APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Runcheng Liu,Jie Yan,Wen Yang,Cuiyun Qu,Mingshun Jiang
Sensitive detection of metabolites in biofluids is fundamentally limited by surface-related challenges, including insufficient enrichment, nonspecific adsorption, and poor interfacial durability. Here, we report an interface-engineering strategy for surface plasmon resonance (SPR) biosensors based on tri-functional Au@ZIF-8 core–shell nanostructures. By integrating plasmonic enhancement, molecular sieving, and photocatalytic activity into a single interface, the architecture simultaneously addresses trade-offs between sensitivity, selectivity, and reusability. The ZIF-8 shell serves as a size-selective molecular sieve for target enrichment and protein exclusion, while the plasmonic Au core provides electromagnetic field enhancement and enables light-driven degradation of adsorbed species. Finite element simulations were employed to analyze the interfacial optical response and near-field distribution, quantitatively revealing the interplay between field confinement and molecular capture volume to identify an optimal shell thickness. This interface, integrated onto a tilted fiber Bragg grating (TFBG)-SPR platform, was validated using uric acid. The system exhibits a detection limit of 3.28 × 10 −10 M, 93.4% recovery in artificial serum, and over 92.2% signal retention after ten visible-light-driven regeneration cycles. This work establishes a generalizable, robust, and regenerable interface framework for high-fidelity sensing in complex biological environments.
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Cong Liu,Qing-shan Wang,Heng-fei Cui,Hao-wen Zhu,Ming-yang Liu,Rui-tang Guo
The highly selective generation of products in the photoelectrocatalytic (PEC) CO 2 reduction reaction is significantly hindered by the complex multi-electron transfer process. In this work, we designed and synthesized a Cu 2 O-Au@TiO 2 composite with a unique “core–shell–satellite” architecture via a facile wet-chemical approach. In this architecture, the Au nanocore strengthens visible-light harvesting through localized surface plasmon resonance (SPR) and injects hot electrons into the mesoporous TiO 2 shell, while the outer Cu 2 O selectively exposes highly active (111) facets and establishes low-mismatch interfaces with TiO 2 . This configuration promotes directional charge migration through virus-like synaptic channels, thereby accelerating multi-electron CO 2 reduction. The cooperative mechanism of SPR enhancement, crystallographic facet matching, and dynamic charge transfer enables efficient and selective conversion of CO 2 to C 2 H 4 . Under visible-light irradiation and applied potential, the optimized composite achieves a remarkable C 2 H 4 yield of 174 ± 3.2 μmol·cm −2 ·h −1 with a sustained current density exceeding 75 mA·cm −2 . These findings highlight a rational structural design that synergistically couples plasmonic excitation with interfacial charge management, establishing a promising paradigm for developing high-performance photoelectrocatalytic systems toward solar-driven CO 2 reduction.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Yingying Xu,Xiali Zhang,Shengwei Yang,Jiang Liu,Yan Li,Peng Li,Guanghui Zhang,Jiao Yang,Yingchun Li
Cardiac Troponin I (cTnI), a critical biomarker for diagnosing acute myocardial infarction (AMI), plays an essential role in clinical practice. While traditional lateral flow immunoassays (LFIA) are widely used for cTnI detection due to their simplicity and rapid results, they often suffer from limited quantification capability, low sensitivity, and compromised accuracy, limiting their broader clinical application. To overcome these issues, we developed a dual-signal LFIA (dLFIA) by incorporating Au@CoO nanoparticles (NPs) for quantitative and precise cTnI determination. The synthesized Au@CoO NPs present black color as colorimetric signals and its peroxidase-like activity was adopted to yield chemiluminescence (CL) signals. It is worth noting that sodium perborate was employed to replace hydrogen peroxide as the co-reactant for the aim of enhancing long-term stability and CL intensity. Such dual-signal strategy offers self-checking merit, significantly improving detection reliability. What is more, a portable assay device was designed for automatic release of the reagents involved, further simplifying the detection process. The dLFIA demonstrated a wide linear range with limits of detection of 0.39 ng/mL in colorimetric mode and 0.22 ng/mL in chemiluminescent mode, which are 8 and 15 times more sensitive than traditional LFIA, respectively. This dLFIA platform can act as a promising assay tool for point-of-care testing, particularly in AMI diagnosis and potentially in other applications.
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DOI
高影响因子
BIOELECTROCHEMISTRY
·
2026
·
IF 4.9
Mingzhu Yang,Dujuan Li,Ao Wang,Yifan Zhang,Jiale Ouyang,Xinyi Wang,Liang Hong,Dingyi Tong,Minghua Wang,Jianhan Lin,Qiong Luo,Gaofeng Wang
Breast cancer, a globally prevalent malignancy in women, requires early diagnosis to improve patient outcomes, where ctDNA serves as a key biomarker. In the present study, an electrochemical biosensor based on CRISPR/Cas12a and Au@UiO-66 nanozyme synergistic dual amplification was developed to achieve ultrasensitive detection of breast cancer marker ctDNA. Au@UiO-66-modified ssDNA probes were anchored to the gold electrode via thiol groups. The intact ssDNA probe anchors Au@UiO-66 nanozyme to the electrode, where its peroxidase-like activity efficiently catalyzes H 2 O 2 reduction to generate amplified reduction peak currents. Target ctDNA activates Cas12a's trans-cleavage capacity by binding specifically to crRNA. Under the presence of the target, Au@UiO-66 nanozymes are released, resulting in a discernible drop in the peak current linked to H 2 O 2 reduction. Benefiting from the optimized experimental conditions, the biosensor demonstrates a broad linear detection range (from 10 fM to 10 nM) for the target ctDNA, along with an exceptionally low detection limit of 6.14 fM. Successful detection in human serum samples demonstrates its practicality. The platform's high specificity is attributed to the programmable crRNA design, enabling detection of specified DNA sequences and showcasing significant adaptability for diagnosing multiple genetic targets, highlighting its potential in clinical cancer diagnosis.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2026
·
IF 5.1
Yongkai Xie,Zhongyao Zhang,Xiangxue Zhang,Wenyao Chen,De Chen,Xinggui Zhou,Xuezhi Duan
Strong metal-support interactions (SMSI) are pivotal for constructing interfacial active sites, yet its precise regulation remains a formidable challenge. Here, we report a facile strategy to modulate the atmosphere-dependent SMSI in Au/ZnO catalysts by strictly regulating the oxygen partial pressure during thermal treatment. We reveal that the encapsulation degree of Au particles exhibits a volcano-shaped dependence on oxygen partial pressure, which drives electron transfer from Au to the support to create abundant interfacial oxygen vacancies (Au–O V –Zn). For the oxidative esterification of methacrolein, mechanistic investigations reveal that these interfacial defects constitute frustrated Lewis acid–base pairs to promote the formation of hemiacetal intermediates, and simultaneously serve as active sites for oxygen activation. The activated lattice oxygen migrates to the Au surface and generate active Au–O species that effectively overcome the kinetic barrier of the rate-determining β-H elimination. Driven by this interfacial synergy, the catalyst exhibiting the most pronounced SMSI achieves state-of-the-art performance with an MMA yield of 91.8%. These findings provide a new strategy for the design of high-performance catalysts via interfacial defect engineering.
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Rongpei He,Zhongxu Li,Ran You,Yujie Xiao,Xiaoyuan Xu,Bing Yan,Juan Du,Baozhan Zheng
Surface-enhanced Raman scattering (SERS) has widespread applications for sensitive detection due to its non-destructive nature, but is still limited by the lower signal sensitivity and reproducibility caused by uncontrolled hotspot distribution on substrates. To address this challenge, a reliable and highly sensitive SERS substrate was developed by in-situ fabrication of well-defined Au-core Ag-shell nanocubes (Au@Ag NCs) on eggshell membrane (ESM-Au@Ag). Notably, the precisely controlled size and morphology of Au@Ag NCs by tuning the synthesis conditions led to significantly enhanced SERS performance. The obtained ESM-Au@Ag exhibited remarkable SERS activity, excellent signal reproducibility, and good stability for crystal violet (CV) detection, achieving an ultralow limit of detection of 1.0 × 10⁻ 10 mol·L −1 and a high analytical enhancement factor of 1.6 × 10 8 . Finite-difference time-domain (FDTD) simulations revealed that this superior performance originates from the significantly localized electromagnetic field enhancement at the sharp edges/corners of the nanocubes, along with their uniform distribution on ESM substrate. Furthermore, the ESM-Au@Ag also showed high sensitivity toward multiple analytes, including Rhodamine 6 G, trinitrophenols, and adenine, indicating its potential for practical applications in environmental monitoring, food safety, clinical diagnosis, and public security. This work opens up a new avenue for designing high-performance SERS substrates with exceptional sensitivity, reproducibility, and stability.
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Guoliang Zhang,Yaolong Zhang,Yu Zhang,Changshun Wang,Jin Tan,Ruxangul Jamal,Tursun Abdiryim,Ahmat Ali
Hydroxyl-functionalized MWCNs and PEDOT are better suited for loading MIP. • The sensor detects pefloxacin at the picomolar level. • Synthesis of ultra-thin tubular PEDOT-OH@Au/MWCNs-OH nanocomposites. • The excellent thin-layered structure offers an efficient electron transport pathway. To safeguard public health and prevent the increase of bacterial resistance, the creation of practical and accurate detection methods for the quantitative analysis of fluoroquinolone antibiotics is essential. In this study, a tubular PEDOT-OH@Au/MWCNTs-OH substrate material was prepared using a one-step in situ oxidation method, with chloroauric acid as the oxidant. Pyrrole (Py) was used as the functional monomer, and pefloxacin (PFX) as the template molecule, to ingeniously design a molecularly imprinted electrochemical sensor (MIP/PEDOT-OH@Au/MWCNT-OH) with sensitive sensing capabilities. As expected, the unique structure and properties of PEDOT-OH@Au/MWCNTs-OH provided the sensor more surface area and enhanced electrochemical activity, increasing the number of distinct recognition sites. Based on experimental results, the MIP/PEDOT-OH@Au/MWCNT-OH sensor showed good anti-interference and stability, a low detection limit of 0.149 nM, S/N = 3, and a broad linear range of 0.002–30 μM. Additionally, the sensor achieved a recovery rate of 97%–103% in detecting PFX in pefloxacin mesylate ointment. This sensor shows promise as a highly selective and sensitive portable detection method for the quantitative analysis of PFX in the environmental monitoring. Download: Download high-res image (239KB) Download: Download full-size image
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DOI
高影响因子
TALANTA
·
2026
·
IF 6.7
Xue Cheng,Shuaishuai Wei,Yu Li,Gengli Huang,Yuxing Yan,Zhouping Wang
Nanozyme-based aptasensors still face challenges, including low catalytic activity and inverse signal correlation, which hinder their advancement in the field of food safety. To address these issues, this study developed a novel nanozyme-based colorimetric aptasensor for the high-performance detection of AFB1. Initially, a gold-silver alloy nanoframework (Au-Ag NFs) was synthesized using liposomes as a template, followed by the deposition of platinum nanoclusters on its surface, resulting in the successful preparation of the Au-Ag NFs@Pt NCs nanozyme. This nanozyme exhibited outstanding oxidase-like activity, efficiently catalyzing the oxidation of TMB, leading to a significant increase in absorbance at 652 nm and a visually observable blue color. The AFB1-specific aptamer was covalently immobilized onto the nanozyme surface through Au-S bonds, forming the Au-Ag NFs@Pt NCs@apt complex and enabling the construction of an integrated “recognition-catalysis” sensing system. Upon target recognition by the aptamer, conformational changes in the Au-Ag NFs@Pt NCs @apt-target complex reduced the masking effect of the aptamer on the surface of the nanoenzyme, thereby enhancing oxidase-like activity. Ultimately, this colorimetric aptasensor achieved an enzyme-like “turn-on” detection of AFB1. The aptasensor achieved a detection limit as low as 22.3 pg/mL, and demonstrated excellent selectivity, stability, and satisfactory recovery in spiked peanut samples. This work not only provides a promising new approach for on-site rapid screening of AFB1, but also offers novel composite material insights for designing high-performance nanozyme sensing platforms targeting other analytes.
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DOI
PubMed
高影响因子
TALANTA
·
2026
·
IF 6.7
Mingzhi Jiao,Xinyang Chen,Bing Deng,Kaiguo Mao,Chenyu Wen
Monitoring and identification of combustible gases are crucial tasks in fields such as industrial safety, environmental protection. In real-world scenarios, different types of combustible gases, such as H 2 , C 2 H 4 , and C 2 H 2 , often coexist, which makes recognition more difficult. To address this challenge, we propose a gas sensor based on a ZnO–Au–SnO 2 heterostructure. The morphology and chemical state of the material were characterized using scanning electron microscopy and X-ray photoelectron spectroscopy, which revealed a uniform distribution of Au and binding-energy shifts indicative of electron transfer between ZnO and SnO 2 . Experimental results demonstrate that modifying Au and SnO 2 significantly enhances the sensor's response to H 2 , C 2 H 4 , and C 2 H 2 . By applying a one-dimensional convolutional neural network (1DCNN) to a sensor array, efficient feature extraction of response signals and high-precision gas classification were achieved. The recognition accuracy for gas mixtures exceeds 96%. Furthermore, the lightweight 1DCNN model has been deployed on a Raspberry Pi edge computing platform, verifying its feasibility on small-sized, low-power devices. The system achieves millisecond-level inference and high-confidence predictions, indicating its potential for real-time on-site gas detection. This study synergistically optimizes the gas sensing system from both material and algorithm aspects, providing a feasible way to the intelligent recognition of multi-component combustible gases.
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yihui Wang,Ting Yu,Huijun Yin,Shangyi Shen,Zhenqi Yang,Bohui Wang,Xingjie Wu,Honglong Chang,Haitao Zhao
Nitrogen dioxide (NO 2 ), a significant atmospheric pollutant primarily emitted from combustion processes, poses substantial environmental and health risks, underscoring the critical need for accurate detection methods. Conventional SnO 2 -based sensors are typically constrained by high operating temperatures and limited sensitivity. This study overcomes these limitations by introducing a novel approach that combines noble metal modification with bandgap-matched light excitation, enabling high-performance NO 2 detection at room temperature. Au/SnO 2 composites with hierarchical nanosheet architectures were synthesized via hydrothermal and impregnation methods, as confirmed by SEM. Their sensing properties were systematically investigated under blue light excitation. Among the samples tested, the 2.5 wt% Au/SnO 2 sensor demonstrated superior performance, exhibiting a remarkable response (149.25 @ 5 ppm), a low detection limit (150 ppb), and excellent selectivity, long-term stability, and humidity tolerance at room temperature. First-principles calculations reveal that the enhanced sensor performance originates from a synergistic effect between Au nanoparticle decoration, which enhances NO 2 adsorption and charge transfer, and the additional photogenerated carriers induced by blue light excitation. This study provides novel material design insights for developing high efficiency room temperature NO 2 sensors.
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Huan Li,Zhiguang Suo,Xueqing Zhu,Min Wei,Huali Jin,Rui Guo,Yong Liu,Renyong Zhao
The widespread misuse of ciprofloxacin (CIP) poses a serious threat to environmental safety and human health, necessitating its trace detection in food matrices. In this study, a novel electrochemical aptasensor was developed for the highly sensitive detection of CIP. Au@ZnCoN-C nanocomposites with superior conductivity were synthesized and employed as the electrode modification material. To improve assay sensitivity, a target-triggered cyclic amplification method relying on RecJf exonuclease was adopted. Notably, a cross-linked DNA framework (CLDF) was utilized for the first time in CIP detection. Its interconnected architecture provides abundant active sites for high-density loading of methylene blue (MB), thereby significantly amplifying the electrochemical response. Under optimized conditions, the aptasensor exhibited a wide linear range from 0.005 to 1000 ng/mL, with a low limit of detection (LOD) of 3.2 pg/mL. Furthermore, the sensor was successfully applied to the analysis of CIP in milk, egg, and pork samples with satisfactory results. Leveraging its high specificity, long-term stability, and high sensitivity, this method provides a robust strategy for the precise monitoring of CIP in food safety applications.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Wenhui Jiang,Shunlan Luo,Kehan Du,Kai Yuan,Yuanhua Cong,Xiaoping Zeng,Dawei Wang,Hongyang Zhao,Huinan Suo,Liu Yang,Xiaowen Ou,Hao Jiang,Qianqian Liu,Jiangyu Wu,Zhuo-Ran Yang
Bacterial biofilms in infected wounds and implant-associated infections are highly tolerant to antibiotics and often coexist with excessive inflammatory reactive oxygen species (ROS), resulting in treatment failure and delayed healing. Here, we report a photothermal-responsive curcumin-loaded gold nanorod-silica hybrid nanocomposite (Cur@T-Au) for antibiotic-free infection control and infectious microenvironment remodeling. Gold nanorods were electrostatically assembled onto hollow mesoporous silica nanoparticles (H Au) and further coated with polyethyleneimine to yield a positively charged carrier (T-Au) with bacterial-adhesive capability. Upon near-infrared irradiation, Cur@T-Au demonstrated rapid photothermal hyperthermia synergized with photothermal-responsive triggered structural degradation for controlled release of curcumin, exhibiting broad-spectrum antibacterial activity and potent antibiofilm efficacy. Meanwhile, Cur@T-Au effectively scavenged free radicals and reduced intracellular ROS, and markedly modulated inflammatory responses. In vivo , Cur@T-Au significantly reduced bacterial burden and accelerated healing in infected wound and implant-related infection models, accompanied by improved tissue regeneration and inflammation resolution. Collectively, Cur@T-Au provides an on-demand photothermal-responsive sequential therapeutic strategy that integrates bactericidal action, ROS mitigation and degradability, offering a promising non-antibiotic platform for treating biofilm-associated infections.
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DOI
高影响因子
危险品化学品经营许可证（带存储）