Chemosensors
·
2023
·Vol. 11
·期 4
·232
·
IF 4.2
Junjie Chen,Suyang Li,Fuqi Yao,Wanbing Xu,Yunfeng Li,Qiang Chen,Pei Liang
Silver particles have been widely used in SERS detection as an enhancement substrate. The large-scale synthesis of Ag particles with controllable size and shape is still a challenge. We demonstrate a high-throughput method for the preparation of monodisperse submicron silver particles using S-shaped microfluidic chips. Submicron silver particles were prepared by a simplified reduction method. By adjusting the concentration of the reducing agent ascorbic acid and the stabilizer PVP, the particle size and morphology could be controlled, obtaining a size distribution of 1–1.2 μm for flower-like silver particles and a size distribution of 0.5–0.7 μm for quasi-spherical silver particles. This microfluidic system can be used to fabricate submicron silver particles on a large scale, continuously and stably, with a production efficiency of around 1.73 mg/min. The synthesized submicron silver particles could realize ultra-sensitive SERS detection, and the lowest concentration of rhodamine 6G (R6G) that could be detected was 10−9M.Keywords:submicron silver particles;microfluidic chip;SERS detection
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiaorong Zhao,Qiulan Li,Hong Li,Yijie Wang,Feijian Xiao,Dezhi Yang,Qinghai Xia,Yaling Yang
In this work, cerium-doped carbon dots (Ce-CDs) both as a reducing agent and template hybrid gold nanoparticles (AuNPs) with weak oxidase-like (OXD) activity was synthesized for the detection of Hg 2+ and aflatoxin B 1 (AFB 1 ). The AuNPs can catalyze efficiently mercury ion (Hg 2+ ) reduction to the metallic (Hg 0 ) to form Au-Hg amalgam (Au@HgNPs). The obtained Au@HgNPs with strong OXD-like activity oxidize without Raman-active leucomalachite green (LMG) into the Raman-active malachite green (MG) and simultaneously as the SERS substrates by the formed Raman “hot spot” through MG-induced Au@HgNPs aggregation. While AFB 1 was introduced resulting in the SERS intensity decreasing due to Hg 2+ with AFB 1 via carbonyl group to inhibit the aggregation of Au@HgNPs. The work paves a new path for the design of a nanozyme-based SERS protocol for tracing Hg 2+ and AFB 1 residues in foodstuff analysis.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Huanhuan Li,Wenhui Geng,Zihan Zheng,Suleiman A. Haruna,Quansheng Chen
The misuse of chloramphenicol (CAP) has led to the development of drug-resistant strains that pose significant threats to public health. Here, we propose a universal flexible surface-enhanced Raman spectroscopy (SERS) sensor utilizing gold nanotriangles (AuNTs) and polydimethylsiloxane (PDMS) film for rapid detection of CAP in food samples. Initially, AuNTs@PDMS with unique optical and plasmonic properties were used to collect spectra of CAP. Afterward, four chemometric algorithms were executed and compared. Accordingly, random frog-partial least squares (RF-PLS) exhibited optimum results with correlation coefficient of prediction (Rp = 0.9802) and the lowest root-mean-square error of prediction (RMSEP = 0.348 µg/mL). Furthermore, the sensor's efficacy to detect CAP in milk samples was confirmed, and the findings were compatible with the conventional HPLC approach ( P > 0.05). Therefore, the proposed flexible SERS sensor could effectively be used to monitor milk quality and safety.
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RSC Advances
·
2023
·Vol. 13
·期 15
·10135-10143
·
IF 3.9
Yangjie Chen,Juan Hao,Zhihang Yin,Qinghui Wang,Youting Zhou,Lingpu Jia,Huiming Li,Wenlong Liao,Kunping Liu
Internal standard molecule 4-mercaptobenzoic acid (4-MBA) embedded Au core-Ag shell nanorods (Au-MBA@Ag NRs) were prepared by a seed-mediated growth method, then loaded on octahedral MIL-88B-NH2 to obtain a novel ratiometric SERS substrate of Au-MBA@Ag NRs/PSS/MIL-88B-NH2 (AMAPM) for detecting rhodamine 6G (R6G) in chili powder. The porous structure and excellent adsorption ability of MIL-88B-NH2, allowed for increased loading of Au-MBA@Ag NRs, thereby shortening the distance between adsorbed R6G and the “hot spot” resulting from local surface plasmon resonance (LSPR) of Au-MBA@Ag NRs. Based on the SERS characteristic peak ratio of R6G to 4-MBA, the ratiometric SERS substrate displayed improved accuracy and excellent performance for R6G detection, with a wide linear range of 5–320 nM and a low detection limit of 2.29 nM as well as fine stability, reproducibility and specificity. The proposed ratiometric SERS substrate offered a simple, fast and sensitive sensing strategy for R6G detection in chili powder, which demonstrated potential applications in food safety and the analysis of trace analytes in complex matrices.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2022
·
IF 3.268
Peizhen Li,Xiuhua Xia,Jiannan Chen,Hang Yu,Yunfei Xie,Yahui Guo,Weirong Yao,He Qian,Yuliang Cheng
Gold-coated silver core–shell nanoparticles (Ag@Au NPs) have been widely used for SERS analysis due to plasmon resonance performances. However, it is a great challenge to fabricate Ag@Au core–shell structures with specified morphology. In this paper, the size and shape of Ag NPs (core) were precisely controlled by a seed-mediated approach, and then the gold shell was completely coated on under the strong reduction of ascorbic acid, resulting in Ag@Au NPs with highly regulated morphology. The obtained Ag@Au NPs achieved a similar or even better SERS enhancement factor (EF) (up to 5.7 × 107) compared to Ag NPs, but significantly higher stability. For the rapid SERS detection of nitrofurantoin metabolite AHD, a limit of detection (LOD) as low as 1 × 10−10 M and a wide linear range from 1 × 10−4 to 1 × 10−8 M were obtained. Furthermore, recoveries for crayfish samples were from 90.5% to 108%, indicating a good performance of the presented method in real sample detection.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Nianlu Li,Mengping Zhang,Xiao Geng,Ranran Liu,Xiao Meng,Wei Zou,Wenwen Chen,Hua Shao,Cuijuan Wang
Poisoning with diquat (DQ) and paraquat (PQ) herbicides has been a public health problem. Unfortunately, rapid detection in biofluids remains challenging. Herein, a hyphenated approach of electro-enhanced adsorption, solid-phase microextraction, and surface-enhanced Raman spectroscopy (EE−SPME−SERS) was exploited for rapid and sensitive in situ analysis of DQ and PQ in human urine and plasma. A porous Ag fiber with an Au layer (p-Ag/Au fiber) was fabricated with multi-functions (SERS substrate, SPME sorbent , and working electrode). Clear trends could be observed between signal intensity and concentration of DQ or PQ with high reproducibility. The method detection limits (MDLs) calculated from the characteristic peak of DQ were 0.064 ppb and 0.65 ppb in urine and plasma, respectively. Corresponding MDLs for DQ and PQ in urine and plasma were 0.036 ppb and 0.35 ppb, respectively. The whole process of “extracting and detecting” was completed within 4 min with satisfactory recoveries. Notably, the EE−SPME−SERS technique could easily realize in situ analysis of DQ and PQ in biofluids with good selectivity, which is practical in clinical diagnosis. This EE−SPME−SERS method provides a potential avenue for efficient pretreatment and in situ poison detection in biological samples.
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OPTICS EXPRESS
·
2023
·Vol. 31
·期 4
·5297-5313
·
IF 3.8
Enze Lv,Junkun Wang,Jing Li,Xiaofei Zhao,Jing Yu,Shicai Xu,Zhen Li,Baoyuan Man,Mei Xue,Mei Xue,Jihua Xu,Jihua Xu,Chao Zhang
The accurate detection of nanoplastics is crucial due to their harmful effects on the environment and human beings. However, there is a lack of detection methods for nanoplastics smaller than 50 nm. In this research, we successfully constructed an Ag/CuO nanowire (NW)/BaTiO3@Polyvinylidene fluoride (PVDF) Bowl-shaped substrate with a nanowire-in-Bowl-shaped piezoelectric cavity structure that can modulate surface-enhanced Raman scattering (SERS) by the piezoelectric effect by the virtue of the tip effect of the CuO NW and light focusing effect of the Bowl-shaped cavity. Due to its unique nanowire-in-Bowl-shaped structure and piezoelectrically modifiable ability, nanoplastics less than 50 nm were successfully detected and quantitatively analyzed. We believe that the Ag/CuO NW/BaTiO3@PVDF Bowl-shaped substrate can provide an efficient, accurate, and feasible way to achieve qualitative and quantitative detection of nanoplastics.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Jialu Shen,Guoqing Chen,Zichen Yang,Yamin Wu,Chaoqun Ma,Lei Li,Taiqun Yang,Jiao Gu,Hui Gao,Chun Zhu
The accurate detection of fructose in human urine can help prevent and screen for diseases such as fructokinase deficiency and hereditary fructose intolerance. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique with selectivity and high sensitivity, which has been widely applied to the detection of targets with complex backgrounds. In this work, 4-mercaptophenylboronic acid (4-MPBA) was modified on the surface of silver nanoparticles (AgNPs) under mild conditions to obtain a boronic acid-functionalized SERS substrate for the detection of fructose in artificial urine. The detection mechanism was based on the deboronization reaction of 4-MPBA on the surface of AgNPs, which was induced by fructose, and the Raman signal of the generated thiophenol (TP) molecules was significantly enhanced by the silver nanoparticles, with a linear increase in SERS peak intensity at 1570 cm −1 . We achieved the detection limits of 0.084 µmol/L in water and 0.535 µmol/L in urine by this method. The relative standard deviation (RSD) in the recovery experiments of urine ranged from 1.01 % to 2.22 %, and the whole detection time was less than 10 min, which indicated that this method is highly reliable for fructose detection and has a good prospect in bioassay and clinical medicine.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Haonan Wang,Chuyi Wang,Jiali Huang,Yunzhen Liu,Yang Wu,Ruiyun You,Jian-Han Zhang,Yudong Lu,Huiying Shen
As a widely used industrial additive of plastic products, phthalate ester (PAE) plasticizers can easily migrate into food, threatening human health. In this work, we proposed a rapid, precise, and reliable method to detect PAE plasticizers in edible oils by using surface-enhanced Raman spectroscopy (SERS) technology. A two-dimensional (2D) silver plate synergizing with a nanosilver sol was prepared as a substrate for SERS to detect potassium hydrogen phthalate (PHP), a hydrolysate of a PAE plasticizer. Detection conditions, such as pH values, drying times, and hydrolysate interference, were optimized. The working curve was well fitted with a linear parameter R 2 of 0.9994, and the minimum detection limit was evaluated as 10 −9 mol/L. Furthermore, the detection accuracy was supported by five edible oil samples. Therefore, using SERS technology to detect PHP is expected to provide an avenue for PAE plasticizer detection in oils and fats, and it features promising potential applications in food safety.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Yansheng Liu,Zhenle Qin,Xiaobo Jia,Jin Zhou,Hongli Li,Xiaohong Wang,Yating Chen,Junpeng Deng,Zhicheng Jin,Guofu Wang
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a great disaster to the economy and human society. Nowadays, SARS-CoV-2 is fading away from people’s memory but it still exists around us. PCR plays an important role in detecting SARS-CoV-2 but it requires a long detecting time, equipped laboratory, and professional operators. In comparison with polymerase chain reaction (PCR), surface-enhanced Raman scattering (SERS) is a promising method for detecting SARS-CoV-2 due to its fast, easily operated, and high-sensitivity properties. In this study, the monolayer Ag nanoparticles (MAgNPs) covered with single-layer graphene (SLG) are applied as a SERS substrate. The angiotensin converting enzyme 2 (ACE2) is selected as a bio-probes that can specifically bind to the SARS-CoV-2 S protein. The SERS-based biosensor is formed by ACE2 functionalized SLG/MAgNPs and the LODs of detecting SARS-CoV-2 S protein in phosphate-buffered saline (PBS) and in pharyngeal swabs solution (PSS) are 0.1 fg mL −1 and 10 fg mL −1 , respectively. This biosensor provides a way of directly detecting SARS-CoV-2 S protein with high sensitivity and specificity. It illustrates a practical potential in the rapid detection of the SARS-CoV-2 virus.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Huimin Zhou,Anni Zhu,Caiyin Wang,Xiaoyu Guo,Ye Ying,Yiping Wu,Xinling Liu,Feng Wang,Ying Wen,Haifeng Yang
5-Hydroxyindole-3-acetic acid (5-HIAA) is regarded as a biomarker for diagnosis of carcinoid tumors, and it is of great significance to developing a precision assay for monitoring 5-HIAA levels. In this work, gold nanoparticles loading on the surface of MOF-199 (Au NPs/MOF-199) is prepared to propose a surface enhanced Raman scattering (SERS) assay for 5-HIAA. When 4-mercaptopyridine (4-MPy) is used as a SERS probe, on Au NPs/MOF-199, limit of detection (LOD) at 10 −9 mol/L can be achieved. In addition, Au NPs/MOF-199 substrate with good preparation reproducibility shows long-term storage stability at 4 °C. Under optimal condition, the Au NPs/MOF-199-based SERS method is applied to determine 5-HIAA in serum. The concentration linear range is from 10 −9 to 10 −5 mol/L and LOD is of 6.40 × 10 −11 mol/L. Much importantly, Au NPs/MOF-199 substrate exhibits specific response toward 5-HIAA against other metabolites in the serum due to the capturing selectivity from porous MOF-199. The recoveries obtained on spiked human serum samples locate in the span from 94.30% to 106.00% with RSD of 4.01–7.43%. Au NPs/MOF-199-based SERS sensing strategy is a promising avenue for on-field monitoring biomedical species for clinic diagnosis purpose.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Hongyan Xi,Ziqian Shi,Pengfei Wu,Niu Pan,Tingting You,Yukun Gao,Penggang Yin
Antioxidants play an important role in life health and food safety. Herein, an inverse-etching platform based on gold nanorods (AuNRs) and gold nanostars (AuNSs) for high-throughput discrimination of antioxidants was constructed. Under the action of hydrogen peroxide (H 2 O 2 ) and horseradish peroxidase (HRP), 3,3′,5,5′-tetramethylbenzidine (TMB) would be oxidized to TMB + or TMB 2+ . HRP reacts with H 2 O 2 to release oxygen free radicals, which then react with TMB. Au nanomaterials can react with TMB 2+ , at the same time, Au was oxidized into Au (I), leading to the etching of the shape. Antioxidants, with good reduction ability, would prevent the further oxidation of TMB + to TMB 2+ . So the presence of antioxidants will prevent further oxidation while avoiding the etching of Au in the catalytic oxidation process, thereby achieved inverse etching. Distinctive surface enhanced Raman scattering (SERS) fingerprint of five antioxidants were obtained based on the differential ability to scavenge free radicals. Five antioxidants, including ascorbic acid (AA), melatonin (Mel), glutathione (GSH), tea polyphenols (TPP), and uric acid (UA) were successfully distinguished by using linear discriminant analysis (LDA), heat map analysis and hierarchical cluster analysis (HCA). The study exhibits an effective inverse-etching based SERS sensor array for the response of antioxidants, which has great reference value in the field of human disease and food detection.
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