JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2018
·Vol. 29
·期 9
·1-9
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IF 2.448
He Meng,Chen Xiaoyi,Cheng Kui,Dong Lingqing,Weng Wenjian,Wang Huiming
Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO 2 nanorod film incorporated with Zn-containing bioactive glass (TiO 2 /Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO 2 /Zn-BG film were significantly upregulated compared to that of the film without TiO 2 nanorod nanostructure (Zn-BG) or without Zn (TiO 2 /BG). Moreover, a much low Zn 2+ release level on TiO 2 /Zn-BG film was beneficial to promote the osteogenesis, which could be ascribed to that a semi-closed space established by TiO 2 nanorods with adhered cells provided an appropriate micro-environment that facilitated Zn 2+ adsorption.
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JOURNAL OF FLUORESCENCE
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2024
·
IF 2.6
Wang Xuefeng,Mejia Esteban,Zuo Yujing,Lv Zhiyan,Wang Zonghua
The development of fluorescent probes for H 2 S detection especially in living cells is of great significance due to its fundamental role as signal molecule. A promising scaffold for the development of such probes is polydimethylsiloxanes (PDMS), which is cost-effectiveness, non-toxicity, flexibility, and biocompatibility and easy to post-functionalize. Surprisingly, fluorescent probes for H 2 S detection based on PDMS have not been investigated. Moreover, 4-nitro − 2,1,3-benzoxadiazole (NBD) derivates provides high fluorescence quantum yield, a large molar absorption coefficient, and sensitivity to environmental changes. Through reasonable design and adjustment of substituents on the NBD group, precise control of its fluorescence properties can be achieved. Herein, a novel H 2 S fluorescent probe, P-NBD, was designed and synthesized by a one-step aromatic ring nucleophilic substitution of Cl-NBD with a PDMS derivative. Due to the occurrence of the cleavage reaction strategy and the intramolecular charge transfer process, P-NBD can detect H 2 S via a colorimetric method. The limit of detection is down to 93 nM. P-NBD demonstrated considerable detection capability comparable to other reported types of H 2 S probes. Moreover, the probe can also be utilized for H 2 S imaging in HeLa cells. This work provides new insights into the design and synthesis of novel H 2 S probes while also offering experimental evidence for the application of PDMS in cellular imaging.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
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IF 14.7
Xu Yueshan,Wu Daoxiong,Zhang Qinghua,Rao Peng,Deng Peilin,Tang Mangen,Li Jing,Hua Yingjie,Wang Chongtai,Zhong Shengkui,Jia Chunman,Liu Zhongxin,Shen Yijun,Gu Lin,Tian Xinlong,Liu Quanbing
The direct oxidation of methane to methanol under mild conditions is challenging owing to its inadequate activity and low selectivity. A key objective is improving the selective oxidation of the first carbon-hydrogen bond of methane, while inhibiting the oxidation of the remaining carbon-hydrogen bonds to ensure high yield and selectivity of methanol. Here we design ultrathin Pd x Au y nanosheets and revealed a volcano-type relationship between the binding strength of hydroxyl radical on the catalyst surface and catalytic performance using experimental and density functional theory results. Our investigations indicate a trade-off relationship between the reaction-triggering and reaction-conversion steps in the reaction process. The optimized Pd 3 Au 1 nanosheets exhibits a methanol production rate of 147.8 millimoles per gram of Pd per hour, with a selectivity of 98% at 70 °C, representing one of the most efficient catalysts for the direct oxidation of methane to methanol.
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Cell Death & Disease
·
2025
·Vol. 16
·期 1
·1-16
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IF 9.6
Jing Yukai,Zhang Yunfei,Wang Xiaocui,Wang Yufen,Hu Ying,Wen Bin,Dai Xin,Duan Xuemei,Li Haonan,Dong Shumin,Yan Ze,Fan Yufeng,Wang Cong-yi,Liu Xiansheng,Zhang Ruiping
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by the overproduction of autoantibodies and type I interferon, which damages its own tissues, causing multiple organ damage. B cells are thought to play a major role in the pathogenesis of SLE. As a DNA methylation reader, Methyl-CpG-binding domain protein 2 (MBD2) has been extensively studied in the contexts of innate immunity, adaptive immunity, and autoimmune diseases. However, its specific role in B cells and SLE remains unexamined. Herein, we found that MBD2 was highly expressed in B cells of SLE patients and positively correlated with disease activity. Knockout of MBD2 in B cells disturbed B-cell differentiation, dampened B-cell activation, B-cell receptor (BCR) signaling, and T-cell-dependent humoral immune responses in mice. What’s more, MBD2 deficiency effectively attenuated lupus-like symptoms, reduced the germinal center responses, and decreased anti-dsDNA antibodies in lupus model mice. Mechanistically, MBD2 selectively bound to the methylated CpG of Lef-1 induced by IFN-α, inhibiting the transcription and expression of Lef-1 , which repressed Pten transcription and expression, thereby promoting PI3K-Akt-mTOR signaling. This study first demonstrated the role of MBD2 in the pathogenesis of SLE and provided a new target for SLE.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
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IF 3.8
Xiao Xue,Guan Xiaokang,Li Dan,Xu Zhouyi,Lu Qiao
With its exceptional resolving power and sensitivity, mass spectrometry (MS) is widely regarded as the most informative analytical technique for the qualification and quantification of metabolites in plant sciences. However, conventional MS approaches lack spatial information, which is critical for understanding plant physiological mechanisms. To address this limitation, mass spectrometry imaging (MSI) has emerged as a transformative tool, enabling the visualization of metabolite spatial distribution in complex samples and providing deeper insights into plant metabolic processes. This study introduces a novel MSI platform combining laser ablation (LA) with dielectric barrier discharge ionization (DBDI) to obtain MSI images with 40 µm pixel size for in situ metabolic profiling. The LA-DBDI-MSI platform was applied to analyze a traditional Chinese medicine sample, Scutellaria baicalensis Georgi , revealing the spatial distribution of key bioactive compounds in a single experiment. This cost-effective and flexible system demonstrates significant potential for advancing metabolomics research and the development of traditional medicinal materials. Graphical
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WATER AIR AND SOIL POLLUTION
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2025
·Vol. 236
·期 9
·1-17
·
IF 3
Zhang Yong,Kong Lingfen,Huang Chen,Lin Shuiyi,Gui Hongjie
The treatment of rare earth element tailings (REEs) wastewater, a problematic byproduct of rare earth mining processes, presents substantial environmental challenges owing to its characteristic combination of high ammonia nitrogen (NH 4 + -N) concentrations, low organic matter content, and strong acidic conditions. Conventional biological and physicochemical treatment methods exhibit limited efficacy in addressing this complex matrix. To overcome these limitations, this study developed an advanced electrocatalytic oxidation system for NH 4 + -N removal from REEs wastewater pretreated by coagulation-sedimentation. The experimental configuration of system employed a small reactor featuring titanium (Ti) plates coated with thin film layer of high-valent metal oxides. Through systematic parameter optimization, the optimal treatment envelope was established: pH range of 8.5~9.5, electrolysis duration of 35~40 minutes, and catalyst loading ≥ 100 mg/L. Under optimized conditions, the system demonstrated exceptional performance with sustained NH 4 + -N removal efficiency > 99%. Notably, process robustness was confirmed through sensitivity analysis showing minimal performance variation across temperature fluctuations (10~40°C) and initial NH 4 + -N concentration (83.47~368.25 mg/L). Scale-up validation at pilot scale (100 m 3 /d) achieved further comprehensive removal of contaminants including chemical oxygen demand, total phosphorus, NH 4 + -N, and total nitrogen. Full-scale implementation at a REE processing facility in Wuping County, Fujian Province (200 m 3 /d capacity) demonstrated consistent performance over 12-month operation, maintaining NH 4 + -N effluent concentrations below 2 mg/L (99% removal). Techno-economic analysis revealed competitive operational costs of 0.8178 $/m 3 , with energy consumption accounting for 25.8% of total expenditure. These findings suggested that electrocatalytic oxidation technology holds significant potential for full-scale implementation in the treatment of REEs wastewater, providing an effective and sustainable solution for managing NH 4 + -N contamination. Graphical
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Liu Jiahong,Shi Shuying,Liu Yan,Yang Heng,Yin Jing,Jiang Long,Yang Ailin,You Yongshuang,Deng Hao,Xiong Ying
Amorphous sodium zirconium phosphate (NaZrP) with the formula Zr(HPO 4 ) 0.66 (NaPO 4 ) 1.34 ·H 2 O exhibits superior Sr 2+ adsorption capacity (221.85 mg/g) driven by a chemisorption-dominated ion-exchange mechanism. Structural characterization confirms that the amorphous matrix of NaZrP provides accessible active sites (= ZrO 2 POONa/ = ZrO 2 POOH), while kinetic and thermodynamic analyses reveal rapid adsorption kinetics (99% Sr 2+ removal within 5 min) and an endothermic, spontaneous process (ΔG = − 36.56 kJ/mol). In simulated lake water containing competing ions (Na + /K + /Ca 2+ /Mg 2+ ), NaZrP retains 69.10% Sr 2+ uptake efficiency, demonstrating the practical potential for 90 Sr immobilization across diverse aquatic systems.
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IONICS
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2025
·
IF 2.6
Song Jie,Zhang Yunyan,Xu Shimei,Wu Yiqian,Xiao Rengui,Ke Xiang
Dual-ion batteries have got significant attention in recent years due to their efficient ion insertion mechanism, abundant electrode material options, and chemical stability, showcasing advantages such as high operating voltage, low cost, and enhanced safety. Organic electrode materials are often used in dual-ion batteries due to their designability and high theoretical capacity. However, the compatibility between organic electrode materials and current collectors affects the cycling and capacity performance of dual-ion batteries. In this paper, a novel thin film structure of sulfuric acid-doped polyaniline composite copper oxide is electropolymerized on the surface of copper foil current collector. The synergistic effect of electropolymerization-driven oxidation and copper oxide templating facilitates the formation of doped polyaniline nanoparticles, transforming the polymer into long-range ordered crystalline structures with a particle size of 10 nm. Because of the crystalline nanostructure of doped polyaniline and copper oxide, there is an interface change between the anode and active material during charge–discharge cycles, reducing the internal charge transfer resistance from 112 to 40 Ω. While the dual-ion battery shows a significant improvement at high rates, experiments show that the dual-ion battery still retains a capacity of 44 mAh g −1 after 2000 cycles at 5 C, with a capacity retention rate of 69.7%, but the capacity of dual-ion battery without the modification current collectors is only 12 mAh g −1 after 2000 cycles at 5 C. The paper discusses the mechanism of the smallest size composite polyaniline material and the influence mechanisms on the performance of dual-ion batteries. Graphical
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PHARMACEUTICAL RESEARCH
·
2025
·
IF 4.3
Zhao Xian,Xu Ruijie,Zhai Yuanyuan,Wang Yi,Zhang Yuxin,Tian Yuan,Xu Fengguo,Zhang Pei
Background Irinotecan (CPT-11) is a standard first-line chemotherapy treatment for colorectal cancer (CRC). However, its clinical application is often comprised by gastrointestinal toxicity and limited therapeutic efficacy. Our previous study has revealed that the combination of Vardenafil (Vard) and Linagliptin (Linag) significantly alleviated CPT-11-induced intestinal toxicity in both in vitro and in vivo models. It remains unclear whether this combination can synergistically enhance the anticancer activity of CPT-11. Methods The in vitro synergism of Vard, Linag, and CPT-11 was assessed using cell viability assays on CRC cell lines, including HCT116, SW620, and HT29. An in vivo xenograft mouse model was established to evaluate the drug efficacy of both the original and liposomal forms of Vard and Linag combined with CPT-11. Additionally, untargeted metabolomics was utilized to explore the potential mechanisms underlying the observed synergistic effects. Results In vitro , the combination of Vard and Linag synergistically enhanced the anticancer activity of CPT-11 in CRC cell lines. In vivo , liposomal formulations of Vard and Linag tended to accumulate at the tumor site, improving drug targeting and synergistically enhancing the anticancer efficacy of CPT-11. Untargeted metabolomics analysis revealed that this synergistic effect was probably mediated through the regulation of lysophospholipid metabolism. Conclusion Liposomal Vard and Linag combined with CPT-11 demonstrated a synergistic anti-CRC effect, offering valuable insights into novel combination therapies in CRC treatment. Graphical
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IONICS
·
2025
·
IF 2.6
Wu Jintian,Fang Zixuan,Wang Lifen
This study presented a novel approach to enhance supercapacitor (SC) performance by integrating covalent organic framework (COF)–based electrodes. Anthracene-containing DaTp-COF was in situ grown on graphene (DaTp/rGO) via π-π interactions, addressing the poor conductivity of pure DaTp-COF. The composite exhibited a hierarchical porous structure, facilitating ion transport and high electron conductivity. The resulting DaTp/rGO shows a pseudocapacity induced by push–pull electronic flow of anthracene structures in 0.5 M H 2 SO 4 . When paired with an ionic liquid-derived ionogel electrolyte (offering a wide voltage window), the DaTp/rGO electrode achieved a specific capacitance of 183 F/g and an energy density of 58 Wh/kg at 75 W/kg. Comparative analysis with benzene and anthraquinone-based COFs (DbTp and DqTp) revealed that meso-macroporous structures in DaTp/rGO were critical for ionogel compatibility, enabling efficient double-layer capacitance. The fabricated solid-state SC retained 70% of its initial capacitance after 10,000 cycles, highlighting its durability. This work underscores the crucial role of unique pore structures in COF on the electrochemical properties of supercapacitors, paving the way for high-energy–density energy storage devices.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Si Yang,Jiao Yueyue,Wang Maolin,Xiang Shengling,Diao Jiangyong,Chen Xiaowen,Chen Jiawei,Wang Yue,Xiao Dequan,Wen Xiaodong,Wang Ning,Ma Ding,Liu Hongyang
For di-nitroaromatics hydrogenation, it is a challenge to achieve the multi-step hydrogenation with high activity and selectivity due to the complexity of the process involving two nitro groups. Consequently, many precious metal catalysts suffer from low activity for this multi-step hydrogenation reaction. Herein, we employ a fully exposed Pt clusters catalyst consisting of an average of four Pt atoms on nanodiamond@graphene (Pt n /ND@G), demonstrating excellent catalytic performance for the multi-step hydrogenation of 2,4-dinitrotoluene. The TOF (40647 h −1 ) of Pt n /ND@G is significantly superior to that of single Pt atoms catalyst, Pt nanoparticles catalyst, and even all the known catalysts. Density functional theory calculations and absorption experiments reveal that the synergetic interaction between the multiple active sites of Pt n /ND@G facilitate the co-adsorption/activation of reactants and H 2 , as well as the desorption of intermediates/products, which is the key for the higher catalytic activity than single Pt atoms catalyst and Pt nanoparticles catalyst.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2026
·
IF 3.5
Bekena Fekadu Tadesse,Kuo Dong-Hau,Duresa Lalisa Wakjera
Photocatalysis is one of the latest and the most promising technologies to remove organic pollutants from the environment. In this work, novel Nb/Co-codoped MoOS photocatalyst was prepared by a simple chemical precipitation method and thereafter the as-prepared photocatalysts were systematically characterized by different techniques. The photocatalytic performance of the as-prepared samples was surveyed by the degradation of methyl orange (MO), rhodamine B (RhB), and methylene blue (MB) dyes under visible light irradiation. All the codoped photocatalysts exhibited enhanced photocatalytic activity than pure and mono doped samples for degradation of these dyes with the highest degradation efficiency observed for the sample with 10 % Nb amount, which degrade 94.4 % of MO, 97.1 % of RhB, and 99.7 % of MB within 150, 20, and 40 min irradiation time, respectively. The HPLC test further confirmed the degradation of these dyes. The rate constants of MO, RhB, and MB removal in the photodegradation process over 10Nb-10Co-MoOS were determined. The enhanced photocatalytic activity of the sample was due to high charge separation and inhibition of recombination of photogenerated electron-hole pairs. The scavenger studies indicate that the primary active species in the photocatalytic process for MO and MB were superoxide radicals and for RhB were hydroxyl radicals, indicating 10Nb-10Co-MoOS had be widely used for different dye degradation. The catalyst revealed excellent recyclability and stability even after three runs. Finally, a reasonable reaction mechanism was proposed.
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