MICROCHEMICAL JOURNAL
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2021
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IF 4.821
Yao Wei,Hua Jiang,Pengchi Deng
Sulfhydryl-containing amino acids had a variety of biological functions. Herein, a method was simply set up to determine Cys and GSH with β-CD AgNPs quantitatively. The chemical shifts of Cys and GSH both moved to higher field when β-CD AgNPs were added. The reason was that the sulfhydryl groups could bind to the surface of AgNPs. In addition, the competitive effect of Cys and GSH in mixed solutions was explored via the 1 H chemical shift deviation. Peaks at 3.05 ppm and 2.93 ppm were selected as characteristic signals. This method exhibited an excellent linearity in the range of Cys and GSH in 0.1–20 mM. The detection limits of Cys and GSH were 40 μM and 14 μM, respectively. This method was successfully used to quantitatively determine Cys and GSH in human serum and urine.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Hao Xincai,Sun Xiaodong,Zhu Haizhen,Xie Lixia,Wang Xuanbin,Jiang Nan,Fu Pan,Sang Ming
Trans-resveratrol (RES) exhibits a wide range of biological activities. Various methodological approaches have been established to improve the pharmacokinetic properties of RES. Moreover, additional in vivo studies are required to support clinical application. In this study, RES/HP-β-CD (RHSD) inclusion complex was prepared and characterized by FTIR, PXRD, DSC and NMR data. The effect and potential mechanism of RHSD against cervical cancer were investigated in a mouse xenograft tumor model by qPCR assay, Western blot assay, and immunohistochemical assay. Results showed that RHSD significantly decreased tumor growth compared with free RES, while the effect of preventing tumor growth was more prominent in vivo. Notably, RHSD could inhibit tumor development by suppressing the expression of HPV E6 and E7 oncogenes and upregulating P53 and Rb1 protein in cervical cancer. These findings demonstrated that RHSD was safe and potential for development of a new oral administration drug to treat cervical cancer.
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FERROELECTRICS
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2020
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IF 0.669
Jie Xing,Ming-Hong Wang,Song Wang,Hai-Lin Cong,You-Qing Shen,Bing Yu
In this paper, we report on a successful development and application of diazoresin (DR)/β-Cyclodextrin covalently linked capillary coatings using the layer by layer (LBL) self-assembly technique combined with photochemistry reactions. The modified capillary remarkably suppressed the protein adsorption on the inner surface of silica capillary and successfully separated lysozyme (Lys), myoglobin (Mb), bovine serum albumin (BSA) and ribonuclease A (RNase A). Furthermore, the DR/β-Cyclodextrin covalently linked capillary coatings showed good stability and repeatability. More importantly, this method is more environmentally friendly and simpler than traditional methods for the use of DR instead of highly toxic and moisture-sensitive silane coupling agent.
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TALANTA
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2020
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IF 5.339
Yinhui Yi,Wei Zeng,Gangbing Zhu
Through modifying molybdenum disulfide quantum dots (MoS 2 QDs) with 3-aminophenyl boronic acid and functionalizing further with hydropropyl-β-cyclodextrin (β-CD), a novel nanoprobe based on β-CD functionalized MoS 2 QDs (β-CD-MoS 2 QDs) was developed for the fluorescent detection of parathion-methyl (MP). β-CD-MoS 2 QDs was characterized with various technologies including transmission electron microscopy , X-ray photoelectron spectroscopy, fluorescence and UV–Vis absorption spectra. As for MP detection, MP was hydrolyzed to p-nitrophenol (p-NP) under the alkaline conditions, and p-NP can enter into the β-CD cavity due to the host-guest recognition capability of β-CD, which then results the fluorescence quenching of nanoprobe. Based on this principle, an enzyme-free fluorescence sensing platform were constructed for MP. Under the optimal conditions, β-CD-MoS 2 QDs nanoprobe exhibits wide detection scope (0.01–18.0 ppm) and low detection limits (3.3 ppb) for MP detection. In addition, the nanoprobe has excellent selectivity for MP, and it can be applied to detect MP in real samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Xiaoyi Qu,Bo Ding,Jing Li,Meng Liang,Liqin Du,Yutuo Wei,Ribo Huang,Hao Pang
A novel β-glucosidase gene was isolated from Pseudoalteromonas sp. GXQ-1 and heterologously expressed in Escherichia coli . The activity of the encoded enzyme, PABGL, toward p -nitrophenyl-β-D-glucopyranoside was increased 8.74-fold by the presence of 3 M NaCl relative to the absence of added NaCl. PABGL hydrolyzed a variety of soy isoflavone substrates. For the conversion of daidzin to daidzein, the production rate was 1.44 mM/h. The addition of NaCl enhanced the hydrolytic activity of PABGL toward daidzin and genistein; the maximum activation by NaCl was 3.48- and 6.79-fold, respectively. This is the first report of a halophilic β-glucosidase from Pseudoalteromonas spp., and represents the β-glucosidase with the highest multiple of activation by NaCl. PABGL exhibits strong potential for applications in food processing and industrial production.
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CARBOHYDRATE POLYMERS
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2020
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IF 7.182
Muhammad Usman,Adeel Ahmed,Bing Yu,Song Wang,Youqing Shen,Hailin Cong
Herein, a new adsorbent Nitrilotriacetic acid β-Cyclodextrin-Chitosan (NTA-β-CD-CS) was synthesized for the effective simultaneous removal of dyes and metals. In this process, the β-CD cavities captured Methylene blue (MB) by host/guest contacts, and the remaining functional groups were able to act as adsorption sites for metal ions and Methyl orange (MO). In the single process, the maximum adsorption capacities of NTA-β-CD-CS adsorbent toward the Hg (II) MB and MO were 178.3, 162.6, and 132.5 mg/g, respectively. Sips and Langmuir's model were appropriate to define the adsorption system and mechanism. Most prominently, the NTA-β-CD-CS adsorbent was highly effective in the simultaneous adsorption of metals and cationic dyes and remained consistent with the mono system. The adsorbent performance efficiency remained constant even after four cycles. Therefore, the advantages of non-toxic chemicals, excellent adsorption, and regeneration performance revealed that NTA-β-CD-CS possessed great potential to treat realistic and model wastewater from different industries.
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FOOD CHEMISTRY
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2020
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IF 6.306
Tenghe Zhang,Wencai Huang,Tingting Jia,Yuqiao Liu,Shun Yao
A new kind of multi-component membrane was prepared by combining gelatin solution, porogen and an inclusion complex of ionic liquid (IL) and beta-cyclodextrin (β-CD) in a simple physical manner for selective separation of tea polyphenols (TPs) from green tea crude extracts. After screening, it was found that the resulting membrane containing the IL of dicationic N -vinylimidazole proline salt ([VIm] 2 C 3 [ l - pro ] 2 ) had the excellent performance for the enrichment of the target molecules. Then the newly-developed film was comprehensively characterized by scanning electron microscopy, conductivity, thermogravimetry and spectral analysis. Under pressure driving, the adsorption from an aqueous solution of a mixture of TPs and theophylline on IL@β-CD-Gel membrane showed that the adsorption capacity for TPs was 303.45 mg/g with removal percentages of 94.38%. The experimental data fit well with pseudo-second-order model and Freundlich model. By using this composite material, a new technology of membrane separation for selective adsorption of TPs was finally established.
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Chemical Science
·
2020
·Vol. 11
·期 18
·4791-4800
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IF 9.346
Zhixue Liu,Weilei Zhou,Jingjing Li,Haoyang Zhang,Xianyin Dai,Yaohua Liu,Yu Liu
A unique fluorescent supramolecular assembly was constructed using coumarin-modified β-cyclodextrin as a reversible ratiometric probe and an adamantane-modified cyclic arginine–glycine–aspartate peptide as a cancer-targeting agent via host–guest inclusion complexation. Importantly, the coumarin-modified β-cyclodextrin not only showed higher sensitivity than the parent coumarin derivatives owing to the presence of numerous hydroxyl groups on the cyclodextrin but also provided a hydrophobic cavity for encapsulation of a cancer-targeting agent. The assembly showed a reversible and fast response to biothiols with a micromolar dissociation constant, as well as outstanding cancer cell permeability, which can be used for high-efficiency real-time monitoring of biothiols in cancer cells. This supramolecular assembly strategy endows the fluorescent probe with superior performance for dynamic sensing of biothiols.
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Catalysts
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2020
·Vol. 10
·期 4
·432
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IF 3.52
Li-Hua Du,Rui-Jie Long,Miao Xue,Ping-Feng Chen,Meng-Jie Yang,Xi-Ping Luo
A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM fromThermomyces lanuginosuswas first used to catalyze Michael addition reaction of aromatic amines. Compared with other methods, the salient features of this work include green reaction conditions (methanol as reaction medium), short residence time (30 min), readily available catalyst and a reaction process that is easy to control. This enzymatic synthesis of β-amino acid esters performed in continuous-flow microreactors is an innovation that provides a new strategy for the fast biotransformation of β-amino acid esters.Keywords:enzymatic synthesis;β-amino acid esters;microreactor;aromatic amines;Michael addition
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LANGMUIR
·
2020
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IF 3.557
Hongchao Yan,Yuan Qiu,Jing Wang,Qian Jiang,Hong Wang,Yonggui Liao,Xiaolin Xie
Much attention has been paid to construct photoresponsive host–guest supramolecular gels; however, red-shifting the responsive wavelength remains a formidable challenge. Here, a wholly visible-light-responsive supramolecular gel was fabricated through the host–guest interaction between a β-cyclodextrin (β-CD) dimer and a tetra-ortho-methoxy-substituted azobenzene (mAzo) dimer (binary gelator) in DMSO/H2O (V/V = 8/2). The minimum gelation concentration of the low-molecular-weight binary gelator was 6 wt % measured via the tube inversion method. The substituted methoxy groups shifted the responsive wavelengths of trans-mAzo and cis-mAzo to the green and blue light regions, respectively. The host–guest interaction between mAzo and β-CD as the driving force for gelation was confirmed using the 1H-NMR and 2D 1H NOESY spectra. The supramolecular gel showed good self-supporting ability with a storage modulus higher than 104 Pa. The release of Rhodamine B loaded in the gel as a model drug could be controlled by green light irradiation. We envisioned the potential applications of the wholly visible-light-responsive supramolecular compounds ranging from biomedical materials to smart materials.
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Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 22
·11442-11447
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IF 11.301
Qinglin Liu,Yinle Li,Yanan Fan,Cheng-Yong Su,Guangqin Li
Selective hydrogenation of α,β-unsaturated aldehydes to achieve high selectivity towards a desirable product is still a great challenge mainly because of the complex conjugate system. Herein, Rh nanoclusters encapsulated in MIL-101 (Cr), synthesized by the double solvent method, are able to selectively hydrogenate CC of cinnamaldehyde, an α,β-unsaturated aldehyde and achieve over 98% selectivity with a conversion of 98% to a saturated aldehyde under mild conditions. Fourier transform infrared spectroscopy confirms that MIL-101 acts as an aldehyde protector to suppress the reactivity of CO, and the X-ray photoelectron spectroscopy (XPS) data indicate that the electropositive Rh, owing to the electron transfer from Rh to MIL-101, preferentially absorbs CC rather than CO leading to improvement of the selectivity towards saturated aldehydes. In addition, Rh@MIL-101 can also efficiently catalyse hydrodefluorination of aryl fluorides with good stability. This work provides a basic strategy to develop other selective heterogeneous catalysts via structural modulation for synergetic catalysis.
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FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Mohamed Eid,Remah Sobhy,Peiyuan Zhou,Xianling Wei,Di Wu,Bin Li
Hydrogel nanocomposites (HGNCs), with a hydrophobic inner hollows structure and a hydrophilic exterior, is often used to encapsulate the broadest range of guest molecules. Herein, we established a three-dimensional, nanocomposites, superabsorbent, malleable, and bioadhesive HGNCs via chemical crosslinker poly (ethylene glycol) diglycidyl ether (PEGDGE) to enhance the controlled release and bioavailability of Vitamin E (VE). β-cyclodextrin (β-CD) are integrated as multi-core units in the soy soluble polysaccharide (SSPS) polymer network in which the β-CD cavities act as carriers for (VE) by host-guest interaction. We have examined the detailed structures and morphology by FTIR, DSC , XRD, SEM, TEM , AFM , and CLSM. Overall, increasing the β-CD than SSPS in the reaction mixture (from 10 to 25%) led to enhance the crosslinking degree, improve the elastic behavior (G′>G″), increase the particle size (from 114.2 to 202.9 nm), and the hardness. Besides, decreasing the adhesiveness, pore size, and swelling. Our (HGNCs) did not rupture under compression up to 90% strain with (1.8 MPa) strength. The nanocomposites (1:1) exhibited less nanosized after pectinase and α-amylase hydrolysis (75 and 124 nm, respectively). Also, the (HGNCs) exhibited outstanding swelling-adsorption and sustained release (over 230 h) towards VE in vitro. It showed high encapsulation efficiency and loading capacity (79.10 and 16.04%, respectively). Additionally, the oral administration of VE-loaded HGNCs in rats resulted in a sustained increase of plasma VE levels over 12 h post-administration. The relative pharmacological bioavailability of VE was larger for VE-loaded HGNCs (reached to 7.5-fold increase) compared to free VE suspension. Keywords : Nanohydrogel; β-cyclodextrin; Soy soluble polysaccharide; Vitamin E; swelling; control release.
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