查找使用阿拉丁产品的科研文献

Carboxymethyl chitosan–gelatin edible films incorporating fava bean antimicrobial peptides for active food preservation

Xiang-Yu Huang,Yan-Qin Guo,Li Ding,Xu-Feng Wang,Li Wen,Zhou Xu,Yun-Hui Cheng,Mao-Long Chen

This study developed a sustainable, edible composite film based on carboxymethyl chitosan (CMCS) and gelatin (GL), incorporating antimicrobial peptides from fava beans (FBAP) for active food packaging. The antimicrobial composite film (U-CMCS/GL-FBAP) was prepared via ultrasonication-assisted cross-linking. Structural analysis confirmed enhanced hydrogen-bonding interactions among the components. The film exhibited a water contact angle of 108.3°, indicating modulated surface wettability. The incorporation of FBAP markedly improved the mechanical properties, increasing the tensile strength and flexibility by approximately 2 times and 1.12 times, respectively. The film also demonstrated a low water vapor permeability (WVP) of 3.55× 10 −11  g·m/(m 2 ·s·Pa) and significant antioxidant activity, with a DPPH and ABTS radical scavenging rates of 40.89% and 79.44%. Furthermore, the film demonstrated strong UV-blocking properties and sustained antibacterial activity, achieving a cumulative FBAP release of 65.82% over 96 h. In application trials on winter jujubes and cherry tomatoes, the coating effectively extended the shelf life by 11 days, respectively, primarily by suppressing microbial growth and reducing quality deterioration. Overall, the U-CMCS/GL-FBAP film combines balanced surface properties, enhanced mechanical and barrier performance, antioxidant capacity, and controlled antimicrobial release, offering a promising and sustainable strategy for the high-value utilization of legume by-products in food preservation.

Cationic chitosan/silsesquioxane hybrid cryogel with antibacterial activity for efficient removal of Cr (VI)

Xiaohan Zhao,Yubin Huang,Zhenhong Huang,Hongzhi Liu

The hazards of aqueous Cr (VI) are severe, necessitating adsorbents with high capacity, applicability, and recyclability. In this study, a novel water-soluble cationic quaternary ammonium silsesquioxane (SQ-N) was synthesized and subsequently reacted with chitosan (CS), polyethylene glycol diacrylate (PEGDA), and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP) to fabricate a flexible chitosan hybrid cryogel (PPSC-x (x = 1, 2, 3)) through UV cross-linking followed by freeze-drying. The resulting cryogel was comprehensively characterized using FTIR, XRD, TGA, SEM, EDS, and XPS analyses. The PPSC-x (x = 1, 2, 3) cryogel possessed abundant active sites and superior mechanical properties, rendering them suitable for the efficient removal of Cr (VI) from wastewater. The adsorption process was spontaneous and endothermic, achieving a maximum equilibrium adsorption capacity of 274 mg g −1 at 328 K. The adsorption of Cr (VI) followed a pseudo-second-order kinetic model and conformed to the Langmuir isotherm. PPSC-3 maintained >90% removal efficiency over five cycles and demonstrated notable antibacterial activity against Escherichia coli and Staphylococcus aureus . A prototype device further validated its practical potential for wastewater treatment.

N-Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption

Jianyong Sheng,Limei Han,Jing Qin,Ge Ru,Ruixiang Li,Lihong Wu,Dongqi Cui,Pei Yang,Yuwei He,Jianxin Wang

Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were formulated in our study. The Ins TMC-PLGA NPs were prepared using the double-emulsion solvent evaporation method and were characterized to determine their size (247.6 ± 7.2 nm), ζ-potential (45.2 ± 4.6 mV), insulin-loading capacity (7.8 ± 0.5%) and encapsulation efficiency (47.0 ± 2.9%). The stability and insulin release of the nanoparticles in enzyme-containing simulated gastrointestinal fluids suggested that the TMC-PLGA NPs could partially protect insulin from enzymatic degradation. Compared with unmodified PLGA NPs, the positively charged TMC-PLGA NPs could improve the mucus penetration of insulin in mucus-secreting HT29-MTX cells, the cellular uptake of insulin via clathrin- or adsorption-mediated endocytosis in Caco-2 cells and the permeation of insulin across a Caco-2 cell monolayer through tight junction opening. After oral administration in mice, the TMC-PLGA NPs moved more slowly through the gastrointestinal tract compared with unmodified PLGA NPs, indicating the mucoadhesive property of the nanoparticles after TMC coating. Additionally, in pharmacological studies in diabetic rats, orally administered Ins TMC-PLGA NPs produced a stronger hypoglycemic effect, with 2-fold higher relative pharmacological availability compared with unmodified NPs. In conclusion, oral insulin absorption is improved by TMC-PLGA NPs with the multiple absorption barriers overcome simultaneously. TMC-PLGA NPs may be a promising drug delivery system for oral administration of macromolecular therapeutics.

Rapid and Efficient Purification of Low-Concentration Fluoride-Containing Water Using Cationic Chitosan Fibers

Zhe Liu,Dongfang Wang,Yan Zhu,Songlin Wang

In this study, a bio-based adsorbent, quaternary ammonium-modified cationic chitosan fibers (CCFs), were developed and systematically evaluated for fluoride removal from low-concentration aqueous medium, with particular emphasis on adsorption performance, regeneration behavior, practical applicability, and adsorption mechanisms. The results demonstrate that the fluoride adsorption capacity of CCFs is approximately 15.8 times higher than that of unmodified chitosan fibers (CFs). Furthermore, CCFs exhibit superior fluoride adsorption capacity and remarkably rapid kinetics relative to previously reported chitosan-based adsorbents in the literature. The adsorption process fits well with the pseudo-second-order kinetic model and reaches equilibrium within 10 min. Adsorption isotherm data are well described by both Langmuir and Freundlich models, with a maximum adsorption capacity of 28.5 mg/g. CCFs also show excellent regeneration performance, achieving efficient fluoride desorption within 3 min using a 0.02 mol/L NaCl solution, with no noticeable loss in adsorption capacity after five consecutive adsorption–desorption cycles. The adsorption performance remains effective in natural surface water containing competing ions. Mechanistic investigations reveal that fluoride adsorption is dominated by electrostatic attraction between quaternary ammonium groups (R4N+) on the CCFs surface and fluoride ions, accompanied by ion exchange with chloride ions. Owing to their high efficiency, rapid kinetics, metal-free nature, and facile regeneration, the CCFs developed in this study represent a promising bio-based adsorbent for the advanced purification of low-concentration fluoride-containing water.

Preparation and properties of polylactic acid/chitosan composite nanofiber hydrogel for repairing tracheoesophageal fistula

Zhikui Luo,Qiang Cao,Leilin Zhu,Mengting Tan,Zhichao Xiao,Junai Zhu,Xinyu Liu,Fusen Peng,Ying Zhang

In the present study, polylactic acid (PLA) was incorporated to ameliorate the rheological and mechanical properties of chitosan (CS)-based hydrogels. A novel injectable chitosan/polylactic acid (CS/PLA) nanofiber composite hydrogel, fabricated via the electrospinning technique, was developed for the sealing and repair of fistulas, thereby functioning as an innovative biomaterial for the treatment of tracheoesophageal fistula (TEF). Experimental data demonstrated that the CS/PLA composite nanofiber hydrogel exhibits superior mechanical properties, favorable rheological behavior, and prominent antimicrobial activity. At the optimal ratio, the compressive strength and tensile strength of CS/PLA composite nanofiber hydrogel is 43.7 MPa and 1.38 MPa, and the degradation rate is 68.9% after 10 days. Meanwhile, the antibacterial rates against E. coli and S. aureus CS/PLA composite nanofiber hydrogel reached 82.6% and 76.3%, respectively. In vitro experiments were performed to assess the biocompatibility and cell proliferation capacity of the composite hydrogel. The results revealed that the CS/PLA composite nanofiber hydrogel can effectively facilitate the proliferation and migration of target cells, while simultaneously exhibiting favorable biocompatibility. These findings indicate that the CS/PLA composite nanofiber hydrogel possesses considerable application potential in TEF repair, thereby offering an innovative and efficient biomaterial option for clinical intervention of TEF.

Synergistic modification of V2O5 cathodes with Ca2+ and chitosan: Structural regulation and performance enhancement

Kang Mei,Tengteng Gao,YiJiang Qu,Yanhuai Ding

Vanadium pentoxide (V 2 O 5 ), owing to its high theoretical capacity and layered structure, is considered a promising cathode material for aqueous zinc-ion batteries (AZIBs). However, its practical application is limited by sluggish Zn 2+ diffusion and structural instability during cycling. In this work, Ca 2+ and chitosan co-modified V 2 O 5 (VO-CS-Ca) was synthesized from commercial V 2 O 5 via an alcohol-assisted solvothermal method. XRD analysis revealed that the interlayer spacing of the (200) plane increased from 0.577 to 0.585 nm after co-modification. SEM and BET analyses confirmed the formation of a porous nanoflower-like architecture, with the specific surface area increasing from 14.99 m 2  g −1 for VO to 23.55 m 2  g −1 for VO-CS-Ca. Benefiting from the expanded interlayer spacing and optimized interfacial properties, the VO-CS-Ca electrode delivered an initial specific capacity of 310.5 mAh g −1 at 0.1 A g −1 , maintained 105 mAh g −1 after 1400 cycles at 1.0 A g −1 , and retained 92 mAh g −1 after 4500 cycles at 5.0 A g −1 . EIS and GITT results confirmed reduced charge-transfer resistance and enhanced Zn 2+ diffusion kinetics, while ex-situ XRD/XPS revealed reversible V 5+ /V 4+ redox behavior and structural evolution during Zn 2+ storage. These results indicate that Ca 2+ /chitosan co-modification effectively tailors the interlayer structure and surface/interface environment of V 2 O 5 , offering a feasible route for high-performance V 2 O 5 cathodes in AZIBs.

Formulation and functional performance of edible chitosan films incorporating Clausena lansium leaf essential oil

Li Jie,Perera Vindya,Cao Shihao,Zhang Mengluo,Ding Yuheng,Tang Minmin,Zhu Tingting

Edible composite films were developed by incorporating Clausena lansium leaf essential oil (CLEO) into chitosan (CS) matrix to enhance the functionality of food-contact films. The optimal formulation (2.0% CS, 1.5% glycerol and 0.4% CLEO) was determined using principal component analysis and response surface methodology. The optimized films exhibited favorable physicochemical, mechanical, and barrier properties. Fourier transform infrared spectroscopy and SEM verified successful CLEO incorporation into the polymer matrix without compromising structural integrity. Furthermore, CLEO significantly enhanced antioxidant and antibacterial activities, with DPPH and ABTS⁺ scavenging rates of 49.15 ± 1.25 and 52.25 ± 3.33%, respectively, and inhibition rates of 72.84 to 98.63% against tested pathogenic bacteria. Preliminary biological evaluation indicated good cytocompatibility, with cell viability above 90%; however, this does not constitute a comprehensive food safety assessment. Overall, CLEO represents a promising natural functional additive for chitosan-based edible films, although further validation in real food systems is required to confirm practical preservation efficacy.

Physically crosslinked polyphenol-chitosan edible coating for the application of walnut kernels during roasting

Xinhui Wang,Junjun Zhou,Bing Qi,Zhou Chen,Siting Li,Aijin Ma,Yingmin Jia

This study developed an edible chitosan-based coating incorporating the main polyphenols from walnut kernel seed coats (gallic acid, ferulic acid, and ellagic acid) to enhance the oxidative stability and sensory quality of fresh walnut kernels during roasting. SEM and AFM analysis revealed that gallic acid-loaded chitosan films exhibited a uniform yet rough morphology, while zeta potential measurements (36–41 mV) confirmed improved film stability. The gallic acid-loaded film demonstrated superior wettability (contact angle: 21.45°) and low water vapor permeability (2.87 × 10 −3  g/(mm∙h∙kPa)), ensuring strong adhesion. FTIR and UV–Vis analyses confirmed hydrogen-bonded crosslinking between polyphenols and chitosan. Thermal stability increased, with DSC and TGA peaks at 181.97 °C and 343 °C for the gallic acid-loaded film. Coated kernels exhibited significantly lower oxidation, with peroxide and acid values (0.04 g/100 g, 0.5 mg/g) outperforming uncoated samples. These findings suggested that gallic acid-loaded chitosan coatings effectively improve walnut kernel quality during roasting.

Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals

Haiquan Mao,Chun Wei,Yongyang Gong,Shiqi Wang,Wenwen Ding

Environmentally benign and biodegradable chitosan (CS) membranes have disadvantages such as low mechanical strength, high brittleness, poor heat resistance and poor water resistance, which limit their applications. In this paper, home-made cellulose nanocrystals (CNC) were added to CS to prepare CNC/CS composite membranes through mechanical mixing and solution casting approaches. The effects of CNC dispersion patterns and CNC contents on the properties of composite membranes were studied. The analysis of the surface and cross-section morphology of the membranes showed that the dispersion performance of the composite membrane was better in the case that CNC was dissolved in an acetic acid solution and then mixed with chitosan by a homogenizer (Method 2). CNC had a great length-diameter ratio and CNC intensely interacted with CS. The mechanical properties of the composite membrane prepared with Method 2 were better. With a CNC content of 3%, the tensile strength of the composite membrane reached 43.0 MPa, 13.2% higher than that of the CNC-free membrane. The elongation at break was 41.6%, 56.4% higher than that of the CNC-free membrane. Thermogravimetric, contact angle and swelling analysis results showed that the addition of CNC could improve the heat and water resistance of the chitosan membrane.

A chitosan-doped high strength, water-retentive, antifreeze conductive hydrogel for human electrocardiogram detection

Li Xiaomeng,Jiang Chenjia,Xie Huiwen,Zhang Hong

The development of flexible hydrogels with robust mechanics, high water content, and reliable conductivity is critical for next-generation wearable bioelectronics. However, conventional poly(vinyl alcohol) (PVA) hydrogels suffer from insufficient mechanical strength and rapid water loss, limiting their practical applications. Here, we present a chitosan-doped, phytic acid–based dual-network hydrogel that combines a PVA backbone with a secondary network of chitosan (CS), hydroxyethyl methacrylate (HEMA), and sulfobetaine methacrylate (SBMA). The resulting hydrogel exhibits relatively high tensile strength (107 kPa) and elongation (415%), together with excellent water retention and antifreeze performance arising from synergistic hydrogen bonding and electrostatic interactions between PA and CS. Importantly, the hydrogel maintains stable ionic conductivity under various deformations and enables accurate and reproducible detection of human electrocardiogram (ECG) signals, comparable to that of commercial electrodes. This work provides a practical strategy to design multifunctional hydrogels for reliable physiological monitoring and flexible wearable electronics.

Effect of quaternization degree on physiochemical and biological activities of chitosan from squid pens

Jun Huang,Zhen-Hua Cheng,Hai-Hua Xie,Jin-Yan Gong,Jian Lou,Qing Ge,Yong-Jiang Wang,Yuan-Feng Wu,Shi-Wang Liu,Pei-Long Sun,Jian-Wei Mao

Chitosan was prepared by alkaline N -deacetylation of β-chitin from squid pens, and N -(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (HTCC) derivatives, with different degrees of quaternization (DQ) ranging from 0.77 to 1.06, were synthesized. It was identified by FT-IR, 1 H NMR and XRD analysis. All of the HTCC showed good water solubility in a wide pH range. The moisture absorption and retention abilities of all the HTCC were much better than that of the chitosan. The moisture absorption and retention values of all the HTCC at 43% RH for 24   h were above 49% and 92%, respectively. The scavenging ability of HTCC against hydroxyl and ABTS radicals improved with increasing concentration. The effectiveness of HTCC against hydroxyl radicals was lower than that of chitosan. These results indicated that HTCC, which has a much better moisture absorption and retention capacity, may act as a potential moisturizer in vitro.

Preparation and evaluation of SiO2-deposited stearic acid-g-chitosan nanoparticles for doxorubicin delivery

Hong Yuan,Xin Bao,Yong-Zhong Du,Jian You,Fu-Qiang Hu