JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Longyun Dong,Fengming Bi,Ze Li,Yu Kuai
A high-solid-content emulsion system exhibiting pH-responsive reversible coagulation and redispersion behavior was successfully developed through reversible addition–fragmentation chain transfer (RAFT) polymerization. The system was constructed using amphiphilic macro-RAFT copolymers comprising poly(acrylic acid) (PAA) as the hydrophilic block and poly(methyl methacrylate) (PMMA) as the hydrophobic segment. These block copolymers were precisely designed with hydrophilic–lipophilic balance (HLB) values optimized for effective oil-in-water (O/W) emulsion stabilization. The influence of the hydrophilic-to-hydrophobic ratio in macro-RAFT copolymers on the stability, rheological properties, and reversible coagulation–redispersion behavior of the resulting emulsions was systematically investigated. Rotational viscometry, gel permeation chromatography (GPC), dynamic light scattering (DLS), and zeta potential measurements revealed that the macro-RAFT copolymers, when effectively anchored at the oil–water interface, significantly enhanced emulsion stability while maintaining low viscosity and exhibiting excellent reversible solid–liquid transition behavior upon pH modulation. Emulsions stabilized by macro-RAFT copolymers with extended hydrophilic segments demonstrated remarkably low viscosities (~700 mPa·s) even at a high solid content of 60 wt.%. These emulsions exhibited excellent colloidal stability, as evidenced by zeta potentials consistently maintained below −34.0 mV after five consecutive coagulation–redispersion cycles. Furthermore, the variations in particle size and particle size distribution (PSD) remained within 20% and 10%, respectively, highlighting the system's robust reversibility and structural integrity.
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高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Jialin Liang,Yu Zhang,Liang Zhang,Xiao Xiao,Zhihua Mo,Yan Zhou
Conventional hydroxyl radical (•OH)-based treatments ( i.e. , iron-based advanced oxidation technologies (Fe-AOTs) and electrochemical processes) are generally considered efficient approaches for sludge dewatering via destroying the stable extracellular polymeric substances (EPS) structure in sludge. However, extremely acidic conditions ( i.e. , pH 2.8–3.2) in such processes hinder their commercial viability, primarily due to corrosive and environmental issues. Singlet oxygen ( 1 O 2 ), known for its selective oxidation and environmental stability, can break down protein structures even at low levels. 1 O 2 -based processes may enable efficient sludge dewatering under neutral conditions by disrupting complex EPS structures. Therefore, in this study, we for the first time proposed a 1 O 2 -based electrochemical process with a catalytic cathode of pyrite-modified graphite (electro-FeS 2 @graphite) for sludge dewatering under neutral conditions. Results showed that under optimized conditions, the electro-FeS 2 @graphite system achieved superior sludge dewatering (47.9 % water content over ten cycles) compared to existing Fe-AOTs and electrochemical methods. Electron paramagnetic resonance, quenching tests, and reactive oxygen species probes confirmed that the FeS 2 @graphite catalytic cathode mainly generated 1 O 2 species for efficiently eliminating hydrophilic aromatic structures and enhancing sludge dewatering without pH regulation. A three-step mechanism was proposed for the enhanced sludge dewaterability in the electro-FeS 2 @graphite system: (i) in situ high H 2 O 2 yield at FeS 2 @graphite cathode, (ii) considerable 1 O 2 generation within the system, and (iii) selective attack on hydrophilic aromatic structures by 1 O 2 . The operational cost of the proposed system was also substantially lower than that of the above-mentioned treatments. Overall, these findings highlight the effectiveness of 1 O 2 -based electrochemical process in achieving stable and cost-effective sludge dewatering without acidification.
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PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·806
·
IF 5.3
Qinglong Liu,Dewei Ma,Haoze Cheng,Keke Yang,Bo Hou,Ziwen Heng,Yu Qian,Wei Liu,Siyuan Chen
Oral administration remains the most patient-friendly drug delivery route, yet its efficacy is limited by physiological barriers including gastric degradation and inefficient cellular uptake. pH-responsive nanogels have shown promise for gastrointestinal drug delivery, though their effectiveness is often constrained by poor membrane interaction. Inspired by natural membrane-anchoring mechanisms, a series of comb-like anionic polymers were designed via grafting alkylamines of different chain lengths (C10, C14, C18) at varying densities (10–30%) onto a biodegradable poly(L-lysine isophthalamide) (PLP) backbone. These pH-responsive comb-like polymers self-assembled into nanogels for loading the hydrophobic chemotherapeutic agent camptothecin. The alkyl length and grafting density significantly influenced pH-responsive behavior, membrane disruption, and drug release profiles. The optimal formulation—the nanogel prepared with PLP grafted 30% C14—achieved a high drug-loading capacity, ideal particle size and stability, and offered superior protection in acidic conditions (only 7 ± 5% release at pH 1.2 over 24 h), while enabling rapid intestinal release (78 ± 2% at pH 7.4 within 24 h). The nanogels significantly enhanced cellular uptake, cytoplasmic delivery, and cytotoxicity against colorectal carcinoma cells. This study demonstrates the key role of hydrophobic modification in designing effective oral nanocarriers, providing a promising platform for the treatment of intestinal diseases.
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高影响因子
Processes
·
2025
·Vol. 13
·期 10
·3203
·
IF 2.8
Kaster Kamunur,Olesya Tyumentseva,Lyazzat Mussapyrova,Aisulu Batkal,Ardak Karagulanova,Rashid Nadirov
Coal ash represents an abundant secondary resource of rare earth elements (REEs), but their recovery is hindered by low concentrations in leachates and the presence of large amounts of competing matrix elements such as Fe, Al, Ca, and Mg. In this study, a stepwise pH-controlled precipitation approach was applied to real sulfuric acid coal ash leachates for selective recovery of Ce and La. The process combined impurity scrubbing, oxidative precipitation of Ce, and phosphate precipitation of La. Nearly complete recovery was achieved, with >95% of both Ce and La recovered and >99% phase purity. Selectivity analysis further demonstrated strong discrimination of REEs over matrix elements, with Ce showing >400 selectivity over Fe, Al, and Ca, and La showing ~170 over the same ions and ~17 over Ce. These results show the efficiency of the approach under realistic multi-element conditions.
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高影响因子
OPTICS AND LASER TECHNOLOGY
·
2025
·
IF 5
Shi Wang,Yue Li,Yafang Pan,Xiaolong Song,Liu Wang,Mingli Wang
Modifying nanoparticle assembly can alter the electric field strength within “hot spots,” offering promise for enhancing surface-enhanced Raman scattering (SERS) performance. In this work, by modifying the surface of Ag nanoparticles (AgNPs) with glutathione (GSH), a pH-responsive substrate, Ag-GSH nanoparticles (AGGNPs), was prepared. Under acidic conditions, hydrogen bonds form between protonated GSH molecules, inducing aggregation of AGGNPs and causing a red shift in the absorption peak. The SERS enhancement factor (EF) increased from 5.6 × 10 5 to 1.36 × 10⁶ and exhibited a good linear relationship with pH. In practical apple sample detection, the natural acidic environment of the fruit pulp enabled SERS self-optimization. Without external acid addition, the signal for thiram at 1383 cm −1 was significantly enhanced, achieving a minimum detection concentration of 10 −11 M. This approach effectively provides a novel pathway for developing highly efficient SERS sensing strategies and offers fresh insights for expanding SERS applications in agricultural detection.
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Materials Today Bio
·
2025
·
IF 10.2
Xiaohuan Guo,Bingbing Cai,Qi Fang,Yanyan Chen,Yuzhu Zhou,Zhixing Liang,Changchun Wen,Yan-Cheng Liu,Hong Liang
The high level of glutathione (GSH) in tumor cells can consume reactive oxygen species (ROS), seriously affecting the efficacy of chemodynamic therapy (CDT). Although it took a great deal of effort, developing a tumor-specific CDT that efficiently depletes GSH remains a formidable challenge. Herein, we propose a pH-responsive nanocatalyst containing the active molecule norcantharidin (NCTD) and Cu 2+ for dual GSH depletion, achieving efficient GSH depletion. Due to the weakly acidic tumor microenvironment (TME), the catalyst releases NCTD and Cu 2+ in a pH-responsive manner for the synergistic therapy of chemotherapy (CT) and CDT. Both components consume GSH and subsequently produce ROS, reducing the antioxidant capacity of cancer cells while increasing oxidative stress. This disrupts cellular redox homeostasis, leading to mitochondrial dysfunction and inducing tumor cell apoptosis. This work not only develops nanomaterials with dual GSH depletion capabilities for high-efficiency CDT but also achieves synergistic CT and CDT tumor therapy with the addition of NCTD, an active ingredient of traditional Chinese medicine.
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高影响因子
MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Ning Yang,Yule Song,Junliang Song,Jian Qin,Mingwei Fu,Feng Yao,Huan Xu
Renal fibrosis (RF), a critical pathogenic mechanism in chronic kidney disease (CKD), now has exceedingly few therapeutic alternatives. This study presents a new sigma1 receptor (σ1R)-targeted nanodelivery system utilizing the natural polyphenolic medicine resveratrol (Res) as a therapeutic agent, addressing its low bioavailability and inadequate targeting properties, thereby providing a significant advancement in the treatment of RF. We engineered and produced a multifunctional material, aminoethyl anisamide-poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate (APC)-with benefits including active targeting, prolonged circulation, and pH sensitivity. In vitro investigations demonstrated that in the high glucose-induced HK-2 cell fibrosis model, the absorption efficiency of APC-modified liposomes was markedly enhanced, effectively suppressing the expression of fibrotic and inflammatory factors. In two typical animal models of RF, namely diabetic nephropathy and glomerulonephritis, APC@Res demonstrated therapeutic advantages, including modulation of the TGF-β1/Smad3 signaling pathway to impede fibrosis, a notable reduction in oxidative stress levels, enhanced renal function parameters, and diminished expression of inflammatory and fibrotic markers. This study innovatively employs the renal microacidic environment and sigma1 targeting to develop an effective delivery system, offering a novel treatment strategy for reversing RF.
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Yilin Han,Xianxuan Li,Lingwan Zhang,Kai Zhong,Yanping Wu,Hong Gao
The development of active packaging with sustained antimicrobial and antioxidant functions is crucial for extending the shelf life of highly perishable fruits. In this study, we developed a novel composite film by incorporating dihydromyricetin (DMY)-loaded zeolitic imidazolate framework-8 (ZIF-8) nanoparticles into a chitosan (CS) matrix. Scanning electron microscopy (SEM) confirmed the good compatibility between ZIF-8@DMY and the chitosan matrix at optimal loadings (2.5–15wt%). Importantly, the incorporation of ZIF-8@DMY significantly enhanced the mechanical properties of the composite films, increasing tensile strength by approximately 4.8-fold (from 1.77 to 8.50 MPa). Concurrently, critical physical properties including water vapor permeability, hydrophilicity and UV-vis transmittance were also enhanced. The composite films exhibited intelligent pH-responsive release of DMY. Furthermore, the ZIF-8@DMY/CS films exhibited potent in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus , with the 5% ZIF-8@DMY/CS film reducing E. coli counts by 5.38 log CFU/mL. In the grape preservation test, the 5% ZIF-8@DMY/CS film effectively mitigated weight loss and retained higher levels of total soluble solids (TSS) and ascorbic acid (V C ) over10 days of cold storage. These findings highlight that ZIF-8@DMY/CS composite films are a promising smart active packaging material for preserving the postharvest quality of fresh produce.
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高影响因子
POLYMER
·
2026
·
IF 5.1
Yuanhang Xiao,Changqi Chen,Jiaxin Chen,Chunhua Wang,Wei Lin
Amphoteric compounds as metal-free alternatives offer a promising pathway to address the environmental and health challenges associated with chromium salts, as well as the charge mismatch between organic tanned leather and anionic dyes. Herein, we design a multifunctional amphoteric triazine derivative (EDTB) through synergistic modulation of reactivity, molecular size, and surface charge, which features multiple active chlorines, pH-responsive aggregation behavior, and high isoelectric point to achieve efficient tanning and enhanced dyeing performance. EDTB can assemble to form micron-scale aggregates through electrostatic interactions, which enables uniform diffusion and multipoint covalent crosslinking within collagen matrix, while regulates the interfacial electrostatics of fiber to improve the absorption and fixation of dyes. The EDTB-tanned leather exhibits superior hydrothermal stability ( T s ∼82 °C), mechanical strength (tensile strength >24 MPa, tear strength >66 N/mm), and color depth (K/S value of 15.0) compared to leather tanned with commercial tanning agent (i.e., F-90). Moreover, the pickling- and basifying-free EDTB tanning system demonstrates reducing chloride discharge, improving wastewater biodegradability, and lowering the carbon footprint by over 40% relative to chrome tanning. This work establishes a versatile amphoteric triazine-based tanning strategy integrating high tanning efficiency and dyeing assistance, offering a practical and scalable solution for advancing sustainable leather manufacturing.
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Han Yin,Haiyan Li,Feng Guo,Wenhao Bo,Yue Li,Hongxin Luo
Achieving durable corrosion protection in epoxy coatings remains challenging because barrier degradation, chloride penetration, and insufficient inhibitor utilization occur simultaneously during long-term exposure. Herein, mesoporous silica nanocapsules (MSN-BC) co-encapsulating benzotriazole (BTA) and cetyltrimethylammonium bromide (CTAB) were synthesized via a one-pot method, where CTAB functioned dually as a pore-forming agent and a corrosion inhibitor. Magnesium‑aluminum layered double hydroxide (LDH) nanosheets were subsequently grown in situ on the nanocapsule surfaces. The nanocapsules showed pH-responsive inhibitor release and strong Cl − adsorption. A key finding from electrochemical impedance spectroscopy (EIS) was that the dual-inhibitor (MSN-BC) system exhibited superior corrosion protection compared with nanocapsules containing only CTAB or BTA, indicating an enhanced combined inhibition effect. This interpretation was further supported by density functional theory (DFT) calculations, which suggested favorable co-adsorption of BTA and CTAB on the Q235 steel surface. At an optimal loading of 1 wt% in epoxy, MSN-BC-LDH dispersed uniformly, reduced coating porosity, and improved barrier performance. After 60 days in 3.5 wt% NaCl solution, the coating maintained an impedance modulus of 8.2 × 10 8 Ω·cm 2 at 0.01 Hz, one order of magnitude higher than pure epoxy. The enhanced protection arises from coating densification, LDH-enabled Cl − trapping, and synergistic dual-inhibitor action.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Hang Xu,Feng Li,Taohai Li
Responsive superhydrophobic films have gained increasing interest for their tunable wettability and adaptive functionality, yet their poor environmental stability limits use in complex wastewater treatment. Herein, a multifunctional membrane integrating pH-responsive wettability, photocatalytic activity, efficient oil–water separation, and strong flame retardancy is reported. A ZnNb 2 O 6 /BiOBr composite with superior photocatalytic activity achieved 80% degradation of hydrochloric tetracycline (HTC). Based on this material, a ZnNb 2 O 6 /BiOBr/ODA patterned coating strategy was developed to construct a pH-responsive superwetting membrane capable of reversible transitions between superhydrophobic and superhydrophilic states, serving as a conductive/non-conductive liquid identification based on wettability differences and response under extremely acidic (pH ≤ 3) conditions indicator. The membrane also exhibits remarkable flame suppression, >97% oil–water separation efficiency, and excellent reusability under harsh conditions, including crude-oil-contaminated seawater. This work provides a robust and intelligent membrane platform for environmental monitoring, wastewater purification, oil spill remediation, and fire-safe applications.
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高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.5
Minghong Feng,Teng He,Haiqian Zhao,Tao Chen,Wenjing Lin,Chufen Yang
To address the challenges of poor stability and weak targeting capability in polymeric micelles, which negatively impact controlled drug release performance, pH-responsive polymers PCL-PDEAEMA-PHEMA-PPEGMA (P1, P2, and P3) with distinct block lengths were designed and synthesized in this work. These copolymers were rigorously characterized using 1 H NMR, FT-IR, and GPC. Subsequently, polymer P3 was selected for modification based on comparative analyses of critical micelle concentrations (CMC) and drug-loading performance. Polymer P3 underwent esterification with lipoic acid (LA) and folic acid (FA) to yield LA-P3 and FA-P3, respectively. These derivatives were blended at a mass ratio of 1:1 (LA-P3:FA-P3), and dithiothreitol was employed to initiate self-crosslinking, resulting in the preparation of actively targeted crosslinked mixed micelles (C-MIX). The results revealed that C-MIX@PTX drug-loaded micelles prepared at a feeding ratio of 15 mg PTX/30 mg polymer exhibited a smaller size (134.7 nm) compared to non-crosslinked micelles, with a drug-loading content of 15.31 ± 1.79% and an encapsulation efficiency of 38.42 ± 5.22%. In vitro release studies demonstrated that under neutral conditions, C-MIX@PTX achieved a cumulative drug release of 16.8% at 120 h, significantly lower than non-crosslinked micelles. Under acidic/reductive conditions, C-MIX@PTX showed a cumulative drug release of 77.1% at 120 h, slightly lower compared to non-crosslinked micelles. Cytotoxicity assays confirmed that both MIX and C-MIX were biocompatible low-toxicity carrier materials, while LA-P3@PTX, FA-P3@PTX, MIX@PTX, and C-MIX@PTX exhibited inhibitory effects on HepG2 cells, FA-P3@PTX with folate-modified demonstrated enhanced efficacy.
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