BMC MICROBIOLOGY
·
2026
·Vol. 26
·期 1
·716
·
IF 5.4
Zhang Yu-Lin,Gou Hong-Zhong,Li Zhen-Jiao,Xi Jia-Hui,Wang Xiao-Juan,Shang Jin,Zhu Dan,Ren Long-Fei,Shu Xiao-Jun,Zhang Lei
Background Effective diagnoses and treatments for liver fibrosis (LF) are lacking. The gut microbiota (GM)–bile acid (BA) axis is critically associated with LF development and may represent a potential target for delaying or reversing LF. Methods We combined fecal microbiomics and BA-targeted metabolomics to characterize the GM–BA axis in rats with carbon tetrachloride (CCl₄)-induced LF and used fecal microbiota transplantation (FMT) and probiotics (Bifidobacterium quadruple viable tablet solution) to regulate the GM–BA axis to investigate the role of the GM–BA axis in LF and its related mechanisms. Results The GM composition and GM β-diversity differed significantly between the control and model rats. Clostridia and others were significantly increased, whereas Bifidobacteriales and others were significantly decreased in model rats. Serum BA metabolism differed significantly between the groups. The concentrations of 19 BAs were significantly increased in model rats. FMT improved the disordered GM by increasing Bifidobacteriales and others and decreasing Clostridia and others. Probiotics improved the disordered GM by decreasing Clostridia, Lachnospiracea_incertae_sedis and others. FMT and probiotics improved BA metabolism by decreasing BAs such as tauroursodeoxycholic acid (TUDCA). FMT and probiotics were associated with a reduced degree of LF in model rats. Conclusions The GM–BA axis is strongly associated with LF, and the use of FMT and probiotics may contribute to regulating the GM–BA axis and to alleviating LF. Graphical
✓ 已验证
DOI
高影响因子
Journal of Neuroimmune Pharmacology
·
2026
·Vol. 21
·期 1
·33
·
IF 6.1
Zhang Chu,Ma Yunhan,Shi Zhidan,He Xinqi,Hu Jiayi,Chen Shuting,Wu Hao,Tian Meng,Yan Chuang,Xing Mengtao,He Ling
Aging is a major risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD). Targeting cellular senescence has therefore emerged as a promising therapeutic strategy. Resveratrol (RV), a natural polyphenolic compound, exhibits anti-aging properties through the regulation of autophagy and oxidative stress; however, its mechanisms in AD remain incompletely understood. In this study, we investigated the effects and underlying mechanisms of RV in an Aβ1–42-induced AD model. In vivo, RV administration significantly reduced the expression of aging-related markers and activated autophagy-associated signaling pathways. In vitro, RV treatment markedly attenuated Aβ1–42-induced cell viability loss and excessive reactive oxygen species (ROS) production. Further mechanistic analyses demonstrated that RV-induced autophagy activation was closely associated with the AMP-activated protein kinase/UNC-51-like kinase 1 (AMPK/ULK1) and silent information regulator 1/nuclear factor-kappaB (SIRT1/NF-κB) pathways. Collectively, these findings suggest that RV alleviates AD-related pathological processes by promoting autophagy and delaying cellular senescence, highlighting its potential as a therapeutic agent for age-related neurodegenerative diseases. Graphical
✓ 已验证
DOI
PubMed
高影响因子
NATURE
·
2026
·Vol. 655
·期 8123
·624-630
·
IF 56.1
Yang Wujie,Cai Jianfeng,Chen Aoyuan,Li Xiang,He Ping,Zhou Haoshen
Ether-based electrolytes have shown great success for lithium metal electrodes 1 , 2 , 3 , 4 , 5 . However, during the charging process of high-voltage full cells, the desolvation of solvents and anions to accommodate Li ions released from the positive electrode exacerbates oxidative decomposition of the electrolyte 6 . In addition, the continuous consumption of components over extended cycling substantially alters the solvation structure, resulting in deteriorating redox stability. Here we incorporate a targeted ligand anti-solvent (TLAS) into an anion-rich ether-based electrolyte. The TLAS barely participates in the solvation of Li + owing to its relatively weaker association ability in a static state. Under the strong electric field of high-voltage full cells, the orientation and distribution of the TLAS undergo substantial transformation, with coordination ability activated on the positive electrode surface. The TLAS-mediated dynamic solvation behaviour bypasses the inherent decoordination and recoordination of solvents and anions on the positive electrode in conventional electrolyte systems, thus minimizing electrolyte reconstruction and interphase deterioration. Leveraging this gradient solvation electrolyte, we develop a 450 Wh kg −1 lithium metal pouch cell that achieves a long cycle life exceeding 750 cycles (80% capacity retention). Furthermore, we validated a lithium metal pouch cell with a high energy density of 605 Wh kg −1 , which achieves 150 cycles with 96% capacity retention. This gradient solvation strategy provides a feasible pathway of electrolyte engineering for metal-ion batteries.
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·561
·
IF 5.4
Wang Xiaoxi,Wang Haitong,Feng Bin,Liu Yu,Zhao Xinyuan,Chen Wenwen,Wei Haiyan,Zhang Wei,Wang Mengjie,Liu Chuanxi,Shang Ming,Wang Cuijuan
We developed an on-site surface-enhanced Raman scattering (SERS) sensor for rapid detection of difenoconazole (DIF) and flusilazole (FLU) in environmental water. The substrate combines gold nanostars (AuNSs) with covalent organic frameworks (COF) and is implemented on a portable round 20-well quartz plate, enabling in situ testing. After a simple filtration process, environmental water can be directly dripped onto the SERS-active AuNSs/COF composite, thereby simultaneously achieving the adsorption of the target compound and SERS detection. There is a good linear relationship between the SERS intensity of the characteristic peak and the logarithmic concentration of the analyte, with correlation coefficients (R 2 ) from 0.923 to 0.986, meeting the monitoring needs of non-laboratory scenarios. The entire workflow completes within 9 min, offering a faster alternative to conventional methods while maintaining high sensitivity and reproducibility. Detection limits reach 0.88–1.17 ppb for DIF and FLU. Distinct SERS fingerprints enable reliable discrimination of mixed pesticides across environmental water, supporting rapid on-site monitoring and cost-effective pesticide surveillance. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2026
·Vol. 83
·期 10
·549
·
IF 4.2
Du Jiajie,Chen Sixian,Ding Rui,Wang Yingpeng,Shi Qisong
Traditional rigid sensors often lack sufficient flexibility, while pure poly(vinylidene fluoride) (PVDF) piezoelectric materials suffer from limited β-phase content and suboptimal mechanical properties. To address these challenges, we synthesized WO₃@UiO-66-NH₂ heterojunction materials via a hydrothermal method and integrated them with electrospinning technology to fabricate flexible TPU/PVDF composite piezoelectric sensor films. Characterization and performance evaluation identified an optimal PVDF-to-TPU mass ratio of 8:2. Moreover, incorporation of 0.5 wt% WO₃@UiO-66-NH₂ yielded the highest β-phase content in PVDF, along with enhanced dielectric properties, energy storage density, and piezoelectric output. The resulting flexible piezoelectric sensor demonstrates a sensitivity of 1.87 V/N, with response and recovery times of 40 ms and 140 ms, respectively. It reliably monitors diverse human activities and physiological signals, including wrist and knee joint flexion, vocalization, swallowing, respiration, and grasping. Combining excellent flexibility, high sensitivity, and rapid response, this sensor shows considerable promise for applications in human health monitoring and motion detection.
✓ 已验证
产品关联
DOI
高影响因子
npj Materials Degradation
·
2026
·
IF 7.5
Xue Hanzhe,Guo Wenxi
With the rapid development of renewable energy technologies, droplet electricity generators (DEGs) have emerged as a promising approach to harvest low-frequency and random mechanical energy from falling droplets. However, conventional triboelectric PDMS suffers from a low dielectric constant and charge leakage, limiting charge storage, separation, and output performance. Inspired by the skin structure of planthoppers, we develop a self-powered biomimetic pyramidal-structured DEG based on a fluorinated TiO 2 nanoparticle-decorated pyramid-structured PDMS film (F-TiO 2 @P-PDMS). The resulting micro/nano hierarchical superhydrophobic film exhibits an increased dielectric constant and enhanced electrical output compared with pure PDMS. The device maintains stable performance under both low- and high-frequency droplet impacts. When integrated into a self-powered cathodic protection system, it shifts the corrosion potential of 304 stainless steel from −180 to −390 mV, demonstrating effective corrosion protection. This work offers a strategy for efficient droplet energy harvesting and green anticorrosion applications.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Biotechnology
·
2026
·Vol. 4
·期 2
·14
·
IF 8.8
Huang X,Jia Q,Li G,Yang X,Xu S,Liu J,Li W,Liu Y,Xie W,Cao L.
Enzymatic depolymerization of polyethylene terephthalate (PET), the world's most widely used polyester, in seawater at ambient temperature offers a promising and energy-efficient route for freshwater-free plastic recycling. While a number of PET hydrolases have been reported in recent years, their potential under saline conditions remains largely unexplored. Here, we screened eight enzymes in artificial seawater at 30 °C and engineered the most active one, IsPETase, using a semi-rational strategy focused on rigidifying flexible sites. The resulting variant M8 showed simultaneous enhancementsin thermostability (ΔT m = + 27.3 °C), activity (1.14-fold increase) and soluble expression yield (14.3-fold increase). The overall depolymerization efficiency of M8 surpassed that of the thermostable benchmark enzymes DuraPETase and LCC-ICCG by 32.2- and 10.4-fold, respectively. Notably, M8 achieved continuous and efficient depolymerization of 15% (w/v) PET powder in natural seawater at 37 °C, yielding monomers at a rate of 15.4 mM/day, a concentration sufficient to support downstream bacterial assimilation. This work provides an efficient enzymatic platform and paves the way for fully integrated, seawater-based plastic bioconversion processes.
✓ 已验证
DOI
PubMed
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Liu Wenjing,Cong He,Wang Xin,Jiao Yawen,Meng Rui,Liu Shan,Zhang Kaijin
The distinct conditions of the marine habitat drive microorganisms to synthesize exopolysaccharides possessing unique structural features and a broad spectrum of bioactive properties. An extracellular polysaccharide (AVP1) was obtained from the fermented liquid of a marine Aspergillus versicolor CS13 from the Yellow River Delta sediment. AVP1 was characterized as a mannogalactan with a molecular weight of approximately 16.2 kDa and a mannose-to-galactose molar ratio of 1.0: 2.4. The polysaccharide AVP1 was constituted by a backbone of →2)-α- d -Man p -(1→ and →5)-β- d -Gal f -(1→ units, and branch at C-6 of →5)-β- d -Gal f -(1→ units. The side chains contained →6)-α- d -Man p -(1→ and α- d -Man p -(1→ units. AVP1 possessed an obvious α‑amylase inhibitory activity in vitro. AVP1 significantly enhanced insulin sensitivity and glucose consumption in insulin-resistant (IR)-HepG2 cells, and alleviated sodium palmitate (PA)-induced insulin resistance. Moreover, AVP1 effectively reduced total cholesterol (TC) and triglyceride (TG) levels, while increased the activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). It also decreased malondialdehyde (MDA) content and reactive oxygen species (ROS) levels, thereby improved lipid metabolism and mitigated oxidative stress in IR-HepG2 cells. These results demonstrated that AVP1 exhibited notable restorative effects in IR-HepG2 cells and possessed strong activity to alleviate insulin resistance in vitro. This study provides a basis for the development of novel marine-derived hypoglycemic agents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Decai Wang,Tong Zhou,Yalan Cui,Chen Bao,Shuaiqi Yuan,Chengchen Wu,Qian Liu,Chao Liu,Jiannan Hu,Mingrong Liu,Ziling Li,Xinyue Ma,Yunfei Zhu,Jingjing Sun,Shuyun Xu,Yuzhou Wu
The persistent opening of the mitochondrial permeability transition pore (mPTP) plays a critical role in bronchial asthma pathogenesis. The ATP synthase c subunit (c subunit) constitutes a core component of mPTP. A novel c subunit inhibitor, 1,3,8-triazaspiro [4.5] decane derivatives (PP10), effectively suppresses pathological mPTP opening without impairing ATP synthesis. Although intraperitoneal PP10 administration mitigates airway inflammation in asthmatic mice, its hydrophobicity hinders inhaled delivery to airway epithelial mitochondria, requiring penetration of the mucus layer, cell membrane, and mitochondrial outer membrane. To overcome this, we developed inhalable human serum albumin-triphenylphosphine-polyethylene glycol-PP10 nanoparticles (HSA-TPP-PEG-PP10 NPs). These NPs demonstrated efficient mucus penetration, high drug loading, mitochondria-targeting capability, and biosafety. They suppressed house dust mite/lipopolysaccharide (HDM/LPS)-induced mPTP opening, inhibited the mitochondrial DNA (mtDNA)-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, reduced inflammation in human bronchial epithelial (HBE) cells, and alleviated airway inflammation in asthmatic mice upon inhalation.
✓ 已验证
DOI
PubMed
高影响因子
CELL DEATH AND DIFFERENTIATION
·
2026
·
IF 13.6
Luan Jing,He Jiyuan,Wu Dantong,Duan Yaning,Hou Guoyuan,Ma Shuang,Qin Jianhua,Sun Na,He Yuanzheng,Zhang Wei,Gao Minghui
Ferroptosis is a type of regulated necrosis driven by iron-dependent lethal accumulation of lipid peroxides. Selenoprotein thioredoxin reductase (TrxR) plays crucial roles in cellular redox homeostasis. However, its role in ferroptosis remains unclear. Here, we report TrxR1 positively regulates ferroptosis. The selenocysteine of TrxR1 is required for its regulation of ferroptosis. Mechanistically, the CRL4A CRBN E3 complex ubiquitinates KEAP1 at K84 and K312, driving KEAP1 degradation. Overexpression of TrxR1 increases KEAP1 stability by suppressing CRL4A CRBN E3 complex mediated KEAP1 ubiquitination and degradation, enhances the interaction between NRF2 and KEAP1, promotes NRF2 ubiquitination and drives NRF2 degradation, which results in downregulation of GPX4 expression, thereby sensitizing cells to ferroptosis. Furthermore, high level of TrxR1 sensitizes cancer cells to ferroptosis in vivo. CRBN inhibitor thalidomide and IKE combination treatment results in markedly retarded tumor progression. Our study reveals a crucial pro-ferroptotic role for TrxR1 and nominates it as a potential biomarker for guiding future ferroptosis-inducing therapies in select cancers.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Yang Sixie,Chang Bo,Wang Chang,Wang Yigang,Wen Zhang,Liu Yiwen,Zhou Haoshen,He Ping
The global shift to renewable energy has intensified demand for lithium-ion batteries. Conventional lithium sources and extraction methods—such as brine evaporation and ore roasting—are time- and resource-intensive, geographically constrained, and environmentally damaging, underscoring the need for more sustainable resources and extraction strategies. Here we report an electrodialysis-based approach for direct lithium carbonate extraction from seawater, using ambient carbon dioxide as the carbon source. The method integrates a solid-state lithium-conducting membrane with Li–air chemistry, enabling lithium enrichment and carbonate formation in a single step without added precipitants. The Li–air configuration imparts intrinsic ion selectivity via thermodynamically driven displacement reactions. Experimental results confirm the production of lithium carbonate (93.8% purity) with an applied voltage below 2 V, while reducing chemical input and energy consumption compared to conventional processes. This work has the potential to provide a low-impact route for accessing lithium resources and contributes to the sustainability of future battery supply chains.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 18
·1392
·
IF 3.2
Liu Fangyu,Gui Kaixuan,Zheng Yuhao,Dong Shun
The development of high-performance microwave-absorbing materials from renewable resources is a crucial pathway toward achieving green electromagnetic protection. In this work, biomass-derived porous carbon with a terrace-like pore structure was successfully fabricated from potato via a synergistic pyrolysis-chemical activation strategy. The influence of KOH concentration on microstructural evolution and microwave absorption performance was systematically investigated. The results demonstrate that at an optimal KOH concentration of 2 mol/L, the material exhibits a honeycomb-like architecture composed of terrace‑like pores, exhibiting excellent microwave absorption performance: a minimum reflection loss of −64.97 dB at a matching thickness of 2.1 mm and an effective absorption bandwidth of 6.82 GHz (11.18–18.00 GHz) at a thickness of 2.53 mm. The excellent performance originates from the synergistic effects of conductive loss provided by the terrace-like conductive network, polarization relaxation loss induced by multi-level interfaces and broadband impedance matching enabled by the gradient pore structure. This study offers a feasible preparation strategy and theoretical support for synthesizing lightweight, high-efficiency and broadband microwave-absorbing materials from agricultural waste.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）