CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Hongya Wang,Fengyin Zhou,Shiyu Wang,Muya Cai,Xiaodan Zhang,Danfeng Wang,Yanyang Guo,Yongxin Wu,Hao Shi,Xiang Chen,Dihua Wang,Huayi Yin
Extracting molecular iodine (I 2 ) from iodine resources is crucial for ensuring a sustainable I 2 supply, as high-grade brines/mines are depleting. Conventional extraction methods use chlorine gas (Cl 2 ) and sulfur dioxide (SO 2 ) and generate secondary wastes. To address these challenges, we propose an electrochemical method to extract I 2 from iodine resources or I − -containing wastewater using electrons instead of Cl 2 and SO 2 . First, an I − -vacancy BiOI film adsorbs iodide salts (primarily NaI) extracted from seaweeds. The extracted iodide salts are then electrochemically split into I 2 vapor (>99.6 %) and Na alloys in molten salt at 630 °C. The liquid metal cathode reduces energy consumption and prevents I 2 from reacting with Na. The resulting Na alloys can be used directly or further processed to produce pure Na. Life cycle assessment shows that this process has a global warming potential of only 1.48 kg CO 2 per kg of I 2 and an end-point environmental impact of 57.9 mPt due to the avoidance of Cl 2 (154.0 mPt for the conventional method). This study offers a clean approach to reducing reagent usage, decreasing solid waste, and promoting environmentally sustainable resource extraction.
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高影响因子
JOURNAL OF TEXTURE STUDIES
·
2025
·Vol. 56
·期 5
·e70040
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IF 2.5
Jiale Kuang,Xiaojun Sun,Yan Zhang,Yanfeng Li,Shikun Liu,Shixin Yu,Jingjing Liu
Astringency is a complex oral sensation characterized by dryness and constriction in the mouth. It is typically induced by polyphenol-rich foods and beverages such as wine and tea. The quantitative assessment of astringency intensity has become a prominent research focus in the food science field. In this study, an in vitro oral tribological method was developed based on a soft–hard friction interface. An oral-like sensory structure was constructed using biomimetic materials to replicate tongue–palate contact. The frictional behavior carried out in this structure is similar to that of the palate-tongue friction contact in the oral cavity. Thus, the structure allows for the detection of the effect of changes in the nature of food in the oral cavity on the tongue and the palate, which can be quantified by the coefficient of friction. Porcine gastric mucin (PGM), which shares functional similarities with salivary proteins, was employed as a model sensory material. This allowed the device to capture the interaction mechanisms between astringent compounds (e.g., tannins) and salivary proteins. A calibration curve was established by fitting friction coefficient data across a range of tannin concentrations. Subsequently, commercial wine samples were tested. The tribological system detected changes at the mucin–wine soft–hard interface, and the measured friction coefficient served as a quantitative indicator of astringency intensity. This study provides a feasible and reproducible experimental approach for the quantification of food astringency.
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PubMed
高影响因子
Nature Energy
·
2025
·
IF 60.1
Liu Yuan,Mao Huican,Bai Rui,Weng Suting,Zhang Qiangqiang,Rong Xiaohui,Chen Xiao,Zhang Chu,Han Shuai,Ding Feixiang,Wang Xuefeng,Lu Yaxiang,Zhao Junmei,Wei Fei,Chen Liquan,Hu Yong-Sheng
Side reactions between high-voltage cathodes and electrolytes remain a critical obstacle to the advancement of solid-state batteries—particularly for Na-ion systems—due to the higher Na + /Na redox potential. Despite recent extensive efforts, achieving a long cycle life is still challenging at the 4.2 V cut-off (versus Na + /Na). Here we design a room-temperature isotropic epitaxial growth to achieve a relatively uniform and dense metal–organic framework epilayer on Na 3 V 2 O 2 (PO 4 ) 2 F surfaces. Despite using polyethylene oxide, a typical ether-based solid polymer electrolyte, the cathode with isotropic epilayer exhibits enhanced cycling performance at the 4.2 V cut-off (retaining up to 77.9% of its initial capacity after 1,500 cycles). Combining experimental measurements and theoretical analyses, the key factor governing isotropic epitaxial growth behaviour is explicitly elucidated. Furthermore, we develop a self-designed high-sensitivity characterization method, in situ linear sweep voltammetry coupled with gas chromatography–mass spectrometry, to elucidate the failure mechanism of polyethylene oxide on Na 3 V 2 O 2 (PO 4 ) 2 F surfaces and and to reveal the excellent electrochemical stability of the isotropic epilayer. Interestingly, the universality of this approach has also been validated, highlighting its strong potential as an effective strategy for enabling high-energy-density batteries.
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Nature Nanotechnology
·
2025
·
IF 34.9
Zhao Kai,Yan Yu,Jin Xiao-Kang,Pan Ting,Zhang Shi-Man,Yang Chi-Hui,Rao Zhi-Yong,Zhang Xian-Zheng
Chemoresistance and immunosuppression are common obstacles to the efficacy of chemo-immunotherapy in colorectal cancer (CRC) and are regulated by mitochondrial chaperone proteins. Here we show that the disruption of the tumour necrosis factor receptor-associated protein 1 ( TRAP1 ) gene, which encodes a mitochondrial chaperone in tumour cells, causes the translocation of cyclophilin D in tumour cells. This process results in the continuous opening of the mitochondrial permeability transition pore, which enhances chemotherapy-induced cell necrosis and promotes immune responses. On the basis of this discovery we developed an oral CRISPR–Cas9 delivery system based on zwitterionic and polysaccharide polymer-coated nanocomplexes that disrupts the TRAP1 gene in CRC. This system penetrates the intestinal mucus layer and undergoes epithelial transcytosis, accumulating in CRC tissues. It enhances chemotherapeutic efficacy by overcoming chemoresistance and activating the tumour immune microenvironment in orthotopic, chemoresistant and spontaneous CRC models, with remarkable synergistic antitumour effects. This oral CRISPR–Cas9 delivery system represents a promising therapeutic strategy for the clinical management of CRC.
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PubMed
高影响因子
JOURNAL OF PETROLOGY
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2025
·Vol. 66
·期 9
·
IF 3.5
Liu Zairong,Chou I-Ming,Ta Kaiwen,Li Zhongjuan,Wang Yu,Klemme Stephan
Kimberlite magmatism provides critical information about the mineralogical and chemical composition of the deep mantle and geodynamic processes within the deep lithosphere and upper asthenosphere. Understanding the fractional crystallization processes of kimberlite magma after separation from its source and before emplacement is essential for quantifying the degassing of kimberlite magmas, which is responsible for their explosive eruption styles. While mineral fractionation has been proposed to explain compositional variations in the evolved aphanitic kimberlites, the mineral assemblages and the extent of crystallization during magma transport remain poorly constrained. In this study, we conducted a series of experiments with the proposed primary kimberlitic magma composition at 3.0–2.0 GPa and 1200–900 °C, under both graphite-saturated reducing conditions and nickel–nickel oxide (NNO)-buffered oxidizing conditions in a piston-cylinder apparatus. This study presents the first experimental investigation into the effects of redox conditions on the fractional crystallization of kimberlite magma. Our results show that olivine crystallizes under all conditions studied, followed by clinopyroxene with decreasing temperature. Orthopyroxene is stabilized under reducing conditions at 3.0–2.4 GPa. Phlogopite, rutile, magnesian ilmenite, and apatite crystallize after clinopyroxene under both redox conditions, while carbonates (mainly dolomite) are observed only under oxidizing conditions in the absence of melt and at temperatures ≤1000 °C. The crystallization of magnesian ilmenite occurs mainly under oxidizing conditions, indicating that its presence in kimberlite does not imply diamond-preserving reducing conditions. Our study shows that, as the temperature of kimberlite magma decreases to and below 1200 °C, olivine ± pyroxene fractionation becomes increasingly significant, and low oxygen fugacity promotes a higher extent of crystallization. This silicate-dominated fractional crystallization could account for the formation of aphanitic kimberlites from Kimberley and Uintjiesberg, South Africa. The residual melt after fractionation is a transitional carbonate–silicate melt and becomes progressively depleted in SiO2 and evolves toward carbonatitic compositions with decreasing temperature, irrespective of redox conditions, which may explain the co-occurrence of carbonatite and kimberlite in the Premier pipe, South Africa. Our experiments confirm that oxygen fugacity strongly controls the stability of carbonates and transitional melts, with transitional melts stable at lower oxygen fugacity than carbonates. Progressive oxidation during magma cooling facilitates promotes the full complete crystallization of kimberlite magma, which may potentially resulting inform the formation of intrusive kimberlite bodies within the lithospheric mantle.
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TECHNOLOGY IN CANCER RESEARCH & TREATMENT
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2025
·
IF 2.8
Chao Han,Caiping Chen,Li Xue,Xiang Lu
IntroductionBreast cancer metastasis remains the leading cause of disease-related mortality. While calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) has been implicated as a metastasis suppressor in other cancers, its role in breast cancer remains poorly defined. This study aimed to investigate the prognostic significance and functional impact of CAMSAP3 in breast cancer.MethodsCAMSAP3 protein expression was evaluated by immunohistochemistry in 137 primary breast cancer specimens and correlated with clinicopathological features and survival outcomes. Kaplan–Meier and Cox regression analyses were performed to assess distant relapse-free survival (DRFS). Functional assays, including wound healing and Transwell invasion assays, were conducted in MDA-MB-231 and HCC1937 cells following CAMSAP3 overexpression or knockdown. External mRNA-level validation was performed using the Kaplan–Meier Plotter database.ResultsHigh CAMSAP3 expression was significantly associated with favorable features, including lower histological grade, hormone receptor positivity, reduced proliferation index, and fewer triple-negative phenotypes. Patients with high CAMSAP3 expression exhibited significantly improved DRFS, which was independently validated using a public mRNA dataset showing improved distant metastasis-free survival (DMFS). In vitro, CAMSAP3 overexpression inhibited migration and invasion of MDA-MB-231 cells, while CAMSAP3 knockdown enhanced these phenotypes in HCC1937 cells.ConclusionCAMSAP3 is a potential metastasis suppressor and independent prognostic marker in breast cancer. Its high expression is associated with less aggressive tumor characteristics and improved survival, possibly through inhibition of cancer cell migration and invasion.
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PubMed
高影响因子
Science China-Materials
·
2021
·Vol. 64
·期 9
·2313-2324
·
IF 8.273
Gao Yang,Wang Yuanrui,Xia Shan,Gao Guanghui
Ionic hydrogel-based sensors have shined a spotlight on wearable electronics. However, the sensitivity and reliability of hydrogel devices are significantly hampered by the weak adhesion of skin-sensor interface as well as inferior temperature tolerance. Here, inspired by the structure and composition of dermis, a novel skin-attachable and environment-stable hydrogel was designed by integrating collagen into the LiCl-containing chemically cross-linked polyacrylamide hydrogel. The hydrogel exhibited skin-like mechanical properties of low modulus, superior stretchability as well as excellent elasticity. Furthermore, the introduction of collagen endowed the hydrogel with robust and seamless interfaces with diverse materials, including the curved skin. As a result, the hydrogel is capable of serving as a human-machine interface for collecting reliable electrocardiography (ECG) signals and discerning various human motions, with high sensitivity (gauge factor = 10.7), fast response, negligible hysteresis as well as extensive monitoring range. Notably, the hydrogel that can mimick the temperature-tolerant mechanism of most organisms possesses persistent stabilization of adhesive, conductive, sensory and mechanical performances at subzero or ambient conditions. The skin-inspired strategy paves an effective way for the design of multifunctional materials with potential applications in next-generation electronics.
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Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 11
·2644-2658
·
IF 7.779
Xiaoyan Yang,Xiaoling Zeng,Xing Ming,Li Yang,Alberto J. Fernández-Carrión,Sihao Deng,Lunhua He,Xiaojun Kuang
BiVO4 scheelite is one of the few tetrahedra-based structures able to display vacancy-mediated oxide-ion conduction upon the use of an acceptor-doping strategy, leading to oxide-ion migration. In order to modulate the ionic migration process, it is of utmost importance to understand the different parameters affecting it. Here we review phase formation, oxygen vacancy stabilization, and migration for a wide variety of acceptor metal dopants in scheelite BiVO4. Among them, Ca2+-doped materials present the widest solid-solution range, leading to optimized oxide-ion conductivities at moderately high temperatures (σb: ∼10−3 S cm−1 at 500 °C), mainly as a result of their smaller size mismatch with Bi3+ and lower oxygen vacancy defect energy. The results gathered herein provide a useful guide for designing new oxide-ion conductors and tailoring oxide conductivity through the proper selection of doping agents according to several criteria, such as the oxygen defect formation energy, atom size mismatch, polarizability, and bond-dissociation energy with oxygen.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2016
·Vol. 20
·期 8
·2207-2216
·
IF 2.327
Cai Weizi,Liu Jiang,Xie Yongmin,Xiao Jie,Liu Meilin
A direct carbon solid oxide fuel cell (DC-SOFC) is an all-solid-state electricity generation device that operates directly with solid carbon as fuel, without any liquid medium and feeding gas. Tubular electrolyte-supported solid oxide fuel cells (SOFCs), with silver-gadolinium doped ceria (Ag-GDC) as both anode and cathode materials, are fabricated and operated directly with activated carbon as fuel. The kinetics of the DC-SOFCs is carried out through analyzing the correlations of the cell reaction rates to the emitting rates of CO and CO 2 . It turns out that higher operating current corresponds to higher rates of consuming and producing CO, through electrochemical oxidation at the anode and the Boudouard reaction at the carbon fuel, respectively. The rate of consuming CO can be maintained constant by controlling the operating current while the rate of producing CO decreases with time because of carbon consumption. When the CO producing rate becomes smaller than the CO consuming rate, the operation will be terminated. Compared to the rates of the chemical reactions, the diffusion rates of CO and CO 2 are so fast that their impeding effect on the cell performance can be neglected.
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Nanoscale Research Letters
·
2018
·Vol. 13
·期 1
·1-7
·
IF 3.125
Xue Hun,Lin Xinyi,Chen Qinghua,Qian Qingrong,Lin Suying,Zhang Xiaoyan,Yang Da-Peng,Xiao Liren
The S-doped Sb 2 O 3 nanocrystals were successfully synthesized using SbCl 3 and thioacetamide (TAA) as precursors via a facile one-step hydrothermal method. The effects of pH of the precursor reaction solution on the product composition and property were determined. The results indicated that the doping amount of S could be tuned by adjusting the pH of the precursor solution. Furthermore, the S entered into the interstitial site of Sb 2 O 3 crystals as S 2− , which broadened the absorption wavelength range of the Sb 2 O 3 nanocrystal. The S-doped Sb 2 O 3 exhibited an excellent visible-light-driven photocatalytic activity in the decomposition of methyl orange and 4-phenylazophenol. Last, a possible photocatalytic mechanism of the S-doped Sb 2 O 3 under visible light irradiation was proposed.
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JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Yi-Xuan Li,Xiang Ding,Fei Chen,Kuo Cao,Chun-Hua Chen
NaClO 4 is utilized as a salt-type electrolyte additive to improve the electrochemical performance in both Li-rich/graphite full cells and Li-rich/Li half cells. The corresponding characterizations such as scanning electron microscopy and X-ray photoelectron spectroscopy reveal that the NaClO 4 -added electrolyte can suppress the transition metal dissolution from Li-rich cathode and form a stable conductive cathode electrolyte interface layer to protect Li-rich cathode and promote Li + ions transfer. A small amount (0.1 wt%) of NaClO 4 additive enables Li-rich/graphite full cells to maintain 86% capacity after 50 cycles and Li-rich/Li half cells to maintain 95% capacity after 100 cycles, showing a great application potential.
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Frontiers in Cell and Developmental Biology
·
2024
·
IF 4.6
Romualdo Sciorio,Luca Tramontano,Gerard Campos,Pier Francesco Greco,Giuseppe Mondrone,Anna Surbone,Ermanno Greco,Riccardo Talevi,Nicola Pluchino,Steven Fleming
Over the past 40 years there has been a worldwide critical change in the field of assisted reproduction technology (ART), leading to the increased application of single blastocyst transfer, which is extremely important to avoid the risks of multiple pregnancy and associated complications for both mother and babies. Indeed, advancements in ART over the last few decades have been obtained thanks to several improvements, including ovarian stimulation, embryo culture conditions and, of course, progress in cryopreservation methods, especially with the application of vitrification. The ability to cryopreserve human embryos has improved significantly with vitrification compared to the initially adopted slow-freezing procedures. Since the introduction of vitrification, it has become the gold standard method to effectively cryopreserve human blastocysts. However, some new protocols are now being explored, such as the short warming procedure and even shorter exposure to the equilibration solution before vitrification, which seem to provide optimal results. Therefore, the main aim of the current narrative review, will be to illustrate the benefit of vitrification as an effective method to cryopreserve the human blastocyst and to illustrate new protocols and variations which in future may increase the performance of vitrification protocols.
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