POLYMER
·
2026
·
IF 5.1
Chenying Zha,Xiaoyi Liu,Cheng Zhang,Zeshuang Qiao,Hongwei Bai
Stereocomplex-type polylactide (SC-PLA) composed of alternatingly packed enantiomeric chains has recently been regarded as a promising engineering bioplastic with favorable physical properties. However, it is challenging to realize its commercial applications since homocrystallization is fiercely competed with the SC crystallization in the melt-processing of enantiomeric poly( l -lactide) (PLLA) and poly( d -lactide) (PDLA) blends holding relatively high molecular weights (>100 kg/mol). Herein, a facile yet efficient strategy is proposed to facilitate the SC crystallization by using zinc acetate (Zn(OAc) 2 ) to strengthen intermolecular interactions. It is impressive to find that the addition of only 0.01 wt% Zn(OAc) 2 induces the selective formation of SC crystals (SCs) without any homocrystals (HCs), under various melt-crystallization conditions, exhibiting an extremely high efficiency in enhancing SC crystallizability. Moreover, the crystallization kinetic is significantly enhanced. Such enhancement could be ascribed to the metal-oxygen coordination between Zn 2+ ions from Zn(OAc) 2 and carbonyl group of PLAs, which favors the interactive collaboration between enantiomeric chains and thus lowers the barrier to the formation of SCs. This work provides valuable guidance for developing advanced SC-PLA materials with desirable crystallizability.
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高影响因子
ELECTROANALYSIS
·
2026
·Vol. 38
·期 4
·e70143
·
IF 2.6
Hongying Wang,Ran Zhang,Minzi Li,Shaohong Zhang,Ying Wu,Zhijuan Wang
Nanozymes have attracted considerable attention as a promising class of artificial enzymes with significant development potential in recent years. Herein, a nitrogen-doped hollow porous carbon nanocomposite embedded with Co 3 O 4 nanoparticles (Co 3 O 4 -HPNC) was successfully synthesized through the controlled carbonization and subsequent slow oxidation of bimetallic Co/Zn zeolitic imidazolate frameworks (ZIFs). The Co 3 O 4 -HPNC features a hollow architecture conposed of numerous small nanoparticles, forming a porous flocculent morphology that enhances mass transport efficiency. It exhibited remarkable peroxidase-like activity, catalyzing the oxidation of colorless 3,3 ′ , 5,5 ′ -tetramethylbenzidine (TMB) to blue oxidized TMB (oxTMB) in the presence of H 2 O 2 . This reaction was driven by the generation of hydroxyl radicals (·OH), as confirmed by fluorescence and electron paramagnetic resonance (EPR) results. Notably, the oxidization process was significantly inhibited by the addition of L-cysteine (L-Cys), leading to a visible fading of the blue color and a corresponding decrease in UV–vis absorbance. Moreover, Co 3 O 4 -HPNC demonstrated good selectivity and strong anti-interference capability toward L-Cys detection. Based on these findings, a simple and effective colorimetric method was developed for quantifying L-Cys with a linear range of 1–50 μM and a detection limit of 0.13 μM (S/N = 3). This Co 3 O 4 -HPNC-based colorimetric platform holds significant potential for applications in biosensors and clinic diagnostics.
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AICHE JOURNAL
·
2026
·
IF 4.4
Yuan Li,Zhiwei Zhao,Feifei Zhang,Yating Wang,Yanjie Wang,Xiaoqing Wang,Jinping Li,Jiangfeng Yang
The production of high-purity CH 4 (>99.99%) is critical for energy and advanced industrial applications, but the simultaneous removal of N 2 and O 2 remains a significant challenge. Herein, we report a Cu(I) coordination-engineered metal–organic framework (Cu-CFA-1) based on theoretical design and experimental validation, which demonstrates remarkably selective adsorption of N 2 and O 2 over CH 4 , reversing the CH 4 selectivity of the parent material. In situ infrared spectroscopy and computational modeling studies revealed that the threefold coordination of Cu(I) by nitrogen ligands (Cu(I)-3N) significantly enhances its electron-donating capability, enabling targeted adsorption of π-acidic gases (N 2 /O 2 ) through charge-transfer effects. Breakthrough experiments demonstrated that Cu-CFA-1 can provide high-purity CH 4 in a single adsorption–desorption cycle from ternary (N 2 /O 2 /CH 4 ) and even six-component (N 2 /O 2 /CH 4 /CO 2 /C 2 H 6 /C 3 H 8 ) gas mixtures. This work provides an energy-efficient solution for CH 4 purification from multicomponent systems, and establishes a theoretical and practical foundation for the mechanism of π-acidic gas adsorption.
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BioNanoScience
·
2026
·Vol. 16
·期 9
·569
·
IF 4
Wu Weijun,Yao Zhiyong,Ling Lei,Chen Kai,bi Chen Zhong,Xu Xiaoguang,Tao Yun,Wu Dingsheng,Feng Quan
Poly-L-lactic acid (PLLA) fibrous materials have been widely applied in biomedical and packaging fields due to biodegradability and biocompatibility. However, practical use is often restricted by inherent drawbacks such as poor antibacterial activity, high brittleness and inferior hydrophilicity. This study prepared PLLA/O-CUR composite nanofiber membranes by incorporating curcumin-loaded organically modified montmorillonite (O-CUR) into a PLLA matrix to overcome these limitations. The structure and morphology of the resulting membranes were characterized using FTIR, XPS, EDS and SEM. The results demonstrated remarkable enhancement in mechanical properties, with elongation at break increased by 200%, along with significantly improved hydrophilicity, evidenced by a water contact angle of 43°. Furthermore, the resultant nanofiber membrane achieved a 100% bacterial inhibition rate against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ), showing complete suppression of bacterial proliferation. The enhanced performance is attributed to the synergistic effect between the natural antibacterial property of CUR and the layered structure of modified MMT. Moreover, the nanofibrous membrane undergoes progressive degradation within 64 days in PBS and within 35 days in soil, achieving synergistic integration of functionality and biodegradability. This work presents a feasible strategy for developing multifunctional PLLA-based materials, demonstrating promising potential for use in active food packaging, wound dressings, and antimicrobial textiles.
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MOLECULES
·
2026
·Vol. 31
·期 16
·2758
·
IF 5.1
Yanping Zhang,Haichao Zuo,Chenxi Zhang,Di Gao,Yibo Wen,Xinxin Jiang
In this study, total flavonoids from Polygonum perfoliatum L. (PPTF) were extracted using ionic liquid-assisted ultrasound and purified by macroporous resin. After optimization, the total flavonoid content increased from 33.9% to 71.2%. HPLC identified hyperoside, kaempferol-3-O-rutinoside, and quercetin. In vitro experiments showed that PPTF exhibited good free radical scavenging activity and inhibitory effects on α-glucosidase and α-amylase. Within the concentration range of 3.13–12.50 μg/mL, PPTF was non-toxic to HepG2 cells and improved glucose uptake, promoted glycogen synthesis, and reduced lipid accumulation in insulin-resistant cells in a dose-dependent manner. In a type 2 diabetic mouse model induced by high-fat diet combined with streptozotocin, intragastric administration of PPTF for four weeks significantly lowered fasting blood glucose in the high-dose group, improved oral glucose tolerance and insulin sensitivity, increased hepatic and muscle glycogen, normalized serum lipid profiles, and alleviated pathological damage in the liver and pancreas. PPTF exhibits favorable hypoglycemic and lipid-regulating effects in both cellular and animal models, demonstrating its potential for development as an adjunctive functional product for glycemic management.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yiming Zhao,Jingyuan Zhang,Junmei Liu,Jiatong Han,Dan Xu,Jing Wang,Fengzhi Lyu,Lin Qin,Donghui Xu,Ge Chen,Guangyang Liu
Defect-engineered Cu–TCPP/ZIF-L nanosheet membrane: tannic acid coordinates with Cu 2+ to create defect sites, while ZIF-L serves as an interlayer spacer to suppress π–π stacking and restore transport. • The optimized membrane achieves 691.20 L·m -2 ·h -1 ·bar -1 , a 75.5× increase over pristine Cu–TCPP. • Efficient dye removal under static conditions: 97.77% (CV) and 97.87% (MG), suitable for agricultural water purification. • Adsorption–degradation self-cleaning via single-layer chemisorption/ion exchange and catalytic oxidation by O₂· - / 1 O₂; cucumber seedling tests confirm irrigation safety. Dye-laden wastewater from aquaculture and agricultural runoff poses serious environmental challenges, calling for membranes that can deliver both high water flux and efficient dye removal. However, MOF-based composite membranes often still face trade-offs between permeance and separation efficiency, and their practical performance is limited by fouling and insufficient self-regeneration. We hypothesize that defect engineering of Cu–TCPP via tannic-acid-mediated metal–phenolic network (MPN) disruption, together with ZIF-L nanosheet interlayer modulation, can create favorable transport pathways and strengthen adsorption/ion-exchange interactions while enabling ROS-driven self-cleaning. A defect-engineered Cu–TCPP/ZIF-L nanosheet-modified PVDF membrane was prepared using an MPN strategy with tannic acid, and its dye removal performance toward malachite green and crystal violet, together with the underlying mechanisms, was systematically investigated. The optimized membrane achieves a 75.5-fold increase in water permeance to 691.20 L/(m 2 ·h·bar) while maintaining high removal efficiencies of 97.87% for malachite green and 97.77% for crystal violet, and it exhibits self-cleaning behavior enabled by superoxide radicals and singlet oxygen. This work demonstrates an integrated Cu-TCPP–TA/ZIF-L/PVDF membrane design that combines MPN-mediated defect regulation with ZIF-L-assisted lamellar structure modulation for adsorption–degradation-based dye removal in agricultural water-related scenarios. Download: Download high-res image (170KB) Download: Download full-size image
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Lu Zhao,Wenhe Zhang,Min Li,Qi Liu,Zhuobing Zhang,Xiao Gao,Bin Qin,Ikuro Abe,Xian Jia,Song You
l-Leucine dehydrogenase (LeuDH)-mediated direct asymmetric reduction amination of prochiral α-keto acids represents an ideal approach for the synthesis of l-phenylglycine and its derivatives. However, limited substrate acceptance hinders their applications. Herein, we systematically investigated the substrate acceptance of LeuDHs for benzoylformic acid and its monosubstituted derivatives, revealing the correlation between substrate structure and enzyme activity. Meanwhile, to efficiently augment the LeuDH overall catalytic activity toward monosubstituted benzoylformic acids, we reported a two-stage screening strategy using o-chlorobenzoylformic acid (2e) as the starting screening substrate. A superior mutant library with 10–127-fold enhanced catalytic efficiency toward ortho-(M2-1 (L40V/V294A) and M2-2 (E114V/V294G)) and meta- and para-(M2-4 (E114L/V294G)) substituted benzoylformic acids was generated, and following future backtracking analysis, mutant M2-3 (L40V/T134G) with further increased catalytic activity of meta-substituted substrates was obtained. Furthermore, gram-scale asymmetric synthesis of l-phenylglycine (3a), L-p-fluorophenylglycine (3d), and L-o-chlorophenylglycine (3e) was performed with high substrate loading (1 M) and space-time yields up to 1800, 2016, and 2208 g/L·day, respectively. This study provides efficient biocatalysts for the synthesis of l-phenylglycine and its derivatives and establishes a referable engineering workflow for the collective evolution of amino acid dehydrogenase against differently positioned substituted substrate panels.
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PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Kaiyue Zuo,Naiyu Liu,Peng Zhou,Yingrui Wei,Jian Lin,Xinjie Zhu
Low-density lipoprotein receptor (LDLR), which serves as one of the most major entry receptors for many viruses in both human and mouse cells, plays a vital role in virus infection. However, there are no effective small molecules available to inhibit LDLR expression and exhibit antiviral effects. Here, we screened Bruceine A (BA), a natural product derived from the major constituents in Brucea javanica(L.) Merr. which inhibited vesicular stomatitis virus (VSV) infection in vitro. Mechanistically, BA blocked viral adsorption and internalization, facilitating antiviral effects through lysosome-mediated degradation of LDLR. Genetic knockdown of Ldlr exhibited strong antiviral effects. To the best of our knowledge, BA is the first LDLR-selective inhibitor, and our findings reveal that BA may serve as a potent and broad-spectrum virus entry inhibitor based on LDLR entry receptor.
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PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Jiangai Long,Sheng Ma,Renming Wan,Aolin Sun,Zhenyi Zhu,Ruoyi Wang,Zhaopei Guo,Wantong Song
Cationic polymers have garnered considerable attention as mRNA carriers due to their structural tunability and chemical diversity. Nevertheless, their broader application remains limited by poor stability under physiological conditions and cytotoxicity associated with excessive charge density. Here, we report thiourea-modified poly( l -lysine) (PLL-T) carriers constructed by combinatorial side-chain modification with ionizable and hydrophobic isothiocyanates. The resulting thiourea linkage introduced two hydrogen bonding donor sites, enabling stronger hydrogen bonding with mRNA. These hydrogen bonding could synergize with electrostatic and hydrophobic interactions, forming multiple cooperative interactions with mRNA. This design enhanced mRNA encapsulation, colloidal stability, and high transfection efficiency without increasing cytotoxicity. The optimized PLL-1A1B(T) variant achieved over 10,000-fold higher transfection efficiency than the parent polymer PLL, and outperformed the commercial gold-standard Lipofectamine MessengerMAX in both HEK293T and RAW264.7 cells. Compared with its amide-linked analogue PLL-1A1B(A), in which the amide linkage provided only a single hydrogen bonding donor site, PLL-1A1B(T) exhibited superior mRNA encapsulation (91 % vs. 42 %), higher storage stability, and over 50-fold increase in intramuscular transfection. Unlike PLL-1A1B(A), which induced high levels of inflammation, PLL-1A1B(T) exhibited minimal inflammation in vivo. Importantly, PLL-1A1B(T) enabled efficient delivery of mRNA cancer vaccines and elicited potent CD8 + T cell mediated antitumor immunity. A single administration of PLL-1A1B(T)@E6/E7 mRNA vaccine achieved 77 % tumor suppression rate (TSR) in the TC-1 tumor model. Moreover, in combination with anti PD-1, PLL-1A1B(T)@OVA mRNA vaccine achieved 90 % TSR in the B16-OVA tumor model. This study demonstrates hydrogen bonding-driven carriers engineering as a versatile strategy to tune nucleic acid-carrier interactions, offering a potent and safe platform for mRNA therapeutics.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Chenxi Wu,Xiaojin Tian,Ziyan Song,Wang Rui,Hezhao Bai,Hailin Li,Yidan Wang,Wenzhi Yang,Fei Tian
Designing adsorbents with high sensitivity, superior adsorption capacity, molecular specificity, and batch-to-batch reproducibility remains a significant challenge in separation science. For the first time, we synthesized a functionalized magnetic metal-organic framework (Fe₃O₄@SiO₂@MIL-101@CLCS), to adsorb magnoflorine, hesperidin, nitidine chloride, and chelerythrine from Toddalia asiatica (L.) Lam via electrostatic interactions and π-π stacking. In order to systematically analyze the target components, this study established a magnetic solid-phase extraction coupled with high-performance liquid chromatography-diode array detection (MSPE-HPLC-DAD) method, and comprehensively optimized the extraction and elution conditions. After optimization, the adsorption rates of Fe₃O₄@SiO₂@MIL-101@CLCS on the above four active ingredients were ranged from 52.52% to 82.43%, and the elution rates were all higher than 96.40%. The adsorbent retained good adsorption capacity after 5 reuse cycles and had excellent recyclability. The method demonstrated excellent linearity (r² ≥ 0.999), with a limit of detection (LODs) of 0.17–0.92 μg/mL and a limit of quantification (LOQs) of 0.30–1.65 μg/mL, confirming high accuracy and precision. This approach not only enhances analytical efficiency in traditional Chinese medicine studies but also expands the potential of magnetic solid-phase extraction for natural product research.
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PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Xiaona Gao,Xinke Gao,Tengteng Wang,Rentai Song,Yanshen Li,Nada K. Alharbi,Ashwag Shami,Fahad Al-Asmari,Fakhria A. Al-Joufi,Yulin Zhu
Foods in our daily life are susceptible to contaminate by L. monocytogenes due to its high stress resistance and wide distribution, which poses great risks to food safety. Carvacrol is the natural compound that has been recognized as the safe additives and can be utilized safely by food industry. The current study aimed to study the inhibitory effect and mechanism of carvacrol against L. monocytogenes . The results showed that carvacrol treatment resulted in disruption of cell integrity of L. monocytogenes , further led to leakage of intracellular substances. In addition, carvacrol treatment inhibited the activity of topoisomerase and β-galactosidase, which in turn affected the gene duplication and energy utilization of L. monocytogenes . Based on transcriptome analysis, it was found that 126 differential expression genes (DEGs) were existed between carvacrol treated groups and control groups, which were highly enriched in transmembrane transporter activity and transporter activity. In addition, those DEGs were enriched in 4 metabolic pathways with obvious enrichment including phosphotransferase system, starch and sucrose metabolism, quorum sensing, alanine, aspartic acid and glutamic acid metabolism. Finally, carvacrol treatment can inhibit the secretion or activity of hemolysin in L. monocytogenes , which was consistent with the result in transcriptome analysis. In conclusion, carvacrol could be a potential antimicrobial substance to inhibit the contamination of L. monocytogenes in foods.
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Tianjie Nie,Yue Gao,Ya Gao,Wenqian Wang,Ziqiang Wang,Huiying Zhang,Haitao Chen,Shuqi Wang,Baoguo Sun
Odor–induced saltiness enhancement has become an effective way of reducing salt consumption, as recommended for health purposes, without compromising consumer acceptability. In this study, the odorants in fried white mushrooms were investigated using solvent-assisted flavor evaporation, chromatography–mass spectrometry, and gas chromatography–olfactometry. A total of 40 odorants were identified, with 27 exhibiting relative odor activity values ≥0.1. Among them, 8 compounds were considered relating to saltiness by gas chromatography–olfactometry/associated taste analysis. Sensory analysis revealed that 2,5-dimethylpyrazine, 2-ethyl-3,5-dimethylpyrazine, 3-(methylthio)propanal, and 1-octen-3-one significantly enhanced the saltiness perception of 0.3 % NaCl solution ( p < 0.05). The electroencephalography confirmed compared with NaCl solution (0.3 %), the brain response energy values were increased significantly by adding 3-(methylthio)propanal and 1-octen-3-one ( p < 0.05). This research explored the possibilities of mushroom-derived odorants in enhancing perceived saltiness and provided methodological supports for odor-induced taste enhancement research.
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