ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Hangyang Ling,Rui Zhang,Jiaxin Niu,Gongxian Sun,Xu Sun,Yao Li,Yeting Hu,Hua Yang,Han Zhang,Xiangdong Kong
Tumor microenvironment-responsive nanomedicines offer significant advantages in enhancing treatment specificity and minimizing systemic toxicity. Nevertheless, the therapeutic efficacy of single-modality treatments is often limited by tumor heterogeneity, necessitating the development of multimodal nanoplatforms capable of leveraging multiple tumor microenvironment characteristics for efficient synergistic therapy. In this study, a multifunctional nanocomposite comprising cobalt zeolitic imidazolate framework-67-encapsulated Au nanodendrites coloaded with tirapazamine is developed for tumor-selective therapy. To address the inherent limitations of traditional preclinical models, human healthy and colorectal cancer organoids are utilized as advanced in vitro assessment platforms. Mechanistic studies revealed that multibranched Au nanodendrites disrupt cellular membrane integrity, whereas the acidic condition induces the degradation of the cobalt zeolitic imidazolate framework-67, facilitating targeted drug release. These combined actions synergistically amplify intracellular reactive oxygen species generation and disrupt mitochondrial membranes, leading to the selective elimination of tumor cells. This work presents a highly efficient, tumor microenvironment-responsive nanotherapeutic platform and demonstrates the critical value of organoid-based evaluation systems in advancing the clinical translation of targeted nanomedicines.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Liu Tao,Li Dan,Hu Wenying,Neha,Mohan Brij,Sun Wei
The need for sensitive and reliable adenine (Ade) detection in complex biological systems has driven the development of advanced electrochemical sensing platforms. In this work, we developed a molecularly imprinted electrochemical sensor based on a ternary interface composed of homogeneously distributed Au nanoparticles (AuNPs), nitrogen/sulfur co-doped graphene quantum dots (NSGQDs), and nitrogen-doped graphene (NGR) on disposable screen-printed electrodes. Unlike conventional conductive modifiers that primarily promote electron transfer, NSGQDs served as nucleation-directing mediators, regulating the growth and anchoring of AuNPs on NGR and thereby producing a more uniform, lower-resistance transduction layer. This improved interfacial homogeneity facilitated signal transduction and supported the formation of a more consistent poly(o-phenylenediamine) molecularly imprinted film for Ade recognition. Under optimized conditions, the sensor exhibited two linear ranges of 0.05–20.0 μM and 20.0–150.0 μM, with a limit of detection of 0.012 μM and a limit of quantification of 0.036 μM. The sensor also showed good selectivity, reproducibility, reusability, and stability, with satisfactory recoveries in spiked human serum samples. These results indicate that improved control over AuNPs nucleation and interfacial uniformity can translate into broader linearity, lower detection limits, and more dependable electrochemical sensing of Ade in complex matrices. Graphical abstract
NSGQDs drive uniform formation of AuNPs on N-doped graphene, creating a fast-transport transducer for poly(o-phenylenediamine)-imprinted adenine sensing with high selectivity, low Rct, and serum-level applicability.
The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Optical Materials
·
2025
·
IF 3.8
Xiaolong Yin,Tong Shi,Jiacheng Li,Yu Wang,Jizhe Song,Hongyan Zhao,Zhixiu Wang,Cuixia Bi
In this work, Au@Ag nanostars were successfully synthesized via a seed-mediated growth method, using presynthesized Au nanostars as structural templates. The structure of the Au@Ag nanostars can be precisely controlled by adjusting the concentration of AgNO3 and Au nanostar seeds. The structural configuration of the Au@Ag nanostars can be precisely tuned from partially encapsulated cores to fully encapsulated architectures. The Au@Ag nanostars display tunable localized surface plasmon resonance (LSPR) characteristics in response to changes in the Ag shell thickness. The Raman enhancement of 4-ATP indicates that surface-enhanced Raman spectroscopy (SERS) performs optimally when Ag fully encapsulate the Au nanostars, confirming the results from FDTD theoretical simulations. The remarkable sensitivity of SERS detection originates from the enhanced electromagnetic fields generated at both the nanogaps and branched ends of the Au@Ag nanostars, coupled with their optimized LSPR characteristics. The detection limit achieved an exceptionally low level of 10–15 M. Effective detection of pesticides such as thiram and carbaryl was also achieved. The structural configuration of the Au@Ag nanostars fully leverages the synergistic effects between Au and Ag, along with the nanogaps, to significantly enhance the sensitivity and stability of SERS detection. This study provides theoretical and experimental references for plasma metal nanostars with significantly enhanced electromagnetic fields and offers insights for future SERS studies.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Zhenzhong Li,Haohao Chang,Zhiwei He,Zhongyang Su,Mingjian Duan
A novel and efficient immobilized Au nanoparticle catalyst, Au-SH/SO3H-COP, has been synthesized via the in situ reduction of Au3+ ions by thiol groups within a thiol-functionalized covalent organic polymer (SH-COP). This approach leverages the thiol groups as intrinsic reductants, eliminating the need for external agents. Simultaneously, during Au nanoparticle formation, anchored sulfonic acid (–SO3H) sites are generated, which function as Brønsted acid co-catalysts to synergistically enhance catalytic performance. Characterization results confirmed the formation of uniformly dispersed Au nanoparticles with a narrow size distribution centered at 2–3 nm. The covalent anchoring of nanoparticles to the SH-COP support through unreacted thiol groups effectively prevents aggregation and leaching. For the model hydration of phenylacetylene, Au-SH/SO3H-COP exhibited excellent catalytic activity, achieving 92% yield without additional acid additives. Moreover, it displayed broad substrate compatibility across diverse alkynes (aryl and aliphatic), affording 84–94% yields. The catalyst also showed high recyclability, retaining 89% yield after six cycles with negligible Au leaching, underscoring its robustness and reusability.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jun Li,Ronghao Liu,Xiaolu Yin,Yanzhao Yang
Two types of ionic liquids, Ethyl 2-(4-methylmorpholin-4-ium-4-yl)acetate bis(trifluoromethanesulfonyl)imide ([EMMi][NTf 2 ]) and Ethyl 6-(4-methylmorpholin-4-ium-4-yl)hexanoate bis(trifluoromethanesulfonyl)imide ([EHMMi][NTf 2 ]), which have exceptional extraction capabilities, were designed and synthesized. A solvent-free extraction system was established. By using only 16 mg of [EMMi][NTf 2 ], controlling the upper critical solution temperature (UCST) temperature to 333 K, and increasing the reaction time to 10 min, the Au(III) extraction efficiency can reach 98.6%. The theoretical calculations provided insight into the potential efficacy of utilizing ionic liquids for the extraction of Au(III), whereas the molecular dynamics simulations revealed the fundamental factors driving this extraction process, primarily attributed to the electrostatic interaction and van der Waals interaction interplay between the cations of the ionic liquid and Au(III). The anion exchange mechanism can be discerned from UV Vis and 13 C-NMR spectra. [EMMi][NTf 2 ] demonstrated an extraction efficiency of 97.31% and effectively extracted Au(III) from the CPU diluent solutions. [EMMi][NTf₂] exhibited remarkable stability (>89% efficiency after 5 cycles) and exceptional profitability (output–input ratio: 2006%), making it a sustainable and economically viable extractant.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CONTROL
·
2025
·
IF 6.3
Shanshan Xue,Limei Yin,Lixin Ma,Heera Jayan,Usman Majeed,Hesham R. El-Seedi,Xiaobo Zou,Zhiming Guo
As a major contaminant in apples, patulin (PAT) poses a significant threat to human health and the economy. Establishing highly sensitive and accurate quantitative detection methods for PAT is crucial for ensuring food safety and protecting consumer health. Herein, a competitive ratiometric surface-enhanced Raman spectroscopy (SERS) aptasensor was fabricated. 4-Mercaptobenzoic acid (4-MBA) was embedded as an internal standard (IS) within a gold-silver core-shell structure, later assembled onto Fe 3 O 4 nanoparticles and coupled with complementary aptamer strands to form magnetic probes. Additionally, an aptamer targeting PAT and the Raman reporter molecule 5,5′-Dithiobis-(2-nitrobenzoic acid) (DTNB) were anchored onto gold bipyramids (AuBPs), creating reporter probes. The recognition and binding of the target PAT to the aptamer led to the detachment of the reporter probe after magnetic separation, reducing the DTNB signal. Thus, the ratio of SERS peak intensities (I DTNB /I 4-MBA ) quantified PAT demonstrated a linear range of 0.1–200 ng/mL and a limit of detection (LOD) of 0.070 ng/mL. The implementation of magnetic separation significantly streamlined the sensor fabrication process, whereas the ratiometric strategy substantially enhanced the reproducibility and stability of PAT detection. Furthermore, this method was successfully applied to the determination of PAT in apples and their products, showing potential for practical applications in food safety.
✓ 已验证
产品关联
DOI
高影响因子
ChemNanoMat
·
2026
·Vol. 12
·期 1
·e202500720
·
IF 2.6
Xinbing Jiang,Xingyu Jin,Zizhuo Nie,Wenyu Cheng,Yuxi Fei,Bo Peng,Yuhang Liu,Jiuhong Wang,Libo Zhao,Shujiang Ding
Room-temperature ammonia (NH 3 ) detection is crucial for environmental safety and human health. In this study, a ternary PANI@Au-TiO 2 ammonia-sensitive composite was synthesized via in situ polymerization of polyaniline (PANI) with simultaneous reduction of chloroauric acid to form Au nanoparticles, followed by ultrasonic compounding with TiO 2 nanoparticles. The structural and morphological characterization confirmed the uniform distribution of Au and TiO 2 nanoparticles in the PANI matrix. Gas sensing experiments demonstrated that the PANI@Au-TiO 2 sensor exhibited markedly enhanced NH 3 response, achieving a high sensitivity of 0.0527/ppm compared to PANI, PANI@Au, and PANI-TiO 2 counterparts. Moreover, the PANI@Au-TiO 2 ternary composite sensor displayed excellent linearity within the NH 3 concentration range of 3–30 ppm, along with a low detection limit, good repeatability, and high selectivity toward ammonia. The enhanced performance is attributed to the synergistic effects of the p–n heterojunction, Schottky junction, and catalytic activity of Au nanoparticles, which facilitate efficient charge transfer and amplify the interaction with NH 3 molecules. These findings demonstrate that the hybrid sensing film based on PANI@Au-TiO 2 ternary composites exhibits excellent ammonia detection performance at room temperature, thereby offering a promising pathway for the development of advanced ammonia sensors.
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 11
·877
·
IF 3.504
Guangyu Lei,Jingwen Ma,Zhen Li,Xiaobin Fan,Wenchao Peng,Guoliang Zhang,Fengbao Zhang,Yang Li
In this paper, a facile route has been developed to prepare magnetic trimetallic Au-Ag-γ-Fe2O3/rGO nanocomposites. The impact of the preparation method (the intensity of reductant) on the catalytic performance was investigated. The nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The prepared nanocomposites show fine catalytic activity towards the reduction reaction of 4-nitrophenol (4-NP). The nanocomposites also have superparamagnetism at room temperature, which can be easily separated from the reaction systems by applying an external magnetic field.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Weihao Chen,Maosen Fu,Qiang Zhao,Aijun Zhou,Wen Huang,Jinshu Wang
Li metal has been proven to increase the energy density of rechargeable Li batteries significantly. However, the growth of Li dendrites has hindered the practical application of Li metal. Herein, an Au modified carbon cloth (Au-CC) was prepared by a simple one-step hydrothermal method . Benefiting from the miscibility of Li and Au on the surface of skeleton, the Au-CC can regulate the uniform plating/stripping process of Li effectively and alleviate the formation of Li dendrites, leading to a superior electrochemical performance (near 100% CE for 200 cycles at 2 mA cm −2 ). The as-fabricated Au-CC/Li electrode delivers a ultralong lifespan of 1200 h with low voltage hysteresis at 1 mA cm −2 for 1 mAh cm −2 in symmetric cells. By assembling the full-cell batteries using LiFePO 4 and Au-CC/Li as cathode and anode respectively, the capacity retention of 80.8% is achieved after 200 cycles at 3C.
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Zhiwei Qiu,Tao Yang,Rui Gao,Guifen Jie,Wanguo Hou
In this study, a novel Cu-based metal−organic frameworks (Cu-MOFs) composite material was prepared, and used to develop a sensitive and efficient electrochemical ratiometric sensor for dopamine detection. Gold nanoparticles (NPs) and the conductive poly(xanthurenic acid) p(XA) were assembled on the Cu-tetrakis (4-carboxyphenyl) porphyrin (TCPP) surface by electrodeposition and cyclic voltammetry (CV) method, which greatly improved the electrocatalytic performance of the Cu-MOF modified electrode . Two substances (dopamine/DA, paracetamol/PA) with different electrochemical peaks were added to the electrolyte solutions , where DA was the analyte and PA was as a reference. The ratiometric value of differential pulse voltammetry (DPV) oxidation current (I DA /I PA ) linearly increased with the increasing concentration of DA with low detection limit. This electrochemical ratiometric approach based on the metal−organic framework composites is expected to be a valuable strategy for detection of other analytes.
研究领域:
分析化学
·
生物传感器
·
神经化学
·
电分析化学
·
纳米材料
·
药物分析
✓ 已验证
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2025
·
IF 13.5
Yujin Deng,Yishuang Chen,Lijie Zhang,Huile Jin,Yun Yang,Quanlong Xu,Shun Wang
Integrating plasmonic metal nanocrystal/semiconductor hybrids is a novel approach to contribute photocatalyst with high performance. However, a deep insight of activity acceleration remains elusive because of the complex physicochemical behavior of localized surface plasmon resonance (LSPR) effects. Herein, Au nanobipyramids (NBs) capable of strong local electric field (LEF) are precisely synthesized and encapsulated in TpBD-COF via an in-situ growth strategy. As expected, the optimized AuNBs/TpBD-COF hybrid displays a remarkable improvement in photocatalytic H 2 generation reaction, with apparent quantum efficiency (AQE) of 0.58% at 420 nm. Electromagnetic simulation and femtosecond transient absorption spectroscopy demonstrate the critical role of amplified local electric field in generating charge-separated excitons and thus yielding more hot carriers (energetic electron/hole pairs) for H 2 evolution in TpBD-COF. These findings provide a deep insight to examine the LSPR effects for improving the COF-based photocatalytic performance.
✓ 已验证
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 12
·期 12
·11818-11832
·
IF 1.5
Yuli Wei,Huihui An,Wu Yang,Hao Guo
In this work, a simple, sensitive and rapid electrochemical sensor for bisphenol A determination based on a 3D Au NPs-poly-L-glutamate/graphene nanocomposite was proposed and the structures of the nanocomposite were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopic (FTIR) and X-ray diffraction (XRD). The electrochemical behaviors of bisphenol A on the nanocomposite GCE were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). In the potential range of 0.0 ~ 1.0 V, an irreversible oxidation peak appeared on the modified electrode in 0.1 mol L -1 phosphate buffer solution (pH = 6.0). Under the optimum conditions, the anode peak current of bisphenol A increased linearly with the its concentration in the ranges from 0.009 μmol L -1 to 0.1 μmol L -1 and 0.1 μmol L -1 to 1.0 μmol L -1 with the detection limit down to 3×10 −10 mol L -1 (S/N = 3) and the corresponding linear regression equations were Ipa ( μA)= − 0.1129 C ( μmol L -1 ) + 0.5532 (N = 6, R 2 = 0.9057) and Ipa ( μA) = − 0.05970 C ( μmol L -1 ) + 0.02182 (N = 5, R 2 = 0.9950) respectively. The proposed method was successfully used for the determination of bisphenol A content in wastewater and milk samples, and the recoveries were in the range from 98.10% to 104.9%.
研究领域:
分析化学
·
环境监测
·
食品安全
·
电化学传感
·
纳米生物技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）