INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Bingren Tian,Xia Qiao,Songlin Guo,Aiqin Li,Yanan Xu,Jia Cao,Xu Zhang,Duan Ma
The development of nanoparticles loaded with natural active ingredients is one of the hot trends in the pharmaceutical industry. Herein, chitosan was selected as the base material, and sodium tripolyphosphate was chosen as the cross-linking agent. Chitosan nanoparticles loaded with β-acids from hops were prepared by the ionic cross-linking method. The results of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that chitosan nanoparticles successfully encapsulated β-acids. The loading capacity of chitosan nanoparticles with β-acids was 2.00 %–18.26 %, and the encapsulation efficiency was 0.58 %–55.94 %. Scanning electron microscopy (SEM), transmission electron microscope (TEM), particle size, and zeta potential results displayed that the nanoparticles revealed a sphere-like distribution with a particle size range of 241–261 nm, and the potential exhibited positive potential (+14.47–+16.27 mV). The chitosan nanoparticles could slowly release β-acids from different simulated release media. Notably, the β-acids-loaded nanoparticles significantly inhibited Staphylococcus aureus ATCC25923 ( S. aureus ) and Escherichia coli ATCC25922 ( E. coli ). Besides, β-acids-loaded chitosan nanoparticles were cytotoxic to colorectal cancer cells (HT-29 and HCT-116). Therefore, applying chitosan nanoparticles can further expand the application of β-acids in biomedical fields.
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高影响因子
GREEN CHEMISTRY
·
2023
·Vol. 25
·期 23
·10091-10100
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IF 9.8
Mo Zhang,Zheng Li,Yeqin Feng,Xing Xin,Guo-Yu Yang,Hongjin Lv
Selective hydrogenolysis of abundant C–O bonds of β-O-4 linkages in natural lignin or lignin models has been considered as a key strategy for the generation of value-added organic chemicals. Herein, we report a mild, efficient, and selective photocatalytic strategy for hydrogenolytic cleavage of lignin β-O-4 models by using Ni-containing polyoxometalate (POM) catalysts and CdS quantum dots. Upon blue LED light irradiation, the present photocatalytic system can effectively transform various lignin β-O-4 models to the corresponding hydrogenolysis products (phenols and ketones) with >95% conversion and >93% product selectivity. A tentative photocatalytic mechanism is proposed based on various experimental and spectroscopic analyses. The facile strategy presented in our work could be extended to the photocatalytic preparation of various value-added chemicals from natural biomass or other biomass derivatives in the near future.
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ChemistrySelect
·
2023
·Vol. 8
·期 45
·e202303041
·
IF 2.1
Li-li Wang,Cheng-yuan Tian,Li-na Feng,Xiao-he He,Zhi-cheng Zhao
Graphical Hydroxyapatite/tricalcium phosphate composite is an effective drug carrier with good biocompatibility and degradation performance. The ordered porous composites have great potential in quantitative drug delivery. Hydroxyapatite(HA) has received more and more attention as a drug carrier due to its excellent biocompatibility and bioactivity. However, the poor biodegradability of HA, low drug loading and uncontrollable release rate limits its application. In this paper, in order to study the effect of different HA and tricalcium phosphate (β-TCP) phase contents on the drug release performance of the composite, co precipitation template method was used to prepare the composite with different Ca/P ratios (1.5~1.63) using polystyrene colloids as templates, and the Ca/P ratio which had the greatest effect on its morphology was selected. With the ibuprofen (IBU) as the drug model, the results showed that the IBU-loading performance of the composite was significantly better than that of the ordered-porous pure phase HA. When the Ca/P ratio was 1.5, the composite had the highest adsorption capacity for IBU, reaching 94.5 mg/g. In vitro release tests revealed that IBU release rates from composites with different Ca/P ratios were slower than those from pure-phase HA in the initial 10 h, and reached the release equilibrium after the subsequent 30 h. Then, when the Ca/P ratio was 1.5, the composite had a cumulative release rate of 86.35 % for IBU. The loading and slow release properties of this ordered porous HA/β-TCP composite for IBU make it a potential candidate for controlled release of IBU in the future.”
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JOURNAL OF FOOD SCIENCE
·
2023
·
IF 3.9
Huimin Bi,Jianqiu Yang,Houwei Jiang,Fangyu Fan
Rosa roxburghii Tratt seed oil (RSO) and β-carotene (βC) were chosen to prepare proliposomes by the thin-film dispersion method. The characteristics of unloaded proliposome, RSO proliposome (L-R), βC proliposome (L-β), and RSO/βC proliposome (L-R-β) were analyzed, and their antioxidant activity, storage stability, and release properties were investigated. The proliposomes had an encapsulation efficiency (RSO, βC) higher than 83.10%, nanometer size, smooth surface, and irregular structure. L-R-β showed better dispersibility, stability, and antioxidant activity than L-R and L-β. Simultaneous encapsulation of RSO and βC reduced the phospholipid oxidation of proliposomes and improved the retention rate of RSO in storage environments of 4, 25, and 40°C. Moreover, the RSO and βC release kinetics of proliposomes in the simulated saliva fluid and gastric fluid phases can be described by the first-order model, and the Korsmeyr–Peppas method was applied to describe their release mechanism in the simulated intestinal fluid phase.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Kai Huang,Shurong Zhang,Xiao Guan,Cheng Li,Sen Li,Yongyong Liu,Jialong Shi
This study aimed to produce novel plant-based milk from quinoa with the addition of oat β-glucan (OGB). The stability of quinoa milk was characterized by zeta potential, particle size, separation index (SI), rheological property, backscattered light intensity (ΔBS), and microstructure. Results showed that OGB addition efficiently prevented the phase separation of quinoa milk, and the highest SI and zeta potential values were obtained at the optimal pH 6.0. Quinoa milk presented a higher apparent viscosity and a narrower particle distribution with the increased OGB concentration, however, it did not affect the zeta potential. Moreover, OGB improved the storage stability with an increased SI and a ΔBS. Microstructure analysis suggested that OGB could prevent phase separation by constructing a network structure, and an increased amount of OGB led to forming a gel-like structure. An excessive viscosity would decrease the sensory acceptance, therefore the final OGB concentration of 16% was selected.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-10
·
IF 5.833
Zhou Xi,Wang Shuangling,Zhang Cong,Lin Yulong,Lv Jie,Hu Shuyang,Zhang Shanshan,Li Meng
A sensitive and rapid colorimetric biosensor has been developed for determination of amyloid-β peptide (Aβ) and study of amyloidogenesis based on the high peroxidase-like activity of porous bimetallic ZnO-Co 3 O 4 nanocages (NCs). Due to the high binding ability of Aβ monomer to ZnO-Co 3 O 4 NCs, the catalytic activity of ZnO-Co 3 O 4 NCs can be significantly suppressed by Aβ monomer. This finding forms the basis for a colorimetric assay for Aβ monomer detection. The detection limit for Aβ monomer is 3.5 nM with a linear range of 5 to 150 nM ( R 2 = 0.997). The system was successfully applied to the determination of Aβ monomer in rat cerebrospinal fluid. Critically, the different inhibition effects of monomeric and aggregated Aβ species on the catalytic activity of ZnO-Co 3 O 4 NCs enabled the sensor to be used for tracking the dynamic progress of Aβ aggregation and screening Aβ inhibitors. Compared with the commonly used thioflavin T fluorescence assay, this method provided higher sensitivity to the formation of Aβ oligomer at the very early assembly stage. Our assay shows potential application in early diagnosis and therapy of Alzheimer's disease (AD).
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Shifeng Xiao,Yafei Lu,Qiuping Wu,Jiaying Yang,Jierui Chen,Suyue Zhong,David Eliezer,Qiulong Tan,Chengchen Wu
Alzheimer's disease is a neurodegenerative disease which severely impacts the health of the elderly. Current treatments are only able to alleviate symptoms, but not prevent or cure the disease. The neurofibrillary tangles formed by tau protein aggregation are one of the defining characteristics of Alzheimer's disease, so tau protein has become a key target for the drug design. In this study, we show that fisetin, a plant-derived polyphenol compound, can inhibit aggregation of the tau fragment, K18, and can disaggregate tau K18 filaments in vitro . Meanwhile it is able to prevent the formation of tau aggregates in cells. Both experimental and computational studies indicate that fisetin could directly interact with tau K18 protein. The binding is mainly created by hydrogen bond and van der Waal force, prevents the formation of β-strands at the two hexapeptide motifs, and does not perturb the secondary structure or the tubulin binding ability of tau protein. In summary, fisetin might be a candidate for further development as a potential preventive or therapeutic drug for Alzheimer's disease.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Liupeng Yang,Amir E. Kaziem,Yigang Lin,Chao Li,Yuting Tan,Suqing Huang,Dongmei Cheng,HanHong Xu,Zhixiang Zhang
In this study, a pesticide controlled release system with dual response characteristics of pH and enzyme triggering was developed. Indoxacarb (IDC) was loaded into hollow mesoporous silica (HMS) nanoparticles , carboxylated β-cyclodextrin (β-CD) acted as a capping molecule to couple with the amino-functionalized HMS, and their well-defined morphological structures were confirmed by scanning electron microscopy and transmission electron microscopy . The results showed that the prepared IDC loaded HMS-CD had high loading efficiency (26.42%, w/w) and showed excellent dual response properties to pH and the α-amylase enzyme. IDC loaded HMS-CD nanoparticles showed better insecticidal activity against Spodoptera frugiperda than applying the same dose of IDC emulsifiable concentrate, and the toxicity of IDC loaded HMS-CD to zebrafish was reduced by more than 5-fold, indicating that insecticide delivery systems based on β-CD-anchored HMS nanoparticles could potentially be applied for sustainable control of pests and reduce harm to non-target organisms and the environment.
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Sa Liu,Lina Mo,Gangyuan Bi,Shenggui Chen,Diwei Yan,Junzhong Yang,Yong-Guang Jia,Li Ren
Digital light processing (DLP) 3D printing has been utilized to fabricate controlled porous β-tricalcium phosphate (β-TCP) scaffolds, which promote cell adhesion and angiogenesis during bone regeneration. However, the current limitation of DLP 3D printing for the fabrication of β-TCP scaffold is how to prepare a low viscosity ceramic slurry and remove the toxicity of residual non-polymerized slurry. The present study has developed a low viscosity ceramic slurry system by mixing β-TCP with photosensitive acrylate resin, and the viscosity of slurry is about 3 Pa s and the solid content of β-TCP can be as high as 60 wt%. After optimizing the ratio of slurry, printing, degreasing and sintering processes, the maximum compressive strength of the DLP printed scaffolds reaches up to 9.89 MPa, while the porosity keeps ca. 40%. According to the proliferation of cells, it confirms the preserved biocompatibility of DLP-fabricated β-TCP scaffolds. These porous scaffolds made by DLP 3D printing technology is of great significance for bone regeneration, and will also help to expand the application of DLP technology in biomedical field.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Xiujing Yin,Song Liu,Yukun Qin,Ronge Xing,Kecheng Li,Chunlin Yu,Xiaolin Chen,Pengcheng Li
Chitooligosaccharide grafted with β-aminobutyric acid based on the idea of bioactive molecular splicing was prepared, and the differences in drought resistance activity before and after grafting were compared. The mechanism was investigated by comparing the differences of the derivative with the Control and Drought about metabolomes . The results showed that the expected derivative was successfully synthesized, named COS-BABA, and had better drought resistance-inducing activity than the raw materials. We suggest that COS-BABA induced drought resistance through second messenger-induced activation of signaling pathways related to traumatic acid and indol-3-lactic acid, which enhanced nucleic acid metabolism to accumulate nucleotides and decreased some amino acids to facilitate protein synthesis . These proteins are regulated to strengthen photosynthesis , resulting in the promotion of carbohydrate metabolism. The accumulation of unsaturated fatty acids stabilized the cell membrane structure and prevented nonstomatal water dissipation. This study provides ideas for the development of more effective drought resistance inducers.
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Nanoscale
·
2021
·Vol. 13
·期 22
·9989-10001
·
IF 7.79
Jitang Chen,Si Li,Xin Liu,Sha Liu,Chen Xiao,Zhijie Zhang,Shiyou Li,Zifu Li,Xiangliang Yang
Photodynamic therapy (PDT) is frequently used in cancer treatment in clinical settings. However, its applications in stroma-rich solid tumors, e.g., triple negative breast cancer, are limited by abnormal mechanical microenvironments. Solid stress accumulated in stroma-rich solid tumors compresses tumor blood vessels, hampers the delivery of photosensitizers (PSs) in tumor tissues, and poses a major challenge for potent PDT. Here, we report a novel combination strategy to augment PDT based cancer therapy by combining hydroxyethyl starch–chlorin e6 conjugate self-assembled nanoparticles (HES–Ce6 NPs) with the transforming growth factor-β (TGFβ) inhibitor LY2157299 (LY). HES–Ce6 conjugates, as synthesized by one step esterification reaction, could self-assemble into uniform HES–Ce6 NPs, which exhibited enhanced photostability and generated more reactive oxygen species (ROS) under 660 nm laser irradiation than free Ce6. Prior to PDT, intragastric administration of LY decreased collagen deposition, alleviated solid stress, and decompressed tumor blood vessels. As a result, the reconstructed tumor mechanical microenvironment promoted accumulation and penetration of HES–Ce6 NPs into tumor tissues, contributing to augmented antitumor efficacy of HES–Ce6 NP mediated PDT. Modulating tumor mechanical microenvironments using TGFβ blockade to enhance the delivery of PSs in tumors with excessive extracellular matrix represents an efficient strategy for treating stroma-rich solid tumors.
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JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Xiaoping Wang,Hui Li,Kaijun Quan,Liang Zhao,Zuguang Li,Hongdeng Qiu
β -Cyclodextrin can be functionalized by derivation of reactive hydroxyl on the ring due to its special chiral environment and structural characteristics, which can be used to identify or separate a variety of chiral substance. In this manuscript, a series of excellent chiral stationary phases for high-performance liquid chromatography were developed for enantioseparation by using anhydride modified β -cyclodextrin bearing chiral ( R / S )˗ α ˗phenethylamine or ( S )-(+)-2-amino-1-propanol. They were characterized by elemental analysis, Fourier transform infrared spectra (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and BET. These chiral stationary phases presented good resolution and repeatability, about 17 kinds of enantiomers were effectively separated. And most of enantiomers were separated better than those reported in the literature in the same both normal and reversed phase modes. The RSD values of R s for repeatability and column-to-column were below 0.44% and 2.83%, respectively. All results revealed that these new CSPs show great prospect for chiral separation in actual applications.
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