BIOMACROMOLECULES
·
2023
·
IF 6.2
Jiaying Li,Yuji Pu,Sai Li,Bin He,Jianlin Chen
The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn’s disease is extremely cloudy. Maintaining the level of remission lesions in colitis is the default treatment attitude at present. Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment. Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release. Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine. In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres. In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
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COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 8
·879-891
·
IF 2.4
Li Danyang,Xu Wenshuang,Liu Hui
Stimuli-responsive hydrogel could respond rapidly to environmental changes, whereas the limitation of gel scale usually led to a single route of drug delivery and restricted application. Herein, a pH and temperature dual responsive nanogel CS/P(MAA-co-NIPAM) was successfully prepared by radical polymerization. The change of both turbidity and hydration diameter at different conditions indicated that the nanogel possessed obvious pH and temperature sensitive properties. Specifically, the hydration diameters of the nanogel were 234 nm at T = 20 °C and 145 nm at T = 45 °C. The schematic flowable characteristic by injection experiment indicated that CS/P(MAA-co-NIPAM) might have the potential application possibility of injectable drug delivery. In addition, with doxorubicin as the model drug, the drug loading efficiency of the nanogel was 84.00% and the maximum release efficiency reached 66.30% at pH = 2.0 & T = 20 °C. The nanogel was able to realize drug delivery process in physiological environment according to in-vitro controlled releasing experiments.
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MICROCHEMICAL JOURNAL
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2023
·
IF 4.8
Hao Gou,Jingxian He,Rong Nie,Daqian Xu,Honghong Rao,Guohu Zhao
The effective synthesis of graphene oxide (GO) modified with chitosan (CS) via covalent bond exhibited the properties of a wide surface area and high chiral selectivity. The successful synthesis of composites was characterized by the FTIR, XPS and electrochemical methods. Then a novel chiral electrochemical sensor based on chitosan covalently binding with the graphene (RGO/CS) was fabricated for discrimination of tyrosine (Tyr) enantiomers. The results showed that the chiral selector CS preferably combined with D-Tyr rather than L-Tyr, which was attributed to the favorability of host–guest interactions between CS and Tyr enantiomers. In comparison, recognition efficiency was significantly improved after CS was grafted onto RGO, which might be attributed to the formation of intermolecular forces between Tyr enantiomers and CS. Furthermore, the structure of CS could play an important role in enantioselective discrimination. The as-synthesized material was successfully exploited for the recognition of Tyrosine enantiomers, indicating that the developed sensor has wide application prospects.
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TRIBOLOGY INTERNATIONAL
·
2023
·
IF 6.2
Lumin Yang,Renjie Li,Xiaozhu Liao,Tao Li,Yunsong Kong,Xiaoduo Zhao,Rui Wang,Zhengfeng Ma,Zengjie Fan,Yong-min Liang,Shuanhong Ma,Feng Zhou
Osteoarthritis (OA) caused by the articular cartilage degeneration is closely related to the lubrication dysfunction of joint . At present, injecting biolubricants into the joint cavity is regarded as an effective strategy for the treatment of arthritis. Herein, a biocompatible chitosan (CS)-based nanoparticles (NPs) biolubricant ( [email protected] NPs) with dual function of lubrication and anti-inflammatory was fabricated. Zwitterionic polyelectrolyte brush poly(2-methacryloyloxyethyl phosphorylcholine, PMPC) was grafted onto the NPs via atom transfer radical polymerization (ATRP) strategy, while the anti-inflammatory drug (diclofenac sodium, DS) was encapsulated within them. Under the synergistic effect rolling lubrication and hydration lubrication mechanisms, the obtained biolubricant exhibited superior lubrication performance in either artificial joint materials or cartilage contacts, which presents great potential for OA treatment.
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Foods
·
2023
·Vol. 12
·期 6
·1149
·
IF 5.2
Feixu Mo,Wenzhi Li,Youhua Long,Rongyu Li,Yi Ding,Ming Li
Magnolol is a natural compound extracted from the traditional Chinese medicineMagnolia officinalis, which exhibits antimicrobial properties. However, magnolol is insoluble in water and consists of a phenolic hydroxyl group, which is volatile; these factors hinder its application. In this study, a safe and environmentally friendly method to improve the microbial resistance and storability of harvested fruits is developed using the water-soluble carrier carboxymethyl chitosan (CMCS) and magnolol. Magnolol was loaded on CMCS particles to form[email protected]antimicrobial particles, a preservation coating agent.[email protected]particles effectively solved the problems of water insolubility and agglomeration of magnolol and reduced the size distribution D50 value of magnolol from 0.749 to 0.213 μm.[email protected]particles showed greater toxicity againstStaphylococcus aureus,Escherichia coli, andBotryosphaeria dothideathan that of magnolol alone, with effective medium concentration (EC50) values of 0.9408, 142.4144, and 8.8028 μg/mL, respectively. Kiwifruit treated with the[email protected]solution showed delayed changes in fruit hardness and soluble solid and dry matter contents and significantly higher ascorbic acid (vitamin C) and soluble total sugar contents and sugar:acid ratios compared with that of the control fruit. In addition, no disease spots were observed on fruit treated with the[email protected]solution within 7 days after inoculation withB. dothidea. In conclusion,[email protected]particles showed antimicrobial activity on harvested fruits, effectively delayed the hardness and nutritional changes of fruits during storage, and improved the storability of kiwifruit.Keywords:[email protected]particles;foodborne pathogen;preservation coating agent;Staphylococcus aureus;kiwifruit
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xia Xu,Yanbo Zeng,Zheng Chen,Yang Yu,Haibin Wang,Xuhua Lu,Jiulong Zhao,Shige Wang
In this study, a composite hydrogel (QMPD hydrogel) composed of methacrylate anhydride (MA) grafted quaternary ammonium chitosan (QCS-MA), polyvinylpyrrolidone (PVP), and dopamine (DA) was designed for the sequential wound inflammation elimination, infection inhibition, and wound healing. The QMPD hydrogel formation was initiated by the ultraviolet light-triggered polymerization of QCS-MA. Furthermore, hydrogen bonds, electrostatic interactions, and “π-π” stacking between QCS-MA, PVP, and DA were involved in the hydrogel formation. In this hydrogel, the quaternary ammonium groups of quaternary ammonium chitosan and the photothermal conversion of polydopamine are capable of killing bacteria on wounds, which showed the bacteriostatic ratios of 85.6 % and 92.5 % toward Escherichia coli and Staphylococcus aureus , respectively. Moreover, the oxidation of DA sufficiently scavenged free radicals and introduced the QMPD hydrogel with good anti-oxidant and anti-inflammatory abilities. Together with the extracellular matrix-mimic tropical structure, the QMPD hydrogel significantly promoted the wound management of mice. Therefore, the QMPD hydrogel is expected to provide a new method for the design of wound healing dressings.
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MATERIALS CHEMISTRY AND PHYSICS
·
2023
·
IF 4.6
Jinhua Deng,Meng Zhu,Zhaoli Wang,Yong Liu
Flocculation is considered an alternative, eco-friendly demulsification technology for treating emulsified oily wastewater. However, conventional flocculants produce a large amount of oily sludge, causing environmental risk as well as oil loss. To address this, we fabricated a demulsifying agent made of iron-modified chitosan (FeO X -CS) for demulsification and reducing the production of oily sludge. The hydrophilicity of the chitosan was enhanced after FeO X modification, which enhanced the hydrogen bond between the flocculant and the oil droplet, and improved the demulsification efficiency. The demulsification efficiency of the FeO X -CS for the oil-in-water (O/W) model emulsions is over 60% after 3 recycles. The demulsification efficiency of FeO X -CS excessed 97% within 60 min at the dosages of FeO X -CS 20 mg/L, initial model emulsion concentration of 200 mg/L, and pH of 7. The demulsified oil mainly exists in water surface and FeO X -CS surface. Thus, the synthesized FeO X -CS is a potential for treating emulsified oily wastewater.
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Small
·
2023
·Vol. 19
·期 35
·2302060
·
IF 13.3
Ping Li,Bo He,Xuan Li,Yunfei Lin,Shaokun Tang
2D materials that can provide long-range ordered channels in thin-film form are highly desirable for proton exchange membranes (PEMs). Covalent organic framework nanosheets (CONs) are promising 2D materials possessing intrinsic porosity and high processability. However, the potential of CONs in PEMs is limited by loose sheet stacking and interfacial grain boundary, which lead to unsatisfied mechanical property and discontinuous conduction pathway. Herein, chitosan (CS), a natural polymer with rich NH 2 groups, is designed as the linker of dual-sulfonate CONs (CON-2(SO 3 H)) to obtain CON-2(SO 3 H)-based membrane. Ultrathin CON-2(SO 3 H) with high crystallinity and large lateral size is synthesized at water–octanoic acid interface. The high flexibility of CS chains and their electrostatic interactions with SO 3 H groups of CON-2(SO 3 H) enable effective connection of CON-2(SO 3 H), thus endowing membrane dense structure and exceptional stability. The stacked CON-2(SO 3 H) constructs regular hydrophilic nanochannels containing high-density SO 3 H groups, and the electrostatic interactions between CON-2(SO 3 H) and CS form interfacial acid–base pairs transfer channels. Consequently, CON-2(SO 3 H)@CS membrane simultaneously achieves superior proton conductivity of 353 mS cm −1 (under 80 °C hydrated condition) and tensile strength of 95 MPa. This work highlights the advantages of proton-conducting porous CON-2(SO 3 H) in advanced PEMs and paves a way in fabricating robust CON-based membranes for various applications.
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LANGMUIR
·
2023
·
IF 3.9
Yaozong Li,Yingying Peng,Yang Hu,Jian Liu,Teng Yuan,Wuyi Zhou,Xianming Dong,Chaoyang Wang,Bernard P. Binks,Zhuohong Yang
Poly(ε-caprolactone) (PCL)-incorporated lignin-chitosan biomass-based nanocomposite porous scaffolds have been effectively prepared by templating oil-in-water Pickering high internal phase emulsions (HIPEs). PCL is dissolved in oil and chitosan and lignin nanoparticles originate in water. The continuous phase of the emulsions is gelled by cross-linking of chitosan with genipin and then freeze-dried to obtain porous scaffolds. The resulting scaffolds display interconnected and tunable pore structures. An increase in PCL content increases the mechanical strength and greatly reduces the water absorption capacity of the scaffolds. Scaffolds loaded with the anti-bacterial drug enrofloxacin show a slow drug release profile, adjustable release rate, and favorable long-term anti-bacterial activity. Moreover, Pickering emulsion templates with suitable viscosity are used as 3D printing inks to construct porous scaffolds with personalized geometry. The results imply that the simplicity and versatility of the technique of combining freeze-drying with Pickering HIPE templates is a promising approach to fabricate hydrophobic biopolymer-incorporated biomass-based nanocomposite porous scaffolds for biomedical applications.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yong Zhang,Bingyu Mei,Binhao Shen,Lingyi Jia,Jun Liao,Wenkun Zhu
A novel chitosan-based composite with rich active sites was synthesized by uniformly dispersing biochar into the cross-linked network structure formed by chitosan and polyethyleneimine . Due to the synergistic effect of biochar (minerals) and chitosan-polyethyleneimine interpenetrating network (amino and hydroxyl), the chitosan-based composite possessed an excellent adsorption performance for uranium(VI). It could rapidly (<60 min) achieve a high adsorption efficiency (96.7 %) for uranium(VI) from water and a high static saturated adsorption capacity (633.4 mg/g), which was far superior to other chitosan-based adsorbents. Moreover, the separation for uranium(VI) on the chitosan-based composite was suitable for a variety of actual water environments and the adsorption efficiencies all exceeded 70 % in different water bodies. The soluble uranium(VI) could be completely removed by the chitosan-based composite in the continuous adsorption process, which could meet the permissible limits of the World Health Organization. In sum, the novel chitosan-based composite could overcome the bottleneck of current chitosan-based adsorption materials and become a potential adsorbent for the remediation of actual uranium(VI) contaminated wastewater.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Chennan Liu,Junhong Ling,Li-Ye Yang,Xiao-kun Ouyang,Nan Wang
Infection represents a major clinical barrier that delays wound healing , while the overuse of antibiotics can lead to bacterial resistance . Hence, it is of particular important to develop a new type of dressing to combat bacterial resistance. Herein, a carbon nitride-polydopamine‑silver complex (C 3 N 4 -PDA-Ag) was prepared using the photocatalyst C 3 N 4 and silver nanoparticles (Ag NPs) to achieve a synergistic antimicrobial effect. The solution casting method was then employed to further modify the C 3 N 4 -PDA-Ag complex by compounding it with chitosan (CS), thereby forming a C 3 N 4 -PDA-Ag@CS film. The results revealed that the C 3 N 4 -PDA-Ag@CS film exhibits superior antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa compared to the CS group. The hemolysis, cytotoxicity, and in vivo implantation experiments indicated that the composite film possesses excellent in vitro and in vivo biocompatibility. In addition, the composite dressing promoted wound healing in infected mice by facilitating collagen deposition and accelerating epidermal regeneration. Collectively, the findings of this study clearly demonstrate that the C 3 N 4 -PDA-Ag@CS composite dressing has excellent antibacterial properties , biocompatibility, and enhances wound healing, thus providing a strategy for the application of photocatalytic materials for the treatment of infected wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Miaoyu Gan,Caoyu Guo,Wenying Liao,Xiaoli Liu,Qi Wang
A natural biopolymer bilayer film based on chitosan and bacterial cellulose with a protective layer of pullulan was developed by a two-step solution casting method. Curcumin was incorporated as an active antioxidant and antibacterial agent into the inner layer. The films with different curcumin concentrations were systematically characterized. Fourier transform infrared spectroscopy and X-ray diffraction analyses showed high compatibility between curcumin and the polysaccharide matrix through intermolecular interactions, which was verified by enhanced mechanical and barrier properties. The curcumin incorporation improved the thermal stability by >35.4 %, along with lower visible and ultraviolet light transmittance (< 8.6 %) and water solubility (< 25.1 %). The film had both antibacterial and antioxidant properties, and the sustained release of curcumin was largest (> 58.8 %) in the fatty food simulant lasting for over 155 h. The results suggested that the film containing 0.2 % curcumin had ideal physical and functional properties, suggesting its potential as a novel packaging material for the preservation of high-fat food.
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