli,Yuan Shijun,Yang Qinglin,Gu Panpan,Li Nan,Ma Qingping,Liu Jie,Zhang Xinke,Zhang Na,Liu Yongjun
Cytotherapy is a strategy to deliver modified cells to a diseased tissue, but targeting solid tumours remains challenging. Here we design macrophages, harbouring a surface glypican-3-targeting peptide and carrying a cargo to combat solid tumours. The anchored targeting peptide facilitates tumour cell recognition by the engineered macrophages, thus enhancing specific targeting and phagocytosis of tumour cells expressing glypican-3. These macrophages carry a cargo of the TLR7/TLR8 agonist R848 and INCB024360, a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, wrapped in C16-ceramide-fused outer membrane vesicles (OMV) of Escherichia coli origin (RILO). The OMVs facilitate internalization through caveolin-mediated endocytosis, and to maintain a suitable nanostructure, C16-ceramide induces membrane invagination and exosome generation, leading to the release of cargo-packed RILOs through exosomes. RILO-loaded macrophages exert therapeutic efficacy in mice bearing H22 hepatocellular carcinomas, which express high levels of glypican-3. Overall, we lay down the proof of principle for a cytotherapeutic strategy to target solid tumours and could complement conventional treatment.
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2012
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IF 4.525
Bo Yuan,Qiang Chen,Wen-Quan Ding,Ping-Sheng Liu,Shi-Shan Wu,Si-Cong Lin,Jian Shen,Yue Gai
AB diblock copolymers comprised of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and poly(3-methacryloxypropyl trimethoxysilane) (PMTSi) segments, which are used for biocompatible coatings, were investigated. Block copolymers with various compositions were synthesized by atomic transfer radical polymerization (ATRP). The obtained copolymers were dissolved in an ethanol solution, and dynamic light scattering showed that all block copolymers were capable of existing as micelles. After a convenient “one-step” reaction, the cellulose membranes could be covalently modified by these copolymers with stable chemical bonds (C–O–Si and Si–O–Si). Block copolymers with different PMPC chain length were applied to surface modification to find the most suitable copolymer. The functional MPC density can be controlled by adjusting the ratio of the two monomers (MPC and MTSi), which also affect surface properties, including the surface contact angle, surface morphology, and number of functional PC groups. The low-fouling properties were measured by protein adsorption, platelet adhesion and activation, and cell adhesion. Protein adsorption of bovine serum albumin (BSA), fibrinogen, and human plasma were also tested and a moderate monomer composite was attained. The protein adsorption behavior on the novel interfaces depends both on MPC density and PMPC chain length. Platelet adhesion and activation were reduced on all the modified surfaces. The adhesion of Human Embryonic Kidney 293 (293T) cells on the coated surfaces also decreased.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Qiongyi Huang,Wenjing Xie,Peiyao Liu,Qingwei Yu,Jingying Li,Xinyu Wei,Chunying Jiang,Peixuan Tan,Ding Cao,Ying Tang
Green synthetized Ag nanoparticles are increasingly used as antimicrobial agents topically applied to human skin for sanitization and medical purposes. Despite the widespread use, little was known on their antibiofilm efficacy and dermocompatibility. This study reports a systematic investigation into the impacts of green synthetized 0–3D Ag nanostructures, including 0D nanospheres, 1D nanowires, 2D nanoprisms and 3D nanoflowers as well as Ag nanospheres modified by different phytochemicals, on anti-biofilm efficacy and biocompatibility at the nano-skin interface. It was revealed that varying the Ag morphology induces distinct effects on two established polyspecies models consisting of skin-borne microbes ( S. aureus-S. epidermidis and S. aureus-C. albicans ). Ag nanospheres and nanowires are advantageous in inhibiting the formation of early biofilms (47–61 %) while Ag nanoprisms and nanoflowers are more effective in destroying mature biofilms (68–70 %). ROS-mediated oxidative stress, physical damage to cell membrane integrity, “contact killing” of microbial cells and suppression of adhesion-related gene expression are mechanisms involved in the anti-biofilm actions of these green synthetized Ag nanostructures. Furthermore, the dermocompatibility assessments were performed in reconstructed human epidermis. Although all exposed epidermis models remained > 50 % tissue viability, more Ag nanospheres were transdermally adsorbed than other morphologies while Ag nanoprisms were shown to be more cytotoxic. These findings provide insights into the impacts of 0–3D green synthetized Ag nanostructures on skin-borne polyspecies biofilms and dermocompatibility at the nano-skin interface, highlighting the importance of taking morphology and phytochemical modification into consideration for the rational design of sustainable Ag-based antimicrobials tailored for topical applications.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Mengyuan Wang,Jingchao Kang,Lin Chen,Gongchen He,Yaping Liu,Xiaojing Fan,Xin Lv,Xinglian Xu,Guanghong Zhou,Xianchao Feng
As a natural antioxidant, Epigallocatechin-3-gallate (EGCG) needed to be added in high doses to maintain the quality of meat products. However, high doses of EGCG caused the excessive aggregation of myofibrillar protein (MP), which damaged the gel properties of MP gels. Therefore, the purpose of this study was to investigate the mitigation of EGCG-induced loss of MP gelling potential by L-Lysine (L-Lys). The results showed that the addition of 20 mM L-Lys induced excessive unfolding and loose aggregation of MP at 10 µmol/g EGCG, and hence, reducing the solubility (14.5%) and the tryptophan fluorescence, and forming a network structure with a large aperture. Therefore, the cooking loss was decreased from 29.20% to 15.13%, and the strength of MP gels was decreased from 0.35 N to 0.17 N. However, L-Lys hindered the hydrogen bonding interactions and hydrophobic interactions between MP and EGCG by competing the binding sites of MP at 50 µmol/g EGCG, which was supported by the Zeta potential, surface hydrophobicity, FTIR and molecular docking analysis. Thus L-Lys mitigated the protein aggregation caused by 50 µmol/g EGCG, improved the solubility (23.02%∼86.99%) and apparent viscosity, which were beneficial for the formation of a continuous network structure in MP gels. Therefore, the cooking loss of MP gels was decreased from 52.40% to 41.30%, and the gel strength was enhanced from 0.13 N to o.22 N with 20 mM L-Lys addition. The present study could provide a new strategy for increasing the amounts of EGCG in meat products without damaging the gel properties of meat products.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Chenlu Zhu,Zebin Liu,Lishi Ren,Siming Jiao,Xuebing Zhang,Qiukuan Wang,Zhimin Li,Yuguang Du,Jian-Jun Li
Endo -fucoidanases are important in structural analysis of fucoidans and preparation of fuco-oligosaccharides. However their enzymological properties and analysis of degradation products are scarcely investigated. Truncated endo - α (1 → 3)-fucoidanase Fda1 (tFda1B from Alteromonas sp. was overexpressed and characterized, showing highest activity at pH 7.0, 35 °C, and 1.0 M NaCl. Its K m and k cat were 3.88 ± 0.81 mg/mL and 0.82 ± 0.17 min −1 . Fe 3+ and Mn 2+ enhanced activity by 100% and 19.5% respectively. Co 2+ and Cu 2+ completely inactivated tFda1B, whereas Ni 2+ , Mg 2+ , Zn 2+ , Pb 2+ , Ca 2+ , Ba 2+ and Li + decreased activity by 58.8%, 56.0%, 50.6%, 47.7%, 28.9%, 15.6% and 37.5%, respectively. Catalytic residues were identified through structure and sequence alignment, and confirmed by mutagenesis. Degradation products of Kjellmaniella crassifolia fucoidan by tFda1B were characterized by LC-ESI-MS/MS, confirming tFda1B belongs to endo -(1 → 3)-fucoidanases, and backbone of K. crassifolia fucoidan is 1 → 3 fucoside linkage. This endo - α (1 → 3)-fucoidanase would be useful for elucidating fucoidan structures, and be used as a food enzyme.
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PubMed
高影响因子
Algal Research-Biomass Biofuels and Bioproducts
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2020
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IF 4.008
Xiaodan Wang,Yanan Song,Baoling Liu,Wei Hang,Renjian Li,Hongli Cui,Runzhi Li,Xiaoyun Jia
The objective of this study is to characterize effects of autophagy inhibition by 3-methyladenine on astaxanthin and fatty acid accumulation in Haematococcus pluvialis cultivated under high light condition. The present data show that 0.02 mM 3-methyladenine treatment effectively inhibited autophagosome formation but no impact on the cell growth and biomass of H. pluvialis , leading to a large increase in cellular reactive oxygen species (ROS), astaxanthin and fatty acid accumulation as well as palmitic acid enrichment under high light of 700 μmol·m −2 ·s −1 . Furthermore, the key genes such as phytoene synthase ( PSY ), β-carotene ketolase ( CRTO ), and β-carotene hydroxylase ( CRTR-b ) in astaxanthin pathway are upregulated significantly whereas the expressions of the lipid-related genes biotin carboxylase ( BC ) and diacylglycerol acyltransferase ( HpDGAT2D ) just increased slightly in the 3-methyladenine-treated cells. Astaxanthin accumulation is not perfectly linear with fatty acid biosynthesis in H. pluvialis treated by 3-methyladenine under high light. Overall, autophagy might function importantly in astaxanthin and lipid enrichment in H. pluvialis under stress condition. The findings provide new insights to further investigation on the metabolic regulation in microalgae .
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Wenbi Tuo,Jun Zhao,Xiaoli Yi,Siwei Xiong,Weidong Zhang,Yunzhi Tian,Yingying Du,Yanqing Shu,Yanan He,Yan Qu
Food safety is essential for protecting public health. This study introduces a novel microneedle (MN) patch that employs a pH-responsive colorimetric mechanism for the real-time, easy, and visible detection of meat freshness. The patch is a pH-responsive colorimetric microneedle (C3G/HAMA@MN) patch composed of eco-friendly bio-based components, specifically methacryloylated hyaluronic acid (HAMA) and cyanidin-3-O-glucoside (C3G). Its mechanical strength reaches 7 N per needle, capable of penetrating over 85% of meat tissue. The distinctive structural design allows the microneedle tip to quickly and directly penetrate the meat tissue, extracting interstitial fluid in situ and promptly transferring it to the backing layer. The backing layer visually indicates pH changes in real time. The color change from light to dark matches freshness levels at different deterioration stages. Without sophisticated instruments, consumers may notice the patch's color change in two minutes using their vision, allowing for simple and reliable food quality inspection. A powerful new instrument for on-site food safety monitoring combines real-time display, easy interpretation, and biodegradable materials.
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高影响因子
SENSORS
·
2025
·Vol. 25
·期 24
·7462
·
IF 3.5
Yuanyue Lu,Yong Mei,Yingying Gu,Ye Tao,Yuhan Yang,Jiao Yu,Yang Zhang,Lin Liu,Xin Li
An electrochemical immunosensor was fabricated to identify CA15-3, a biomarker for breast cancer (BC). A composite sensor substrate made of “zeolitic imidazolate framework-8” (ZIF-8) and “reduced graphene oxide” (rGO) was chosen and its conductivity was further improved by the addition of chitosan (CS)-doped gold nanoparticles (AuNPs). The CS@AuNPs are able to conjugate with antibodies via the strong Au-S interaction, which offers multiple active sites for antibody immobilization and enhances the sensor performance. This immunosensor is capable of ultrasensitive detection of CA15-3 by specific antigen–antibody –interactions. In healthy people, normal serum CA15-3 is up to 25 U/mL. Under optimized experimental conditions, the alteration in the signal intensity measured by the sensor was related to the CA15-3 activity. The quantitative relationship was linear over 0.001–400 U/mL with a limit of detection (LOD) of 0.0031 U/mL at a “signal-to-noise ratio” (S/N) of 3 and a “correlation coefficient” (r2) of 0.9983. The developed immunosensor showed great accuracy, stability, and selectivity, and was able to detect CA15-3 in human serum samples. These results validate its potential as a reliable analytical platform for BC diagnosis and early clinical screening.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）