CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Qiang Liu,Jinbang Li,Jiawei Dai,Zewang Hu,Cong Chen,Xiaopu Chen,Yagang Feng,Jiang Li
Ytterbium doped lutetium oxide (Yb:Lu 2 O 3 ) transparent ceramics were fabricated by vacuum sintering combined with hot isostatic pressing (HIP) of the powders synthesized by the co-precipitation method. The effects of calcination temperature on the composition and morphology of the powders were investigated. Fine and well dispersed 5 at% Yb:Lu 2 O 3 powders with the mean particle size of 67 nm were obtained when calcined at 1100 °C for 4 h. Using the synthesized powders as starting material, we fabricated 5 at% Yb:Lu 2 O 3 ceramics by pre-sintering at different temperatures combined with HIP post-treatment. The influence of pre-sintering temperature on the densities, microstructures and optical quality of the 5 at% Yb:Lu 2 O 3 ceramics was studied. The ceramic sample pre-sintered at 1500 °C for 2 h with HIP post-treating at 1700 °C for 8 h has the highest in-line transmittance of 78.2% at 1100 nm and the average grain size of 2.6 µm. In addition, the absorption and emission cross sections of the 5 at% Yb:Lu 2 O 3 ceramics were also calculated.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2014
·
IF 3.902
Chi Wang,Hao Li,Shaohua Liao,Di Zhang,Min Wu,Bo Pan,Baoshan Xing
The K d of sulfamethoxazole (SMX) on activated carbon (AC) was larger than that of SMX on single-walled carbon nanotubes (SC), but the competition of SMX with carbamazepine (CBZ) for adsorption sites was weaker on AC than SC. Thus, a large K d value does not necessarily reflect a high affinity. The analysis of the apparent sorption , competition, desorption hysteresis, and the sorption thermodynamics for SMX and CBZ did not provide sufficient information to distinguish their sorption affinities. The release of the adsorbed CBZ was not altered with SMX as the competitor, but SMX release increased significantly after CBZ addition. The higher sorption affinity of CBZ may be explained by the interactions of the CBZ benzene rings with the aromatic structures of the adsorbents. Although the thermodynamic meaning cannot be described, the release ratio of the adsorbed pollutants provides useful information for understanding pollutant sorption strength and associated risks.
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2015
·Vol. 22
·期 13
·10107-10115
·
IF 2.828
Wang Guanghui,Wang Yin,Hu Suhang,Deng Nansheng,Wu Feng
It is necessary to find an effective soil remediation technology for the simultaneous removal of hydrophobic organic contaminants and heavy metals from contaminated soils. In this work, a novel cysteine-β-cyclodextrin (CCD) was synthesized by the reaction of β-cyclodextrin with cysteine, and the structure of CCD was confirmed by 1 H-NMR, 13 C-NMR, FT-IR spectroscopy and elemental analysis. Pot-culture experiments were conducted to investigate the effects of CCD on the phytoremediation of soil co-contaminated with phenanthrene and lead. The results showed that CCD can enhance the phytoremediation of soil co-contaminated with phenanthrene and lead. When CCD was added to the co-contaminated soil, the concentrations of phenanthrene and Pb in roots and shoots of ryegrass ( Lolium perenne L . ) significantly increased, the presence of CCD is beneficial to the accumulation of phenanthrene and Pb in ryegrass, and the residual concentrations of phenanthrene and Pb in soils significantly decreased. Under the co-contamination of 500 mg Pb kg −1 and 50 mg PHE kg −1 , the bioconcentration factor of phenanthrene and Pb in the presence of CCD was increased by 1.43-fold and 4.47-fold, respectively. After CCD was added to the contaminated soils, the residual concentration of phenanthrene and Pb in unplanted soil was decreased by 18 and 25 %, respectively. However, for the planted soil, the residual concentration of phenanthrene and Pb was decreased by 48 and 56 %, respectively. CCD may improve the bioavailability of phenanthrene and Pb in co-contaminated soil; CCD enhanced phytoremediation technology may be a good alternative for the removal of hydrophobic organic contaminants and heavy metals from contaminated soils.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
·
2015
·Vol. 63
·期 2
·214-219
·
IF 1.362
Xiao Zhou,Yan Liu,Qipeng Yuan,Hao Liang
A novel multi-enzyme co-immobilized nanoparticle was prepared by the bis-aryl hydrazone conjugation strategy for enhancing the overall reaction efficiency and specificity. It can be seen that the molar substitution ratios of succinimidyl 6-hydrazinonicotinamid acetone hydrazone or succinimidyl 4-formylbenzoate to glucose oxidase (GOX) or horseradish peroxidase (HRP) increased with the concentration of the linking reagents. The amount of the immobilized conjugates on the support was measured to be 22.8 ± 1.6 mg/g-particle, and it meant that more than 90% of the GOX–HRP conjugates were successfully attached onto the polystyrene (PS) nanoparticles. Moreover, the immobilized bi-enzymes conjugate on the PS nanoparticles increased about 1.6-fold compared with that of free enzymes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 10
·2127-2136
·
IF 4.726
Wei Zhang,Xiaoyan Zhou,Tao Liu,Dong Ma,Wei Xue
The co-delivery of multiple drugs has become the primary strategy in cancer therapy in recent years, because this technique could promote synergistic actions, reduce side effects and deter the development of drug resistance. To achieve a controlled and sustained release of the loaded drugs, a supramolecular hydrogel based on the host–guest interactions between a hyperbranched polyglycerol derivative and α-cyclodextrin was prepared and used to co-load camptothecin and doxorubicin for sustainedly synergistic tumor therapy. The gelation kinetics, hydrogel strength and supramolecular structure of the obtained hydrogel were studied by dynamic and steady rheometry under various concentrations of α-CD. The sustained dual drug release from the supramolecular hydrogel in vitro, and their synergistic effect in vitro and in vivo were also explored. Moreover, the supramolecular hydrogel showed receivable blood compatibility and non-cytotoxicity by in vitro and in vivo assays. Therefore, this supramolecular hydrogel could potentially be applied in sustainedly synergistic tumor therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2015
·
IF 3.163
Weihua Xu,Alvianto Wirasaputra,Shumei Liu,Yanchao Yuan,Jianqing Zhao
A highly effective 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO)-based flame retardant (D-bp) was successfully synthesized via the addition reaction between DOPO and Schiff-base obtained in advance by the condensation of 4,4’-diaminodiphenyl methane (DDM) and 4-hydroxybenzaldehyde. D-bp was used as co-curing agent to improve the flame retardancy of DDM/diglycidyl ether of bisphenol A (DGEBA) system. Non-isothermal curing kinetics, thermal and flame-retardant properties of cured epoxy resins were studied by differential scanning calorimeter (DSC), thermogravimeric analysis (TGA), UL94 vertical burning test, limited oxygen index (LOI) and cone calorimeter test. The morphology of residues after cone calorimeter test was observed by scanning electron microscope (SEM). The results revealed that the epoxy thermosets exhibited excellent flame-retardancy and passed V-0 rating of UL 94 test with LOI of 39.7% when the phosphorus content was only 0.5 wt%.
✓ 已验证
产品关联
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2014
·
IF 2.199
Zuxin She,Qing Li,Zhongwei Wang,Cui Tan,Juncen Zhou,Longqin Li
A highly anticorrosion and self-cleaning superhydrophobic surface with hierarchical flowerlike structures fabricated on AZ91D magnesium alloy is reported in this work. The hierarchical micro/nanostructures were created through electrodeposition of Ni–Co alloy coating. Followed by modification of stearic acid, a superhydrophobic surface with a water contact angle as high as 167.3 ± 1.3° and an ultra-low sliding angle of about 1° was achieved. The anticorrosion performance of the superhydrophobic surface was studied by using a combination of potentiodynamic polarization and EIS in neutral 3.5 wt.% NaCl solutions. The superhydrophobic surface can present an excellent anticorrosion effect with the inhibition efficiency of 99.99% to the bare magnesium alloy and its corrosion rate being 0.06% of that of bare magnesium alloy. The resulting superhydrophobic surface showed excellent superhydrophobicity in a wide range of pH values from 1 to 14. Besides, the as-prepared superhydrophobic surface possessed good chemical stability and self-cleaning effect. It's believed that the highly anticorrosion and self-cleaning superhydrophobic surface can efficiently protect magnesium alloy from corrosion and expand its application scope.
✓ 已验证
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 1
·160-166
·
IF 0.875
Zuo Huajiang,Wen Wanhua,Wu Dingcai,Fu Ruowen,Tang Chunyi
Copolymers of quaternary ammonium monomer(QAM) and hydrophilic co-monomer were successfully synthesized by free radical polymerization. It was discovered that the hydrophilic co-monomers with poor antibacterial activity significantly enhanced the activity of QAM substituted with a long alkyl chain[ i.e. , N , N -dimethyl- N -dodecyl methacrylate ammonium bromide(DMAEMA-DB)]. When a suitable molar ratio of DMAEMA-DB to co-monomer was selected, the activity of the copolymers was up to 123 times that of the homopolymer of DMAEMA-DB against S. aureus , and 282 times that of it against E. coli . But unlike DMAEMA-DB, the co-monomers might weaken the activity of QAM substituted with a short alkyl chain[ i.e. , N , N -dimethyl- N -butyl methacrylate ammonium bromide(DMAEMA-BB)]. Moreover, it was found that copolymers of DMAEMA-DB were much more biocidal than those of DMAEMA-BB. Therefore, it could be speculated that the long alkyl chain plays an important role in the antibacterial activity, and that the hydrophilic co-monomers are beneficial to polymeric guaternary ammonium compounds(PQACs) to exert the positive effect of the long alkyl chain to the greatest degree.
✓ 已验证
产品关联
DOI
高影响因子
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
·
2013
·Vol. 432
·期 3
·1980-1988
·
IF 5.521
Rodler F.,Kürster M.,Barnes J. R.
With time series spectroscopic observations taken with the Near-Infrared Spectrometer (NIRSPEC) at Keck II, we investigated the atmosphere of the close orbiting transiting extrasolar giant planet, HD 189733b. In particular, we intended to measure the dense absorption line forest around 2.3 μm, which is produced by carbon monoxide (CO). CO is expected to be present in the planetary atmosphere, although no detection of this molecule has been claimed yet. To identify the best-suited data analysis method, we created artificial spectra of planetary atmospheres and analysed them by three approaches found in the literature, the deconvolution method, data modelling via χ2 minimization and cross-correlation. As a result, we found that cross-correlation and χ2 data modelling show systematically a higher sensitivity than the deconvolution method. We analysed the NIRSPEC data with cross-correlation and detect CO absorption in the day-side spectrum of HD 189733b at the known planetary radial velocity semi-amplitude with 3.4σ confidence.
✓ 已验证
产品关联
DOI
高影响因子
Oncotarget
·
2015
·
IF 6.359
Peng-fei Liu,Yan-wei Cao,Shu-dong Zhang,Yang Zhao,Xiao-guang Liu,Hao-qing Shi,Ke-yao Hu,Guan-qun Zhu,Bo Ma,Hai-tao Niu
A tumor microenvironment may promote tumor metastasis and progression through the dynamic interplay between neoplastic cells and stromal cells. In this work, the most representative and significant stromal cells, fibroblasts, endothelial cells, and macrophages were used as vital component elements and combined with bladder cancer cells to construct a bladder cancer microenvironment simulation system. This is the first report to explore bladder cancer microenvironments based on 4 types of cells co-cultured simultaneously. This simulation system comprises perfusion equipment, matrigel channel units, a medium channel and four indirect contact culture chambers, allowing four types of cells to simultaneously interact through soluble biological factors and metabolites. With this system, bladder cancer cells (T24) with a tendency to form a ‘reticular’ structure under 3 dimensional culture conditions were observed in real time. The microenvironment characteristics of paracrine interactions and cell motility were successfully simulated in this system. The phenotype change process in stromal cells was successfully reproduced in this system by testing the macrophage effector molecule Arg-1. Arg-1 was highly expressed in the simulated tumor microenvironment group. To develop “precision medicine” in bladder cancer therapy, bladder cancer cells were treated with different clinical ‘neo-adjuvant’ chemotherapy schemes in this system, and their sensitivity differences were fully reflected. This work provides a preliminary foundation for neo-adjuvant chemotherapy in bladder cancer, a theoretical foundation for tumor microenvironment simulation and promotes individual therapy in bladder cancer patients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2015
·
IF 2.023
Liandong Hu,Saixi Pang,Qiaofeng Hu,Deliang Gu,Dongqian Kong,Xiaoyun Xiong,Jianying Su
Background The current study aimed to investigate whether the novel folate (FT) modified nanoparticles (NPs) co-loaded with docetaxel (DT) and curcumin (CU) (named as FT-NPs) could enhance the delivery efficiency to tumor compared with the NPs without FT (non-targeted NPs). Methods FT-NPs were successfully formulated in this article. In vitro cytotoxic activity against A549 cells and in vivo antitumor activity of FT-NPs in S180 cell bearing mice were conducted. Cellular uptake test was used to evaluate uptake efficiency of FT-NPs. Histological observation was used to determine the lung security. Besides, the physical chemical properties such as stability, particle size, zeta potential , drug encapsulation efficiency, transmission electron microscopy (TEM) were also conducted. Results FT-NPs exhibited stronger growth inhibition effects on A549 cells compared with non-targeted NPs, moreover, the novel FT-NPs indicated more effective antitumor efficacy in inhibiting tumor growth. Confocal laser scanning microscopy indicated that the uptake of FT-NPs was facilitated and effective. Histological observation meant that FT-NPs were biocompatible and appropriate for pulmonary administration. Conclusion These results confirmed that FT-NPs with relatively high drug loading capacity could effectively inhibit tumor growth and reduce toxicity. The novel FT-NPs could produce as an outstanding nanocarrier for the targeted treatment of cancers .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2015
·
IF 3.088
Cheng Wang,Min Li,Tie Yang,Xuefang Ding,Xiuli Bao,Yang Ding,Hui Xiong,Ying Wu,Wei Wang,Jianping Zhou
A new cationic polymer eprosartan-graft-PEI (ESP) containing eprosartan (ES) and polyethylenimine 1.8K was successfully developed and employed as a safe gene vector to assemble a drug (ES) and gene co-delivery complex (ESP/pDNA). Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes. The CS/ESP/pDNA complexes with desirable particle size and zeta potential, exhibited amidase-responsive drug release and CS-mediated endocytosis in vitro . As compared with ESP/pDNA complexes, in vivo imaging results demonstrated decreased reticuloendothelial system uptake and remarkably increased tumor accumulation of CS/ESP/pDNA complexes. All these findings indicated the potential of CS/ESP/pDNA as a promising tumor-targeted drug and gene co-delivery system.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）