Polymers
·
2019
·Vol. 11
·期 1
·166
·
IF 3.164
Haiquan Mao,Chun Wei,Yongyang Gong,Shiqi Wang,Wenwen Ding
Environmentally benign and biodegradable chitosan (CS) membranes have disadvantages such as low mechanical strength, high brittleness, poor heat resistance and poor water resistance, which limit their applications. In this paper, home-made cellulose nanocrystals (CNC) were added to CS to prepare CNC/CS composite membranes through mechanical mixing and solution casting approaches. The effects of CNC dispersion patterns and CNC contents on the properties of composite membranes were studied. The analysis of the surface and cross-section morphology of the membranes showed that the dispersion performance of the composite membrane was better in the case that CNC was dissolved in an acetic acid solution and then mixed with chitosan by a homogenizer (Method 2). CNC had a great length-diameter ratio and CNC intensely interacted with CS. The mechanical properties of the composite membrane prepared with Method 2 were better. With a CNC content of 3%, the tensile strength of the composite membrane reached 43.0 MPa, 13.2% higher than that of the CNC-free membrane. The elongation at break was 41.6%, 56.4% higher than that of the CNC-free membrane. Thermogravimetric, contact angle and swelling analysis results showed that the addition of CNC could improve the heat and water resistance of the chitosan membrane.
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高影响因子
CARBOHYDRATE POLYMERS
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2018
·
IF 5.158
Zhuoyue Song,Youdong Hu,Longkai Qi,Tingting Xu,Yongsheng Yang,Zhanchi Xu,Xiaoping Lai,Xiaoli Wang,Danyan Zhang,Shijie Li
The aim of this study was to synthesize magnetic chitosan microspheres (MCM) for the deproteinization of crude polysaccharides from Ostrea rivularis Gould (ORP), and evaluate their adsorption properties. Firstly, MCM were synthesized by microemulsion process. Then they were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) and vibrating-sample magnetometer (VSM). At last, MCM was applied as a magnetic separable adsorbent for deproteinization of ORP. The results showed that MCM had smooth surface with particle diameter of 2–6 μm. The adsorption kinetics and adsorption isotherms were well fitted by the pseudo-second order equation and the Freundlich equation, respectively. Comparing with the Sevag method, MCM exhibited higher deproteinization ratio, higher polysaccharides recovery, and miner pollution. In addition, the deprotenaization capacity can be regenerated. Therefore, MCM would be used as promising adsorbents for the deproteinization of polysaccharides.
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CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Xiang Li,Huaili Zheng,Yili Wang,Yongjun Sun,Bincheng Xu,Chuanliang Zhao
Modified natural polymer flocculants has been the focus of research in environmental engineering field. Natural large molecular compound, chitosan (CTS) with many functional amino and hydroxyl groups can be easily modified to enhance its original functions. This work presents an environmentally friendly chitosan-based cationic polyacrylamide flocculants (CTS-g-PAMA) with enhanced function of sterilization and flocculation . CTS-g-PAMA was synthesized through Ultraviolet (UV)-initiated copolymerization. Structure characterization of FTIR, 1 H NMR, XRD and UV spectrum confirmed the successful grafting of AM and MAPTAC. Scanning electron microscopy (SEM) analysis results showed that CTS-g-PAMA exhibited a porous structure with a prodigious surface area. CTS-g-PAMA was then applied to treat a series of simulated waste water containing kaolin or Escherichia coli . Flocculation tests indicated that CTS-g-PAMA not only showed excellent flocculation effect but also showed high sterilization capability. A series of ONP concentration measurement tests through UV spectra analysis and 3D EEM analysis of suspension before and after flocculation were conducted to study sterilization mechanism, and results revealed the sterilization effect of CTS-g-PAMA was essentially bactericidal, not just antibacterial.
研究领域:
环境工程
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高分子化学
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水处理技术
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材料科学
·
微生物学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2014
·
IF 3.096
Jun Huang,Zhen-Hua Cheng,Hai-Hua Xie,Jin-Yan Gong,Jian Lou,Qing Ge,Yong-Jiang Wang,Yuan-Feng Wu,Shi-Wang Liu,Pei-Long Sun,Jian-Wei Mao
Chitosan was prepared by alkaline N -deacetylation of β-chitin from squid pens, and N -(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (HTCC) derivatives, with different degrees of quaternization (DQ) ranging from 0.77 to 1.06, were synthesized. It was identified by FT-IR, 1 H NMR and XRD analysis. All of the HTCC showed good water solubility in a wide pH range. The moisture absorption and retention abilities of all the HTCC were much better than that of the chitosan. The moisture absorption and retention values of all the HTCC at 43% RH for 24 h were above 49% and 92%, respectively. The scavenging ability of HTCC against hydroxyl and ABTS radicals improved with increasing concentration. The effectiveness of HTCC against hydroxyl radicals was lower than that of chitosan. These results indicated that HTCC, which has a much better moisture absorption and retention capacity, may act as a potential moisturizer in vitro.
研究领域:
高分子科学
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海洋生物化学
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材料科学
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抗氧化研究
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化妆品科学
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高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.1
Xiyuan Guo,Yuanfeng Pan,Yuanjian Xie,Pingxiong Cai
Pesticides are essential for agricultural production; however, their improper application can result in ecological damage and potential threats to human health. Therefore, the development of pesticide-controlled-release systems is crucial for the sustainable progress of agriculture and society. This work presents a novel strategy for fabricating a polyelectrolyte hydrogel bead-based pesticide-controlled-release system. The process involves blending a sodium alginate/carboxymethyl chitosan (SA/CMCS) solution with cystine dihydrochloride (CYS), followed by introducing the mixture into a citric acid (CA) solution. The abundant protonated amino groups (-NH 3+ ) and carboxylate anions (-COO-) within the system facilitate the formation of CMCS/SA-CYS/CA composite hydrogel beads (CHGB), subsequently loaded with thiamethoxam (TMX) to create TMX-loaded CHGB (TCHGB) for investigations into drug loading and responsive release. The CHGB exhibits remarkable swelling properties (up to 4200%), along with pH and redox sensitivity. And the release of TMX from TCHGB displays favorable responsiveness to pH and redox stimuli. Under alkaline conditions (pH 9.0) and reductive surroundings (containing glutathione), the cumulative release ratio of TMX surpasses 95%. Furthermore, it has been demonstrated that the release kinetics of TMX comply with Fickian diffusion described by the Korsmeyer-Peppas model. The discoveries of this study hold considerable research and practical value in the domain of controlled-release agricultural chemicals.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121235
·
IF 7.2
Na-won Baek,Shin-hee Lee
This study presents a novel enzyme-assisted coagulation (EAC) system as a low-carbon, energy-free strategy for the efficient treatment of azo dyes in textile wastewater. The EAC system integrates enzymatic oxidation with natural polymer-based coagulation and operates effectively under mild conditions without external energy input. Using horseradish peroxidase (HRP) and chitosan as model components, the system was applied to three representative azo dyes—Allura Red, Eriochrome Black, and Sunset Yellow—achieving decolorization efficiencies exceeding 98 %. Analytical techniques, including UV–Vis spectroscopy, FTIR, HPLC, and GC–MS, confirmed effective dye degradation and the stable aggregation of byproducts. The EAC mechanism involves the dual functionality of chitosan, which initially acts as an adsorbent and flocculant to enhance enzyme accessibility and subsequently serves as a stabilizing matrix that immobilizes and facilitates the removal of degradation products. This synergistic interaction between HRP and chitosan offers an efficient, biodegradable, and environmentally friendly approach for sustainable dye wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Pengcheng Zhang,Rong Xue,Chuan Yu,Mingjun Jiang,Yichen Dong,Yijin Li,Guangming Wan,Keyong Tang,Xialian Fan
Simultaneous rapid hemostasis and on-demand removal remains a key challenge for hemostatic materials for deep tissue injury. To address this issue, we developed a chitosan (CS)/sodium alginate (SA) composite sponge utilizing a dual cross-linking strategy with epichlorohydrin and calcium ions (Ca 2+ ). The calcium-crosslinked network can be rapidly dissociated through Ca 2+ -Na + ion exchange in a NaOH/Na₂EDTA solution, enabling non-invasive removal of the hemostatic sponge within 5 min, thus meeting clinical demands for controllable material retrieval. Moreover, the sponge surface was coated with oxidized dextran-dopamine (ODP), whose catechol and aldehyde groups effectively promote blood cell adhesion and accelerate the hemostatic response. Moreover, the sponge surface was coated with oxidized dextran-dopamine (ODP), whose catechol and aldehyde groups effectively promote blood cell adhesion and accelerate the hemostatic response. In the rat femoral artery injury model, the hemostasis time was only 86 s, and the blood loss was 64% less than that of commercially available chitosan hemostatic sponges. The hemostatic sponge exhibits a compression strength exceeding 100 kPa and a bacteriostasis rate greater than 99%. This work provides a new method for the development of intelligent response hemostatic materials, breaking through the dilemma of traditional hemostatic materials in wound debridement and residual infection.
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DOI
PubMed
高影响因子
DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 4
Dingsheng Wen,Liping Zhang,Peiwen Deng,Huaan Li,Xiaohua Feng,Lu Wen,Gang Chen
Effective drug delivery to the inner ear is severely limited by the restrictive nature of the round window membrane (RWM). In this study, coumarin-6 labeled chitosan nanoparticles were administered via intratympanic injection in guinea pigs to investigate their spatiotemporal transport across the RWM and entry into the inner ear. The nanoparticles exhibited prolonged residence on the RWM and efficient presence in the perilymph in a time- and concentration-dependent manner. Mechanistic analyses demonstrated that nanoparticle transport occurred through coordinated paracellular and transcellular pathways. Transient modulation of tight junctions facilitated paracellular diffusion, while active transcellular transport involved multiple endocytic routes. Following cellular uptake, nanoparticles underwent intracellular trafficking and were released into the perilymph via Golgi-mediated exocytosis. Collectively, these findings reveal an in vivo, RWM-specific transport cascade characterized by coordinated paracellular tight-junction modulation, multiroute endocytic uptake, and Golgi-mediated exocytotic release into the perilymph, providing mechanistic insight into nanoparticle disposition in the inner ear and supporting their potential for local drug delivery. Significance statement This study defines an in vivo, RWM-specific transport cascade governing nanoparticle disposition in the inner ear. It demonstrates coordinated paracellular and transcellular transport enabling nanoparticle entry into the perilymph, advancing mechanistic insight into physiological barrier regulation of inner ear drug delivery and supporting rational design of nanocarrier-based otologic therapies.
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DOI
PubMed
高影响因子
Journal of Industrial Textiles
·
2022
·
IF 2.926
Hongyan Wu,Shuang Yan,Yang Wang,Changhuan Zhang
In order to make full use of the advantages of Chitosan in the process of wound repair and overcome the difficulty that Chitosan can not be electrospinned alone, Chitosan/Polybutylenes succinate nanofiber membrane was prepared by electrospinning, and its properties were tested and analysed. The results show that the content of Chitosan will affect the properties of composite fiber membrane, such as liquid absorption and hemostatic properties. When the content of Chitosan is 90%, the comprehensive performance of Chitosan/Polybutylenes succinate fiber membrane is the best and is most suitable for wound hemostatic dressing.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Nian Xiang,Chuanyang Chen,Yuming Lin,Wang Li,Zuzeng Qin,Yiheng Ruan,Tongming Su,Xuan Luo,Xinling Xie
Stimuli-responsive fertilizers show great potential for precision nutrient delivery but are often limited by single responsiveness and unsynchronized release with plant growth demands. This study developed a novel polysaccharide-based thermo-pH dual stimuli-responsive gating microcapsule (CSMC-g-PNM) via atom transfer radical polymerization (ATRP). N-isopropylacrylamide (NIPAM) and methacrylic acid (MAA) were sequentially grafted into the chitosan microcapsules (CSMC), with thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) acting as a macromolecular initiator for the subsequent grafting of MAA by reactivating dormant chain ends. Independent chain lengths of PNIPAM and PMAA were achieved by controlling grafting time, endowing the microcapsules with reversible and dual-responsive gating properties. The PNIPAM and PMAA chains acted as dual-responsive gating mechanisms, extending below the low critical solution temperature (LCST) (25 °C) or above pKa (pH 8), closing the gates to slow release. Conversely, when the temperature exceeds 40 °C or is below the pKa (pH 3), the chains contract, opening the gates to accelerate release. CSMC-g-PNM demonstrated sustained urea release (cumulative release 80.79% over 168 h), following First-order kinetics and Korsmeyer-Peppas diffusion-erosion mechanisms. Biodegradation studies affirmed the system’s environmental compatibility, showing a controlled weight loss of up to 19.74% after 35 days in soil. Furthermore, pot experiments demonstrated significant agricultural efficacy, with maize seedlings treated with CSMC-g-PNM-6 in acidic soil achieving a plant height of 44.1 cm, significantly outperforming the 33.1 cm observed with unmodified microcapsules. This work provides a robust and sustainable strategy for designing intelligent nutrient delivery systems, advancing the development of solutions for precision agriculture.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Ruirui Guan,Yuhui Su,Shanshan Li,Shuo Yang,Xiaoyun Li,Xiaoying Wang
Standard dressings struggle to conform to irregular wounds, which can easily lead to bacterial infection and impair the healing process. In this study, an injectable, self-healing hydrogel inspired by mussel and oyster adhesion was developed from dihydrocaffeic acid-modified chitosan, oxidized sodium alginate, and Laponite nanosheets. Benefiting from the synergistic reinforcement of dynamic imine bonds and the physical filling of the nanosheets, along with other physical interactions, the hydrogel can be extruded through a syringe and form filaments approximately 0.5 mm in diameter. By enabling slow catechol oxidation while limiting oxygen diffusion in the confined nanospace, Laponite nanoplatelets conferred the hydrogel a wet adhesion strength of 520.2 kPa on porcine skin at 24 h. The hydrogel with Laponite is shown to reduce the survival rates of both S. aureus and E. coli to below 0.35%, indicating effective bactericidal efficacy. In vitro experiments demonstrated that the hydrogel significantly promotes the proliferation, migration, and angiogenesis of HUVECs. Animal experiments confirmed that the hydrogel accelerates epidermal regeneration and collagen deposition, reduces the inflammatory factor TNF-α, and upregulates the expression of angiogenesis-related genes. More importantly, the hydrogel achieved a 96.7% closure rate for S. aureus -infected wounds by day 13.
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PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 3
·102
·
IF 3.5
Li Xiaomeng,Jiang Chenjia,Xie Huiwen,Zhang Hong
The development of flexible hydrogels with robust mechanics, high water content, and reliable conductivity is critical for next-generation wearable bioelectronics. However, conventional poly(vinyl alcohol) (PVA) hydrogels suffer from insufficient mechanical strength and rapid water loss, limiting their practical applications. Here, we present a chitosan-doped, phytic acid–based dual-network hydrogel that combines a PVA backbone with a secondary network of chitosan (CS), hydroxyethyl methacrylate (HEMA), and sulfobetaine methacrylate (SBMA). The resulting hydrogel exhibits relatively high tensile strength (107 kPa) and elongation (415%), together with excellent water retention and antifreeze performance arising from synergistic hydrogen bonding and electrostatic interactions between PA and CS. Importantly, the hydrogel maintains stable ionic conductivity under various deformations and enables accurate and reproducible detection of human electrocardiogram (ECG) signals, comparable to that of commercial electrodes. This work provides a practical strategy to design multifunctional hydrogels for reliable physiological monitoring and flexible wearable electronics.
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高影响因子
危险品化学品经营许可证（带存储）