查找使用阿拉丁产品的科研文献

Supramolecularly engineered ZIF-L/GO/Pebax mixed-matrix membranes with intercalated network structures for enhanced CO2/N2 separation

Shumin Li,Wenjun Su,Zeyang Di,Suyue Zhong,Junjie Ma,Jian Li

Membrane separation has emerged as a competitive energy-efficient approach for carbon capture and flue gas treatment. Membrane materials and structures are the core of gas separation membranes, which collectively govern gas molecular mass transfer and separation behaviors. Two-dimensional (2D) graphene oxide (GO) porous nanosheets hold great promise for gas separation due to their nanoscale thickness and structural tunability, but they are often limited by low permeability. Herein, we propose a supramolecular strategy to fabricate ZIF-L/GO/Pebax mixed matrix membranes with intercalated network architectures for efficient CO 2 /N 2 separation. Leaf-like ZIF-L expands the interlayer spacing of GO nanosheets and constructs high-speed continuous gas transport pathways within the membrane. This unique intercalated structure provides abundant CO 2 -philic sites, significantly enhancing CO 2 solubility and enabling highly selective gas molecular sieving. Moreover, hydrogen bonds and chelation coordination interactions between ZIF-L/GO and polymer matrix ensure excellent interfacial compatibility while reinforcing structural stability. This supramolecular structural engineering approach effectively mitigates the limitations of traditional membranes, achieving CO 2 permeability of 1000.8 Barrer and CO 2 /N 2 selectivity of 45, exceeding the 2008 Robeson upper bound and approaching the 2019 limit. Additionally, the membrane displays superior mechanical properties and long-term operational stability, providing a promising avenue toward high-performance materials for efficient CO 2 capture.

L-lysine-regulated NiCo-LDH nanoarrays on carbon cloth for broadband microwave absorption at an ultrathin matching thickness

Mingtao Hu,Ying Wang,Beibei Zhang,Fei Jin,Hongliang Ge,Jiabing Dai,Feng Gao,Qiong Wu

Achieving a broad effective absorption bandwidth at an ultrathin matching thickness remains a central challenge in the design of microwave absorbing materials. Herein, to the best of our knowledge, an amino-acid-mediated molecular regulation strategy is introduced for the first time into conductive textile/LDH microwave absorber design. L -lysine is employed as a molecular regulator to modulate the nucleation and growth of NiCo-LDH nanoarrays on flexible conductive carbon cloth, leading to the formation of denser and more uniform vertically aligned nanoarrays from the initially loose and disordered deposits. The optimized 1.0Lys sample achieves a minimum reflection loss of −25.0 dB at 17.2 GHz with an ultrathin matching thickness of only 1.00 mm and delivers a broad effective absorption bandwidth of 4.24 GHz at 1.09 mm, demonstrating that strong and broadband absorption are realized under ultrathin matching conditions. The enhanced absorption originates from the synergistic effects of L -lysine-regulated dense nanoarrays, abundant heterogeneous interfaces, molecule-related polar groups, high-frequency dielectric attenuation, and improved impedance matching. In addition, CST-based radar cross section simulations reveal effective high-frequency scattering suppression under different observation angles, highlighting its potential applicability in complex electromagnetic environments. This work provides a previously unexplored amino-acid-mediated molecular regulation route for designing flexible microwave absorbers with broad effective absorption bandwidths at ultrathin matching thicknesses.

Terahertz spectral characterization of L-carnitine derivatives: combined experimental study using microfluidic technology and density functional theory calculations

Shiyi Yang,Mingyu Wang,Xinyi Bai,Bo Su,Shengbo Zhang,Hailin Cui,Cunlin Zhang

Terahertz (THz) spectroscopy is an effective method for material analysis, as molecules exhibit unique fingerprint spectra in this band. L-carnitine, a vitamin-like nutrient widely used in weight-loss health foods and nutritional additives, was investigated. Using THz time-domain spectroscopy (THz-TDS) and microfluidic chips, we measured the solid and solution absorption spectra (0.3–2.5 THz) of Acetyl-L-Carnitine Hydrochloride (ALC-HCL) and L-Carnitine L-Tartrate (LCLT). Results showed distinct spectral characteristics despite structural similarities. Density functional theory simulations identified the molecular vibrations and origins of the absorption peaks. A correlation was observed between the solid and solution states. This research provides a reference for analyzing food nutritional additives.

Production of high antioxidant activity flavonoid monoglucosides from citrus flavanone with immobilised α-L-rhamnosidase in one step

Liu Aolu,Huang Baohua,Lei Lin,Lu Yu-Jing,Zhou Jin-Lin,Wong Wing-Leung

The rhamnosyl group of naringin dihydrochalcone, neohesperidin dihydrochalcone, naringin and hesperidin was selectively removed by enzymatic hydrolysis using an immobilised α-L-rhamnosidase. Monoglycosylated products, including trilobatin, hesperetin dihydrochalcone-7-O-glucoside, prunin and hesperetin-7-O-glucoside, were isolated and characterised by 1H and 13C NMR and ESI-MS. To optimise the enzymatic reaction conditions and its process costs, the hydrolysis of neohesperidin dihydrochalcone to produce trilobatin was selected as a model reaction. Using a ratio of neohesperidin dihydrochalcone: immobilised α-L-rhamnosidase equal to 1:0.6, the trilobatin yields was over 98%. The recycle of enzyme was also investigated, obtaining trilobatin with a yields of 80% even when the twentieth reaction cycle was conducted. Moreover, antiradical and antimicrobial activities of the obtained flavonoid monoglucosides were examined by DPPH, FRAP and ORAC methods, and compared with the efficacy of parental flavonoid glycosides and their aglycone. The results highlight that some of the obtained flavonoid monoglucosides show significant improvement in the antioxidant activity.

Pollen of Brassica campestris L. ameliorates hyperuricemic and obstructive nephropathy by targeting the β-catenin/TCF4-ferroptosis pathway

Jiao Kong,Yujia Chen,Shuanghui Lu,Lvexiang Yuan,Tao He,Minlei Dong,Yingqiong Zhang,Xiaoyi Pan,Hui Zhou,Huidi Jiang

Ethnopharmacological relevance The pollen of Brassica campestris L. (BCP, syn. Brassica rapa L. subsp. oleifera (DC.) Metzg.), included in the Chinese Pharmacopoeia as a licensed patent medicine (Pule'an tablets), is used clinically for kidney-qi deficiency-related lower urinary tract symptoms in chronic prostatitis and benign prostatic hyperplasia. Prostatic obstruction is a common cause of obstructive uropathy that may progress to renal fibrosis. However, the renoprotective effects and the underlying mechanism remain to be fully elucidated. Aim of the study To study the renoprotective effects, the active fraction, the effective components of BCP and the underlying mechanisms. Materials and methods Mouse models of hyperuricemic nephropathy (HN) and unilateral ureteral obstruction (UUO) were established to evaluate the renoprotective effects of BCP. Transcriptomics and liquid chromatography-mass spectrometry were applied to explore potential mechanisms and intrarenal constituents. Erastin- and uric acid (UA)-induced HK-2 cells were employed to validate the cytoprotective effects of the potential active compounds, whose binding capability with direct target was confirmed by CETSA/SPR. Results BCP dose-dependently reduced UA levels and reversed the protein expression of UA-producing enzymes and renal transporters (for reabsorption and excretion) in HN mice. Additionally, BCP improved renal injury and fibrosis in HN mice and UUO mice by reducing UA and direct renoprotection, in which the flavonoids of BCP played a crucial role. Meanwhile, BCP alleviated renal fibrosis by inhibiting the β-catenin/TCF4-ferroptosis axis, which was achieved mainly by its bioactive components, kaempferol and kaempferol-3-glucuronide (K-3-G), in HK-2 cells. Furthermore, kaempferol and K-3-G were demonstrated to directly bind with β-catenin, block the transcriptional activation of β-catenin, and subsequently suppress ferroptosis. Conclusions BCP and its major bioactive compounds, kaempferol and K-3-G, exert nephroprotective effects by inhibiting the β-catenin/TCF4-ferroptosis axis.

Bioactive constituents of Olea europaea L. leaf extract ameliorate metabolic-associated steatohepatitis via the PPARγ/AMPK/ACC Axis

Xia Zhang,Yuying Li,Chengfu Zhang,Huali Zhang,Jing Zhao,Dong Pei,Tingfu Jiang,Lichun Zhao,Qingli Qu

The therapeutic potential of Olea europaea L. leaf in hepatitis is recognized, yet its active constituents against metabolic dysfunction-associated steatohepatitis (MASH), a specific form of hepatitis driven by metabolic disturbances, remain poorly defined. This study integrated HPLC fingerprinting of Olea europaea L. leaf extracts (OLE) with chemometrics and bioactivity profiling to identify anti-MASH components. Bioactivity was assessed using a palmitic acid-induced steatohepatitis model in L02 cells. Spectrum–effect relationships derived from pearson correlation and partial least squares regression highlighted four putative active compounds, designated P7, P8, P10, and P11. HPLC-MS identified these as cynaroside (P7), apigenin-7-O-glucoside (P8), oleuroside (P10), and ligustroside (P11). Subsequent in vitro and in vivo evaluations in a zebrafish MASH model confirmed that P7, P8, and P10 exhibited significant anti-MASH activity. Notably, a robust synergism was observed between cynaroside and oleuroside, which their 1:1 M combination yielded a ZIP synergy score of 11.965 and a combination index (CI) of 0.3151, indicating strong synergy at lower doses. These results identify key anti-MASH constituents in OLE and provide a mechanistic basis for using multi-component OLE, highlighting a synergistic approach for MASH management.

Construction of dual-mode bimetallic MOF/carbon fiber biosensor and its application in visual detection of L-cysteine

Jing Xu,Yuedan Wang,Changhui Li,Mufang Li,Xue Liu,Liyan Yang,Dong Wang,Yan Tan

A bimetallic ZnNi-MOF was grown on carbon fiber via a one-pot hydrothermal method. Compared with single-metal MOFs, the resulting material exhibited enhanced luminescence and electrochemical activity, which enabled the construction of a flexible dual-mode sensor for rapid fluorescence-electrochemical detection of L-cysteine. Electrochemical detection exhibited a linear range of 1 nM-10 μM with a limit of detection (LOD) of 0.017 nM, while fluorescence sensing gave a linear range of 1 μM-1 M with a LOD of 0.89 μM. Both modes showed good selectivity and stability. Flexible sensors were also prepared by impregnating filter paper and textiles, wet spinning, and hydrogel microspheres. By combining the sensor with mobile phone software that collects the RGB values of the fluorescence color change, visual detection of L-cysteine can be achieved. The sensor successfully determined L-cysteine in human sweat and milk, with recoveries of 93–114% and RSDs of 2.43–5.32%, demonstrating promising applications in intelligent wearable monitoring, precision medicine, and food safety.

Effects of Foliar Calcium and Magnesium Application on Peach (Prunus persica L.) Nutrition Status and Fruit Quality Formation

Chang Lu,Xudong Wang,Xiaoying Guo,Bilal Hussain,Shane Wang,Xiaoe Yang

Peach fruit quality—including sweetness, firmness, and nutritional value—is strongly determined by mineral nutrition, yet limited soil availability of calcium (Ca) and magnesium (Mg) under production activities often constrains high-quality fruit formation in juicy peach production. This study aimed to evaluate the effects of foliar application of Ca and Mg on leaf nutrient status and fruit quality in peach ( Prunus persica L. Batsch). Seven treatments were established, including 0.1% (T1), 0.2% (T2), and 0.3% (T3) CaCl 2 solutions, 0.1% (T4), 0.2% (T5), and 0.3% (T6) MgSO 4 solutions, and a water-sprayed control (CK). All treatments were applied during the fruit development stage, and RNA sequencing analysis was performed on the highest-concentration MgSO 4 treatment group. The results of this study showed that high-concentration treatments (0.3% CaCl 2 , T3; 0.3% MgSO 4 , T6) significantly increased leaf chlorophyll and Ca/Mg accumulation relative to CK. For Ca treatments, T3 significantly increased sucrose content, whereas T2 enhanced glucose accumulation and total phenolic content, indicating that appropriate CaCl 2 supplementation may improve fruit quality through regulation of carbohydrate metabolism and antioxidant responses. T6 produced the greatest gains in soluble sugars, soluble solids, vitamin C, and antioxidant capacity, indicating a close link between leaf Mg status and carbohydrate accumulation. Transcriptomic analysis of peach leaves further revealed that Mg supplementation modulated genes involved in starch and sucrose metabolism, contributing to sugar accumulation. This study revealed that foliar application of 0.3% MgSO 4 offers an effective strategy for improving peach fruit quality.

L-ascorbic acid-modulated interfacial polymerization for high-flux nanofiltration membranes toward PFAS removal and natural water purification

Kaiyuan Ma,Bin Liu,Longchao Zhou,Shan Niu,Qianxin Zhang,Haiou Huang,Gang Yu

l -ascorbic acid regulates the interfacial polymerization microenvironment. • A thinner polyamide layer with enhanced negative charge and a more uniform pore structure was obtained. • AA-3 increases water permeance by 38% while maintaining approximately 96% Na 2 SO 4 rejection. • AA-3 achieves 84.7–99.8% rejection for 17 PFAS under the tested conditions. The global occurrence of per- and polyfluoroalkyl substances (PFAS) poses a serious threat to aquatic ecosystems and human health, thereby necessitating the development of advanced water purification technologies. In this study, l -ascorbic acid (AA) was introduced as a multifunctional regulator into the interfacial polymerization (IP) of piperazine (PIP) and trimesoyl chloride, providing a green and sustainable route for fabricating high-flux nanofiltration (NF) membranes. Owing to its abundant hydroxyl groups, AA alters the aqueous-phase reaction environment and reduces PIP transport toward the water/organic interface, thereby moderating the IP process and promoting the formation of a thinner and more uniform nanonodular PA layer. Among the tested membranes, AA-3 was selected as the optimized membrane because it provided the most favorable overall balance between water permeance and selectivity, achieving a water permeance of 21.0 L m −2  h −1 bar −1 while maintaining 95.9% Na 2 SO 4 rejection. When applied to treat river water affected by saltwater intrusion, the membrane demonstrated effective purification performance while allowing partial passage of Ca 2+ and Mg 2+ ions. Furthermore, the membrane exhibited excellent removal efficiencies for 17 PFAS compounds, with rejection ranging from 84.7 to 99.8%. These results demonstrate that AA-regulated IP offers a promising strategy for developing next-generation environmentally friendly NF membranes for efficient PFAS control and drinking water protection. Download: Download high-res image (290KB) Download: Download full-size image

Low-permittivity MgP2O6 and NiP2O6 microwave dielectric ceramics: crystal structure, properties, and P–V–L bond theory analysis

Zhenjun Qing,Wanting Yang,Haiyan Li

Phase-pure MgP 2 O 6 and NiP 2 O 6 metaphosphate ceramics were synthesized via solid-state reaction. Both crystallize in a monoclinic C2/c structure, with NiP 2 O 6 exhibiting a contracted unit cell due to the smaller ionic radius of Ni 2+ compared to Mg 2+ . The optimum sintering temperature for MgP 2 O 6 was 975 °C, yielding ε r  = 5.1, Q × f  = 45,300 GHz, τ f  = −14.7 ppm/°C, while for NiP 2 O 6 it was 925 °C, yielding ε r  = 5.4, Q × f  = 66,100 GHz, τ f  = −8.7 ppm/°C. The slightly higher ε r of NiP 2 O 6 stems from higher bond ionicity and polarizability density. The superior Q × f is attributed to a higher packing fraction, larger lattice energies, and weaker phonon damping, as evidenced by a narrower Raman FWHM. The improved τ f arises from stronger A–O and P–O bond energies, resisting thermal vibrations. These results indicate MgP 2 O 6 and NiP 2 O 6 as promising low-permittivity microwave ceramics and suggest that A-site cation engineering provides a promising proof-of-concept for tailoring dielectric properties in metaphosphates.

L-Theanine Prevents Autophagy Impairment to Counteract Cadmium-Induced Hepatic Mitochondrial Dysfunction, Ferroptosis, and Glucolipid Dysmetabolism in Mice

Background: Cadmium (Cd) exposure impairs the autophagic response, a core mechanism for cell preservation and organismal homeostasis, eventually resulting in metabolic disturbances, mitochondrial dysfunction, and oxidative stress. L-theanine (LT) exhibits multiple health benefits with a high safety profile. However, the effects of LT on Cd exposure-induced impairments in autophagy and autophagy-related physiological functions remain unclear. Methods: This study investigated the effects of LT on the survival time of mice acutely exposed to Cd and the regulating effect of LT on autophagy and subsequent metabolic dysfunction in mice subjected to subchronic Cd exposure. Results: The results showed that acute Cd exposure resulted in 100% mortality within 8 h. However, LT treatment significantly prolonged the median survival time of mice from 4 h to 16 h and reduced the mortality to 60%. In the context of subchronic Cd exposure, autophagy was inhibited, as evidenced by the downregulation of the AMPK/mTOR signaling pathway mediated by DPP-4 and SIRT1. This exposure also promoted lipid peroxidation and ferroptosis, indicated by the inactivation of the AMPK/p-ACC axis and marked alterations in ferroptosis markers. Furthermore, mitochondrial dysfunction was suggested by the downregulation of the SIRT1/PGC-1α/Nrfs/TFAM signaling pathway and reductions in COX and SDH activities. Additionally, glucolipid metabolism was impaired, as indicated by the downregulation of the AMPK and PI3K/AKT signaling pathways and elevated lipid and glycogen accumulation in the liver of mice. LT significantly decreased the level of DPP-4 and upregulated SIRT1, leading to the activation of AMPK. This activation restored autophagy response by downregulating mTOR, promoted energy homeostasis by reducing lipid biosynthesis and enhancing fatty acid oxidation, blocked lipid peroxidation and ferroptosis through the phosphorylation of ACC at the serine 79 site and reducing the ubiquitination-mediated degradation of GPX4, and maintained mitochondrial function by upregulating the PGC-1α/Nrfs/TFAM signaling pathway. Conclusions: Collectively, LT effectively ameliorates mitochondrial dysfunction, ferroptosis and glucolipid dysmetabolism in Cd-exposed mice, and these effects are accompanied by findings consistent with modulation of autophagy-related signaling in the liver.

Compound Enzyme-Assisted Extraction and Characterization of Trigonella foenum-graecum L. Polysaccharides and Their Ameliorative Effects on MAFLD

Wen-Xuan Zhao,Rui Zhang,Guo-Qiang Li,Cun-Ping Wang,Yan-Feng He,Hong-Tao Bi

Trigonella foenum-graecum L. seed polysaccharides (FSP) belong to a very important species of biological macromolecules with prebiotic activity, which are the basic substances that have broad application potential in food and pharmaceutical fields. However, systematic studies focusing on the compound enzyme-assisted extraction of FSP and their hepatoprotective effects remain limited. This study aimed to optimize the compound enzyme-assisted extraction of FSP, analyze the structural features of deproteinized FSP (DFSP), and evaluate its therapeutic potential against metabolism-associated fatty liver disease (MAFLD). The results showed that the optimal extraction conditions were an enzymatic hydrolysis temperature of 50°C, an enzymatic hydrolysis pH of 5.3, an enzymatic hydrolysis time of 1.9 h, and a liquid-to-solid ratio of 23:1 mL g −1 , under which the polysaccharide yield reached 24.88% ± 0.15%. The molecular weight distribution of fenugreek seed polysaccharides was 7157.46, 2785.65, and 642.61 Da, and they were mainly composed of mannose and galactose. In vivo experiments indicated that DFSP exerted a liver-protective effect on MAFLD mice, accompanied by improvements in lipid metabolic parameters, antioxidant capacity, and inflammatory responses. Therefore, this study provides a scientific basis for further investigations into the fine structure and potential hepatoprotective effects of DFSP. Graphical