JOURNAL OF MEDICINAL CHEMISTRY
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2024
·
IF 6.8
Li Wei,Rajesh Kushwaha,Tumpa Sadhukhan,Haorui Wu,Anyi Dao,Zhishang Zhang,Haotu Zhu,Qiufang Gong,Jiaxi Ru,Chao Liang,Pingyu Zhang,Samya Banerjee,Huaiyi Huang
The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. Ru2 showed impressive 700 nm light-triggered anticancer activity under normoxia and hypoxia compared with the clinically used photosensitizer Chlorin e6. The mechanistic studies showed that Ru2 induced intracellular redox imbalance and perturbed the energy metabolism and biosynthesis in A549 cancer cells. Overall, this work provides a new strategy for developing efficient metal-based complexes for anticancer phototherapy under NIR light.
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ACS Applied Energy Materials
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2024
·
IF 5.4
Wenyan Zhang,Yihan Wang,Weidong Tao,Hangmin Guan,Chaoqun Jiang,Wenjie Tian,Lingyun Hao
Montmorillonite (MMT), a layered hydrated aluminum silicate mineral, emerges as a promising catalyst support due to its substantial specific surface, ion storage capacity, thermal stability, and cost-effectiveness. Despite the success of MMT-based photocatalysts in degrading compounds, their potential for the photocatalytic hydrogen evolution reaction (HER) is underexplored. Furthermore, the reliance on noble metals and dye sensitization in MMT-based photocatalysts leads to elevated costs. This study introduces an MMT-based photocatalyst modified with Fe species (denoted as Fe@MMT) for photocatalytic HER without the reliance on noble metals and dye sensitization. The incorporation of Fe species has a dual impact, expanding the light harvesting region of MMT and modulating the aluminum-silicate framework. Simultaneously, it facilitates the exfoliation of individual sheets from stacked MMT layers, generating abundant active sites and inner electronic fields that can promote the separation of photoexcited electrons and enhance the photon-to-electron conversion. In comparison to pristine MMT, Fe@MMT exhibits a 43% reduction in the charge transfer resistance in the dark and a 52% reduction under illumination. Additionally, the majority carrier density within the space charge region increased by 33%. Due to these advantages, the photocatalytic HER efficiency over Fe@MMT was improved, approximately 2.9 times that of pristine MMT.
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ADVANCED MATERIALS
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2024
·
IF 27.4
Jinyi Li,Yang Liu,Jiejun Zeng,Siyu He,Xitong Zhu,Xiaoyue Sun,Yizheng Jin
Tin-based perovskites are more environmentally friendly than their lead-based alternatives. Perovskite light-emitting diodes (PeLEDs) using iodide-based tin perovskites have achieved considerable advancements in efficiency. However, PeLEDs using bromide-based tin perovskites have not progressed as rapidly, primarily due to challenges in controlling their crystallization processes. Here, an interfacial reaction-assisted crystallization method is introduced to achieve bright and efficient CsSnBr 3 PeLEDs. It is started by forming an intermediate phase through the coordination of SnBr 2 with ethylenediamine derivatives. Subsequently, a protonation reaction is designed between the intermediate phase and the acidic polyethylenedioxythiophene: poly(styrene sulfonate) hole-transport layer to generate high-quality CsSnBr 3 films. Additionally, the use of potassium thiocyanate additives effectively enhances the photoluminescence efficiency of the CsSnBr 3 films. These efforts result in CsSnBr 3 -based PeLEDs achieving a maximum luminance of 787 cd m −2 and a peak external quantum efficiency of 0.91%, demonstrating the most efficient and brightest CsSnBr 3 -based PeLEDs to date. This work opens an avenue to better control the crystallization of tin-based perovskite.
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ACS Nano
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2024
·
IF 15.8
Shuting Yang,Bing Qi,Mingzi Sun,Wenjing Dai,Ziyun Miao,Wei Zheng,Bolong Huang,Jie Wang
Persistent luminescence describes the phenomenon whereby luminescence remains after the stoppage of excitation. Recently, upconversion persistent luminescence (UCPL) phosphors that can be directly charged by near-infrared (NIR) light have gained considerable attention due to their promising applications ranging from photonics to biomedicine. However, current lanthanide-based UCPL phosphors show small absorption cross sections and low upconversion charging efficiency. The development of UCPL phosphors faces challenges due to the lack of flexible upconversion charging pathways and poor design flexibility. Herein, we discovered a lattice defect-mediated broadband photon upconversion process and the accompanying NIR-to-NIR UCPL in Cr-doped zinc gallate nanoparticles. The zinc gallate nanoparticles can be directly activated by broadband NIR light in the 700–1000 nm range to produce persistent luminescence at about 700 nm, which is also readily enhanced by rationally tailoring the lattice defects in the phosphors. This proposed UCPL phosphor achieved a signal-to-background ratio of over 200 in bioimaging by efficiently avoiding interference from autofluorescence and light scattering. Our work reported a lattice defect-mediated photon upconversion phenomenon, which significantly expands the horizons for the flexible design of UCPL phosphors toward broad applications ranging from bioimaging to photocatalysis.
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iScience
·
2024
·
IF 4.6
Yi Xiao,Kai Feng,Graham Dawson,Valeri P. Tolstoy,Xingda An,Chaoran Li,Le He
Photothermal conversion represents one crucial approach for solar energy harvesting and its exploitation as a sustainable alternative to fossil fuels; however, an efficient, cost-effective, and generalized approach to enhance the photothermal conversion processes is still missing. Herein, we develop a feasible and efficient photothermal conversion strategy that achieves simultaneous light and heat management using supported metal clusters and WSe 2 interlayer toward enhanced CO 2 hydrogenation photothermal catalysis. The interlayer can simultaneously reduce heat loss in the catalytic layer and improve light absorption, leading to an 8-fold higher CO 2 conversion rate than the controls. The optical and thermal performance of WSe 2 interlayered catalysts on different substrates was quantified using Raman spectroscopy. This work demonstrates a feasible and generalized approach for effective light and heat management in solar harvesting. It also provides important design guidelines for efficient photothermal converters that facilitate the remediation of the energy and environmental crises faced by humans.
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ANALYTICAL SCIENCES
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2012
·Vol. 28
·期 5
·475-479
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IF 1.255
XiaoXiao HUANG,YiJuan LONG,HaiJie ZHANG,QinLong WANG,Rui ZHU,HuZhi ZHENG
Dihydrolipoic acid (DHLA) modified gold nanoparticles (AuNPs) were used as a highly selective probe for the detection of prion proteins. We discovered that AuNPs undergo aggregation selectively in the presence of recombinant prion protein (rPrP), and such selective aggregation enhanced the resonance light scattering (RLS) intensity from AuNPs tremendously. Based on this phenomenon, we established a new assay for rPrP detection. This new assay is label-free, highly selective, and sensitive. The linear range for rPrP detection is from 2.0 × 10−10 to 2.0 × 10−8 mol L−1 with excellent discrimination against other interfering compounds, and the detection limit is 7 × 10−11 mol L−1. This assay has been successfully applied for rPrP detection in E. coli lysate, bovine serum samples and human plasma samples. Compared with other methods, the detection approach described here can achieve high selectivity and sensitivity without any complicated labeling or expensive instruments.
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Chemical Science
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2011
·Vol. 3
·期 3
·868-873
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IF 0
Meng Li,Zhen Liu,Jinsong Ren,Xiaogang Qu
Metal ions play important roles in amyloid aggregation and neurotoxicity. Metal-ion chelation therapy has been used in clinical trials for Alzheimer's disease (AD) treatment. Here we report a novel strategy to design and construct a light controlled-release prochelator by using magnetic nanoparticles as a therapeutic agent for AD. By taking advantage of good biocompatibility, high selectivity toward metal ions of prochelators, and their ability to cross the blood–brain barrier (BBB), the newly synthesized nanoparticle–prochelator conjugates can efficiently inhibit Aβ aggregation, decrease cellular reactive oxygen species (ROS) and protect cells against Aβ-related toxicity, as demonstrated by spectral, TEM, gel electrophoresis and cellular toxicity studies. Since nanoparticles can cross the blood–brain barrier (BBB) which can overcome the drawbacks of unstable small chemicals or peptides, light-triggered functional NPs may provide a new method to constructAβ inhibitors. Therefore, our results shed light on the design of controlled-release multifunctional systems for AD treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Hang Wu,Liang Zhu,Lei Xie,Taiyu Zhou,Tengbo Yu,Yingze Zhang
Bacterial infections, excessive reactive oxygen species (ROS) accumulation and a persistent inflammatory response severely impede the wound healing process. In this study, we developed a novel multifunctional hydrogel dressing (LCPN) based on lipoic acid modified chitosan (LAMC), polypyrrole nanoparticles (PPy NPs) and nicotinamide mononucleotide (NMN) for accelerated healing of infected wounds. The synthesized LCPN hydrogel has several properties. Modification of lipoic acid significantly enhances the water solubility of chitosan making it easier to dissolve and absorb wound secretions. Interestingly, owing to the breaking and restructuring of disulfide bonds, LCPN can be quickly bonded under UV light without relying on photoinitiators. In addition, the incorporation of PPy NPs not only enhances the electrical conductivity of LCPN hydrogel, but also confers photothermal antimicrobial capability to LCPN hydrogel. More importantly, the sustained release of NMN in LCPN hydrogel can significantly enhance cell proliferation, migration and antioxidant capacity, which is conducive to accelerated wound healing. In vivo and in vitro experiments have shown that LCPN hydrogel has excellent biocompatibility and the ability to promote wound healing. Therefore, the prepared multifunctional hydrogel is expected to be used as a novel dressing to accelerate wound healing.
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Journal of Materials Chemistry B
·
2024
·Vol. 12
·期 14
·3481-3493
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IF 6.1
Ting Liu,Kangkang Huang,Yuxia Yang,Shengwu Wen,Jingxian Zhang,Suiping Deng,Shaozao Tan,Langhuan Huang
Bacterial infection is the most common risk factor that causes the failure of implantation surgery. Therefore, the development of biocompatible implants with excellent antibacterial properties is of utmost importance. In this study, NIR light-driven AgBiS2@ZIF-8 hybrid photocatalysts for rapid bacteria-killing were prepared. AgBiS2@ZIF-8 exhibited excellent photocatalytic activity due to the rapid transfer of photoelectrons from AgBiS2 to ZIF-8, resulting in abundant reactive oxygen species (ROS) to kill bacteria. Meanwhile, AgBiS2@ZIF-8 exhibited a noteworthy photothermal effect, which could effectively convert NIR light into heat. Subsequently, the NIR light-driven antibacterial activity of AgBiS2@ZIF-8/Ti against S. aureus and E. coli was studied. The experimental results showed that AgBiS2@ZIF-8 displayed enhanced photodynamic therapy (PDT) and photothermal therapy (PTT) performance. Under irradiation with 808 nm NIR light for 10 min, AgBiS2@ZIF-8/Ti could effectively eliminate 98.55% of S. aureus in vitro, 99.34% of E. coli in vitro and 95% S. aureus in vivo. At the same time, AgBiS2@ZIF-8/Ti had good biocompatibility. Therefore, AgBiS2@ZIF-8/Ti showed potential as an antibacterial material, which provided a strategy to fight polymicrobial infections.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Ting-Ting Li,Meng-Meng Xie,Hong-Yang Wang,Jun-Sheng Wang,Jia-Horng Lin,Ching-Wen Lou
It is a challenge to effectively degrade phenanthrene (PHE) pollutants, which are widely present in aquatic environments, in order to reduce harm to humans and ecosystems. In this study, an S-scheme TiO 2 /g-C 3 N 4 photocatalytic system is constructed using 0D TiO 2 nanospheres and 2D g-C 3 N 4 nanosheets for the removal of PHE from water under sunlight irradiation. The effects of irradiation time, quality ratio of TiO 2 to g-C 3 N 4 , and cycle time on the performance of the TiO 2 /CN photocatalyst are investigated. The experimental results show that the ratio of TiO 2 to g-C 3 N 4 significantly affects the photocatalytic activity of the photocatalyst. Under the optimal ratio of TiO 2 to g-C 3 N 4 (50 % TiO 2 /CN), the apparent reaction rate constant for phenanthrene reached 0.00796 min −1 , which is 11.5 times higher than that of pure TiO 2 (0.00069 min −1 ). The tests of optical performance and photoelectrochemical properties further confirmed that the construction of the TiO 2 /g-C 3 N 4 S-type photocatalyst successfully enhanced the spatial separation efficiency of photogenerated carriers and ensured a continuous supply of energy during the redox reaction process. Converting highly toxic phenanthrene into a non-toxic green degradation product provides an practical strategy for the safe treatment of PHE in aqueous environments through the use of visible-light-driven heterojunction photocatalysts. Additionally, the data collected on phenanthrene degradation in this study will provide valuable references for developing degradation methods for other PAHs, such as naphthalene, anthracene, and pyrene.
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Polymer Chemistry
·
2011
·Vol. 2
·期 5
·1085-1090
·
IF 0
Qingli Hao,Wu Lei,Xingen Xie,Mingzhu Xia,Fengyun Wang,Xujie Yang
Conducting poly(acenaphthylene) (PAcN) films were synthesized electrochemically by direct anodic oxidation of acenaphthylene (AcN) in boron trifluoride diethyl etherate (BFEE) containing additional 20% anhydrous ethyl ether (by volume). The oxidation potential onset of AcN in this medium was measured to be 0.92 V, which was much lower than that determined in CH3CN containing 0.1 mol L−1 tetra butylammonium tetrafluoroborate (Bu4NBF4, 1.34 V). PAcN films obtained from BFEE + 20% EE showed good electrochemical behavior and good thermal stability with an electrical conductivity of 0.43 S cm−1. The average molecular weight with a polydispersity index of 1.06 was determined by gel permeation chromatography to be Mw = 426,000 g mol−1 for the electrochemically synthesized polymer. The structure and morphology of the polymer were investigated by ultraviolet-visible spectroscopy, infrared spectroscopy, nuclear molecular resonance spectroscopy and scanning electron microscopy, respectively. Fluorescent spectra indicated that the electrochemically polymerized PAcN was an excellent green light-emitting material (fluorescence quantum yield as high as 0.3). All these results indicate that the striking PAcN films obtained have potential applications in various fields.
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CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Yan Cao,Zipeng Xing,Yingcai Shen,Zhenzi Li,Xiaoyan Wu,Xu Yan,Jinlong Zou,Shilin Yang,Wei Zhou
Mesoporous black Ti 3+ /N-TiO 2 spheres with high crystallinity are fabricated by a facile evaporation-induced self-assembly (EISA) method, using urea as nitrogen resource, combined with a mild calcinations (350 °C) after an in-situ hydrogenation under an argon atmosphere. The prepared materials are characterized by X-ray diffraction, Raman, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The results indicate the prepared sample is uniform mesoporous black Ti 3+ /N-TiO 2 spheres with high crystallinity of anatase, high surface area of ∼100 m 2 g −1 , large pore size of 6.5 nm and narrow band gap of 2.11 eV, could be easily controlled with the diameter from 200 to 800 nm. Meanwhile, the photoresponse extends to near-infrared region owing to Ti 3+ and N codoping. The visible-light-driven photocatalytic degradation ratio of methyl orange is up to 96% and photocatalytic hydrogen production rate is ∼150 μmol h −1 , which are several times higher than that of pristine TiO 2 . Besides, the possible photocatalytic mechanism is proposed. The excellent photocatalytic activity can be ascribed to N and Ti 3+ doping resulting in high visible light utilization and enhanced separation of photogenerated charge carriers, and the mesoporous networks offering more surface active sites.
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