ACS Applied Nano Materials
·
2024
·
IF 5.3
Qingqing Liu,Xin Deng,Lihua Zhu,Ping Huang,Weizhen Wang,Liqing Li,Zhiqing Yang,Huan Zhang,Junyuan Xu,Hengqiang Ye
To obtain a recyclable and environmentally friendly solid catalyst with excellent catalytic properties and selectivity for 4-nitrophenol (4-NP) hydrogenation, herein, covalent organic frameworks (COFs) are used as the support. Tiny PdCo alloy particles are confined in the pores of the COFs to acquire PdCo/COFs, with an extremely narrow PtCo size distribution (6.28 ± 2.85 nm). The effect of Pd+Co loading and the Pd/Co atomic ratio on the catalytic behaviors of PdCo/COFs for 4-NP hydrogenation is explored. The as-gained PdCo/COFs catalyst (Pd─1.72, Co─1.23 wt %) exhibits good catalytic behaviors (conversion─90.5%, selectivity to 4-aminophenol (4-AP) > 99.0%, and conversion─11.0%, selectivity to 4-aminophenol (4-AP) > 99.0%, TOF─turnover frequency─44.2 min–1) for 4-NP hydrogenation under quite moderate reaction conditions (40 °C, 3.0 MPa hydrogen pressure), and PdCo/COFs have superior stability. Additionally, the catalytic property of PdCo/COFs is better than that of monometallic supported catalysts (Pd/COFs or Co/COFs) and PdNi/COFs. It can be considered that the formation of the PdCo alloy particles is beneficial to the activation of 4-NP. The PdCo/COFs catalysts are analyzed by XRD, XPS, ICP-OES, SEM-EDX, BET, TEM, HRTEM, STEM-EDX elemental analysis, and aberration-corrected STEM (AC-STEM), confirming that tiny PdCo alloy particles are uniformly loaded on the COFs. The PdCo/COFs samples have the advantages of outstanding stability and thus their own desired industrial application potential.
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高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Feng Jia,Yongqing Wang,Zhiqiang Chen,Jingxian Jin,Lei Zeng,Li Zhang,Huaijian Tang,Yanyan Wang,Pei Fan
Background 10-Hydroxydec-2-enoic acid (10-HDA), a unique and marker compound in royal jelly, has a wide range of bio-activities. However, its role in regulating inflammation of vascular smooth muscle cell (VSMC), which is essential to a set of vascular diseases, is still unknown. Purpose Our study aimed to investigate whether 10-HDA exerts effect on VSMC inflammation via interacting with toll-like receptor 4 (TLR4), a pivotal inflammatory initiator. Methods A package of proteins, which might participate in TLR4-mediated signaling, influenced by 10-HDA were analyzed in mouse VSMCs with Angiotensin Ⅱ(Ang Ⅱ) or lipopolysaccharide (LPS) stimulation. Accordingly, pro- or anti-inflammatory cytokines, reactive oxygen species (ROS), and anti-oxidants that are closely relevant to inflammatory process were determined. The possible mode for 10-HDA interacting with TLR4 was also characterized. Moreover, involvement of a key miRNA in 10-HDA regulating VSMC inflammation was identified. Results In the presence of Ang Ⅱ, 10-HDA inhibited the TLR4 expression in a dose-dependent manner. In such occasion, 10-HDA hindered the up-regulation of specificity protein 1 (SP1) and serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C), the phosphorylation of extracellular signal-regulated kinase 1/2, TGF-β-activated kinase 1, and nuclear factor-κB p56, as well as the enhancement of myeloid differentiation primary response gene 88. Apart from SP1 and PPP6C, the level change of these proteins by 10-HDA was similar with LPS stimulation. The effect might be resulted from 10-HDA blocking TLR4 through multiple atomic interactions. 10-HDA mitigated the increase of pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-2 (IL-2), and IL-6, as well as increased the anti-inflammatory cytokine IL-10, in the Ang Ⅱ- or LPS-induced VSMCs. Correspondingly, the level of ROS was attenuated and the anti-oxidants such as glutathione and superoxide dismutase were fortified. The data indicated the anti-inflammatory potential of 10-HDA in VSMCs, which was associated with 10-HDA's capability of relieving oxidative stress. Additionally, the expression of miR-17–5p was saved by 10-HDA from Ang Ⅱ- or LPS-treated VSMCs, which might be relevant to SP1 and PPP6C targeting. Conclusion The present work of 10-HDA, for the first time, revealed its ability to alleviate VSMC inflammation by targeting TLR4 and therefore modulate the downstream inflammatory participants. Our data will cast light on the utilization of 10-HDA in VSMC inflammation-related vascular disorders.
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高影响因子
Processes
·
2025
·Vol. 13
·期 1
·232
·
IF 2.8
Jiulong Che,Jian Zhang,Qing Lang,Jiayuan Yu,Yixiao Yang,Longqi Luo,Zhiyi Liu,Jiahui Ye,Gang Wang
Dual-ion batteries (DIBs) were demonstrated as a promising technology for large-scale energy storage due to their low cost, recyclability, and impressively fast charge capability. Graphite as a commonly used cathode material in DIBs, however, suffers from poor compatibility with commercial Li-ion electrolytes and graphite anodes, making it difficult to directly utilize the well-established infrastructure for Li-ion batteries. Herein, we report a small aromatic amine molecule 4,4′,4″-tris(diphenylamino)triphenylamine (N4) functioning as a compatible anion host in the EC-containing Li-ion electrolyte. With an average discharge voltage of 3.6 V (vs. Li+/Li), the N4 electrode delivers a reversible specific capacity of 108 mAh/g, which is much higher than 29 mAh/g for the graphite cathode at the same condition. The high capacity retention of 91.3% was achieved after 500 cycles at 1 A/g. The N4 electrode also exhibited good rate performance. Via different characterization techniques like Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, the energy storage mechanism of N4 was revealed as a conversion between amine and quaternary amine cations, accompanied by PF6−(de-)insertion. As consequences, the assembled N4||graphite DIB w showed a high discharge capacity of 90 mAh/g within 1.5–4.1 V, and good cycling stability with a 98% capacity retention after 40 cycles. Decent rate performance was achieved in the N4||graphite DIB as well. This work provides new insights into designing a compatible anion host for affordable DIBs.
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SOLID STATE SCIENCES
·
2024
·
IF 3.4
Dong Yanping,Xiqiang Tian,Hongji Zhao,Jintao Luo
The fabrication of small Pd nanoparticles (NPs) anchored on titanium dioxide (TiO 2 ) supports remains a great challenge due to its high surface energy. Herein, flower-like three dimensional (3D) TiO 2 microstructures assembled from needle flakes are fabricated thru a facile evaporation-induced assisted hydrothermal method, and then modified with amines group (3D-TiO 2 -NH 2 ). Small and uniform dispersed Pd nanoparticles were anchored on the surface of 3D-TiO 2 -NH 2 supports using polyol reduction method. Remarkably, the obtained 3D-TiO 2 -NH 2 supported Pd-based catalyst (Pd@3D-TiO 2 -NH 2 ) demonstrated an optimal 4-NP catalytic hydrogenation efficiency ( k = 1.09 min −1 ), which is 1.56 and 3.52 times superior than that of the Pd@3D-TiO 2 ( k = 0.699 min −1 ) and Pd@TiO 2 –P25 ( k = 0.31 min −1 ) catalysts, respectively. In-depth investigation of the structure-property relationship by SEM, XRD, N 2 adsorption-desorption isotherm, TEM, XPS, CO chemisorption and CO-FTIR reveal that the optimal catalytic hydrogenation activity of Pd@3D-TiO 2 -NH 2 can be credited to its 3D hierarchical structure (interconnected needle flakes) and the amines group existing on the surface of flower-like three dimensional hierarchical TiO 2 , which control the Pd particles size (2.7 nm) and uniform dispersion (43.5%) to generate more surface active Pd 0 entities over Pd@3D-TiO 2 -NH 2 .
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CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 96
·期 3
·679-687
·
IF 1.356
Zhongrui Liang,Lichao He,Wenchao Wang,Zhiyong Zhou,Zhongqi Ren
Tuberculosis is a serious bacterial infection in developing countries, especially in areas with drug resistance. The development of the anti-tuberculosis drug ethionamide (ETA) is therefore particularly important. We have designed a new route for ETA synthesis and considered the drug's amenability to large-scale manufacture. We evaluated different routes for the synthesis of ETA and selected the most suitable process for the industrial production of this material, which involved the Minisci reaction of 4-cyanopyridine with propionic acid using a AgNO 3 /(NH 4 ) 2 S 2 O 8 catalyst system under acidic conditions. The effects of different parameters on the reaction were studied, and the production of the intermediate of 2-ethyl-4-cyanopyridine was twice recrystallized from methanol to obtain pure ETA. In the Minisci reaction, the system was stirred for an additional 20 min at 80 °C after the addition of ammonium persulphate solution. The subsequent formation of thioamide was conducted at 40 °C to 60 °C for 1.5 h with a 1:5:2 molar ratio of 4-cyanopyridine, propionic acid, and ammonium sulphide. The purity of the crude ETA reached 98.77 % after two recrystallization steps. This process could be scaled up on a much larger scale (1 kg), leading to the yield of alkylation reaction and overall yield of the production process as 44.06 % and 31.26 %, respectively.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Weidong Li,Haichao Li,Lin Luo,Sen Ma,Renjie Huang,Zheng Li,Lu Lin,Xianhai Zeng
The precise fractionation of hemicellulose from lignocellulosic biomass remains a challenging task, complicated by the incorporation of lignin into the reaction liquor due to cleavage of β O 4 bonds, especially via a green strategy. The bifunctional 4-hydroxybenzoic acid (4-HA), a renewable plant phenolic acid, achieved selective and efficient separation of bamboo hemicellulose. Compared to conventional p-toluenesulfonic acid (p-TsOH) treatment, the separation yield of hemicellulose via 4-HA was up to 93.83 % while retaining ∼98 % of cellulose and ∼91 % of lignin in residual bamboo. The nucleophilic reaction of phenolic hydroxyls stabilized β O 4 bonds and prevented lignin degradation, ensuring that carboxyl groups in 4-HA selectively cleaved glycosidic bonds. That was proven by more β O 4 bonds (25.56/ 100 C 9 ), aliphatic hydroxyl groups (1.53 mmol·g −1 ), and fewer condensed structures in resultant bamboo lignin. This study provided a novel green strategy for the highly- selective and efficient separation of hemicellulose from lignocellulosic biomass preserving lignin structural integrity.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-14
·
IF 5.3
Xiong Lihao,Tong Yuqi,Song Jiayi,Chen Sihan,Liu Yu,Liu Jinquan,Li Le,Zhen Deshuai
A novel fluorescence/colorimetric dual-mode detection strategy for uranium ions (UO 2 2+ ) is presented based on a cerium-sulfonyl calix[4]arene (SC4A) platform. The exo- and endo-rim sites of SC4A can coordinate with Ce 3+ and Ce 4+ ions, respectively, quenching Ce 3+ fluorescence and influencing the oxidase-like activity of Ce 4+ . In the absence of UO 2 2+ , the solution of 3,3,5,5-tetramethylbenzidine (TMB) remains blue, but upon UO 2 2+ binding, Ce 3+ dissociates from SC4A, restoring fluorescence, while UO 2 2+ interacts with oxTMB, turning the solution from blue to colorless. This dual-mode system provides a linear fluorescence detection range of 30–800 nM with a detection limit of 20.20 nM, and a colorimetric range of 30–800 nM with a detection limit of 27.78 nM. By combining high-sensitivity fluorescence with visual colorimetric analysis, the proposed method possesses high sensitivity, accuracy, and reliability. Notably, smartphone-based color capture facilitates rapid and convenient sample analysis, enabling straightforward quantification at varying UO 2 2+ concentrations. The method has been successfully applied to real water and urine samples, demonstrating its practical utility in environmental and biological monitoring of UO 2 2+ . Graphical abstract
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Small Methods
·
2024
·
IF 10.7
Yue Jian,Litao Han,Xiangrui Kong,Tianliang Xie,Dongxing Kou,Wenhui Zhou,Zhengji Zhou,Shengjie Yuan,Yuena Meng,Yafang Qi,Guangxing Liang,Xianghua Zhang,Zhi Zheng,Sixin Wu
High-crystalline-quality absorbers with fewer defects are crucial for further improvement of open-circuit voltage ( V OC ) and efficiency of Cu 2 ZnSn(S,Se) 4 (CZTSSe) solar cells. However, the preparation of high-quality CZTSSe absorbers remains challenging due to the uncontrollability of the selenization reaction and the complexity of the required selenization environment for film growth. Herein, a novel segmented control strategy for the selenization environment, specifically targeting the evaporation area of Se, to regulate the selenization reactions and improve the absorber quality is proposed. The large evaporation area of Se in the initial stage of the selenization provides a great evaporation and diffusion flux for Se, which facilitates rapid phase transition reactions and enables the attainment of a single-layer thin film. The reduced evaporation area of Se in the later stage creates a soft-selenization environment for grain growth, effectively suppressing the loss of Sn and promoting element homogenization. Consequently, the mitigation of Sn-related deep-level defects on the surface and in the bulk induced by element imbalance is simultaneously achieved. This leads to a significant improvement in nonradiative recombination suppression and carrier collection enhancement, thereby enhancing the V OC . As a result, the CZTSSe device delivers an impressive efficiency of 13.77% with a low V OC deficit.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Junlei Zheng,Haifeng Gao,Chengcheng Jin,Miaomiao Tian
A novel solid phase extraction (SPE) adsorbent, polyethylene glycol (PEG) immobilized zirconium ion-modified zeolite-imidazole framework (ZIF) molecular-imprinted polymer (ZIF@PEG@Zr@MIPs), was developed for detecting hippuric acid (HA) and 4-methylhippuric acid (4-MHA) in human urine using HPLC-UV. Zirconium ions (Zr 4+ ) anchored on the porous ZIF act as binding sites, facilitating coordination and electrostatic interaction with HA and 4-MHA carboxyl groups. Dopamine (DA) imprinting introduces additional sites, enabling π-π conjugation and hydrogen bonding with HA and 4-MHA, enhancing specific adsorption. The adsorbent, using HA as a template, demonstrated adsorption capacities of 37.98 mg g −1 for HA and 32.99 mg g −1 for 4-MHA. Imprinted factors ( IF ) were 2.68 for HA and 2.17 for 4-MHA, with a limit of detection (LOD) of 0.015 mg L −1 for HA and 0.011 mg L −1 for 4-MHA. The SPE-HPLC-UV method achieved 84.8–96.2% recovery and 0.3–2.2% relative standard deviation (RSD), illustrating its potential in health monitoring and environmental safety.
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INORGANICA CHIMICA ACTA
·
2024
·
IF 2.7
Zhengwei Wu,Jiawen Bao,Hongyang Zhang,Wanlin Wei,Boyang Zheng,Yingying Luo,Zhonglu You
Molecular nanoclusters comprising a heterometallic 3 d -4 f stoichiometry are an interesting class of compounds. In this paper, a chloro-containing Schiff base 4-chloro-2-(2-hydroxy-3-ethoxybenzylideneamino)phenol (H 2 L) was prepared by condensation reaction of 3-ethoxysalicylaldehyde with 2-amino-4-chlorophenol in methanol. The Schiff base is predisposed to chelate within a cluster core both 3 d and 4 f metal ions. Reaction of H 2 L with nickel salts afforded a tetranuclear Ni II complex [Ni 4 L 4 (MeOH) 4 ] ( 1 ), while with nickel salts and lanthanide(III) nitrate three tetranuclear Ni II -Ln III complexes [Ni 2 Eu 2 L 4 (NO 3 ) 2 (DMF) 2 ] ( 2 ), [Ni 2 Er 2 L 4 (NO 3 ) 2 (DMF) 2 ] ( 3 ), [Ni 2 Tb 2 L 4 (CH 3 COO) 2 (DMF) 2 ]·4DMF ( 4 ) were obtained. H 2 L and the complexes have been characterized by elemental analysis, IR, UV–Vis spectra. H 2 L has also been characterized by 1 H and 13 C NMR spectra. Molecular structures of the compounds have been determined by single crystal X-ray determination. In the complexes, the Schiff base ligands coordinate to the metal atoms via ether oxygen, imino nitrogen and two phenolate oxygen atoms. All the Ni atoms in the complexes are in octahedral coordination. The rare earth metal atoms are eight coordinated by the phenolate and ether oxygen of the Schiff base ligands, and anionic and solvent oxygen atoms, forming square antiprismatic coordination. The compounds were evaluated for their antibacterial activities on Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Pseudomonas fluorescens , and antifungal activities on Candida albicans and Aspergillus niger , and gave interesting results.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Cong Zhang,Yangkun Xiong,Mingyang Gong,Haixia Zhao,Shan Li,Xin Chen,Xiaochuan Ye,Zhenpeng Qiu
Hyperuricemic nephropathy, a common subtype of chronic kidney disease (CKD), has become an important global public health issue and is closely related to the dramatic increase in fructose consumption. Pachymic acid, the primary active ingredient of the edible fungal herb Poria cocos, has demonstrated the protective capacity against renal injury, but its beneficial effect on hyperuricemic nephropathy remains unclear. In this study, a fructose-diet-induced hyperuricemia nephropathy mouse model was established to reveal the efficacy of pachymic acid in inhibiting hyperuricemic nephropathy the progression. Our results showed that pachymic acid restored abnormal renal function indexes and pathological manifestations such as tubular dilatation and glomerular fibrosis in fructose-fed mice. Transcriptome sequencing results showed marked alterations in glutathione metabolism and ferroptosis signaling pathways in the kidneys of fructose-fed mice after pachymic acid treatment. Mechanistically, pachymic acid activated the Nrf2/GPX-4 signaling pathway by directly binding to Nrf2 and promoting its nuclear translocation, thereby inhibiting ferroptosis, oxidative stress, and inflammatory responses in the kidneys of fructose-fed mice. Consistent results were observed in uric acid-treated HK-2 cells. Notably, both Nrf2 inhibitor ML385 and GPX-4 inhibitor RSL3 treatments reversed the protective effects of pachymic acid against renal injury by suppressing ferroptosis in vitro and in vivo. Summary, our study provides compelling evidence that pachymic acid ameliorates renal injury in fructose-fed mice by inhibiting ferroptosis through targeted activating an Nrf2/GPX-4 pathway, suggesting that dietary supplementation with Poria cocos or pachymic acid might be an effective strategy for CKD prevention, particularly in the subtype of fructose-diet-driven hyperuricemic nephropathy.
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高影响因子
Chemical Biology & Drug Design
·
2025
·Vol. 106
·期 1
·e70158
·
IF 3.3
Yong Zhu,Chuanmin Yi,Jin Zhao,Lei Wang,Tao Huang,Bo Xiang,Lvhai Zhang,Xiangfang He,Linke Wu
Platinum-based and pyrimidine drugs are first-line treatments for gastric cancer (GC), but their efficacy is often affected by drug resistance. High spalt-like transcription factor 4 (SALL4) expression is associated with poor prognosis, but its role in 5-fluorouracil (5-FU) resistance is not yet clear. In this study, we investigated the effect of SALL4 on 5-FU resistance in GC cells by bioinformatics analysis, real-time quantitative reverse transcription polymerase chain reaction, cell counting kit-8, colony formation assay, and western blot. The results showed that SALL4 was highly expressed in GC and significantly correlated with the fatty acid oxidation (FAO) pathway. Knockdown of SALL4 resulted in a notable attenuation of cellular proliferative capacity and heightened susceptibility to 5-FU resistance in GC cells, while overexpression of SALL4 enhanced 5-FU resistance. Rescue assays confirmed that SALL4 fostered 5-FU resistance in GC cells by enhancing FAO. Our research confirmed that SALL4 promoted the resistance of GC cells to 5-FU by enhancing the FAO pathway. This suggests that drug development targeting SALL4 may help overcome chemotherapy resistance in GC.
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