CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xingbo Wang,Xiaoqing Han,Jiao Yan,Yanjing Wang,Panpan Song,Yaqing Kang,Xueyan Zhang,Xiaoman Shi,Guan Xue,Abdur Rauf,Daguang Zhang,Haiyuan Zhang
Reprogramming of tumor associated macrophages (TAMs) from M2 to M1 phenotype is becoming a feasible strategy for tumor immunotherapy, however, its efficacy is potentially constrained by the acellular components of immunosuppressive tumor microenvironment (TME). Herein, hollow MnO 2 (HMnO 2 ) nanoparticles were loaded with autophagy inhibitor chloroquine (CQ), carried both lactate oxidase (LOX) and glucose oxidase (GOX) on their surface, and further were camouflaged with tumor cell membrane, forming the final mCMLG nanoparticles for TME immunostimulation. After intravenous injection, mCMLG nanoparticles effectively accumulated in the tumor area and were taken up by tumor cells. Under the acidic conditions, MnO 2 reacted with endogenous hydrogen peroxide (H 2 O 2 ) to generate O 2 and Mn 2+ , resulting in the exposure of LOX and GOX as well as the release of CQ. The exposed enzymes reduced the level of lactate (a predominant acellular component), alleviating the inhibition on TAM reprogramming; hydroxyl radical (·OH) generated by Fenton-like reaction of Mn 2+ could directly promote this reprogramming, thus effectively facilitating the reprogramming of TME from immunosuppressive to immunostimulatory. Moreover, ·OH also induced chemodynamic therapy (CDT) effect against tumor cells, which was further amplified by CQ. This study corroborates that mCMLG nanoparticles can effectively inhibit tumor growth through the enhanced immunotherapy and CDT.
研究领域:
纳米技术
·
癌症免疫治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jing Wu,Shuqing Xiang,Ming Zhang,Ninglin Zhou,Mingqian Wang,Li Li,Jian Shen
Wounds caused by bacterial infections have become a major challenge in the medical field; however, the overuse of antibiotics has led to increased resistance and bioaccumulation. Therefore, it is urgent to develop an antibacterial agent with excellent antibacterial properties and biosafety. Here, we designed an antibacterial platform that combines photothermal and chemical kinetics therapies. Platinum–cobalt (PtCo) bimetallic nanoparticles (NPs) were first prepared, and then PtCo@MnO2 nanoflowers were obtained by adding MES buffer solution and KMnO4 to the PtCo bimetallic nanoparticle suspension using ultrasound. When light strikes metal NPs, they can strongly absorb the photon energy, resulting in photothermal properties. In addition, Pt and Co were used as the oxidase mimics, and MnO2 was used as the catalase mimic. In summary, the photothermal capacity of PtCo@MnO2 nanoflowers with rough surfaces can effectively disrupt the permeability of the bacterial cell membranes. Further, by catalyzing H2O2, PtCo@MnO2 nanoflowers can generate large amounts of hydroxyl free radicals, which can damage bacterial cell membranes, proteins, and DNA. In addition, MnO2 can effectively alleviate the hypoxic environment of the bacterially infected areas and activate deep bacteria, thus achieving the goal of complete sterilization. The in vitro and in vivo results showed that PtCo@MnO2 displayed excellent antibacterial properties and good biocompatibility.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
微生物学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-17
·
IF 10.6
Chen Wenting,Hu Fangfang,Gao Qian,Zheng Caiyun,Bai Que,Liu Jinxi,Sun Na,Zhang Wenhui,Zhang Yanni,Dong Kai,Lu Tingli
Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this therapy still needs to be improved by weakly acidic pH and over-expression of glutathione (GSH) in tumor microenvironment (TEM), which hinders its future application. Herein, we reported a multifunctional bimetallic composite nanoparticle MnO2@GA-Fe@CAI based on a metal polyphenol network (MPN) structure, which could reduce intracellular pH and endogenous GSH by remodeling tumor microenvironment to improve Fenton activity. MnO2 nanoparticles were prepared first and MnO2@GA-Fe nanoparticles with Fe3+ as central ion and gallic acid (GA) as surface ligands were prepared by the chelation reaction. Then, carbonic anhydrase inhibitor (CAI) was coupled with GA to form MnO2@GA-Fe@CAI. The properties of the bimetallic composite nanoparticles were studied, and the results showed that CAI could reduce intracellular pH. At the same time, MnO2 could deplete intracellular GSH and produce Mn2+ via redox reactions, which re-established the TME with low pH and GSH. In addition, GA reduced Fe3+ to Fe2+. Mn2+ and Fe2+ catalyzed the endogenous H2O2 to produce high-lever ROS to kill tumor cells. Compared with MnO2, MnO2@GA-Fe@CAI could reduce the tumor weight and volume for the xenograft MDA-MB-231 tumor-bearing mice and the final tumor inhibition rate of 58.09 ± 5.77%, showing the improved therapeutic effect as well as the biological safety. Therefore, this study achieved the high-efficiency CDT effect catalyzed by bimetallic through reshaping the tumor microenvironment.Graphical Abstract
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wenhao Ding,Guolang Zhou,Xiangjie Guo,Cheng Liu,Tianshi Wang,Yongsheng Fu,Jingzhou Yin,Lili Zhang,Edison Huixiang Ang
The natural reactivity of Zn metal in aqueous environments leads to surface deterioration and uncontrolled dendrite growth, posing challenges in the advancement of Zn-ion batteries. In this research, we introduce an environmentally friendly and cost-effective electrolyte additive, ammonium oxalate (AO), to significantly extend the cycle life of Zn-ion batteries with minimal usage. Oxalate ions within AO actively participate in the solvation of hydrated Zn ions and attach to the Zn anode surface prior to H 2 O molecules, creating a robust solid-electrolyte interface (SEI) layer. This SEI layer serves a dual purpose: it inhibits further reactions with H 2 O and restricts the two-dimensional movement of Zn ions, promoting the preferential growth of the (0 0 2) crystal plane. Consequently, Zn||Zn cells exhibit an impressive lifespan surpassing 1800 h (at 1 mA cm −2 , 1 mAh cm −2 ), and Zn||Cu cells experience a tenfold increase in cycling life. Moreover, Zn||MnO 2 full cells, incorporating this low-cost and highly efficient inorganic additive, maintain an outstanding 80.84 % capacity retention after 1200 cycles at 1 A g −1 . This breakthrough with AO offers a promising avenue for the practical implementation of Zn-ion batteries, emphasizing their cost-effectiveness and environmental sustainability.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-12
·
IF 5.479
Tang Xiao,Zeng Xueyi,Liu Huimei,Yang Yili,Zhou Haibo,Cai Huaihong
A nanohybrid probe was fabricated from manganese dioxide nanosheets (MnO 2 NSs), molybdenum disulfide quantum dots (MoS 2 QDs) and o-phenylenediamine (OPD) for ratiometric detection of glutathione (GSH) in aqueous solutions and living cells. The MoS 2 QDs act as the fluorescent “turn off-on” units. The MnO 2 NSs have 3 functions, viz. (a) as fluorescence quencher, (b) as fluorescence initiator for oxidized OPD (ox OPD) and (c) as selective recognizer of GSH. The quenched blue fluorescence of the MoS 2 QDs can be restored by introducing GSH that reduces the MnO 2 NSs. However, the green fluorescence of ox OPD is decreased through the loss of peroxidase activity of MnO 2 NSs in the presence of GSH. Therefore, the ratio of the fluorescence intensities at 560 and 400 nm (from ox OPD and MoS 2 QDs, respectively) linearly decreases with increasing concentrations of GSH. Under the optimal conditions, the detection limit for GSH is as low as 90 nM. The method was successfully applied to the determination of GSH in human serum samples. This nanohybrid also is shown to be membrane-permeable and to have low cytotoxicity. This paved the way to intracellular sensing of GSH in living normal HFF and cancerous HeLa cells. Additionally, by combining with logic gate, this assay was successfully applied to visually discriminate changes in the intracellular GSH. The combination of ratiometric fluorometry and peroxidase mimicking can provide a wide range of application in bioanalysis and intracellular imaging.
Schematic representation of the ratiometric fluorometric detection and cellular imaging of glutathione using a nanohybrid composed of MoS 2 quantum dots and MnO 2 nanosheets with dual (blue and green emission and peroxidase mimicking properties.
研究领域:
生物分析
·
细胞生物学
·
医学诊断
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Jiacheng Xu,Shun Wang,Chenyun Zhang,Jing Zhang,Lihua Xu,Yue Shi,Guoqiang Xu,Shuiliang Yao
Catalyst surface active oxygen species have an important influence on plasma catalytic oxidation . However, the reaction process of CO and O 3 migration and transformation on the catalyst surface during discharge at different temperature is still unclear. In this study, β- and γ -MnO 2 are selected to unveil the roles of different oxygen species under in-plasma catalysis configuration at different temperature in CO oxidation. Operando TPR-DRIFTS-MS is used to reveal CO and O 3 oxidation pathways. The results show that O 3 can react with CO at room temperature, and O 3 is also converted to other reactive oxygen species on the catalyst surface. As the temperature increases, the oxygen species of the catalyst itself (Mn O and Mn-O-Mn) can react with CO to form oxygen vacancies (Mn-□-Mn and Mn=□). Mn-□-Mn are beneficial for O 2 decomposition and promotes the regeneration of Mn O and Mn-O-Mn. The carbonate covered on the surface of the catalyst is the rate-determining step of CO oxidation. It is hoped that Mn-based catalysts with more reactive oxygen species and oxygen defects will be prepared to facilitate low-temperature CO oxidation under plasma conditions.
研究领域:
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the American Chemical Society
·
2024
·
IF 14.4
Luhan Wei,Yang Hu,Yiwei Huang,Ying Lu,Zihan Xu,Nian Zhang,Qiyang Lu
Redox-active transition metal oxides (TMOs) play crucial roles in diverse energy storage and conversion technologies, such as batteries and pseudocapacitors. These materials show intricate electrochemical charge storage processes, encompassing both bulk ion-intercalation, typical of battery electrodes, and pseudocapacitive-like behavior localized near the surfaces. However, understanding the underlying mechanisms of charge storage in redox-active TMOs is challenging due to the coexistence of these behaviors. In this study, we propose an integrated approach that combines operando electrochemical and optical techniques to disentangle the contributions of bulk and surface phenomena. Using birnessite δ-MnO2–x as a model system, we account for surface pseudocapacitive-like layers and employ a refined model that incorporates both surface reactions and bulk chemical diffusion. This methodology allows us to extract essential kinetic parameters, establishing a fundamental framework for unraveling surface and bulk electrochemical processes. This advancement provides a valuable tool for the rational design of energy storage devices, enhancing our ability to tailor these materials for specific applications.
研究领域:
材料科学
·
电化学
·
能量存储
✓ 已验证
DOI
高影响因子
SOLID STATE IONICS
·
2020
·
IF 3.107
Lishuang Xu,Junxia Meng,Puheng Yang,Huaizhe Xu,Shichao Zhang
Lithium-rich layered oxide cathode material Li 1.2 Ni 0.13 Co 0.13 Mn 0.54 O 2 has been successfully synthesized via a self-template method followed with sol-gel reaction, microspheres consisting of three-dimensional (3D) nanothorn MnO 2 are used as the template and Mn source. The as-prepared sample (denoted as LNCM-T) exhibits well-layered structure and high crystallinity , which is confirmed by XRD and HRTEM . The results of electrochemical performances show that the LNCM-T sample has excellent high-rate capability with a discharge capacity of 159.7 mA h g −1 at a current density of 1250 mA g −1 . Besides, it delivers a high initial Coulombic efficiency of 84.3% with a discharge capacity of 243.8 mA h g −1 at room temperature . The remarkable cycling stability and excellent rate capability of LNCM-T sample are ascribed to the enhanced layered structural stability, short lithium-ion diffusion path and reduced charge transfer resistance .
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Fan Wang,Yueying Zheng,Xinggang Wei,Dawei Lan,Jintao Zhu,Yingjie Chen,Ziquan Wo,Tao Wu
This study designed a composite material with internal synergistic effects among multiple components to achieve highly selective adsorption of Cu (II). Through controlled synthesis, the Fe 3 O 4 /MnO 2 (3 1 0)/ZIF-67 composite was successfully fabricated, leading to significant improvement in adsorption selectivity , capacity, and adsorption rate. The experimental results showed that the composite is of outstanding selectivity in the adsorption of Cu (II), with a partition coefficient K of Cu (II) that was 2.2–5.3 times higher than that of other coexisting ions. Moreover, the composite exhibited a remarkable adsorption capacity of 1261.0 mg g −1 and a fast adsorption rate of 840.7 mg g −1 h −1 at 298 K. Additionally, its magnetic property facilitated easy separation from wastewater, thereby enhancing its potential for commercial applications. The synergetic effect mechanism was analyzed through characterizations and DFT calculations. Furthermore, the recyclability of the composite was investigated, which showed that after seven cycles, the adsorption efficiency remained at 85% of its initial efficiency. It can be concluded that Fe 3 O 4 /MnO 2 (3 1 0)/ZIF-67 has potential to address challenges posed by heavy metal pollution in copperplating effluents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2017
·
IF 0
Xueliang Cui,Yunfeng Zheng,Meng Tian,Zhengping Dong
In this study, magnetic SiO 2 @Fe 3 O 4 @m-MnO 2 microspheres with uniform morphology and mesoporous MnO 2 shell were successfully prepared. The MnO 2 sheets structured mesoporous shell could provide a large specific surface area, thereby increasing the catalytically active sites. Thus, magnetic SiO 2 @Fe 3 O 4 @m-MnO 2 microspheres were used as a catalyst support. Palladium nanoparticles (Pd NPs) were successfully anchored with high dispersion on SiO 2 @Fe 3 O 4 @m-MnO 2 surface, successfully obtained Pd(6%)/SiO 2 @Fe 3 O 4 @m-MnO 2 nanocatalyst with a Pd weight percentage of 6%. The obtained nanocatalyst was employed in the hydrodechlorination of highly toxic 2,4-dichlorophenol and catalytic reduction of the widely used nitroaromatics and organic dyes under ambient conditions. In these catalytic reactions, the Pd(6%)/SiO 2 @Fe 3 O 4 @m-MnO 2 nanocatalyst with large and accessible pore surface area exhibited excellent catalytic activity as compared to other noble metal supported catalysts. The Pd(6%)/SiO 2 @Fe 3 O 4 @m-MnO 2 nanocatalyst could also be easily and conveniently recovered from the reaction mixture by using an external magnet, attributed to its magnetism, thus preventing the catalyst loss. Moreover, it could also be reused for at least six times without significant decrease in the catalytic activity, indicating its excellent reusability and stability. This study provides a useful platform and a new perspective for fabricating mesoporous MnO 2 microspheres based noble metals modified catalysts for environmental catalysis.
研究领域:
环境催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
TALANTA
·
2025
·
IF 6.1
Xin Xu,Ting Ying,Zhanghuan Yang,Ze Zhang,Liang Hu,Tong Shen,Dejian Li,Rui Zhu,Dong Chang
The development of portable exosome detection platforms is crucial for noninvasive early diagnosis of lung cancer, particularly in resource-limited settings. Herein, we engineered a paper-based colorimetric biosensor utilizing a MnO 2 /CeO 2 heterojunction nanozyme for visual quantification of plasma exosomes. The heterojunction synergistically integrates the high surface area of CeO 2 (45.689 m 2 /g) with the nanorod shaped MnO 2 , generating an interfacial electron transfer pathway that enhances peroxidase-like activity by 1.77 and 5.87 fold (K m = 1.197 mM, V max = 0.884 M/min) compared to individual components. Molecular recognition was achieved through dual-target immobilization: exosome-specific aptamers and anti-CD63/FGG/FGB antibodies conjugated on a chitosan-modified cellulose substrate. A smartphone-based hue-saturation-value (HSV) analysis system embedded in the platform enabled rapid on-site screening within 15 min, followed by microplate scanning of suspected high-risk samples, achieving a detection range of 10 2 –10 8 particles/μL with an ultralow detection limit of ∼2 particles/μL. Integration of a logistic regression model incorporating CD63, FGG, and FGB absorbance values further improved classification robustness. Clinical validation using 194 plasma samples demonstrated exceptional diagnostic accuracy in discriminating malignant from benign pulmonary nodules (AUC = 0.996), with a 95 % confidence interval ranging from 0.797 to 1.05, with 98.51 % sensitivity and 95.52 % specificity. This work establishes a multimodal strategy combining heterojunction nanozyme catalysis, paper-based microfluidics, smartphone-assisted imaging, and machine learning, offering a scalable paradigm for liquid biopsy applications in primary healthcare.
研究领域:
生物传感器
·
纳米技术
·
癌症诊断
·
即时检测
·
微流控技术
·
机器学习
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Qiaoting Yang,Junhao Deng,Dunru Zhu,Fei Yu,Yi-Xuan Li,Jérome Chauvin,Xue-Ji Zhang,Serge Cosnier,Dan Shan
Electrochemiluminescence (ECL) platforms are often constrained by aggregation-caused quenching (ACQ), inefficient charge transfer, and instability under high driving potentials, thereby limiting their sensitivity and reproducibility. Herein, an energy-level rule-guided strategy is reported to construct a distinctive lanthanide-organic framework (LnOF), [Tb 2 ( µ 2 -OH) 2 (TBAPy)], through the controlled self-assembly of Tb 3+ and 4,4′,4″,4‴-(pyrene-1,3,6,8-tetrayl)tetrabenzoic acid (H 4 TBAPy). This LnOF features the rod-shaped [Tb( µ 2 -OH) 2 (-CO 2 ) 2 ] chains, a large π -stacking distance (6.685 Å) between pyrene rings, and a 3D sea topology, effectively suppressing ACQ and antenna-type energy transfer from the TBAPy triplet state to Tb 3+ , thereby preserving pyrene-based fluorescence while inhibiting the luminescence of Tb 3+ . Importantly, the low-coordinated [TbO 6 ] octahedron exposes multiple open metal sites to coordinate with coreactant S 2 O 8 2− and facilitate its decomposition to SO 4 •− radicals during electrochemical reactions. This process markedly reduces interfacial resistance and enables robust low-bias ECL amplification. Furthermore, a MnO 2 interfacial gate enables ratiometric ECL OFF/ON switching upon glutathione reduction, delivering internally referenced signal outputs with an ultralow limit of detection of 6.8 × 10 −4 n m across a wide range (0.01–500 n m ). This kind of functional material design establishes a generalizable blueprint for LnOF-based ECL systems, advancing programmable and low-bias luminescent sensing with exceptional sensitivity and stability.
研究领域:
材料科学
·
分析化学
·
电化学
·
发光材料
·
传感器设计
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）