CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Duo Zhang,Ying-Nan Dou,Rui Gao,Xian-Fa Zhang,Hui Zhao,Xiao-Li Cheng,Shan Gao,Ying-Ming Xu,Li-Hua Huo
Rapid, highly sensitive detection of mustard gas is a critical requirement in public safety and national defense. However, achieving highly sensitive, ppb-level detection of mustard gas under low-power conditions remains a significant challenge. Focusing on the typical blister agent simulant 2-chloroethyl ethyl sulfide (2-CEES), a solvothermal method was employed combined with controlled thermal treatment to fabricate an ultrathin porous NiFe 2 O 4 /NiO nanosheets heterostructure sensor derived from an Fe-Ni-MOF in-situ grown on a ceramic tube in this study. This material possesses uniformly distributed intimate heterogeneous interface, a high specific surface area (95.8 m 2 ·g −1 ), and abundant surface active sites, thereby significantly enhancing its adsorption and catalytic oxidation capability toward 2-CEES. At a low operating temperature of 130 °C, the sensor demonstrates a high response of 41.5 toward 10 ppm 2-CEES, a rapid recovery capability of only 84 s, and a low detection limit of 20 ppb, along with excellent selectivity, humidity resistance, reproducibility, and long-term stability. Through systematic characterization including XPS, in-situ DRIFTS, TPD, and DFT calculations, the multi-step catalytic oxidation pathway of 2-CEES on the composite surface is elucidated, along with the mechanism by which the heterostructure enhances gas-sensing performance via band structure modulation, interfacial charge transfer, and the built-in electric field. This study offers both new materials and novel insights for the development of low-power, highly sensitive sensors for trace detection of chemical warfare agents.
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Materials Today Bio
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2026
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IF 11
Shi Zhong,Lulu Qi,Jinxi Huo,Yunqing Sun,Jiayi Feng,Yuanxiang Jin,Hangjun Chen,Qinglian Hu,Yougui Li
Effective oral delivery of natural products is essential for sustained therapeutic effects for type 2 diabetes mellitus (T2DM) therapy. However, compromised bioavailability leads to undesirable effect and hypoglycemia. Herein, biomimetic nanoplatform based on mesoporous polydopamine (MPDA) and inulin gel were designed to enhance the oral delivery of 1-Deoxynojirimycin (DNJ). DNJ was adsorbed via mesopores and hydrogen bonding by MPDA and encapsulated within the inulin hydrogel. The MPDA@Inulin gel exhibited sustained-release properties that allowed DNJ to be released persistently in the small intestine, thereby enhancing its oral bioavailability. Moreover, the capacity of DNJ@MPDA@Inulin gel in controlling the blood glucose levels was evaluated in a high-fat diet induced T2DM model. Notably, after 4 weeks of daily oral administration, DNJ@MPDA@Inulin demonstrated enhanced efficacy in controlling blood glucose levels in T2DM model mice, improving insulin sensitivity. More important, this hydrogel nano-sustained release platform based DNJ delivery system could ameliorate glucolipid metabolism, enhance intestinal mucosal barrier and reshape gut microbial composition. Thus, it is anticipated that inulin-MPDA based oral delivery system have a potential for natural products delivery to improve bioavailability and alleviate T2DM.
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
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2026
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IF 3.1
Xiuling Wang,Shengnan Wang,Xia Xiao,Zihui Jin,Zhenwei Jiang,Biyu Wu,Pan Deng,Wenjin Xiao
Vitamin D deficiency (VDD) is common in type 2 diabetes mellitus (T2DM) and has been linked to dyslipidemia, but the specific lipids associated with low vitamin D status are not well defined. To address this, we sought to characterize lipidomic alterations associated with VDD in T2DM and describe the changes following vitamin D₂ (VD2) supplementation. Specifically, untargeted serum lipidomics with anthropometric and clinical measurements were performed in 219 adults with T2DM, classified as VDD (25(OH)D < 20 ng/mL; n = 138) or non-VDD (25(OH)D ≥ 20 ng/mL; n = 81). A subset of VDD participants (n = 20) completed a 3-month VD2 supplementation trial. Lipids were profiled by UHPLC-HRMS and analyzed in relation to metabolic and anthropometric measures. Our analysis identified 112 lipid species differentially expressed in VDD, characterized by reduced ether-linked phosphatidylcholines (EtherPCs) and elevated ceramide 16:0. EtherPCs showed negative correlation with HbA1c, BMI, as well as body fat, and positive associations with muscle mass and bone mineral content, whereas ceramides inversely associated with these metabolic indices. Following 3-month VD2 supplementation, increases in circulating 25(OH)D and reductions in HbA1c were observed, accompanied by changes on the targeted lipidome, including elevated EtherPCs and reduced ceramide profiles (Cer 20:0, Cer 22:0, Cer 16:0/24:0). In conclusion, VDD in T2DM is associated with a distinct lipidomic profile marked by EtherPCs depletion and ceramide accumulation. The observed lipidomic changes following VD2 supplementation suggest the presence of a VD2-responsive lipid signature, which may have potential implications for metabolic risk management in T2DM.
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JOURNAL OF INORGANIC BIOCHEMISTRY
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2026
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IF 3.1
Yu-Qing Jia,Di-Yu Yang,Xiao-Ying Wu,Zhaoguo Hong,Hai-Ye Li,Yun-Liang Zhang,Hong Liang,Fu-Ping Huang
Chemodynamic therapy (CDT) generates cytotoxic hydroxyl radicals (•OH) in tumors via Fenton/Fenton-like reactions using elevated H₂O₂ and acidity. However, its clinical potential is limited by poor tumor selectivity and the difficulty in balancing catalytic metal ion doses with toxicity. In this work, using HPBio (2-Pyridinecarboxaldehyde biotin bis-hydrazide) as the ligand, a biotinylated tri-nuclear copper(II) complex of POBio-Cu 3 has been in-situ synthesized. The solution assemble behavior and in-situ oxidation process has been investigated by time-dependent ESI-MS technology. In the atomically precise POBio-Cu 3 , biotin moiety was acting as a cancer-targeting unit and multi-nuclear Cu(II) core as a GSH depletor for augmented CDT effect. POBio-Cu 3 could preferentially accumulate in cancerous Hep-G2 cells, due to the cell discrepancy toward normal WI38 cells. The Cu(II) centers in POBio-Cu 3 were available for consuming glutathione (GSH) and amplifying oxidative stress. Furthermore, the results of in vivo experiments showed that POBio-Cu 3 could remarkably inhibit tumor growth without significant damage to major organs.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Peixuan Li,Zhaojie Liu,Jia Yan,Haihua Huo,Yanchen Liu,Siqun Wan,Lu Guan,Feiyang Chen,Qingmei Chen,Jikai Wen,Yiqun Deng,Peiqiang Mu
T-2 toxin, a type A trichothecene mycotoxin, induces severe cytotoxicity primarily through mitochondrial dysfunction and apoptosis. In this study, the protective role of astragaloside IV (AS-IV) against T-2 toxin-induced damage was investigated using the human hepatoma cell line HepG2 as an in vitro model. Our results demonstrated that T-2 toxin significantly reduced cell viability, promoted reactive oxygen species (ROS) accumulation, and impaired mitochondrial function, as evidenced by disrupted respiratory activity, loss of mitochondrial membrane potential, and reduced ATP production. These alterations were accompanied by dysregulated mitochondrial homeostasis, characterized by enhanced mitochondrial biogenesis and excessive mitochondrial fission, along with activation of the mitochondrial apoptotic pathway. Pretreatment with AS-IV mitigated ROS accumulation, rescued impaired mitochondrial respiratory function, stabilized mitochondrial membrane potential, maintained cellular ATP level, and restored mitochondrial homeostasis. Furthermore, AS-IV suppressed T-2 toxin-triggered apoptosis by modulating the BAX/BCL-2 ratio, inhibiting cytochrome c release, and attenuating caspase activation. Together, these findings indicate that AS-IV protects HepG2 cells from T-2 toxin-induced cytotoxicity by maintaining mitochondrial homeostasis and suppressing the intrinsic apoptotic pathway, providing mechanistic evidence for its protective effect.
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DOI
PubMed
高影响因子
Waste and Biomass Valorization
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2026
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IF 3.1
Zhao Kunzhen,Zhang Zhuoma,Hang Xina,Yi LinLin,Li Kaiyuan,Zou Yanyan
Polyether ether ketone (PEEK) is a high-performance thermoplastic with considerable potential for H 2 and syngas productions via pyrolysis. However, its conventional non-catalytic pyrolysis suffers from high energy consumption and low H 2 and syngas yields. This study investigates the catalytic pyrolysis of PEEK using nickel hydroxide (Ni(OH) 2 ) to enhance the gas production efficiency. PEEK mixed with Ni(OH) 2 at different molar ratios (1:0–1:2) was pyrolyzed up to 1073 K under a nitrogen atmosphere. The H 2 yield increased with catalyst loading and reached a maximum of 25.9 mg/g at a PEEK: Ni(OH) 2 ratio of 1:0.5 (13.85 wt%), corresponding to a 264.3% increase compared with non-catalytic pyrolysis. The syngas yield also reached a maximum of 0.75 g/g under the same condition. Thermogravimetric analysis showed that the addition of Ni(OH) 2 significantly lowered the onset decomposition temperature of PEEK from 832 K to 532 K, and transformed its two-stage pyrolysis into a four-stage process with a 10.4% reduction in char residue. In-situ X-ray diffraction revealed that Ni(OH) 2 was progressively transformed into NiO and Ni during heating, indicating the formation of catalytically relevant Ni-containing phases within the pyrolysis temperature range. Scanning electron microscopy showed that the catalyst was distributed within the carbon matrix and altered the morphology of the pyrolysis residue. These observations provide qualitative evidence of morphological changes after catalytic pyrolysis. These findings demonstrate that the catalytic potential of Ni(OH) 2 in facilitating H 2 -rich syngas production from PEEK.
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Nanoscale
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2026
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IF 5.2
Mengrou Wang,Lei Mao,Wenbo Jia,Xinbo Fu,Xin Wang,Jing Chen,Zhuoya Zhu,Zhiwei Zhao,Jun Wu,Damian Onwudiwe,Byung Seong Bae,Mehmet ERTUĞRUL,Muhammad Zaman Ashraf,Jianming Zhou,Qing Li,Wei Lei
Carbon dioxide (CO2 ) emissions have become a key environmental issue of widespread concern at present. Currently, the use of metal oxide based chem-resistive gas sensors are restricted due to their high operating temperature and short lifetime. Therefore, the development of efficient and rapid gas sensors are of great significance in modern research. Lead free double perovskite, Cs2AgBiBr6 (CABB), could be activated by ultraviolet light and generate a large number of free carriers, which have the potential to increase charge density and enhance the gas sensitivity. Photoinduced carriers provide sufficient reactants, which contributes to the activation between target gases and sensitive semiconductors. Heterojunction of ZIF-67/CABB combines gas adsorption by ZIF-67 and photo-activated gas sensitive response by CABB in one device, which response could reach up to -95.55% when illuminated with the light of 365 nm wavelength and 17.34 mW cm -2 incident power density. Average response/recovery time of ZIF-67/CABB heterojunction could reach to 39.07s and 5.04s under UV illumination. The adequate response/recovery time of this fabricated device is 38.89s and 3.17s, with maximum response when at the voltage bias of 5V, which attains the advanced level comparable with commercially available CO2 detectors. The heterojunction system decreases the dark current density from 3.89 A m -2 to 0.78 A m -2 , and also decrease the light current density from 18.48 A m -2 to 5.33 A m -2 compared with pristine CABB at 5 V bias through current-voltage characteristic curves, which promotes the response and stability of the device. The linear dynamic range of the heterojunction gas sensor is 1700ppm-14000ppm, with sensitivity of 0.0013%/ppm. After more than 35 mins continuous stably work, the current density still remains consistent. This efficient, wide working voltage range and stable device presents the future of high-performance photo induced gas detector applications.
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PubMed
高影响因子
BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Jiarong Qiu,Yusen Wang,Menglei Zhu,Liangqing Zhang,Jianfeng Chen
Di(2-ethylhexyl) phthalate (DEHP) is a widespread plasticizer and environmental contaminant. In this study, a highly efficient DEHP-degrading consortium, LCF, was enriched using DEHP as the sole carbon source. LCF achieved >92% DEHP removal within 48 h over a wide concentration range of 50–2000 mg/L, and the degradation followed first-order kinetics with half-lives of 7.63 –12.70 h. LCF maintained high activity under diverse environmental conditions (25–40°C, pH 7–10) and degraded multiple phthalate esters and key intermediates. Further, the corn straw biochar-immobilized microbial agent CSC-LCF improved DEHP removal in simulated wastewater by 33% over the free consortium, likely through coupled adsorption, sustained release, and biodegradation. Community analysis showed that LCF was dominated by Gordonia , Variovorax , and Rhodococcus . Combined with functional prediction and intermediate degradation results, a putative degradation pathway involving ester hydrolysis, aromatic intermediate transformation, and ring-cleavage metabolism was proposed. This study provides a valuable microbial resource and application reference for the bioremediation of phthalate-contaminated environments.
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PubMed
高影响因子
iScience
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2026
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IF 4.5
Na Wang,Huirui Zhu,Dongkun Li,Xuena Wang,Ziyan Zhang,Bao Chai,Meining Li,Tao Gong
Hard-healing or non-healing diabetic wounds feature complex pathogenesis, posing significant challenges to clinical treatment. Platelet-rich plasma (PRP) is rich in various growth factors and possesses significant therapeutic potential, while its clinical application is largely limited by the rapid release of these bioactive factors. In this study, a multifunctional hydrogel dressing (GACP@PRP) based on PRP was fabricated for the promotion of type 2 diabetes wound healing via the physical cross-linking of graphene oxide-silver nanoparticles (GO-Ag NPs),chitosan (CS), and poly(N-isopropylacrylamide) (PNIPAM). The wound dressing possesses injectability, self-healing, favorable porosity, water absorption, moisture retention, adhesiveness, antibacterial and hemostatic functionalities. Moreover, the GACP@PRP hydrogel protects PRP to sustain growth factors release, promote cell proliferation and migration, which significantly accelerated wound healing rate in SD rats full-thickness skin defect model. Together with its great biocompatibility and biosafety, GACP@PRP meets the multiple functional requirements of diabetic wound dressing and is promising for clinical diabetic wounds management.
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PubMed
高影响因子
Journal of Materials Chemistry A
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2026
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IF 9.2
Kaibin Xia,Yuhui Du,Junhui Liang,Zhen Shen,Xiaoqi Fei,Jiahui Hou,Chen Hangning,Du Chenhao,Liuqi Wang,Da Chen
Ammonia-hydrogen energy conversion is perceived as one of the effective methods to solve the storage and transportation problems of hydrogen energy. In recent years, the plasma-assisted strategy has shown great potential in the field of low-temperature ammonia decomposition. However, its enhancement mechanism for reaction kinetics has rarely been studied. Herein, by comparing the morphology and structural changes of catalysts with and without plasma field assistance before and after the reaction, we investigate the influence mechanism of the plasma field on the kinetics of the ammonia decomposition reaction (ADR). We found that the bombardment effect of high-energy particles in the plasma field can not only excite the reactant NH 3 to the activated NH x radical, but also effectively inhibit the agglomeration of active metal Ru in the catalyst, induce the generation of oxygen vacancies and N-containing carriers on the surface of CeO 2 , and thus change the dissociation path of N ≡ N. Ultimately, under the synergistic effect of the plasma and the catalyst, the low-temperature activity of the catalyst is significantly improved. At 350 ℃, the ammonia conversion rate of the plasma-assisted catalyst (Ru/CeO 2 -PEA) reaches 71%, which is much higher than 35% of the thermocatalytic sample without plasma field assistance, and the equilibrium state of ammonia decomposition can be reached at 450 ℃. This work sets out to elucidate the mechanistic details of plasma-assisted ammonia decomposition by establishing an improved theoretical model.
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INORGANICA CHIMICA ACTA
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2026
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IF 3.3
Xiao-Shuo Wu,Yi Chen,Yan-Fen Peng,Shu-Fen Gong,Shan-Qing Li
A new phosphorescent coordination polymer [Pb(2-ClNA) 2 ] n ( 1 ) (2-ClNA = 2-chloronicotinate) was synthesized by the solvent method and characterized using microanalysis, IR spectrum, and thermogravimetric analysis. Single crystal structure analysis reveals that 1 crystallizes in the orthorhombic space group P 2 1 2 1 2 1 . In the structure of 1 , the Pb 2+ ion is seven-coordinated with a holodirected coordination geometry. Two kinds of inequivalent 2-chloronicotinate ligands link Pb 2+ ions to form a three-dimensional (3-D) network framework in μ 3 -κ 2 O1, O2: κ 1 O1: κ 1 O2 and μ 3 -κ 1 O3: κ 1 O4: κ 1 N2 modes, respectively. The 2-chloronicotinate ligands are evenly distributed around the Pb 2+ ions, and π⋯π stacking occurs only in two directions. At ambient conditions, 1 emits bright cyan phosphorescence with a lifetime of 2.76 ms and an absolute quantum yield as high as 16.25% under ultraviolet irradiation. Photophysical analysis reveals that the luminescence of 1 arises from the n → π* transition of the 2-chloronicotinate ligand. The density functional theory (DFT) calculations clarify the luminescence process, confirming that the phosphorescence of 1 is attributed to ligand-centered emission and that the 6s states of the Pb 2+ ions play a significant role in it.
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Frontiers in Communications and Networks
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2026
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IF 2.7
S. Dhanasekar,K. Martin Sagayam,Syed Immamul Ansarullah,Sami Alshmrany
BackgroundThis research highlights the importance of Internet of Things (IoT) technology in reducing the spread of the Omicron variant of COVID-19. In November 2021, the World Health Organization (WHO) reported the emergence of the SARS-CoV-2 Omicron variant (B.1.1.529) in South Africa. Despite ongoing preventive efforts, the pandemic continues to spread, and the rapid transmissibility of Omicron suggests that additional variants may emerge.MethodsThis research discusses several SARS-CoV-2 variations, examines the dynamics and structure of omicron transmission, and offers insights into global immunization campaigns. Furthermore, it addresses several IoT applications, such as temperature sensors in crowded areas for quick identification and isolation of sick individuals, digital telehealth remote doctor-patient interactions, guidance for IoT-assisted ambulances by remote medical experts, virus spread prediction, and health monitoring devices. The deployment of biosensors, artificial intelligence, and the Internet of Medical Things (IoMT) for COVID-19 and Zika virus detection was also reviewed. Wearable sensor integration in pandemic healthcare has been comprehensively assessed for IoT-based detection and protection approaches. IoT applications include hotspot detection, real-time health analysis, remote administration of medication, medical device tracking, and ambulance monitoring was also analysed.ResultsThis article analyses consumer-orientated IoT gadgets such as smartwatches, smart glasses, drones, and autonomous swab test robots to support public health initiatives. It also emphasizes their function in identifying, monitoring, and responding to the Omicron cases.ConclusionThe IoT plays a preventive role by improving real-time observation, supporting prompt action, and reducing face-to-face encounters, which helps contain the spread of Omicron. Moreover, IoT-based systems can track patients in home isolation, ensuring adherence to quarantine rules.
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危险品化学品经营许可证（带存储）