DESALINATION
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2026
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IF 9.9
Zhongsen Yan,Zeqi Yan,Sufen Lin,Haiqing Chang,Kaiqin Xu,Gongduan Fan,Fangshu Qu
Novel CMCS sacrificial layer enhances silica scaling resistance in MD. • CMCS coatings can be removed and re-coated in situ. • Synergy of CMCS layer and smooth PVA substrate boosts silica scaling resistance. • CMCS-PVA membrane showed sustainable anti-silica performance in long-term tests. Membrane distillation (MD) is a promising technology for hypersaline wastewater treatment, yet it is often limited by severe silica scaling. This study proposes a carboxymethyl chitosan (CMCS) sacrificial layer strategy to achieve in situ silica scale removal and restore membrane reusability for MD. The influence of substrate properties on anti-scaling performance was systematically evaluated by depositing the CMCS layer onto Thin Film Composite (TFC) and Polyvinyl Alcohol (PVA) Janus membranes. Characterization results indicated that the CMCS coating significantly improved surface smoothness and introduced silica-resistant functional groups, reducing the average roughness (Ra) of the TFC and PVA membranes from 74.2 to 2.79 nm and from 8.26 to 1.19 nm, respectively. After a single-cycle silica scaling test, the CMCS-TFC and CMCS-PVA membranes retained 92.7% and 97.2% of their initial specific flux, respectively, 26.2 and 2.1 percentage points higher than their pristine counterparts. Notably, the CMCS-modified PVA membrane exhibited superior anti-scaling stability, maintaining a specific flux above 90% for the first 4 cycles and achieving a flux recovery ratio (FRR) exceeding 99% across all cleaning cycles. This synergistic effect between the CMCS sacrificial layer and the smooth PVA substrate effectively inhibited silica penetration, while enabling interfacial renewal and foulant removal via in situ exfoliation and re-deposition of the CMCS layer. This work provides a facile and robust approach for treating silica-rich hypersaline streams. Download: Download high-res image (137KB) Download: Download full-size image
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高影响因子
EUROPEAN SPINE JOURNAL
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2026
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IF 3.2
Wang Min,Gao Feng,Xu Zixuan,Xue Kaiyang,Yu Yang,Wang Fuwei,Zou Jing,Huang Guofu
Purpose Lumbar intervertebral disc degeneration (IVDD) is characterized by abnormal innervation and neurogenic inflammation, contributing to chronic discogenic pain. Electroacupuncture (EA) alleviates IVDD-related pain, yet its underlying mechanisms remain incompletely understood. This study aimed to investigate the role of the axonal guidance factor Netrin-1 in EA-mediated inhibition of myelinated nerve fiber ingrowth into degenerative intervertebral discs and to elucidate the downstream signaling pathways involved. Methods A rabbit axial compression IVDD model was established. Animals were divided into sham, model, EA, model+OV-Netrin-1, EA+sh-Netrin-1, EA+μ-opioid antagonist (β-FNA), and EA+δ-opioid antagonist (NTI) groups. Tarlov scoring, MRI, HE, AB-PAS, immunohistochemistry, TEM, Western blot, RT-qPCR, Co-IP, ELISA and flow cytometry were used to evaluate disc histology, nerve ingrowth, Netrin-1 expression in annulus fibrosus (AF) and dorsal root ganglion (DRG), endogenous opioid peptides, receptor interactions, cAMP/cGMP levels and intracellular calcium concentration. Results EA improved Tarlov scores, restored disc structure and reduced pathological nerve ingrowth in degenerative discs. EA downregulated Netrin-1 in AF but upregulated Netrin-1 in L2 DRG. DRG Netrin-1 overexpression mimicked EA’s anti-neoinnervation effect, whereas Netrin-1 knockdown abolished EA efficacy. EA elevated spinal POMC/M-ENK; blocking μ/δ opioid receptors reversed EA-mediated Netrin-1 upregulation in DRG. Mechanistically, EA promoted UNC5B-DCC complex formation, reduced cAMP, increased cGMP and lowered intracellular Ca 2+ via Netrin-1 receptors to inhibit myelinated axon sprouting. Conclusion EA upregulates DRG Netrin-1 by activating endogenous opioid peptide signaling. Netrin-1 subsequently modulates UNC5B/DCC downstream cAMP-cGMP-calcium pathways to suppress abnormal myelinated nerve fiber ingrowth, thereby alleviating discogenic pain and delaying IVDD progression.
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PubMed
高影响因子
Scientific Reports
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2026
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IF 4.9
Da Binlin,Guo Lei,Li Liming,Zhu Feng,Zhang Juanjuan,Wang Zhiming,Guo Feilong
Hyperammonemia is frequently encountered in cirrhosis; nevertheless, its direct hepatotoxic effects remain poorly characterized. In this study, we aimed to delineate the hepatotoxic effects of chronic hyperammonemia and and explore the related mechanisms of liver injury. Thirty male C57BL/6 mice were randomly divided into three groups ( n = 10 per group): a control group, a hyperammonemia group, and a rifaximin-treated group. Starting on day 0, the hyperammonemia and rifaximin-treated groups were fed a diet supplemented with an amino acid (AA) mixture at a 1:2 ratio to normal powdered (NP) diet for 14 consecutive days to establish chronic hyperammonemia, while the control group received NP diet. From day 8 onward, mice in the rifaximin-treated group received rifaximin by gavage at 100 mg/kg once daily for 7 days; the control and hyperammonemia groups received an equivalent volume of 0.9% saline. Twenty-four hours after the final administration, blood was collected; serum was separated by centrifugation and analyzed on an automatic biochemical analyzer for blood ammonia, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Immediately after blood sampling, mice were euthanized; whole brain and liver were rapidly excised, blotted dry, weighed, and used to calculate brain weight and liver index values. Tissue specimens were fixed for hematoxylin–eosin (H&E) staining to evaluate histopathological damage. Commercial kits were used to measure superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, urea content and glutamine synthetase (GS) activity in the liver tissue. Take paraffin sections of liver tissue and use Terminal Deoxynucleotide Transferase dUTP Nick End Labeling (TUNEL) method to detect the apoptosis level of liver cells. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) were performed on liver samples to measure the mRNA and protein expression levels, respectively. Hyperammonemia significantly increased brain weight index, liver index, blood ammonia, serum ALT and AST ( p < 0.001); rifaximin reversed these changes ( p < 0.001). Liver urea content was significantly lower in the hyperammonemia group (0.245 ± 0.008 mmol/g, p < 0.01) than in the control group (0.281 ± 0.004 mmol/g), and rifaximin obviously rescued this reduction and raised hepatic urea to 0.300 ± 0.014 mmol/g ( p < 0.01). Hepatic GS activity declined remarkably in the hyperammonemia group (8.37 ± 0.50, p < 0.05) compared with the control group (8.87 ± 0.41), and rifaximin treatment effectively increased GS activity (9.42 ± 0.27, p < 0.05). Histologically, H&E-stained brain sections from hyperammonemia mice displayed pronounced cytotoxic edema, while liver sections showed disordered hepatocellular cords, and marked inflammatory infiltration, both of which were mitigated by rifaximin. Compared with the control group, the liver tissue SOD activity in the hyperammonemia model group was significantly reduced, and the MDA content was significantly increased ( p < 0.01); After intervention with rifaximin, SOD activity increased and MDA content decreased ( p < 0.01). TUNEL staining further showed that the apoptosis level of liver cells in the model group mice was significantly increased compared to the control group, while treatment with rifaximin significantly reduced the number of apoptotic cells ( p < 0.0001). Mechanically, hyperammonemia-induced hepatic injury are underpinned by its ability to upregulate MAPK/mTOR signaling and downregulate ULK1 activity, thereby impairing autophagic flux. Hyperammonemia may negatively regulate ULK1 activity through the MAPK/mTOR pathway, impair autophagic flux, promote liver oxidative stress and hepatocyte apoptosis, and lead to liver injury.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Xi Yu,Dan Zhu,Yan Zhao,Yueyang Song,Zejun Zhao,Weisheng Li,Juan Wang,Jinxing Lv,Miao Sun
The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that exposure to adverse environmental factors during pregnancy not only disturbs intrauterine fetal development but also exerts profound negative consequences on offspring. Previous studies have primarily focused on the health risks associated with direct individual exposure to fluoride (a common environmental exposure factor), while the effects of fluoride exposure on offspring during pregnancy have received little attention. In this study, we established the prenatal NaF exposure model by administering drinking water containing 100 mg/L sodium fluoride (NaF) to pregnant dams throughout gestation. We found that prenatal NaF exposure induced intrauterine hyper-osteogenesis and led to an abnormal and sustained, high bone mass phenotype in male offspring. Mechanistically, NaF exposure significantly upregulated osteomodulin (OMD) expression, which subsequently driven the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via the activation of bone morphogenetic protein receptor type 2 (BMPR2). Notably, pharmacological intervention with CDD−1653, a selective BMPR2 inhibitor, effectively rescued the NaF-induced excessive BMSC osteogenesis and attenuated the abnormal bone accumulation in vivo. Taken together, our study demonstrates that prenatal fluoride exposure triggers aberrant activation of osteogenesis in male offspring through the OMD-BMPR2 signaling pathway. These findings uncover the potential molecular mechanisms by which early-life environmental fluoride exposure alters skeletal homeostasis in male offspring and highlight the imperative for public health strategies to mitigate gestational fluoride risks.
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ACS Applied Materials & Interfaces
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2026
·Vol. 18
·期 31
·42824-42836
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IF 7.8
Zhao Quan,Huang Tao,Xu Ou,Fu Jiali,Huang Jiaren,Zhao Yongqiang,Wang Suihao,Liu Dongxi,Chen Weixing,Zou Bingsuo
Organic–inorganic hybrid multimetal halides possess rich photophysical properties and great potential for multicolor emission and multifunctional optoelectronic applications, but their development is limited by phase separation and the difficulty of integrating multiple luminescent functions. Herein, we report a zero-dimensional Pb-In bimetallic halide, (C 9 H 20 N) 7 [InCl 4 ] 2 [Pb 3 Cl 11 ] (C 9 H 20 N + = 1-butyl-1-methylpyrrolidinium), as a structurally well-defined multimetallic crystalline platform. Under 340 nm excitation, the compound exhibits bright green emission at 518 nm with a high PLQY of 96.4%, originating from the [Pb 3 Cl 11 ] 5– cluster tri-polaron formed through phonon-assisted coupling among three [PbCl 6 ] 4– octahedra. Upon Sb 3+ introduction, an additional broadband red emission at 675 nm appears, associated with Sb 3+ -related triplet self-trapped exciton (STE) and Sb 3+ -In 3+ donor–acceptor pair (DAP), enabling excitation-dependent tunable emission from green to red. More importantly, under 365 nm excitation, the undoped crystal shows pronounced anti-thermal-quenching behavior, while the Sb 3+ -doped system exhibits temperature-responsive luminescence regulation and reversible red-orange-green thermochromism over 80–460 K. This work thus integrates efficient cluster-based green emission, Sb 3+ -induced red emission, antithermal-quenching behavior, and reversible thermochromic response in a single Pb-In multimetallic zero-dimensional crystalline platform, showing promise for solid-state lighting, optical anticounterfeiting, and information encryption.
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PubMed
高影响因子
BMC PLANT BIOLOGY
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2026
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IF 5.6
Zhang Yu,Geng Yingxuan,Ma Xiaoli,Huang Zhangjian,Taoerdahong Hailiqian,Chang Junmin
Background Artemisia dracunculus L. (A. dracunculus) is a distinctive plant resource in Xinjiang, possesses both medicinal and culinary value, with distinct regional characteristics. Methods In this study, total flavonoids extracted from A. dracunculus (TFAD) were obtained using a reflux method, with extraction parameters optimized through single-factor experimental design. Ultraviolet-visible spectrophotometry was used for both qualitative and quantitative assessment of TFAD. Samples collected from Jimusaer, Hami, and Tacheng in Xinjiang were analyzed for total flavonoid content and antioxidant activity. Results The optimized extraction conditions included 50% ethanol as the solvent, a solid-to-liquid ratio of 1:30, an extraction temperature of 80 °C, and a duration of 8 h. Under these conditions, the TFAD content in samples from Jimusaer, Hami, and Tacheng was 107.0146 ± 1.4986, 111.9548 ± 1.6136, and 124.8996 ± 1.3801 mg g⁻¹, respectively. Statistically significant regional differences were observed ( p < 0.01), with the highest flavonoid concentration found in samples from Tacheng. Antioxidant activities of TFAD from the three regions were assessed using in vitro free radical scavenging assays, with ascorbic acid (AA) serving as the positive control. TFAD extracted from Jimusaer exhibited the strongest antioxidant capacity, with IC₅₀ values of 31.31 ± 1.19 and 114.04 ± 5.56 µg mL⁻¹ against DPPH and ABTS⁺· radicals, respectively, compared with 7.25 ± 0.56 and 154.18 ± 9.54 µg mL⁻¹ for AA. Conclusion These results suggest that TFAD from the Jimusaer region demonstrates superior antioxidant activity, providing a basis for further exploration and potential utilization of A. dracunculus as a functional resource in Xinjiang.
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Scientific Reports
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2026
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IF 4.9
Wang Chengfeng,Wang Jianfeng,Lu Zebei,Wang Yu,Al Mamun Abdullah,Islam Md Siddiqul,Wang Shuanghu,Zhou Yunfang,Xu Minzhi
Abemaciclib is used for the treatment of breast cancer (BC) in clinics. The combination of abemaciclib and imperatorin or isoimperatorin has been studied in vitro and in vivo to explore the pharmacokinetics of Chinese herbs and anti-cancer medicines. Eighteen male SD rats were randomly allocated to three groups: control, isoimperatorin (50 mg/kg) and imperatorin (50 mg/kg). The concentration level of abemaciclib in the plasma was determined using the UPLC-MS/MS technique on rats. Molecular simulation docking with AutoDock 4.2 software and rat liver microsome incubation were utilized to analyze the inhibitory mechanisms. In this study, we found that co-administration of imperatorin and isoimperatorin resulted in higher AUC (0−∞) and C max values and lower CLz/F values ( p < 0.05). In addition, both imperatorin and isoimperatorion showed moderate inhibition for abemaciclib with IC 50 values of 6.79 µM and 6.56 µM, respectively. Intriguingly, we found that imperatorin, isoimperatorin and abemaciclib exhibit similar binding capacities with CYP3A4. Moreover, the results indicated that imperatorin and isoimperatorin significantly impaired the pharmacokinetics of abemaciclib in vivo. Therefore, our research suggests that the combination of abemaciclib and imperatorin or isoimperatorin should be considered more in clinical practice.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Xinyue Liu,Jianghao Yuan,Bokai Kong,Youqin Wang,Jianghong Gong,Xiangjun Shi,Weike Su
Four nilotinib-flavonoid drug-drug cocrystals were successfully prepared. • NIL-BAI cocrystal exhibited the most significant dual solubility enhancement. • NIL-BAI cocrystal improved nilotinib and baicalin bioavailability in rats. • Drug-drug cocrystals overcome the physicochemical limitations of nilotinib. This study employs a supramolecular cocrystallization strategy to simultaneously enhance the pharmaceutical performance of the poorly water-soluble anticancer drug nilotinib and pharmacologically active flavonoids. Four nilotinib cocrystals were successfully prepared via slurry and room-temperature solvent evaporation methods, using kaempferol, quercetin, baicalin, and luteolin as coformers. The four cocrystals exhibited varying degrees of solubility enhancement. Among them, the nilotinib-baicalin cocrystal demonstrated the most significant dual enhancement effect. Specifically, nilotinib solubility increased by 6.19-fold and baicalin by 1.88-fold at pH 6.8, with corresponding enhancements of 2.06-fold and 47.74-fold at pH 1.2. Critically, pharmacokinetic evaluations in rats revealed that the nilotinib-baicalin cocrystal achieved dual bioavailability enhancement: nilotinib exhibited a 9.48-fold higher C max and a 6.78-fold greater AUC 0–24h , while BAI concurrently demonstrated a 2.1-fold and 2.86-fold increase in its C max and AUC 0-24h , respectively. Overall, this work highlights drug-drug cocrystallization as a highly effective approach for developing multifunctional formulations, offering a promising strategy to overcome the physicochemical limitations of nilotinib and improve therapeutic efficacy. Download: Download high-res image (294KB) Download: Download full-size image
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高影响因子
Frontiers in Nutrition
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2026
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IF 5.5
Quanyong Wu,Boya Ouyang,Hui Cao,Min Zhang,Mohamed A. Farag,Thomas Efferth,Jesus Simal-Gandara,Jianbo Xiao
IntroductionLuteolin is a dietary flavonoid widely distributed in fruits, vegetables, and medicinal plants and is recognized for its antioxidant and health-promoting properties. However, its effects on physiological aging and the influence of developmental stage and biological sex remain poorly understood.MethodsIn this study, Drosophila melanogaster was exposed to luteolin during either adulthood or embryonic development and evaluated for lifespan, healthspan, metabolic regulation, and aging-related molecular changes.ResultsAdult supplementation exerted pronounced female-specific benefits, increasing median lifespan by 11.6%, improving locomotor activity and stress resistance, with little effect on body weight, whereas males showed little response. Notably, short-term supplementation during early adulthood produced sustained protective effects later in life. Mechanistically, luteolin enhanced antioxidant defenses, suppressed IIS/PI3K–mTOR signaling, activated AMPK/MAPK pathways, promoted autophagy and immune homeostasis, and induced metabolic remodeling associated with reduced mitochondrial stress and favorable histone modifications. In contrast, embryonic exposure shortened lifespan and disrupted endocrine and metabolic homeostasis, as evidenced by elevated juvenile hormone levels, reduced catalase activity, and dysregulated IIS signaling.DiscussionThese findings suggest that the biological effects of luteolin on aging are highly dependent on developmental stage and biological sex in Drosophila. The beneficial effects observed in adult females were associated with coordinated changes in nutrient-sensing pathways, metabolism, mitochondrial function, and epigenetic regulation, whereas developmental exposure produced adverse outcomes. Collectively, this study provides new insights into the context-dependent actions of dietary flavonoids in Drosophila and highlights the importance of developmental stage and biological sex when evaluating nutritional interventions for healthy aging.
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高影响因子
Food Frontiers
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2026
·Vol. 7
·期 4
·e70276
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IF 6.3
Xinyi Li,Jingling Kang,Weiyao Wu,Huifan Liu,Yuming Zhong
Tea polyphenols (TP) constitute key functional components in tea leaves, yet their instability during human digestion limits absorption. This study selected 24 representative tea varieties to establish an in vitro dynamic digestion model, investigating the dynamic changes of TP during digestion. Characteristic signals of tea liquor were collected using electronic nose and color difference technology to construct predictive models, enabling the estimation of TP content (TPC) before and after digestion. Results indicate the tea liquor aroma is dominated by hydrogen compounds, and tea fermentation level correlates positively with liquor color intensity. Green tea exhibits the highest TPC and catechin levels, demonstrating potent antioxidant properties. TP remains relatively stable in the stomach but is significantly reduced in the intestine, whilst the catechin components exhibit distinct degradation patterns. The Extreme Gradient Boosting (XGBoost) model predicting TPC based on electronic nose data demonstrated the highest efficacy, with an R 2 : 0.92. The XGBoost model incorporating color difference and TPC achieved the best performance, with an R 2 : 0.81. This research provides robust support for elucidating TP digestion patterns in humans and establishing a tea quality assessment system.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19
Fan Xue,Tianqiang Yin,Zhiyuan Guo,Jingfu Song,Qingjun Ding,Gai Zhao
High-precision in situ monitoring of tribological interface temperature is essential for the reliable operation of aerospace and advanced tribological systems, yet conventional thermocouples and infrared methods suffer from implantation difficulties, delayed response, and environmental interference. Here, we report a novel multifunctional lubricated nanocapsule that leverages the phase-change behavior of deep eutectic solvents (DES) to overcome these limitations. Structural characterization was performed using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectroscopy, and tribological tests were conducted to evaluate both tribological behavior and capacitance-temperature response mechanisms. Experimental results demonstrate that when the interface temperature reaches the melting point of the DES, the capacitance of the tribological system undergoes an abrupt transition, while both the coefficient of friction (COF) and the wear rate decrease to a certain extent. The improvement in dielectric properties is ascribed to the ion polarization effect generated by the molten DES, whereas the enhancement of tribological performance arises from the lubrication protection provided by its liquid phase. This work demonstrates a materials-based strategy for real-time temperature sensing at dynamic tribological interfaces, offering new opportunities for intelligent lubrication and fault prediction in high-end equipment.
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高影响因子
ACS Catalysis
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2026
·
IF 13.6
Shuangfeng Ren,Yihui Li,Ye Chen,Xiaoling Mou,Ziang Zhao,Hejun Zhu,Xiaoyan Liu,Yu Meng,Li Yan,Apoorva Ravi,Amol Amrute,Ronghe Lin,Yunjie Ding
The rational design of selective, earth-abundant Ni-based catalysts for the reverse water–gas shift (RWGS) reaction is often hampered by an incomplete understanding of their operando active states. This study reveals that the CO2 hydrogenation selectivity over Ni–Zn catalysts is governed by a support-dependent, reaction-induced dynamic restructuring, rather than by any static, preformed sites. Through a combination of in situ characterization and theoretical calculations, we demonstrate that the active Ni–Zn intermetallic core encapsulated by ZnO forms dynamically only under the RWGS atmosphere on ZrO2 and TiO2 supports, but not on Al2O3 or during mere H2 reduction. Crucially, we identify in situ-generated CO as the essential inducer of this reconstruction, likely via facilitating ZnO reduction. Furthermore, the product selectivity (CO vs CH4) is dictated by the kinetic competition between CO desorption and its deep hydrogenation, a principle quantitatively linked to the evolved electronic structure of the active surface. This work shifts the paradigm toward designing catalysts that evolve into optimal structures in operando and provides a fundamental kinetic framework for selective CO2 conversion.
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