ACS Catalysis
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2026
·Vol. 16
·期 20
·20616-20627
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IF 13.6
Yuan Jingkang,Zhao Chao,Jin Yu,Hou Qilin,Cui Zhi,Tan Daolin,Ou Honghui,Yan Xiaoqing,Yang Guidong
The electrocatalytic co-reduction of nitrate (NO 3 − ) and carbon dioxide (CO 2 ) into urea represents a potential avenue for achieving efficient urea production. However, this process involves intricate C–N coupling reactions and faces a severe kinetic mismatch between the reduction pathways. This disparity typically leads to a disproportionate coverage of key C- and N-containing intermediates on the catalyst surface, resulting in dominant competitive side reactions. Herein, we report the design of a heterogeneous FeNi@AC catalyst that integrates isolated Fe single atoms and Fe–Ni dual-atom sites at the atomic scale, enabling the efficient conversion of NO 3 − and CO 2 into urea. Combined experimental and theoretical investigations reveal that the isolated Fe single-atom sites retain high nitrate reduction capability. Crucially, the introduction of Ni induces an electronic reconfiguration of the Fe center, which significantly lowers the energy barrier for CO 2 activation (from 0.7 eV to 0.1 eV). This activation effectively bridges the kinetic gap between C- and N-species. Consequently, the FeNi@AC catalyst achieves a urea yield rate of 13.6 mmol g –1 h –1 and a Faradaic efficiency of 51.7% at –0.8 V (vs RHE). This work not only presents an active catalyst for urea synthesis but also provides a site-specific regulation strategy for designing multifunctional atomic-site catalysts tailored for complex tandem reactions.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2026
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IF 3.6
Meiqi He,Wei Zhang,Chengxin Zhu,Ying Liang,Wenjin Guo,Rong Chen
Electrochemical conversion of CO 2 and nitrate into urea offers a sustainable route for nitrogen fixation, yet the reliability of catalytic performance evaluation is frequently compromised by inaccurate product quantification. Current detection methodologies are susceptible to severe interferences from electrolyte pH fluctuations, byproduct accumulation (e.g., NO 2 − , NH 3 ), and complex electrolyte factors. In this study, we systematically decouple the interference mechanisms affecting these mainstream detection methods, revealing that extreme pH conditions lead to significant quantitative deviations in urease-based assays due to enzymatic denaturation. To overcome these limitations, we establish a comprehensive calibration strategy and a multi-method synergistic detection protocol. This approach integrates targeted pH optimization with a logic-guided selection of analytical techniques based on specific concentration ranges and impurity profiles. Validated using a BiOCl-catalyzed urea synthesis system, this integrated protocol demonstrates exceptional accuracy, stability, and cross-method consistency. By offering a standardized, high-throughput-compatible workflow for eliminating false positives and measurement errors, this work provides critical methodological support for the objective assessment of electrocatalytic urea synthesis. Graphical This study systematically evaluates matrix interferences in electrochemical C─N coupling for urea quantification. We define specific boundaries where ammonia and nitrite byproducts cause measurement deviations and elucidate the impacts of pH on detection methods. An integrated multi-method protocol is established and validated using a BiOCl catalyst, delivering a standardized workflow for the objective assessment of performance.
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ChemistrySelect
·
2026
·Vol. 11
·期 37
·e74623
·
IF 2.3
Haomiao He,Xiuqiang Dai,Jing Wei,Yongzhong Wang,Xiaofeng Jin
Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional alterations in the kidneys arising from various etiologies. Cystatin C (Cys C) is regarded as a superior endogenous biomarker because it is less affected by confounding factors such as age and gender. In this work, an electrochemical immunosensor was developed for Cys C detection by electropolymerizing o-phenylenediamine (OPD) on the electrode surface via cyclic voltammetry (CV) to form poly(o-phenylenediamine) (PoPD). The PoPD layer not only accelerated electron-transfer kinetics but also provided a favorable matrix for antibody immobilization. The immunosensor achieved a limit of detection (LOD) of 186.88 ng mL −1 and a linear range of 500–6000 ng mL −1 , while exhibiting satisfactory reproducibility, specificity, and operational stability. Spike recovery studies and direct analysis of human serum samples verified the practical performance of the proposed sensor. A low-cost, portable microfluidic electrochemical device was developed for serum Cys C quantification. The integration of electrochemical sensing with the microfluidic platform offers low sample consumption, simplified operation, fast detection, and promising potential for POCT. Graphical A label-free microfluidic electrochemical immunosensor with a PoPD-modified interface enables rapid Cys C detection across a wide clinically relevant range, covering serum levels from normal to elevated pathological concentrations. This broad detection window, together with low sample consumption, supports practical quantitative analysis in real serum samples and POCT kidney injury screening.
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Xiaoting Li,Muhammad Asif,Yuxin Qin,Shaomin Shuang,Ayesha Aziz
The strong electrostatic associations are responsible for self-assembly. • Successful construction of Ti₃C₂Tx/CuNi heterojunctions. • Enhanced sensing performance of Ti₃C₂Tx/CuNi is obtained in DA detection. • Ti₃C₂Tx/CuNi heterojunctions-based sensor is employed in real-time DA detection. The detection of dopamine (DA) with high efficiency and sensitivity is crucial to understand its involvement in various biological and pathological functions. This study presents the synthesis of a novel composite material by hybridizing layered Ti 3 C 2 T x and CuNi nanoparticles via electrostatic interactions and its application in electrochemical DA detection. The Ti 3 C 2 T x /CuNi nanocomposites were favorably synthesized through hydrothermal approach and well-characterized using different characterization techniques. The performance of this material in electrochemical sensing was subsequently investigated. The key to its efficiency lies in the synergistic interaction between the materials, Ti 3 C 2 T x facilitates rapid electron transfer, while CuNi provides numerous catalytic centers, collectively boosting electrocatalytic aptitude. The sensor demonstrates excellent performance under optimized conditions, featuring a linear concentration range of 2–250 μM, enhanced stability, sensitivity, and a low detection limit of 290 nM (S/N = 3). This research suggests that the developed sensor holds significant promise in the electrochemical detection of DA as a biomarker in real-time detection of DA in blood serum samples. The schematic illustration of different steps involved in synthesis of Ti 3 C 2 T x /CuNi heterojunctions and their sensing performance in DA detection. Download: Download high-res image (141KB) Download: Download full-size image
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COMPOSITES PART B-ENGINEERING
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2026
·
IF 14
Liang Zhou,Muhaiminul Islam Shakil,Jingyi He,Xiyue Zhang,Hongbo Wang
Metal-organic framework (MOF)-derived carbon materials exhibit significant advantages for microwave absorption applications, owing to their high electrical conductivity, structural tunability, and abundant intrinsic defects and heterogeneous interfaces. However, achieving an optimal balance between magnetic and dielectric losses remains challenging for most magnetic metal-based MOFs-derived absorbers. In this study, MIL-125(Ti) was prepared as a template, and TiO 2 @C-x composites were synthesized via a two-step pyrolysis method. Experimental results demonstrate that the pyrolysis temperature significantly affects the graphitization degree of the carbon matrix and the formation of TiO 2 nanoparticles, thereby playing a dominant role in the dielectric and microwave absorption properties of the investigated MIL-125(Ti)-derived core-shell TiO 2 @C composites. Notably, the TiO 2 @C-700 composite delivers an effective absorption bandwidth of 3.2 GHz in 9.2-12.4 GHz at a thickness of 2.01 mm. Therefore, the MIL-125(Ti)-derived TiO 2 @C composites fabricated in this study establish a viable and nonmagnetic strategy for designing tunable, lightweight, and high-performance MOF-derived microwave absorbers.
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CHINESE JOURNAL OF CATALYSIS
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2026
·
IF 17.2
Chengyang Sun,Haochen Zhang,Xiaohui Liu,Yanqin Wang
Catalytic hydrogenolysis offers a promising route for plastic waste upcycling. Herein, we demonstrate that oxygen vacancies (O V ) in CeO 2 supports dramatically enhanced this process. Reduction-engineered Ru/CeO 2 -NH 3 -800 exhibits 40% higher activity at 800 °C than untreated counterparts. Comprehensive characterization revealed unchanged Ru metal sites after treatment, but significantly increased oxygen vacancy content in the CeO 2 support. Isotopic C 6 –D 2 temperature-programmed surface reaction studies revealed that higher O V concentrations correlate with lower C–H bond activation temperatures, directly aligning with observed activity trends. We propose a novel Ru–Ce interfacial mechanism: O V -adjacent Ce 3+ –O sites activate C–H bonds to form *RCCR* intermediates, while dual Ru sites cleave C–C bonds via C–Ru coordination. This work establishes an O V -driven structure-activity relationship for the first time and reveals support-mediated C–H activation as crucial for advanced catalyst design.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2026
·
IF 9.2
Xin-Zhi Tian,Bai-Rui Chen,Ao-Sheng She,Wei Wang,Wen-Ya Zhong,Hai-Long Wang,Chi Xing,Ke-Xian Li,Yi-Hong Wu,Xiao-Wei Wu,Bo Weng,Jia-Min Lu,Yan-Xin Chen
Facing the current energy crisis, developing new green energy and advancing high-quality energy development are crucial, as multimetal sulfide semiconductors have great potential in photoenergy conversion. This study prepared a carbon-containing bimetallic phosphide (NiCoP@C) cocatalyst from a CoNi-based MOF, which was combined with ZnIn 2 S 4 (ZIS) hollow nanoflowers to enhance electrical conductivity and photocatalytic hydrogen production of the composite. XPS shows electron cloud density of ZIS increases in the composite via interfacial electronic reconstruction. FESEM reveals NiCoP@C nanoparticles are evenly anchored on surface and interlayer gaps of ZIS, forming a hierarchical heterostructure with more active sites. Performance tests show Z-NiCoP@C has a photocurrent density of 129.58 μA cm −2 (vs. 34 μA cm −2 of unmodified ZIS). Under 10 W visible light with 10% TEOA as a sacrificial agent, 10-h cumulative H 2 yield of the composite is 19.52 mmol g −1 , with a H 2 evolution rate of 1.95 mmol g −1 h −1 , 7.8-fold that of pristine ZIS (0.25 mmol g −1 h −1 ).
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Chemosensors
·
2026
·Vol. 14
·期 2
·
IF 4.4
Wei Wang,Peiting Zhao,Chenjie Wang,Aixuan Xu,Wei Ma,Gan Wang,Zehua Han,Yishan Lu,Jin Yan,Ran Peng
Efficient detection of heavy metal ions in complex marine environments is essential to the safety of marine organisms and human beings. This study developed a novel screen-printed-electrode (SPE) electrochemical sensor for rapid on-site determination of typical heavy metal ions such as Cu2+, Pb2+, Cd2+, and Hg2+in seawater. The sensor employs a three-electrode system, with the working electrode modified with a composite of metal–organic framework-derived carbon (MOF-C) and multiwalled carbon nanotubes (MWCNTs), thereby significantly enhancing detection sensitivity and selectivity. By optimizing square-wave anodic stripping voltammetry (SWASV) parameters, detection limits of 0.83, 0.40, 1.05, and 0.30 μM for the detection of Cu2+, Pb2+, Cd2+, and Hg2+ions were achieved. In mixed-ion detection, excellent peak separation and strong resistance to interferences were demonstrated. Experimental results demonstrate that the sensor exhibits good linear response, excellent interference resistance, and high practicality, providing a new approach for rapid on-site determination of heavy metal pollution in marine environments.
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JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Ying Li,Fangyuan Qiu,Wanyou Huang,Xuesong Tian,Limei Wang,Ruixia Chu,Hang Li,Yibo Gao
Developing low-cost, high-performing non-noble-metal catalysts for the oxygen reduction reaction (ORR) to replace Pt-based catalysts for practical metal-air batteries remains an enormous challenge. Herein, Co 3 O 4 /α-MnO 2 /C composite catalysts with different mass ratios are synthesized, and a heterostructured Co 3 O 4 /α-MnO 2 /C catalyst is successfully constructed. Benefiting from the synergistic interaction between Co 3 O 4 and α-MnO 2 , together with the enhanced conductivity imparted by the carbon support, the catalyst exhibits outstanding electrocatalytic activity. Furthermore, derivative analysis of the LSV curves is employed to accurately determine the ORR onset potential and half-wave potential, providing a quantitative approach for evaluating the electrochemical activity of the Co 3 O 4 /α-MnO 2 /C catalyst. Furthermore, a Zn-air battery driven by the Co 3 O 4 /α-MnO 2 /C catalyst shows excellent electrochemical performance, delivering a high open-circuit voltage of 1.458 V and long-term cycling stability for 300 h. Notably, its overall performance is close to that of commercial Pt/C catalysts. This work highlights the considerable promise of non-noble-metal catalysts for renewable energy storage and conversion applications.
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Biomaterials Advances
·
2026
·
IF 6.7
Rongrong Mu,Xiaowen Tang,Xinyan Huang,Yajie Ma,Huiming Lin
Fe 2 N@C nanospheres integrate NO release, PTT, and CDT for DFU therapy. • NIR-II-triggered hyperpyrexia amplifies POD-like activity of Fe 2 N@C. • Inorganic Fe 2 N@C acts as a novel NO donor with high release capacity. • Acidic biofilm microenvironment facilitates NO release and CDT activity. • Dynamic therapy possesses great potential on infective DFU therapy. Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes, and its multiple pathological factors render treatment more challenging. We synthesized Fe 2 N@C nanomaterials to integrate synergistic photothermal therapy/chemical dynamic therapy/nitric oxide (PTT/CDT/NO) for DFU therapy. First, Fe 2 O 3 and urea were used as precursors to synthesize Fe 2 N@C nanomaterials via nitridation. The nanomaterial can serve as a new NO donor that releases NO triggered by H + and reactive oxygen species (H 2 O 2 and O 2 ). Furthermore, Fe 2 N@C possess superhigh peroxidase (POD)-like activity (V max = 21.1 Ms. −1 , pH 5.5), catalyzing endogenous H 2 O 2 into hydroxyl radicals ( OH). POD activity can also amplify NO and peroxynitrite (ONOO − ) production. In addition, Fe₂N@C nanomaterials reveal high near-infrared II (NIR-II) light harvest and photothermal conversion efficiency (43.94%). Hyperthermia also synergistically boosts POD-like activity and NO release. Under NIR-II laser irradiation, the combination of PTT/CDT and high NO concentration of can quickly clear bacterial infection. In addition, NO can down-regulate the expression of heat shock proteins (HSPs) to amplify PTT performance. Then, the mild NO supply (without irradiation) further facilitates the reversal of inflammation (M2 macrophage polarization) and tissue regeneration (angiogenesis). This dynamic synergistic therapy promotes fast normal DFU healing. Download: Download high-res image (259KB) Download: Download full-size image
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Shuting Han,Jiaru Wang,Jiao Xue,Junjie Miao,Xingyu Liu,Shuhui Yin,Qian Wang,Jing Jin
Chemoresistance is a significant factor in the failure of cancer treatment. Although some chemotherapeutic combination regimens are linked to DNA damage repair processes, the therapeutic potential of TCM-derived small molecules that target these mechanisms is still underexplored. Alloimperatorin (Alloi) has demonstrated the ability to inhibit tumor growth; however, the efficacy and molecular mechanisms of its combination with chemotherapeutic agents are not yet fully understood. Here, we demonstrate that Alloi sensitizes multiple tumor cell lines to gemcitabine (GEM) both in vitro and in vivo. Using functional assays, we confirmed a potent synergistic inhibitory effect of the Alloi-GEM combination, which markedly suppressed pancreatic cancer progression in vivo with minimal adverse effects. By integrating transcriptome sequencing with network pharmacology, we identified downregulation of c-MYC and Nijmegen Breakage Syndrome 1 gene (NBS1) as a key mechanistic event, a finding subsequently validated through multiple assays. Mechanistically, the Alloi-GEM regimen induces sustained DNA damage via disruption of the c-MYC-NBS1 axis, thereby impairing the DNA damage response pathway. Collectively, our findings establish that Alloi enhances tumor sensitivity to GEM through modulation of the c-MYC/NBS1 axis and identify this combinatorial strategy as a promising approach for cancer treatment. Alloi enhances the antitumor effect of GEM by suppressing the c-MYC/NBS1 axis. Downregulation of c-MYC reduces NBS1 expression and impairs MRN complex-mediated DNA damage response signaling, including ATM/CHK2 activation and DNA repair. As a result, GEM-induced DNA damage is sustained, ultimately promoting tumor cell death. Download: Download high-res image (238KB) Download: Download full-size image
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
·
IF 8.3
Yu Zou,Xu Zhang,Chen Yue Lin,Shu Jun Zhen,Lei Zhan,Cheng Zhi Huang
Home-Förster resonance energy transfer (Homo-FRET) has been widely utilized in artificial light-harvesting systems to construct antenna structures with enhanced energy-capture efficiency. Although these systems typically exhibit remarkable antenna effects and signal amplification capabilities, their application in detection systems remains limited. Herein, we reported a rationally designed homo-FRET mediated three-donor/one-acceptor (3D-A) antenna nanostructure assembled on a rigid DNA tetrahedron scaffold for the quantitative detection of Hepatitis C virus (HCV) DNA. Robust homo-FRET interactions among the three donors significantly amplified the hetero-FRET efficiency to the single acceptor, generating an enhanced antenna effect. Upon target recognition, the system provided a ratiometric readout, where the fluorescence intensity ratio between Cy5 and Cy3 increased proportionally with HCV DNA concentration. The proposed 3D-A nanoprobe exhibited a linear response range from 1 to 100 nM with a detection limit of 65 pM. Furthermore, by simply altering the target-binding sequence, this system offered a high versatile platform for universal DNA detection detection.
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