Materials
·
2025
·Vol. 18
·期 11
·2627
·
IF 3.2
Bowen Shang,Guijian Guan
The integration of chirality into nanomaterials holds significant potential for improving molecular recognition and biomedical technologies. In this work, we fabricated novel chiral horned gold nanostructures (HNS) by controlling the concentration of chiral ligands L-/D-cysteine (Cys). The unique three-dimensional morphology with horns-rotational arrangement enables synergistic optimization of chiral optical responses and surface-enhanced Raman scattering (SERS) performance. The proposed chiral HNSs can be used to recognize amino acid enantiomers, in which homochiral amino acid has distinct affinities to the chiral HNSs of homogeneous handedness. The 4-mercaptobenzoic acid (4-MPBA)-modified D-HNS demonstrates significantly enhanced targeting affinity for D-amino acids in theEscherichia coli(E. coli) cell wall, enabling successful amplification of SERS signals and advancing bacterial detection methodologies. By demonstrating the rotation-selective interaction between chiral HNSs and circularly polarized light (CPL), D-HNS exhibits excellent photothermal conversion efficiency under right-handed circularly polarized light (RCP) irradiation. This enables the synergistic combination of targeted physical disruption and photothermal sterilization, which leads to efficient eradication ofE. coli. The D-HNS hydrogel composite system further expands the practical application of photothermal sterilization. Altogether, chiral HNSs have achieved SERS detection of bacteria and efficient polarization photothermal sterilization, which helps further develop applications based on chiral nanomaterials.
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Food Bioscience
·
2026
·
IF 6.2
Linyu Mei,Zicheng Zhang,Yue Niu,Wenlong Deng,Jiwei Song,Yuan Yao,Ruien Yu,Yunpeng Shao,Xiujian Chou
In this study, a capillary coated with silver nanoparticles-modified zinc oxide nanorods (Ag/ZnO NRs) was developed as an ultrasensitive SERS substrate. The aggregation of Ag nanoparticles (Ag NPs) at the tips and sides of ZnO NRs generates high-density three-dimensional “hot spots”, which, together with the photocatalytic activity of Ag/ZnO and the extended light–analyte interaction time afforded by the capillary structure, enables efficient adsorption and in situ detection of trace pollutants. This substrate exhibits excellent SERS performance, achieving a detection limit of 10 -14 M for Rhodamine 6G (R6G), with a relative standard deviation of less than 12%, With in-situ and rapid detection of microplastics in different liquid environments such as seawater and various beverages, the detection limit of polystyrene microspheres is as low as 50 μg/mL. Therefore, our prepared substrate offers a highly sensitive and reusable solution for in-situ, real-time, and rapid monitoring of trace contaminants in liquid environments.
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RSC Advances
·
2016
·Vol. 6
·期 82
·78852-78857
·
IF 3.289
Shunkai Lu,Shuzhen Ma,Hui Wang,Mingwang Shao
This paper describes a two-step method for preparing the bi-functional cobalt sulfide/noble metal CoS2/Au (CoS/Au) composite with excellent peroxidase-like activity and surface enhanced Raman scattering (SERS) performance. CoS2 (CoS) was firstly synthesized via a hydrothermal method and subsequently used to coat Au nanoparticles. Both of them have high-efficiency peroxidase-like activity to decompose H2O2 into hydroxyl radicals, which can degrade organic pollutants into small non-toxic molecules. Furthermore, these composites also exhibit SERS performance using rhodamine 6G as a molecular probe. Therefore, the bi-functional composites can be applied in degrading R6G molecules as a valid catalyst while the degradation process can be monitored quantitatively in real time using Raman spectroscopy.
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Science China-Materials
·
2017
·Vol. 60
·期 11
·1129-1144
·
IF 3.956
Yang Yanjun,Jiang Xinyu,Chao Jie,Song Chunyuan,Liu Bing,Zhu Dan,Sun Youzhi,Yang Boyue,Zhang Qiaowei,Chen Ye,Wang Lianhui
Magnetic core gold shell nanostructures which integrate both SERS activity and superparamagnetism are widely utilized in SERS-based detection as SERS substrates, sample separation and preconcentration operators, as well as external magnetic field controlled directional carrier. However, most of the reported gold shells coated on the magnetic cores had smooth surfaces rather than branched nanostructures with enhanced SERS activity. Here, a novel type of Fe 3 O 4 -Au core-shell nanoparticles with branched gold shell was prepared by a seed-mediated method together with the shape induction agent AgNO 3 , and their growth process and mechanism, properties, as well as morphologically controlled synthesis were also investigated. The branched gold coated magnetic nanoparticles (B-GMNPs) with improved SERS performance were further utilized to build superparamagnetic and SERS-active capturers by assembling tetrahedral DNA onto their surfaces for sandwich-structured detection of cancer-related biomarker miRNA-21. The experimental results indicate that highly sensitive and specific detections can be obtained by the proposed SERS sensing system including B-GMNPs and tetrahedral DNA, and the limit of detection (LOD) of miRNA-21 in serum is 623 amol L −1 . These B-GMNPs can be used as good SERS substrates with the functions of external magnetic field controlled sample separation and directional enrichment for effective SERS-based biochemical sensing and detections.
研究领域:
纳米材料
·
生物分析化学
·
癌症诊断
·
表面增强拉曼光谱
·
生物传感器
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Wei Xiaolan,Wang Peng,Li Linjin,Luo Zhu,Ye Xinyuan,Long Jiujiang,Liu Xianghui
Biogenic amines (BAs), primarily formed through the microbial degradation of proteins, are important markers indicating food fermentation and spoilage. On the demand of on-site monitoring of food quality and safety, electrochemical and optical sensors have been developed, focusing on the detection of the total volatile amines or a specific amine. However, the multiplex detection of BAs with high accuracy and sensitivity still remains a major challenge. The sensor array strategy that mimics the biological olfactory sense provides an effective and powerful route to achieve multiplex detection of BAs. Herein, (metallo)porphyrin-based hydrogen-bonded organic frameworks embedded with silver nanoparticles were prepared and used as receptors to construct the surface-enhanced Raman scattering (SERS) sensor array, leveraging the multiple chemical interactions and the sharp Raman signals of (metallo)porphyrins, and the porous and flexible structure of the supramolecular frameworks. This SERS sensor array demonstrated a successful discrimination of ten BAs, an accurate quantitation of three BAs, and a successful simultaneous determination of three BAs in pork samples. Using the total volatile basic nitrogen as a spoilage label, the platform achieved over 90% accuracies in freshness discriminations for pork, beef, and chicken samples. In comparison with the existing detection methods, the proposed SERS sensor array strategy based on porphyrin- and metalloporphyrin-based hydrogen-bonded organic frameworks exhibits operational simplicity, rapid response, high sensitivity, as well as multiplex detection capability. Thus, it demonstrates a significant practical potential for applications in the production line and the supply chain of foods.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Lin Zhu,Xiaoyi Zhu,Fangke Wang,Xinru Wang,Bing Zhao,Kangjun Wang
Research on surface-enhanced Raman scattering (SERS) substrates free of noble metals continues to encounter considerable challenges. In this work, a dual-strategy integrating “geometric design” and “defect engineering” is employed to substantially enhance SERS performance. Initially, a pristine-C@TiO 2 @W 18 O 49 composite structure was precisely fabricated via a hydrothermal route. By utilizing the Mie resonance effect generated by the submicron structure of C@TiO 2 , stable electromagnetic hotspots are produced in the near-field region. Subsequently, photoreduction generates abundant oxygen vacancies (OVs) in WO 3 , thereby introducing defect energy levels (Vo) into its band structure and enhancing the charge transfer (CT) efficiency. Through synergistic Mie resonance effects and CT enhancement, this material exhibits remarkable SERS performance toward Rhodamine 6G (R6G), with a detection limit (LOD) of 7.12 × 10 −7 mol/L and an enhancement factor (EF) as high as 1.16 × 10 7 . Moreover, composite material exhibits excellent specific detection for a series of dye molecules (MB, CV, and RhB). This study proposes a novel approach for developing low-cost, high-performance SERS substrates through the coupled effects of electromagnetic enhancement and tunable oxygen vacancy energy levels.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xinlan Wang,Xiong Wu,Menghan Qi,Huasheng Lai,Jianlian Xie
A “signal-off” surface-enhanced Raman scattering (SERS) strategy is developed for the rapid and ultrasensitive detection of total free arsenic in water and traditional Chinese medicine (TCM) beverages. The method employs methimazole (MMI) as a multifunctional probe that first reduces As(V) to As(III) and subsequently forms a As-MMI complex, leading to concentration-dependent attenuation of the characteristic MMI SERS signal. The assay achieves rapid equilibration within 2 min under optimized conditions and exhibits exceptional selectivity for free arsenic over common interfering ions, attributed to the combined redox and As-S complexation mechanisms under acidic pH. Ultrasensitive detection is achieved with a limit of detection of 0.6 fmol/L, more than eight orders of magnitude below the WHO safety guideline for drinking water. Practical applicability is demonstrated through quantitative recovery (93.8–106%) of spiked arsenic in real water and TCM beverage samples with relative standard deviations below 6.1%. This work provides a rapid, selective, and ultra-sensitive platform for free arsenic monitoring in environmental and pharmaceutical quality control applications.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Shibo Cao,Zicheng Yang,Jiayi Yuan,Long He,Xu Sun,Xuewei Ding,Jianmin Sang,Jiangming Wang,Lu Qu,Xiaoyu Zha,Qianying Lv,Lieying Fan,Ming Zong
Lupus nephritis (LN) represents one of the most severe manifestations of childhood systemic lupus erythematosus (cSLE), often progressing rapidly and resulting in renal impairment or even end-stage renal disease. Early diagnosis and precise assessment of disease activity are essential for guiding therapy and improving clinical outcomes. However, conventional serological and urinary biomarkers exhibit limited sensitivity and specificity, while renal biopsy, although the diagnostic gold standard, is invasive and unsuitable for longitudinal monitoring. Surface-enhanced Raman spectroscopy (SERS), a noninvasive analytical approach, offers substantial potential for detecting the molecular characteristics of LNs. In this study, a high-throughput SERS microspot array plate platform was established to perform dual-modal serum and urine SERS metabolic fingerprint analyses in healthy controls (n = 40), systemic lupus erythematosus (n = 40), and LN patients (n = 60). The dual-modal fusion model demonstrated superior performance over single-modal models in both LN diagnosis and disease activity assessment, achieving notably enhanced sensitivity, specificity, and overall accuracy. Furthermore, dual-modal SERS profiling revealed key biomolecular alterations associated with immune activation, inflammatory responses, and renal injury in children, providing molecular-level insights into the pathophysiological mechanisms underlying cSLE and LN.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xinyu Chang,Min Liao,Shujuan Meng,Chenchen Meng,Lingling Chen,Meng Zhang
Antibiotics are widely used in medicine, livestock farming, and agriculture, yet their overuse leads to severe environmental contamination, threatening ecosystems and human health. Surface-Enhanced Raman Scattering (SERS) holds great promise for highly sensitive detection, but its widespread practical implementation is impeded by the lack of substrates that simultaneously possess high reproducibility, ultra-sensitivity, and fabrication economy. Here, we present a hydrophobicity-induced self-assembly strategy to prepare dendritic gold nanoparticles (Au NPs) substrates, overcoming the fundamental trade-off between facile, low-cost preparation and ultrahigh detection sensitivity. By combining diffusion-limited aggregation with an enhanced non-uniform flow field on hydrophobic surfaces, tightly packed dendritic Au NPs are formed. These create ultrahigh-density electromagnetic hot spots with a local field about four times stronger than that of isolated Au NPs pairs. The resulting substrate allows label-free, rapid, and highly sensitive detection of antibiotics, achieving a detection limit of 100 ng L −1 for norfloxacin, 1–2 orders of magnitude better than existing methods. It also discriminates mixtures of norfloxacin and oxytetracycline at 10 μg L −1 via machine-learning-assisted spectral classification, and detecting antibiotic residues down to 1 μg L −1 in river water. Overall, this work offers a simple, cost-effective, and ultrasensitive SERS substrate strategy, providing a practical tool for environmental monitoring, water safety assessment, and biomedical diagnostics.
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ACS Nano
·
2025
·
IF 16
Feng Wang,Hua Wan,Long Chen,Tianyu Qiu,Lei Jiang,Ziwen Guo,Feng Chen,Yue Cao
Simultaneous detection of metabolites and proteins─two chemically and functionally distinct classes of biomolecules─in complex biofluids remains a significant analytical hurdle, yet is critical for early and accurate disease diagnosis. These difficulties arise from intrinsic disparities in molecular abundance, physicochemical properties, and detection mechanisms. Such analytical limitations span a wide range of disease contexts and are exemplified by acute coronary syndrome–induced sudden cardiac death (ACS-SCD), where intertwined metabolic and proteomic dysregulation obscures early diagnostic cues and necessitates robust, multiplexed detection strategies. Here, we present a dual-signal surface-enhanced Raman scattering (SERS) platform─termed Gemini─for ultrasensitive, cross-category quantification of pyruvate (a metabolite) and lactate dehydrogenase B (LDHB, a protein) in plasma-derived exosomes. The system integrates antibody-functionalized gold nanoparticles for LDHB recognition with a boronate-based SERS nanotag responsive to hydrogen peroxide (H2O2) generated from a pyruvate oxidase (POx)–mediated cascade. This strategy yields two spectrally distinct Raman signals within a single assay, enabling ratiometric and interference-free detection. Gemini achieves detection limits of 2.415 μM for pyruvate and 0.032 ng/mL for LDHB. When combined with a support vector machine (SVM) classifier, the platform accurately distinguishes ACS-SCD patients from healthy controls with 85% accuracy (90% sensitivity, 80% specificity), showing diagnostic performance comparable to conventional methods (AUC = 0.82 vs 0.79). This study demonstrates a multiplexed SERS framework for integrated metabolic–proteomic diagnostics and provides a clinically scalable strategy for early cardiovascular risk assessment. Moreover, the Gemini platform offers a broadly applicable paradigm for precision diagnostics across diverse pathophysiological conditions.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-14
·
IF 5.3
Li Minzhe,Zhou Yuzhu,Wei Guimei,Wang Wenyi,Liang Zhixing,Wen Changchun,Lin Xiang-Cheng
In practical applications, constructing bifunctional substrates with highly sensitive surface-enhanced Raman scattering (SERS) detection capabilities and environmentally friendly degradation technologies has significant importance in environmental remediation. Herein, Ag/CuO/CF (ACC) bifunctional composites were successfully fabricated via a two-step process. First, CuO nanowire arrays were grown in situ on a copper foam (CF) substrate using a facile thermal oxidation method. Subsequently, Ag nanoparticles were deposited uniformly onto the CuO nanowire surface via chemical reduction. As a SERS substrate, the ACC platform exhibited exceptional detection capabilities for methylene blue (MB) and malachite green (MG), achieving ultra-high sensitivity with remarkably high enhancement factors and extremely low detection limits for both target molecules. Moreover, the ACC substrates exhibited excellent uniformity, repeatability, and stability, as well as remarkable performance recovery in real sample testing. As a photocatalytic substrate, ACCs exhibited outstanding photocatalytic efficiency for degrading MB and MG, maintaining degradation of 91.97% after five cycles. Such a bifunctional design offers a novel approach for developing a new generation of intelligent environmental remediation technologies. It is particularly suitable for scenarios requiring on-site rapid analysis and immediate treatment, such as the monitoring and elimination of high-risk trace-level pollutants. Therefore, exploring integrated “detection-treatment” strategies holds significant importance for practical environmental applications. Graphical
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TALANTA
·
2023
·
IF 6.1
Jianxia Cheng,Zhiyang Zhang,Longfei Zhang,Jiaqi Miao,Yan Chen,Rongfang Zhao,Meichun Liu,Lingxin Chen,Xiaoyan Wang
Making metal nanoparticle aggregates is a common way to improve surface-enhanced Raman scattering (SERS) enhancement via the formation of hot spots between nanoparticles . Here, we propose a “freeze-thaw-ultrasonication” method to obtain stable colloidal Ag nano-aggregates (AgNAs) with controllable sizes, which can remain stable for a few days. Compared with other method using aggregation reagents (e.g., organic molecules and salt), this method can maintain metal surface charges and adsorption affinity, which ensures the excellent SERS stability and sensitivity. The SERS detection window during the experiment can reach more than 25 min, which makes it a prerequisite for accurate SERS detection during a long-time range. Combining the obtained stable AgNAs with microfluidic devices, we established a sequential SERS on-line continuous detection method for the high-throughput detection of multiplex samples. The UV-Fenton degradation process of methylene blue (MB) is continuously on-line monitored through this platform, which is more sensitive than the UV–Vis Spectrum. Moreover, we have realized the sensitive and accurate detection of 5-nitro-8-hydroxyquinoline (5-NQ) with antibacterial and anticancer activities based on chloride-functionalized silver , which paved a way for SERS high-throughput analysis in bioanalysis and other fields.
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