INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Shimiao Wang,Siqi Liu,Jin Zhao,Jiaqi Chen,Shuang Ma,Lanzhou Li,Yu Li,Chunyue Wang,Di Wang
HCP ameliorates hyperlipidemia in HFD-induced mice, demonstrating its therapeutic potential for metabolic dysregulation. • HCP alleviates depression in HFD and CUMS models, supporting metabolic-neuroprotective effects. • First identification of 2-HG as a shared pathogenic mediator linking hyperlipidemia to depression, establishing it as a core target of HCP. • 2-HG drives the pathogenesis of depression by suppressing BDNF/TrkB/mTORC1 signaling, impairing synaptic function. • Targeting 2-HG offers a novel therapeutic strategy for developing more effective antidepressants against metabolic-related depression. Depression, a prevalent emotional disorder, frequently co-occurs with hyperlipidemia. This study investigated the therapeutic effects of Hericium coralloides polysaccharide (HCP) on comorbid hyperlipidemia and depression in mouse models subjected to a high-fat diet (HFD) and chronic unpredictable mild stress (CUMS). The results demonstrated that HFD and CUMS induced blood lipid abnormalities, depressive-like behaviors, increased levels of ( S )-2-hydroxyglutarate (2-HG), and hippocampal synaptic damage. Notably, 2-HG acted as a pathogenic hub: it inhibited the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/mechanistic target of rapamycin complex 1 (mTORC1) pathway and altered the expression of 5-HT receptors, glycine transporter 2 (GlyT2), and doublecortin-like kinase (Dclk1), thereby aggravating lipid dysregulation and depressive symptoms and reducing synapse numbers and dendritic spine density. HCP regulated the intestinal microbiota and brain metabolites, reducing the levels of Faecalibaculum rodentium , which showed a positive correlation with 2-HG. HCP also lowered blood lipid and 2-HG levels and enhanced synaptic function by activating the BDNF/TrkB/mTORC1 signaling pathway, thereby ameliorating both dyslipidemia and depressive-like behaviors. These findings identify 2-HG as a central mediator linking metabolic and neurological pathologies and show that HCP exerts its therapeutic effects mainly by targeting this novel pathogenic hub. Download: Download high-res image (236KB) Download: Download full-size image
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高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
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2026
·Vol. 96
·期 9
·283
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IF 1
Qing Yan,Chai Chunxiao,Li Kuan,Jiang Ye,Li Jingjing
MOF-based nanozymes are promising for colorimetric biosensing but are often limited by rigid coordination environments and poor active-site accessibility. Here, a 2-methylimidazole-regulated MIL-88B(Fe) nanozyme (2-MIM@MIL-88B) was prepared via an in situ coordination-competition strategy. Compared with pristine MIL-88B(Fe), 2-MIM@MIL-88B retained a spindle-like morphology but showed reduced crystallinity, nitrogen-containing species, pore-texture reorganization, and local Fe-site electronic modulation with increased defect-related centers. These changes correlated with enhanced peroxidase-like activity in the TMB-H 2 O 2 system, despite a reduced BET surface area. In a glucose oxidase-coupled colorimetric assay, 2-MIM@MIL-88B enabled glucose detection over 0.015–0.5 mM with a detection limit of 1.7 µM.
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ADVANCED MATERIALS
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2026
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IF 29.1
Zhihao Sun,Lin Liu,Junwei Zhang,Yuhang Liu,Yifeng Wang,Ying Wan,Fanxing Bu,Bao Zhang,Wanhai Zhou,Dongyuan Zhao,Dongliang Chao
Unlike neutral aqueous batteries with cationic Zn 2+ as the charge carrier, alkaline batteries with anionic [Zn(OH) 4 ] 2‒ and OH ‒ are actually commercially feasible and thermodynamically stable thanks to their ability to suppress hydrogen evolution. Whereas commercial separators in alkaline batteries, without ion regulation capability, fail to suppress severe dendrite and passivation of anionic [Zn(OH) 4 ] 2‒ and accelerate ion transport of anionic OH ‒ . Herein, we tailor the coordination structures of alkali-stable cationic complexes in polymer separators (CCPS) to construct anionic OH ‒ selective transfer channels. Synchrotron spectroscopic characterizations and theoretical calculations reveal that the low-coordination cationic complexes expose more positive charge density, electrostatically attracting more negative charge from [Zn(OH) 4 ] 2‒ . In situ electrochemical digital holography technology and time-of-flight secondary ion mass spectrometry analyses further confirm the homogeneous [Zn(OH) 4 ] 2‒ distribution at the CCPS-electrode interface, oriented Zn deposition, and impeded passivation. As a result, CCPS enables alkaline Zn||Cu cells to operate over 5500 cycles at 1 mA cm ‒2 with a high coulombic efficiency of 99.99%. Alkaline Ni–Zn batteries exhibit ultrastable cycling over 1000 cycles at 6 C and maintain 86.17% of their maximum capacity at 10 C. Our work may provide practical and effective separator strategies to accelerate the commercialization of alkaline batteries.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2026
·Vol. 47
·期 1
·118759
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IF 6.3
Mingfei Cheng,Yiyang Cai,Changzhi Yin,Xiaoqiang Song,Jiaqing Yang,Weicheng Lei,Zihang Chen,Yaqing Hu,Yaodong Liu,Xiaoxiao Li,Wenzhong Lu,Wen Lei
The poor sinterability and intrinsically positive τ f of BaZr(PO 4 ) 2 ceramics were addressed by introducing ZnO as a sintering aid and property modifier. In a conventional solid-state reaction route, ZnO promoted liquid-phase sintering through the in situ formation of BaZn 2 (PO 4 ) 2 , enabling near-full densification (>99% relative density) at 1250 °C. The ZnO content strongly affected phase evolution, microstructure, and microwave dielectric properties. The Q × f value reached a maximum at ∼4 wt% ZnO and then decreased because of losses associated with the secondary phase and increased grain-boundary density. Notably, τ f could be systematically tuned from positive to negative values through compensation by the negative- τ f BaZn 2 (PO 4 ) 2 phase. The optimized composition (4 wt% ZnO) exhibited ε r ≈ 10.1, Q × f ≈ 36,300 GHz, and τ f ≈ +0.4 ppm/°C. These results identify a promising microwave dielectric material that can be densified at a lower temperature and establish a practical strategy for tailoring τ f in phosphate ceramics through controlled secondary-phase formation.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Qingbo Zhang,Zhenxuan Ma,Jiaguang Zheng,Ao Xia,Cong Li,Panpan Zhou
This study presents the synthesis of novel Mg(BH 4 ) 2 @V 2 C, Mg(BH 4 ) 2 @Nb 2 C and Mg(BH 4 ) 2 @Ti 3 C 2 composites using a solution-based nanoconfinement strategy, achieving robust architecture of Mg(BH 4 ) 2 onto Mxene structures. Among these composites, the Mg(BH 4 ) 2 @V 2 C composite exhibited an initial dehydrogenation temperature of 76.4 °C and released 9 wt% hydrogen at 300 °C, which exhibited the optimal hydrogen release behavior. Its two-step dehydrogenation activation energies (104.44 kJ/mol and 118.52 kJ/mol) were significantly lower than those of pure Mg(BH 4 ) 2 , showing improved dehydrogenation kinetics. After four absorption-desorption cycles, the composite could still desorb 4.9 wt% hydrogen, demonstrating excellent cycling stability. Further structural investigations revealed that V 2 C actually acted as a “functionalized” matrix, which improved hydrogen storage through a combination of nanoconfinement and catalytic effects, promoting both hydrogen desorption and absorption. This work provides critical insights for designing high-performance hydrogen storage materials and advances the development of next-generation storage systems.
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BIOORGANIC CHEMISTRY
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2026
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IF 5.1
Ao Yu,Yunlong Li,Yimei Wang,Jian He,Yong Zhou,Huiming Cai,Yiqing Wang,Bo Dai,Yi Shen
Intraoperative fluorescence-guided imaging has transformed oncological surgery, yet clinically approved probes lack specificity for primary tumors and metastatic lymph nodes. Herein, we developed NY-IND, a near-infrared fluorescent (NIRF) probe targeting cyclooxygenase-2 (COX-2). NY-IND not only has high water solubility, but also boasts higher fluorescence quantum yield and excellent biosafety. NY-IND exhibited high binding affinity for the COX-2 target with a dissociation constant (Kd) of 99.69 nM, thereby endowing it with the capacity to specifically recognize COX-2-overexpressing tumor cells and tissues. Significant tumor-to-background ratio (TBR > 6) was still observed 48 h after injection, allowing for clear differentiation between subcutaneous tumors and surrounding tissues. Furthermore, the probe NY-IND exhibited a long tumor retention time (>72 h) in vivo metabolism and provided a longer imaging window for fluorescence-guided tumor surgery. NY-IND showed significantly superior specificity in detecting metastatic tumor lesions including peritoneal metastasis of lung cancer and lymph node metastasis. This work presents a promising tool for real-time intraoperative visualization of tumors and metastases, advancing surgical precision and improving patient prognosis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2026
·Vol. 37
·期 1
·32
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IF 4.5
Yuanzheng Wang,Qilin Jiang,Xin Huang,Shaohong Wu,Jinlong Li,Jian Cao,Zhongxing Liu
The development of bone repair scaffolds has long been a research hotspot in tissue engineering. Owing to its unique capability for personalized customization of scaffold geometry and microstructure, 3D printing technology has been extensively adopted for fabricating bone repair scaffolds. Poly-L-lactic acid (PLLA), endowed with favorable biodegradability, excellent biocompatibility, and reliable in vivo safety, is widely used as a matrix material for 3D printed bone repair scaffolds. PLLA is a bioinert polymer characterized by inferior cell adhesion and osteogenic differentiation capabilities. To mitigate this bioinertness limitation, the present study employed N-methylpyrrolidone (NMP) etching to modify the surface of 3D-printed PLLA bone repair scaffolds. Following NMP etching for 1–24 h, the originally smooth scaffold surface evolved into a hierarchical, petal-like gradient microstructure, accompanied by a marked increase in surface roughness. Correspondingly, the hydrophilicity of the treated scaffolds was also enhanced. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses further confirmed that the crystallinity of PLLA in the scaffolds was significantly enhanced. Concomitantly, the modified scaffolds exhibited a marked improvement in adsorption capacity for green fluorescent protein (GFP), while the adhesion and proliferation of MC3T3-E1 on their surface were also significantly promoted. In vivo animal experiments demonstrated that the NMP-etched scaffolds could accelerate the process of bone defect repair. Collectively, surface modification of 3D-printed PLLA bone scaffolds via NMP etching enables precise modulation of their physicochemical properties, thereby effectively mitigating the inherent bioinertness limitation of PLLA scaffolds. Graphical
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Fan Xu,Yizheng Lv,Longhao Yang,Like Fan,Zhiyi Zhang,Dawei Ni,Wenli Zhang,Junmei Ding,Wanmeng Mu
Thermodynamically driven biosynthesis of D-tagatose attracts increasing attention because it overcomes the reaction equilibrium caused by aldose isomerization or ketose epimerization. Specific aldose reductase and D-galactitol 2-dehydrogenase may drive the conversion of D-galactose to D-tagatose through galactitol as the intermediate. In this study, a novel D-galactitol 2-dehydrogenase was identified from a Rhizobiaceae bacterium with the NCBI accession No. of MDF1774848. The enzyme was expressed in His-tagged form and purified by one-step nickel-affinity chromatography. The recombinant enzyme showed the highest activity at pH 9.5 and 30 °C. It showed galactitol as the optimal substrate and D-sorbitol as the second substate. It's in vivo D-tagatose production ability was verified in a metabolically engineered Escherichia coli strain. Using a previously constructed galactitol-producing strain as a chassis microbe, genomic integration of this D-galactitol 2-dehydrogenase gene resulted in the efficient production of D-tagatose with a titer of 1.85 g/L.
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JOURNAL OF CHEMICAL RESEARCH
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2020
·
IF 0.593
Da-Hua Shi,Meng-qiu Song,Xiao-Dong Ma,Jia-Bin Su,Jing Wang,Xiu-Jun Wang,Yu-Wei Liu,Wei-Wei Liu,Xin-Xin Si
Four 2-phenylthiazole derivatives are synthesized, characterized, and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives are confirmed by 1H and 13C nuclear magnetic resonance spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces analysis. Hirshfeld surface analysis of the prepared compounds showed C–H···O intermolecular interactions. The cholinesterase inhibition activities of the synthesized compounds are tested by Ellman’s method. [2-(4-Benzyloxyphenyl)-thiazol-4-yl]-(3,5-dimethylpiperidin-1-yl)-methanone showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86 µM and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03 µM. A docking study demonstrates that the same compound interacts with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase.
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高影响因子
CHEMICAL PHYSICS
·
2026
·
IF 2.4
Huifang Xu,Song Lu,Jingya Zhang,Sijia Wang,Chenyu Zhao,Bin Liu,Yuanyuan Li
Recently, we have reported the vesicle formation and vesicle-to-micelle transition (VMT) of sodium 2-ketooctanoate, a single-tailed keto-acid salt, in water with increasing concentration. Herein, we demonstrate that, upon prolonged standing at the vesicle-forming concentration, macroscopic fibrous structures spontaneously formed. Cryogenic transmission electron microscopy, atomic force microscopy, and laser scanning confocal microscopy revealed the microscopic pathway: vesicles aggregated and evolved through elongated intermediate structures (threadlike vesicles and chains of vesicles) into long strips, which ultimately assembled into floating fibers. As concentration was increased around the critical micelle concentration (CMC), these fibers transformed into bundles of nanofibers and threadlike micelles, and finally evolved to globular micelles above the CMC. The observed multi-step aggregation behavior is driven by the dynamic coexistence and rearrangement of multiple species, notably “acid-soap” dimers. This constitutes the first report detailing the microscopic transition pathway from fibrous structures to micelles for a single-tailed keto-acid salt amphiphile in water.
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高影响因子
SOLID STATE SCIENCES
·
2016
·
IF 2.041
Long Shi,Dajiang Mei,Jingli Xu,Yuandong Wu
Three new bismuth-based compounds, Bi 2 O(XO 4 )(IO 3 ) 2 (X = S, Se, Cr) have been synthesized by hydrothermal method and characterized by single-crystal X-ray diffraction. Title compounds crystallize in the monoclinic space group P 2 1 /n (No.14) with lattice parameters: a = 7.2391(5), b = 17.9074(12), c = 7.7964(5) Å, β = 109.6521(15) °, Z = 4 for Bi 2 O(SO 4 )(IO 3 ) 2 ; a = 7.2665(4), b = 18.0115(10), c = 7.9310(5) Å, β = 109.7480(10) °, Z = 4 for Bi 2 O(SeO 4 )(IO 3 ) 2 ; and a = 7.2708(6), b = 17.9967(14), c = 7.8998(6) Å, β = 109.799(2) °, Z = 4 for Bi 2 O(CrO 4 )(IO 3 ) 2 , respectively. All compounds exhibit three-dimensional frameworks that are composed of [Bi 4 O 2 ] 8+ clusters, [IO 3 ] − and [XO 4 ] 2− (X = S, Se, Cr) groups. Bi atoms occur in two different coordination types, showing the stereochemical influence of the Bi 3+ lone electron pair. Title compounds were characterized by infrared spectra, solid state UV–vis–NIR diffuse reflectance spectroscopy and thermogravimetric analysis.
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JOURNAL OF MOLECULAR STRUCTURE
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2013
·
IF 1.404
Xue Chen,Yongjun Hu,Jiao Gao
2-Aminothiazole, as a typical heterocyclic amine, may exist amino-imino tautomeric equilibrium in nature. In present report, the optimized structural parameters and vibrational wavenumbers of amino and imino tautomers of the molecule have been predicted by density functional theoretical (DFT) calculation. Comparing the experimental and the calculated Raman spectra, it indicates that the amino tautomer would be the main configuration in the 2-aminothiazole saturated solution. In the concentration-dependent SERS spectra of 2-aminothiazole adsorbed on gold nanoparticles , it is found that the tautomeric equilibrium shifts toward to the amino tautomer when the concentrations is decreased. While the amino tautomer is end-on the surface through the nitrogen atom of thiazole ring at the higher concentrations, the molecule becomes to stand on the metal surface by interacting simultaneously with two nitrogen atoms of the molecule in the diluted solution.
研究领域:
物理化学
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光谱学
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理论化学
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纳米材料
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分析化学
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危险品化学品经营许可证（带存储）