Crystals
·
2026
·Vol. 16
·期 1
·51
·
IF 2.4
Xi Shi,Shiyuan Zhu,Qiongyu Zhou,Bo Liang,Jun Li,Guangji Li,Longquan Chen,Peijun Xu
Ni-Mo alloy coating has shown exciting potential as a candidate to replace chromium coating. In this paper, Ni-Mo alloy coatings were successfully electrodeposited from a citrate/ammonia bath, and the effect of the bath pH values over a wide range (4–10) on the characteristics and corrosion resistance of Ni-Mo alloy coating was studied in detail. Results show that all the deposited Ni-Mo alloy coatings consist of a crystalline solid-solution Ni(Mo) fcc structure. An increase in bath pH values could facilitate the deposition of Mo, thereby increasing the Mo content and decreasing the crystallite size of Ni-Mo alloy coatings. However, there are subtle gaps between the coarse grains on the surface of the Ni-Mo alloy coating deposited at pH 10. These subtle gaps tend to form between the coarse grains on the surface of the electrodeposited Ni-Mo alloy coating because of the relatively high Mo content, refined grains, and appropriate morphology. The Ni-Mo alloy coating deposited at pH 9 exhibits optimal corrosion resistance, attributed to its lowest corrosion current densityicorr(7.31 × 10−6A cm−2), the strongest polarization resistance (11.13 kΩ·cm−2), and impedance value, which are mainly contributed to by the coating resistance and charge-transfer resistance.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Zhuojun Wu,Wenwen Gong,Xiao Wang,Yuhan Zhang,Wei Zhou,Shixiong Yi,Hong Yang,Guilong Peng
The selective oxidation of methyl phenyl sulfoxide (PMSO) to methyl phenyl sulfone (PMSO 2 ) is widely used to probe high-valent metal-oxo species in advanced oxidation processes (AOPs). However, its specificity remains uncertain. This study systematically investigates PMSO oxidation by sodium hypochlorite (NaClO), sodium periodate (PI), and peroxymonosulfate (PMS) under acidic (pH = 3.0 ± 0.2), neutral (pH = 7.2 ± 0.2), and alkaline (pH = 9.2 ± 0.2) conditions. Batch experiments and kinetic simulations using Kintecus V6.80 revealed that NaClO exhibited the highest reactivity across all pH values, with second-order rate constants of 125, 25, and 2.15 M −1 s −1 under acidic, neutral, and alkaline conditions, respectively. PI was reactive only in acidic media (7.5 M −1 s −1 ), while PMS showed comparable oxidation rates under acidic and alkaline conditions (1.25 and 1.28 M −1 s −1 ), but negligible activity at neutral pH. H 2 18 O labeling confirmed 18 O incorporation into PMSO 2 even without metal catalysts, supporting oxygen atom transfer (OAT) as the dominant mechanism. These results demonstrate that PMSO oxidation and 18 O labeling are not exclusive indicators of high-valent metal species and should therefore be interpreted with caution. The study underscores the need for more selective and reliable approaches to identify transition-metal-based oxidants in AOPs.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Jiaying Chen,Mingxia Pu,Yilin Wang,Wenjie Jiang,Sinuo Zhu,Jingzhi Yan,Chunyu Niu,Ye Tao,Ming Cheng,Shanggui Deng
Protein structural features determine distinct molecular interfacial properties. • Molten globule transitions enhance protein solubility, interfacial adsorption, and stabilisation capacity. • SPF formation is strongly correlated with disulfide bond reconstruction. • Well-organised transitions in protein structure enhance their interfacial properties. • pH changes and aggregates conformational transitions exert inconsistent effects on protein interfacial properties. This study investigated the assembly mechanisms, interfacial properties, and structure-function relationships of soybean protein isolate (SPI) via the synergistic effects of pH regulation and heat treatment. Two molten globular (SPG), three aggregated (SPA), and one fibrous (SPF) SPI conformations were successfully prepared. SPG had reduced random coil content; among them, SPG-12 showed the highest solubility (71.6%) and lowest surface hydrophobicity (5025), thus exhibiting optimal emulsifying and foaming properties. Heat induction and pH cycling enhanced SPI solubility and promoted the formation of nanoparticles smaller than 200 nm, while isoelectric point-induced aggregation inhibited ordered structures (e.g., SPA-2 with particle size over 500 nm). SPF formed through three steps: unfolding, then hydrolysis, and finally aggregation; during this process, disulfide bond content first dropped from 63.4% to 32.2% and then recovered to 64.1%, and SPF had improved foaming capacity but reduced stability. This work provides theoretical support for developing plant-based emulsifiers and foaming agents. Download: Download high-res image (244KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Wenbo Zhang,Xin Guan,To Ngai
Probiotics play an important role in human health, but their final viability in the gut is often limited due to many harsh living conditions. A double emulsion is a suitable choice for live probiotic encapsulation and protection due to its liquid state and compartmentalized microstructure. Herein, we report a pH-responsive water-in-oil-in-water (W 1 /O/W 2 ) double emulsion, prepared via a two-step process, to enhance oral probiotic delivery. In the external aqueous phase, sodium caseinate (NaCas) and sodium alginate (SA) acted as synergistic food-grade stabilizers. NaCas provided interfacial activity, while SA increased continuous phase viscosity and imparted shear-thinning behavior, which facilitated emulsification and suppressed droplet mobility during storage. Additionally, NaCas–SA mixture formed a softer, more dissipative interfacial film than NaCas alone, reducing droplet coalescence. Importantly, the system exhibited dual pH-responsive behavior. Under acidic gastric conditions, it underwent rapid in situ gelation, where strong complexation between SA and NaCas strengthened the hydrogel network and robustly immobilized the double emulsion droplets. Conversely, upon transfer to alkaline intestinal conditions, the network disassembled, causing hydrogel dissolution and progressive droplet disintegration for controlled probiotic release. In vitro simulated digestion confirmed the protective efficiency. Unencapsulated probiotics showed substantial viability loss, and a conventional NaCas-only emulsion offered limited protection. In contrast, the pH-responsive NaCas–SA double emulsion preserved probiotic viability with minimal loss. Therefore, these findings support the potential of this system as a promising pH-responsive platform for efficient gut-targeted probiotic delivery.
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Qiuli Zhang,Xuelian Li,Jiahui Liu,Linxin Yi,Chengxian Yin,Rong Wei,Lei Wu
A pH-responsive MBT/Ce-ZIF-8@TA nanocontainer system was developed to enhance the corrosion resistance of epoxy coatings. Porous Ce-ZIF-8 cores loaded with 2-mercaptobenzothiazole (MBT) were encapsulated by a functional tannic acid (TA) shell. In this system, TA acts as a “gatekeeper,” preventing premature leakage in neutral environments while triggering inhibitor release under corrosive stimuli. Release kinetics reveal a distinctive “on-demand” mechanism: while stable at neutral pH, a rapid burst release (87.84% in 24 h) occurs at pH 3.0, ensuring immediate delivery of inhibitors to passivate defects. The nanocontainers are uniformly dispersed in the epoxy matrix, significantly enhancing long-term corrosion protection. After 60 days of immersion in 3.5 wt % NaCl, the composite coating exhibits an impedance modulus 3 orders of magnitude higher than that of pure epoxy. Notably, scratched coatings demonstrate superior active self-protection, with Rc recovering from 7.76 × 109 Ω·cm2 to 1.58 × 1010 Ω·cm2 within 24 h. This enhanced performance is attributed to the synergistic combination of physical barrier reinforcement and pH-triggered chemical passivation by the released inhibitors.
✓ 已验证
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·806
·
IF 5.3
Qinglong Liu,Dewei Ma,Haoze Cheng,Keke Yang,Bo Hou,Ziwen Heng,Yu Qian,Wei Liu,Siyuan Chen
Oral administration remains the most patient-friendly drug delivery route, yet its efficacy is limited by physiological barriers including gastric degradation and inefficient cellular uptake. pH-responsive nanogels have shown promise for gastrointestinal drug delivery, though their effectiveness is often constrained by poor membrane interaction. Inspired by natural membrane-anchoring mechanisms, a series of comb-like anionic polymers were designed via grafting alkylamines of different chain lengths (C10, C14, C18) at varying densities (10–30%) onto a biodegradable poly(L-lysine isophthalamide) (PLP) backbone. These pH-responsive comb-like polymers self-assembled into nanogels for loading the hydrophobic chemotherapeutic agent camptothecin. The alkyl length and grafting density significantly influenced pH-responsive behavior, membrane disruption, and drug release profiles. The optimal formulation—the nanogel prepared with PLP grafted 30% C14—achieved a high drug-loading capacity, ideal particle size and stability, and offered superior protection in acidic conditions (only 7 ± 5% release at pH 1.2 over 24 h), while enabling rapid intestinal release (78 ± 2% at pH 7.4 within 24 h). The nanogels significantly enhanced cellular uptake, cytoplasmic delivery, and cytotoxicity against colorectal carcinoma cells. This study demonstrates the key role of hydrophobic modification in designing effective oral nanocarriers, providing a promising platform for the treatment of intestinal diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Processes
·
2025
·Vol. 13
·期 10
·3203
·
IF 2.8
Kaster Kamunur,Olesya Tyumentseva,Lyazzat Mussapyrova,Aisulu Batkal,Ardak Karagulanova,Rashid Nadirov
Coal ash represents an abundant secondary resource of rare earth elements (REEs), but their recovery is hindered by low concentrations in leachates and the presence of large amounts of competing matrix elements such as Fe, Al, Ca, and Mg. In this study, a stepwise pH-controlled precipitation approach was applied to real sulfuric acid coal ash leachates for selective recovery of Ce and La. The process combined impurity scrubbing, oxidative precipitation of Ce, and phosphate precipitation of La. Nearly complete recovery was achieved, with >95% of both Ce and La recovered and >99% phase purity. Selectivity analysis further demonstrated strong discrimination of REEs over matrix elements, with Ce showing >400 selectivity over Fe, Al, and Ca, and La showing ~170 over the same ions and ~17 over Ce. These results show the efficiency of the approach under realistic multi-element conditions.
✓ 已验证
产品关联
DOI
高影响因子
Biosensors-Basel
·
2023
·Vol. 13
·期 2
·287
·
IF 5.4
Yangjie Li,Site Luo,Yongqiang Gui,Xin Wang,Ziyuan Tian,Haihu Yu
It is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. Here, we report a novel hydrogel optical fiber fluorescence sensor segmentally functionalized with fluorescein derivative and CdTe QDs/3-APBA, which can continuously monitor pH and glucose simultaneously. In the glucose detection section, the complexation of PBA and glucose will expand the local hydrogel and decrease the fluorescence of the quantum dots. The fluorescence can be transmitted to the detector by the hydrogel optical fiber in real time. As the complexation reaction and the swelling–deswelling of the hydrogel are all reversible, the dynamic change of glucose concentration can be monitored. For pH detection, the fluorescein attached to another segment of the hydrogel exhibits different protolytic forms when pH changes and the fluorescence changes correspondingly. The significance of pH detection is compensation for pH errors in glucose detection because the reaction between PBA and glucose is sensitive to pH. The emission peaks of the two detection units are 517 nm and 594 nm, respectively, so there is no signal interference between them. The sensor can continuously monitor glucose in 0–20 mM and pH in 5.4–7.8. The advantages of this sensor are multi-parameter simultaneous detection, transmission-detection integration, real-time dynamic detection, and good biocompatibility.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Mingxia Wang,Tariq Muhammad,Huiling Gao,Jianzhang Liu,Hao Liang
Persistent bacterial infection caused by biofilms is one of the most serious problems that threatened human health. The development of antibacterial agents remains a challenge to penetrate biofilm and effectively treat the underlying bacterial infection. In the current study, chitosan-based nanogels were developed for encapsulating the Tanshinone IIA (TA) to enhance the antibacterial and anti-biofilm efficacy against Streptococcus mutans ( S. mutans ). The as-prepared nanogels (TA@CS) displayed excellent encapsulation efficiency (91.41 ± 0.11 %), uniform particle sizes (393.97 ± 13.92 nm), and enhanced positive potential (42.27 ± 1.25 mV). After being coated with CS, the stability of TA under light and other harsh environments was greatly improved. In addition, TA@CS displayed pH responsiveness, allowing it to selectively release more TA in acidic conditions. Furthermore, the positively charged TA@CS were equipped to target negatively charged biofilm surfaces and efficiently penetrate through biofilm barriers, making it promising for remarkable anti-biofilm activity. More importantly, when TA was encapsulated into CS nanogels, the antibacterial activity of TA was enhanced at least 4-fold. Meanwhile, TA@CS inhibited 72 % of biofilm formation at 500 μg/mL. The results demonstrated that the nanogels constituted CS and TA had antibacterial/anti-biofilm properties with synergistic enhanced effects, which will benefit pharmaceutical, food, and other fields.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Donghui Kou,Tan Shi,Lei Li,Shufen Zhang,Wei Ma
Water is closely linked with our life and pH monitoring is of great significance to biochemistry, environment and industry. Herein, utilizing a controllable post-hydrolysis modification strategy, multilayered photonic crystal based pH sensors consist of mesoporous TiO 2 and partially hydrolyzed poly(acrylamide- N,N’ -methylene bis(acrylamide)) (P(AM-MBA)) layers are proposed. Varying pH from 4.0 to 8.5, the portable sensor transforms its color from violet to red with a linearly increased wavelength of 199 nm as the stopband generates ∼7 nm shift per 0.1 pH unit. The sensor exhibits repeatable response to pH change with a short sensing time of 0.8 s. Through goal-directed molecular regulations by the post-hydrolysis strategy, innovative dot-matrix sensor arrays with multiple sensing elements are created and present distinct color difference maps under diverse pH circumstances. And color based radar maps and PCA analysis greatly promote the detection accuracy and reliability. The dot-matrix sensors provide convenience for color-blind crowd and are applicable for use in human perspirations, suggesting promising potential in clinical applications. Furthermore, quartz crystal microbalance studies reveal the effect of the molecular regulation involving functional group and segment structure modifications on the sensing performance of the polymer based photonic materials, showcasing high reference values for future polymer-related researches.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Wei Gan,Xiangbo Kong,Jiaxing Fang,Xia Shi,Sufang Zhang,Yongxia Li,Liangjian Qu,Fu Liu,Zhen Zhang,Fengbi Zhang,Xingyao Zhang
The pine wood nematode Bursaphelenchus xylophilus is the causal agent of pine wilt disease, whose devastating epidemic has caused severe damage to pine trees. We developed a pH-responsive fluorescent nanopesticide for selective delivery and visualization in pine wood nematode control using thiamethoxam (THI), mesoporous silica nanoparticles (MSNs), and polyamidoamine (PAMAM) dendrimers. THI was encapsulated in MSNs and PAMAM dendrimers to form a THI@PAMAM@MSN nanopesticide with a THI loading rate of 21.8%. The THI released from THI@PAMAM@MSN was acid-sensitive owing to the strong protonation ability of PAMAM, with a cumulative 14-day release of 53.37% and 45.07% under acidic conditions at pH 4.5 and 5.5, respectively, which was greatly enhanced through the synthesis and accumulation of benzoic acid in nematode-infested pines. Owing to the fluorescence properties of THI@PAMAM@MSNs, we could visually demonstrate the transport of THI in pines and its effect on nematodes and vector insects. THI@PAMAM@MSNs exhibited excellent formulation stability, good wettability, and adhesion. In addition, compared with the commercially available preparation of THI@WG, THI@PAMAM@MSNs exhibited a higher transport capacity and control effect on pine wood nematodes (LC 50 = 1.15 μg/mL). The control efficacy of THI@PAMAM@MSNs on pine wood nematodes in the field was 95.50%, 81.22%, and 57.87% at tree heights of 7, 6, and 5 m, respectively, and was significantly higher than that of THI@WG. The design of pH-sensitive nanocarriers increases the release of THI in infested pines, and fluorescence intensity facilitates the characterization of nanoparticles. Therefore, THI@PAMAM@MSNs can be used as a nanoformulation for controlling pine wood nematodes.
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Chen Cheng,Zongcai Tu,Hui Wang
The aim of this study was to investigate the phase behavior and structural properties of fish gelatin complex coacervation with carboxylated chitosan as a function of pH by varying the amount of carboxylated chitosan added (0–0.25%, w/v) while keeping the fish gelatin concentration constant at 0.667% (w/v). Zeta potential indicated that electrostatic interaction drove the complex coalescence of fish gelatin and carboxylated chitosan to form soluble or insoluble complexes. The turbidity of the fish gelatin-carboxylated chitosan complex system was greatest at a carboxylated chitosan concentration of 0.2%. UV and fluorescence spectroscopy indicated that the carboxylated chitosan changed the tertiary conformation of fish gelatin. Circular dichroism showed that complexation of fish gelatin with carboxylated chitosan resulted in a shift from the α-helix to the β-sheet structure of fish gelatin. In particular, at pH 5, the fish gelatin complexed with carboxylated chitosan had a disordered structure. X-ray diffraction and scanning electron microscopy of the composite coacervates both investigated that electrostatic interaction between the two replaced molecular interaction within the carboxylated chitosan to form a new lamellar porous structure. These findings may in future enable the use of fish gelatin-carboxylated chitosan complex systems in the design of new food matrices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）