ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 11.3
Jinchen Jiang,Haixia Meng,Zhenhao Shu,Nannan Zhao,Xiaojun Lin,Jianglan Li,Minjun Qin,Siyu Wu,Lianglin Qiu
As an emerging alternative to perfluorooctanesulfonate (PFOS), 6:2 chlorinated polyfluoroalkyl ether sulfonate (6:2 Cl-PFAES) is associated with male reproductive disorders, yet its testicular targets and mechanisms remain unclear. This study combined in vivo exposure of male C57BL/6J mice (0, 4, 40, and 400 μg/L for 18 weeks) and in vitro assays in primary Leydig cells to demonstrate that 6:2 Cl-PFAES dose-dependently reduced sperm count and serum/testicular testosterone, accompanied by testicular interstitial vacuolation. Transcriptomics and metabolomics demonstrated the concurrent significant enrichment of autophagy pathways and disruption of lipid metabolism. Mechanistically, 6:2 Cl-PFAES suppressed expressions of Sirtuin 1 (SIRT1), ras-related GTP binding protein 7 (RAB7), and deacetylation of forkhead box class O1 (FOXO1), thereby impairing lipophagy flux and promoting lipid droplets accumulation. Molecular docking indicated comparable binding affinity of 6:2 Cl-PFAES and PFOS to SIRT1 (−10.4 kcal/mol), and further research demonstrated that 6:2 Cl-PFAES reduced the deacetylation activity of SIRT1. Crucially, Sirt1 overexpression in transgenic mice (Sirt1TG) or pharmacological activation of SIRT1 (SRT1720) and RAB7 (ML-098) rescued testosterone synthesis and restored lipophagy flux. This study identifies the SIRT1–FOXO1–RAB7 axis as a core target for 6:2 Cl-PFAES-induced suppression of testosterone biosynthesis via lipophagy dysregulation, providing critical molecular insights for assessing the reproductive risks of PFOS alternatives.
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高影响因子
HYDROMETALLURGY
·
2024
·
IF 4.8
Xinyu Cheng,Dong Shi,Yuze Zhang,Xiaowu Peng,Shaolei Xie,Lijuan Li,Yong Niu,Yuxuan Wang,Fugen Song
Cesium is an important strategic resource, and solvent extraction is the most frequently used technology for its extraction from various minerals and brines. However, this common method faces operational and cost problems owing to large alkali consumption. A synergistic extraction system consisting of 4- tert -butyl-2-(α-methylbenzyl) phenol (t-BAMBP) and di-(2-ethylhexyl) phosphoric acid (D2EHPA) was designed and used to extract Cs + from an alkali-free solution. The effects of variables such as: (i) pH, (ii) concentration of t-BAMBP and D2EHPA, (iii) temperature, (iv) Cs + concentration, and (v) coexisting cations, on the Cs + extraction performance of the synergistic system were investigated. The most suitable organic phase composition was 1.0 mol/L t-BAMBP and 0.1 mol/L D2EHPA in kerosene, and the synergistic coefficient was up to 57 at 25 °C and an organic/aqueous phase volume ratio of 1/1. The extraction sequence of cations using the t-BAMBP–D2EHPA synergistic system followed the descending order Cs + > Rb + > Ca 2+ > K + > Li + > Mg 2+ > Na + . The chemical formula of the extracted species was determined as [CsA(HA)(ROH) 2 ] using the slope method. The Cs + extraction process is an exothermic reaction with an enthalpy ( ΔH o ) of −55.3 kJ mol −1 , confirmed by the thermodynamic study. After three-stage countercurrent extraction, the extraction efficiency of Cs + was 92.6%, demonstrating excellent selectivity from coexisting cations. The t-BAMBP–D2EHPA synergistic system showed outstanding economic and environmental advantages and a good application prospect to develop a conceptual process flowsheet for extraction with this system and stripping with HCl to separate cesium salt from salt-lake brine.
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ACS Omega
·
2024
·
IF 3.7
Tengjiao Fan,Lin Shen,Yaxin Huang,Xin Wang,Lijiao Zhao,Rugang Zhong,Peng Wang,Guohui Sun
Lung cancer ranks as the second most diagnosed cancer and the leading cause of cancer-related deaths worldwide. Novel chemotherapeutic strategies are crucial to efficiently target tumor cells while minimizing toxicity to normal cells. In this study, we proposed a combination strategy using energy blocker lonidamine (LND) and cytotoxic drug nimustine (ACNU, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea) to enhance the killing of a human lung cancer cell line and investigated the potential chemo-sensitizing mechanism of LND. LND was found to remarkably increase the cytotoxicity of ACNU to A549 and H1299 cells without significantly affecting normal lung BEAS2B cells. The combination of LND and ACNU also produced significant effects on cell apoptosis, colony formation, cell migration, and invasion assays compared to single drug treatment. Mechanistically, LND decreased intracellular ATP levels by inhibiting glycolysis and inducing mitochondrial dysfunction. Furthermore, the combination of LND and ACNU could intensify cellular oxidative stress, decrease cellular GSH contents, and increase reactive oxygen species (ROS) production. Notably, LND alone dramatically downregulated the expression of DNA repair protein MGMT (O6-methylguanine-DNA methyltransferase), enhancing DNA interstrand cross-link formation induced by ACNU. Overall, LND represents a potential chemo-sensitizer to enhance ACNU therapy through energy inhibition, disrupting redox homeostasis and downregulating MGMT expression in human lung cancer cell line under preclinical and clinical background.
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PubMed
高影响因子
TETRAHEDRON
·
2026
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IF 2.1
Jiahui Ma,Yiming Ma,Huida Qian,Yu Wang,Zhongxue Fang
A silver-catalyzed [3 + 2] cycloaddition of imines with isocyanoacetates was developed. This reaction represents a novel protocol for the efficient and practical synthesis of polysubstituted imidazolines bearing a broad range of substituents with good to excellent yields under mild conditions. The practicality of this cycloaddition was shown by a gram-scale synthesis.
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高影响因子
Inorganics
·
2026
·Vol. 14
·期 7
·183
·
IF 3.4
Xianguang Bai,Huiping Wang,Zebao Lu,Bin Li
A novel carbohydrazide-based ligand (L) and its binuclear Cu(II) complex were successfully synthesized and characterized. Structural analysis confirmed that the Cu(II) complex adopted a monoclinic crystal system with a distorted coordination configuration, in which the multidentate Schiff base ligand chelated and bridged two Cu(II) centers. The in vitro anti-tumor results revealed that the Cu(II) complex exhibited prominent cytotoxicity against five human cancer cell lines with much lower IC50values than the free ligand, copper chloride and cisplatin. Mechanistic studies demonstrated that the Cu(II) complex significantly increased intracellular ROS and MDA levels, decreased the GSH/GSSG ratio, and reduced ATP content, thereby disrupting cellular redox balance and bioenergetic metabolism. In addition, flow cytometry analysis verified that the complex effectively triggered tumor cell apoptosis. In contrast, free CuCl2showed almost no anticancer activity, indicating that the synergistic effect between the Schiff base ligand and copper ions contributed to the excellent anti-tumor performance. This work suggests that the prepared binuclear Cu(II) complex can serve as a promising candidate for developing metal-based anticancer agents.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Xiangyang Gao,Xin Liu,Chenxi Zhou,Qiyan Wang,Ruya Guo
Tailoring efficient bifunctional electrocatalyst with dual-heterojunction is crucial for overall water splitting (OWS). Herein, a multicomponent bifunctional catalyst with dual-heterojunction is rapidly constructed via sequential electrodeposition for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Density functional theory (DFT) calculations reveal that bidirectional electron transfer at the interface induces a double built-in electric field (BIEF) in Pt/CeO 2 -Ni(OH) 2 , which offers additional impetus for electron transport and brings the d -band center closer to the Fermi level, thereby optimizing reaction kinetics and the adsorption of reaction intermediates. Active Pt and CeO 2 nanoparticles (NPs) are uniformly anchored on the stable Ni(OH) 2 nanoflocs, ensuring high exposure of active sites and preventing NPs aggregation. Meanwhile, Ni(OH) 2 , serving as abundant electron donor center, forms dual heterointerface with Pt and CeO 2 (Pt-Ni(OH) 2 and CeO 2 -Ni(OH) 2 ), which ensures structural stability during electrochemical processes. Benefiting from the dual-heterojunction and the unique structure design, Pt/CeO 2 -Ni(OH) 2 exhibits excellent electrocatalytic performance, requiring only 66 mV (10 mA cm −2 ) and 278 mV (100 mA cm −2 ) for HER and OER, respectively. Remarkably, the two-electrode electrolyzer based on Pt/CeO 2 -Ni(OH) 2 electrode requires only 1.49 V to deliver 10 mA cm −2 with an excellent durability for OWS. This work brings light to the rational design and directional construction of bifunctional electrocatalyst hybrid nanomaterials with multiple heterojunctions.
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高影响因子
MONATSHEFTE FUR CHEMIE
·
2026
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IF 2.2
Wang Yun,Zhang Qiang-qiang,Liu Zi-yin,Xie Zhuang-dong
The synthesis of 2-aryl-2,3-dihydroquinolin-4(1 H )-ones from aromatic aldehydes and and 1-(2-aminophenyl)ethanone catalyzed by l -proline in ionic liquids was achieved for the first time. High yields up to 88.7% were achieved. Mild reaction conditions, enhanced rates, improved yields, and reagents’ reactivity, which is different from that in standard organic solvents, are the remarkable features observed in ionic liquids. In addition, the reaction mechanism was studied using computational methods, and the results were consistent with experimental findings. Graphical abstract
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高影响因子
NANO
·
2024
·
IF 1
Junxiang Mo,Jun Li,Jing Li,Yashan Li
The development of composite materials is a key area of research for enhancing the electrochemical performance of electrode materials. In this study, NiCo–S nanostructured hybrid electrode materials were prepared on nickel foam (NF) by using binary metal–organic frameworks (MOFs) as the sacrificial template through a two-step hydrothermal method. Ni–MOF was then deposited on the surface of NiCo–S/NF through the hydrothermal method and subsequently converted into Ni(OH) 2 through a subsequent alkalization treatment. The duration of the Ni–MOF hydrothermal process was varied as a parameter. NiCo–S@Ni–MOF/NF was prepared through hydrothermal reaction for 6 h, 9 h and 12 h, followed by heating in a 6 M KOH solution at 75 ∘ C for 6 h in a water bath. The electrode materials with the best morphology and electrochemical properties were obtained when the hydrothermal reaction time was 6 h. The optimized electrode had a specific capacity of 2533.2 F ⋅ g − 1 at 1 A ⋅ g − 1 and a capacity retention rate of 60.8% at 10 A ⋅ g − 1 , which indicated good rate performance. Additionally, the electrode material demonstrated excellent cycling stability, with a capacity retention rate of 95.3% after 5000 cycles at 50 mV ⋅ s − 1 . The energy density of the hybrid supercapacitor device assembled from this electrode material was 33.5 Wh ⋅ kg − 1 when the power density was 849.89 W ⋅ kg − 1 at a current density of 1 A ⋅ g − 1 .
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.3
Ying Liang,Xianping Liao,Yingshuai Jia,Shiming Guan,Wanling Zhang,Wenbiao Zhang,Yuying Meng,Yi Tang,Qingsheng Gao
Electrooxidation offers a sustainable alternative by utilizing renewable energy to convert biomass-derived cyclohexanol (CHA) to adipic acid (AA), a key industrial chemical for nylon-66 and polyurethane production. While bimetallic Ni-based catalysts enhance the conversion, the role of secondary metals in modulating Ni active-site reconstruction during operation remains unclear, limiting performance optimization. Here, we demonstrate that Cr-doping promoted the dynamic reconstruction of Ni(OH)2 nanosheets to form NiOOH with abundant Ni3+ and oxygen vacancies (OVs), significantly boosting AA electrosynthesis. In situ characterizations reveal that Cr-doping accelerates OH– adsorption and promotes NiOOH formation, while subsequent Cr3+ leaching generates OVs, thus, resolving the long-standing dilemma between stabilizing high-valence Ni and maintaining abundant defects. The optimized catalyst achieves 78.1% AA yield and 85.4% Faradaic efficiency at 1.45 V vs RHE, outperforming undoped Ni(OH)2 and prior systems. Mechanistic studies identify surface Ni3+ and OVs-stabilized *OOH species as the keys for CHA dehydrogenation and cyclohexanone oxidation, respectively. Moreover, a membrane electrode assembly electrolyzer was designed for the efficient coproduction of AA (0.078 mmol h–1 cm–2) and H2 (42.9 mL h–1 cm–2) at a current density of 100 mA cm–2, demonstrating the scalability. This work clarifies the in situ reconstruction of bimetallic sites and provides a design strategy for the efficient electrosynthesis.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Haoyi Guo,Pan Cao,Muxian Liu,Guohui Dai,Bei Liu,Changyu Sun,Chun Deng,Guangjin Chen
Hydrogen is regarded as a promising alternative to fossil fuels; however, approximately 95% of the global hydrogen supply still comes from “gray hydrogen”, with high carbon emissions. Efficient separation of CO2 and H2 is a key challenge in gray hydrogen production. This study proposes a novel H2 recovery process based on an aqueous solution of 2-methylimidazole (2-MeIm). The 2-MeIm aqueous solution possesses both strong CO2 absorption capacity and easy desorption performance, which can reduce energy consumption. Pure component solubility experiments were carried out at temperatures ranging from 283.15 to 353.15 K and pressures ranging from 0 to 2.0 MPa, yielding 66 sets of pure CO2 solubility data and 15 sets of pure H2 solubility data, which were used to regress the binary interaction parameters of the NRTL model. Comparison between the fitted NRTL model parameters and the experimental data indicates that the mean relative error of CO2 is 5.19%, whereas that of H2 is only 0.18%. Further, single-equilibrium-stage phase equilibrium experiments were conducted using a mixed gas stream with a CO2/H2 molar ratio of 40:60 to further validate the accuracy of the fitted NRTL parameters. The results demonstrate that the solubility-based fitted model achieves a mean absolute error (MAE) of 0.03 for gaseous CO2 and a mean relative error (MRE) of 0.93% for liquid-phase CO2, indicating high predictive accuracy. Based on Aspen Plus, this study has developed a rigorous process simulation model with a processing capacity of 100,000 N m3/h. The operating conditions were defined through sensitivity analysis, resulting in the following optimized parameters: 7 theoretical stages for the absorber, an operating pressure of 3.8 MPa, a volumetric gas-to-liquid ratio of 200, and a desorption temperature of 373.15 K. Under these conditions, H2 purity and recovery reached 99.99% and 99.13%, with specific energy consumption of only 260.27 kgoe/t H2 (10.88GJ/t H2). Compared with the conventional Rectisol process, the 2-MeIm-based process not only achieves higher H2 purity and recovery rate, but also significantly reduces total energy consumption by 32.07%. This marked performance enhancement underscores the outstanding energy-saving potential of the 2-MeIm system in the field of H2/CO2 separation.
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International Journal of Electrochemical Science
·
2026
·
IF 3.9
Qianfei Huang,Junqing Yang,Junkai Hu,Changhong He
Developing highly efficient organic corrosion inhibitors plays a crucial role in enhancing copper's resistance to degradation in aggressive environments. This research evaluates the corrosion inhibition efficacy of 2-aminothiophene-3-carboxamide (2ATCA) at the copper interface in simulated seawater medium (3.5 wt% NaCl). The findings indicate that incorporating 0.60 g/L of 2ATCA into the NaCl solution leads to a significant drop in corrosion current density, from 12.1 μA·cm -2 to 1.7 μA·cm -2 , achieving an inhibition efficiency of 86%. The Langmuir adsorption isotherm model was derived by applying the thermodynamic principles governing the corrosion inhibitor's mechanism. The surface characteristics and composition of copper were characterized through a combination of analytical techniques including scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The adsorption inhibition mechanism and reactivity of 2ATCA on the copper surface were further investigated through theoretical computational analysis. This study not only elucidates the adsorption behavior and mechanism of 2ATCA on copper but also provides a foundation for designing more effective organic inhibitors for copper corrosion in marine environments.
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高影响因子
Cell Host & Microbe
·
2026
·
IF 23.2
Shi Chen,Yang Wang,Beibei Chen,Xinyi Hou,Siyu Liu,Sihan He,Jiejun Qi,Ziheng Peng,Haibo Pan,Chunling Liang,Gehong Wei,Shuo Jiao
Rhizosphere microbiomes are essential for plant growth and stress tolerance, yet how microbial diversity shapes drought resilience in soybean remains unclear. Here, we demonstrate that high rhizosphere microbial diversity, generated via dilution-to-extinction manipulation of soil microbiome diversity, improves soybean performance under drought. Integrated metabolomic and transcriptomic analyses identify 2-naphthoic acid as a diversity-induced root exudate that accumulates exclusively under drought. This metabolite selectively recruits Sinorhizobium CS204 via chemotaxis and ATP-binding cassette (ABC) transporter-mediated uptake, as confirmed by in vitro substrate utilization assays and targeted mutant construction. Molecular docking and microscale thermophoresis reveal direct interactions between this metabolite and nitrogen-cycling proteins, enhancing denitrification and nitrogen fixation of S .CS204. Co-application of 2-naphthoic acid and S .CS204 significantly improves plant nutrient acquisition and photosynthesis under drought. Collectively, our study underscores the pivotal role of rhizosphere microbial diversity in triggering the exudation of root metabolites to recruit keystone taxa, establishing microbe-plant synergies that bolster drought tolerance.
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