Theranostics
·
2019
·
IF 8.063
Xiaolong Zhang,Guangming Li,Yichen Guo,Ying Song,Linlin Chen,Qinli Ruan,Yifan Wang,Lixia Sun,Yunfeng Hu,Jingwen Zhou,Bin Ren,Jun Guo
Cancer invasion and metastasis depend on accurate and rapid modulation of both chemical and mechanical activities. The S-nitrosylation (SNO) of membrane cytoskeletal cross-linker protein ezrin may regulate the malignant process in a tension-dependent manner. Methods : The level of nitrosylated ezrin in non-small cell lung cancer (NSCLC) tissues and A549 cell line were evaluated by biotin-switch assay. A few cysteine mutated plasmids of ezrin were used to identify active site for SNO. Newly designed ezrin or mutated-ezrin tension probes based on Förster resonance energy transfer (FRET) theory were applied to visually observe real-time tension changes. Cytoskeleton depolymerizing and motor molecular inhibiting experiments were performed to reveal the alternation of the mechanical property of ezrin after SNO. Transwell assays and xenograft mouse model were used to assess aggressiveness of A549 cells in different groups. Fluorescent staining was also applied to examine cellular location and structures. Results : High inducible nitric oxide synthase (iNOS) levels were observed to induce ezrin-SNO, and then promote malignant behaviors of NSCLC cells both in vitro and in vivo. Cys 117 was identified as the only active site for ezrin-SNO. Meanwhile, an increased level of ezrin tension was observed after iNOS-induced SNO. Enhanced ezrin tension was positively correlated with aggressiveness of NSCLC. Moreover, Microfilament (MF) forces instead of microtubule (MT) forces played dominant roles in modulating ezrin tension, especially after ezrin nitrosylation. Conclusion : This study revealed a SNO-associated mechanism underlying the mechanical tension of ezrin. Ezrin-SNO promotes NSCLC cells invasion and metastasis through facilitating mechanical transduction from the cytoskeleton to the membrane. These studies implicate the therapeutic potential by targeting ezrin in the inhibition NSCLC invasion and metastasis.
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DOI
PubMed
高影响因子
CATALYSIS COMMUNICATIONS
·
2019
·
IF 3.674
Yuanmei Wen,Liaotian Peng,Yang Zhou,Tao Peng,Yu Chen,Xiaoling Cheng,Yongzheng Chen,Jiawei Yang
Here we report a methionine sulfoxide reductase B (MsrB) enzymatic system for the preparation of ( S )-sulfoxides through kinetic resolution of racemic ( rac ) sulfoxides. Eight MsrB homologue recombinant proteins were expressed and their activities on asymmetric reduction of rac -sulfoxides were analyzed. Among these MsrB homologue proteins, one protein from Acidovorax species showed good activity and enantioselectivity towards several aryl-alkyl sulfoxides. The ( S )-sulfoxides were prepared with 93–98% enantiomeric excess through kinetic resolution at initial substrate concentration up to 50 mM. The establishment of MsrB catalytic kinetic resolution system provides a new efficient green strategy for preparation of ( S )-sulfoxides.
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Rong Tian,Jia-Xin Li,Naihao Lu
Bisphenol S (BPS), a common replacement for bisphenol A (BPA) in packaging and food containers, has posed a threat to human health through dietary consumption. In this study, the effects of BPS binding on the redox states and stabilities of hemeproteins were investigated. Spectroscopy and molecular docking indicated that BPS could cause conformational alterations of hemoglobin (Hb) and the conversion of ferrous Hb to ferric Hb, which subsequently led to increased liberation of free hemin. Next, free hemin significantly caused cell membrane damage, reactive oxygen species formation, lipid peroxidation, and a decline of cell viability in endothelial cells. The selective inhibitors of ferroptosis significantly suppressed hemin-induced toxicity, indicating a hemin-mediated ferroptotic cell death mechanism. Our findings illustrate the binding mechanism of BPS with the hemeprotein as well as the cytotoxicity, which have important implications for the environmental and human health impacts of BPA replacements.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Bin Fan,Weikun Chen,Qian He,Bigui Zhou,Zhiyun Xu,Wei Liu,Qingya Wei,Yingping Zou
To achieve the practical application of high energy density lithium–sulfur (Li–S) batteries, it is essential not only to enhance lithium-ion (Li + ) transport but also to effectively suppress the lithium polysulfides (LiPSs) shuttle effect, which remains challenge for the conventional commercial separators. In this study, a fluorinated covalent organic framework (Tp-TFAB COF) material with high selective permeability was employed to modify separators for Li–S batteries. The fluorinated Tp-TFAB COF layer can effectively enhance Li + conduction while providing electrostatic shielding against LiPSs, which were also confirmed by density functional theory calculations. As a result, Li–S batteries with Tp-TFAB/PP-modified separators retained 79.4 % of their initial capacity after 800 cycles at a 0.5C rate, with a low capacity decay of 0.026 % per cycle. Even at a high sulfur loading (7.3 mg cm −2 ), the batteries exhibited an impressive areal capacity of 5.83 mAh cm −2 . This work highlights the selective functionality of the fluorinated COFs nanoscopic channels, demonstrating its potential for applications in energy storage and beyond.
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产品关联
DOI
高影响因子
Advanced Science
·
2018
·Vol. 5
·期 7
·1800026
·
IF 12.441
Zeqing Guo,Huagui Nie,Zhi Yang,Wuxing Hua,Chunping Ruan,Dan Chan,Mengzhan Ge,Xi'an Chen,Shaoming Huang
Lithium–sulfur batteries suffer from poor cycling stability at high areal sulfur loadings (ASLs) mainly because of the infamous shuttle problem and the increasing diffusion distance for ions to diffuse along the vertical direction of the cathode plane. Here, a carbon nanotube (CNT)/graphene (Gra)-S-Al 3 Ni 2 cathode with 3D network structure is designed and prepared. The 3D network configuration and the Al in the Al 3 Ni 2 provide an efficient channel for fast electron and ion transfer in the three dimensions, especially along the vertical direction of the cathode. The introduction of Ni in the Al 3 Ni 2 is able to suppress the shuttle effect via accelerating reaction kinetics of lithium polysulfide species conversion reactions. The CNT/Gra-S-Al 3 Ni 2 cathode exhibits ultrahigh cycle-ability at 1 C over 800 cycles, with a capacity degradation rate of 0.055% per cycle. Additionally, having high ASLs of 3.3 mg cm −2 , the electrode delivers a high reversible areal capacity of 2.05 mA h cm −2 (622 mA h g −1 ) over 200 cycles at a higher current density of 2.76 mA cm −2 with high capacity retention of 85.9%. The outstanding discharge performance indicates that the design offers a promising avenue to develop long-life cycle and high-sulfur-loading Li–S batteries.
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DOI
高影响因子
Small
·
2019
·Vol. 15
·期 46
·1903873
·
IF 10.856
Ya-Qian Wu,Hui-Xian Yang,Yu Yang,Hao Pu,Wen-Jie Meng,Rui-Ze Gao,Dong-Lin Zhao
SnS 2 has been widely studied as an anode material for sodium-ion batteries (SIBs) based on the high theoretical capacity and layered structure. Unfortunately, rapid capacity decay associated with volume variation during cycling limits practical application. Herein, SnS 2 /Co 3 S 4 hollow nanocubes anchored on S-doped graphene are synthesized for the first time via coprecipitation and hydrothermal methods. When applied as the anode for SIBs, the sample delivers a distinguished charge specific capacity of 1141.8 mAh g −1 and there is no significant capacity decay (0.1 A g −1 for 50 cycles). When the rate is increased to 0.5 A g −1 , it presents 845.7 mAh g −1 after cycling 100 times. Furthermore, the composite also exhibits an ultrafast sodium storage capability where 392.9 mAh g −1 can be obtained at 10 A g −1 and the charging time is less than 3 min. The outstanding electrochemical properties can be ascribed to the enhancement of conductivity for the addition of S-doped graphene and the existence of p–n junctions in the SnS 2 /Co 3 S 4 heterostructure. Moreover, the presence of mesopores between nanosheets can alleviate volume expansion during cycling as well as being beneficial for the migration of Na + .
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DOI
高影响因子
ENERGY & FUELS
·
2020
·
IF 3.421
Mingjie Du,Xiaoqing Tian,Ran Ran,Wei Zhou,Kaiming Liao,Zongping Shao
The cycling performance of lithium–sulfur (Li–S) batteries, which is a major parameter determining the practical application of such an advanced high-energy-density battery system (1675 mA h g–1), is strongly affected by the properties of the cathodic sulfur hosts. As a desirable sulfur host, it should possess high surface area, good electronic conductivity, and superior physisorption and chemisorption to polysulfides. Here, by taking advantage of the magnesiothermic denitriding technology, the graphitic carbon nitride (GCN) with a tunable nitrogen content, surface area, and pore volume has been designed as a sulfur host for high-performance Li–S batteries. With a nitrogen content of ∼6%, a surface area of 594 m2 g–1, and a pore volume of about 2 cm3 g–1, the GCN-based host can retain sulfur and allow its reversible convention within cathodic region, thereby delivering a high capacity of 852.2 mA h g–1 at 0.5 C with a low capacity decay of 0.12% per cycle within 300 cycles. This work provides a feasible way to design nitrogen-doped carbon materials with tunable nitrogen content and enlightens the host material design for practical Li–S batteries.
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DOI
高影响因子
Solar RRL
·
2018
·Vol. 2
·期 12
·1800233
·
IF 0
Qingwen Tian,Haiyang Lu,Yachao Du,Junjie Fu,Xiangyun Zhao,Sixin Wu,Shengzhong (Frank) Liu
Environment-friendly process, low production cost, and simple operation are regarded as key factors for scalable kesterite photovoltaic applications. Herein a green ammonium thioglycolate (TGAm)-based aqueous solution route has been developed to deposit Cu 2 ZnSnS 4 films. It is found that sinstering in ambient air is as good as in argon, making the production process more affordable and reproducible. TGAm is more active than other alkylthiols with longer alkyl chains and has a strong coordination capability toward metal ions, which is a key factor in the dissolution of a series of metal oxides. Meanwhile, TGAm is widely used in biopharmaceuticals and hairspray, demonstrating good biological compatibility. Moreover, a low level of Ag doping can be successfully incorporated into the host lattice of the CZTSSe to form a homogeneous (Cu 1−x ,Ag x ) 2 ZnSn(S,Se) 4 (CAZTSSe) alloy material by this aqueous process. Benefiting from the effect of Ag doping, the initial power conversion efficiency is successfully enhanced from 5.86% ( x = 0) to 7.38% ( x = 2%).
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DOI
SOLAR ENERGY
·
2023
·
IF 6.7
Yonggang Zhao,Qiaogang Song,Zhineng Zhou,Yufei Chen,Ying Zhang,Lang Wu,Xu Su,Xinghuan Hu,Shurong Wang
In the solution method, the surface morphology characteristic of the precursor film is essential for obtaining the high quality of the absorber layer. Herein, the post-heating treatment (PHT) precursor films were adopted to modify the morphology significantly and the effects of different PHT temperatures on the properties of precursor films, absorber layer films, and photovoltaic devices were investigated. The precursor film with a more porous surface could be obtained by PHT, which facilitates the downward diffusion of Se easily during sulfoselenization and the formation of a large-grain-spanning monolayer structure. Furthermore, the Cu 2 ZnSn(S, Se) 4 absorber layer surface holes were significantly reduced, owing to sufficient grain growth during sulfoselenization. As a result, the device efficiency with PHT was increased to 11.07% mainly due to improved Cu 2 ZnSn(S, Se) 4 absorber spectral response. This study might provide a new potential method for adjusting precursor film morphology and thus enhancing the corresponding device performance.
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DOI
高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Haoran Li,Jiao Wang,Yanping Wang,Aimei Zhao,Bing Li,Wei Li
The band gap of CdS (E g = 2.4 eV) was narrow, which made it unable to transmit short-wave sunlight through the CIGS absorber layer. Zn(O,S) thin film , prepared by doping O into ZnS, had a wider band gap, and the raw material was green and non-toxic, making it suitable as a buffer layer for solar cells. However, CBD-Zn(O,S) usually takes longer than CdS deposition. In this work, By shortening the deposition time through the fast hydrolysis of TAA . Na 3 NTA was added in the solutions to improve the quality of Zn(O,S) thin films. The effect of Na 3 NTA concentration on the complex ion contents was investigated. When Na 3 NTA was added at a concentration of 0.04 M along with TAA (0.04 M), the film had a high T% of 88.6%, E g of 3.76 eV, and a dense grain distribution. ZnS and ZnO grew at (111) and (100) crystals, respectively. Raman and XPS analyses showed the existence of Zn–S and Zn–O bonds, indicating the high crystalline quality of the Zn(O,S) thin films prepared with CBD. Finally, when the optimal concentrations of ZnSO 4 , NH 4 OH, Na 3 NTA, and TAA were 0.04 M, 0.48 M, 0.04 M, and 0.04 M, respectively, the prepared Zn(O,S) thin films could be used as a cadmium-free buffer layer for solar cells.
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Lijun Yan,Di Li,Tingting Yan,Guorong Chen,Liyi Shi,Zhongxun An,Dengsong Zhang
Due to the wide application of carbon-based materials in supercapacitors, the concern of volumetric capacitance becomes increasingly important. In this work, the N,P,S-codoped hierarchically porous carbon spheres (N,P,S-HCS) have been rationally designed and originally fabricated using the silica colloids as hard templates, polyaniline as carbon and nitrogen sources, phytic acid as phosphorus sources, and ammonium persulfate as sulfur sources. Both high volumetric and gravimetric capacitance can be achieved. The as-prepared N,P,S-HCS shows the highest specific capacitance of 274 F g–1 and 219 F cm–3 at a current density of 0.5 A g–1, which reveals a superior performance. Moreover, the cycling ability of the N,P,S-HCS can be maintained over 95% to the initial capacitance at a high current density of 10 A g–1 for 10 000 charge–discharge cycles. This is mainly contributed to the uniform doping of N, P, and S as well as the hierarchically porous structure of the N,P,S-HCS. Finally, we assemble it into the all-solid-state symmetric supercapacitors with high energy and power densities of 3.4 W h L–1 with 804 W L–1, respectively. The N,P,S-codoped hierarchically porous carbon spheres with high density show both good volumetric and gravimetric capacitance, which make it a promising material for supercapacitors in practical applications. The present investigations may develop a new direction for the design of carbon materials for a good balance of both high gravimetric and volumetric capacitance.
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DOI
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 17
·4683-4690
·
IF 5.976
Bingyan Zhu,Wenyu Ji,Zongquan Duan,Yang Sheng,Ting Wang,Qilin Yuan,Han Zhang,Xiaosheng Tang,Hanzhuang Zhang
During the last three decades, there has been significant development of quantum dot light emitting diodes (QLEDs) due to their widespread applications. However, common QLEDs depend on cadmium, which is toxic and limits their all-inclusive applications. To address this challenge, herein, we report a highly efficient and low turn-on voltage Cd-free inverted QLEDs with eco-friendly Zn–Ag–In–S quantum dots as the emissive layers. The device performance is closely related to the properties of the hole transport layer (HTL), which are explored by employing different hole transport materials, namely, 4,4′,4′′-tris(carbazol-9-yl) triphenylamine (TCTA) and N,N′-bis(naphthalen-1-yl)-N,N′ bis(phenyl)-benzidine (NPB). Although the energy levels of the lowest unoccupied molecular orbitals (LUMO) of TCTA and NPB are similar, electron leakage from the QDs to NPB is observed, which deteriorates the device performance. An excellent QLED can be achieved if a thick TCTA layer is introduced next to the QDs. Additionally, the QLED with a stepwise HTL consisting of TCTA/NPB presents a slightly higher current efficiency than the TCTA-only device, revealing that the reduction in holes accumulated at the QDs/HTL interface is beneficial for enhancing the device efficiency. Compared to the previously reported Zn–Ag–In–S based QLEDs, our device exhibits a low turn-on voltage of 2.2 V and the highest luminance (over 2000 cd m−2) and efficiency (larger than 2.1 cd A−1).
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DOI
高影响因子
危险品化学品经营许可证（带存储）