CHEMOSPHERE
·
2019
·
IF 5.108
Runren Jiang,Donghai Wu,Guanghua Lu,Zhenhua Yan,Jianchao Liu
Broadening the range of light absorption and inhibiting charge carrier's recombination are vital to improving photocatalytic activity. In this study, a novel full spectrum light-driven carbon quantum dots (CQDs) modified 2D-2D ZnIn 2 S 4 /BiOCl van der Waals (VDW) heterostructures were prepared by a facile hydrothermal method. It exhibits remarkable degradation efficiency for removing various antibiotics from water (i.e. tetracycline (TC), ciprofloxacin (CIP) and oxytetracycline (OTC) under visible and near-infrared (NIR) light. The enhancement of photocatalytic performance is due to the 2D-2D VDW heterostructures and CQDs not only accelerate the interfacial charge separation and transfer but also provide massive reactive canters to facilitate degradation reaction. Besides, the optical absorption capacity of CQDs modified 2D-2D ZnIn 2 S 4 /BiOCl VDW heterostructures are obviously enhanced because of the up-conversion photoluminescence (UC-PL) properties of CQDs. Furthermore, the degradation process of TC is assessed by three-dimensional excitation-emission matrix (3D-EEMs) and liquid chromatography-tandem mass (LC-MS/MS) spectrometry analysis. Active species trapping experiments and electron spin resonance (ESR) testify that O 2 − , OH, and holes play a crucial part in the photocatalytic degradation process. This work affords a new promising approach for CQDs modified 2D/2D VDW heterojunction with enhanced photoactivity in organic pollutant degradation for full spectrum light utilization.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Kexin Zhang,Chenfei Zhang,Ying Li,Ting Li,Yansong Yin,Kaipeng Wang,Anqi Wang,Mingjia Zheng,Zhong Zhang,Haijun Wang
In this study, we proposed a novel application of an established material by developing ingestible nanoparticles made from bovine serum albumin loaded with indocyanine green. These nanoparticles, referred to as ICG@BSA NPs, response to near infrared (NIR) laser exposure by generating reactive oxygen species. This process, known as photodynamic therapy (PDT), is designed to targeted kill vector-borne organisms. As a representative model of vectors, housefly larvae trended to uptake more protein-based ICG@BSA NPs than free ICG. This led neither to an obvious influence on larval development nor to a significant impact on the intestinal microbial population. In contrast, under NIR laser irradiation, ICG@BSA NPs could efficiently induce generation of ROS for killing larvae via damaging intestinal wall and inducing subsequent intestinal bacteria leakage. This protein-based ingestible nanoparticles integrate the independence of pesticides, pronounced PDT efficacy, and environmental friendliness, making this nanoplatform promising for controlling vector-borne organisms and associated diseases.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zelin Sang,Zepeng Liang,Grace Xuelian Huang,Zhenhua Chen,Xiuli Ren,Xifan Mei
Spinal cord injury (SCI) is one of the most devastating acute diseases. Zn 2+ has been verified plays a crucial role in SCI repair, however, how to continuously release zinc ions at the lesion site is still a cutting-edge challenge. Therefore, it is urgent to design a novel nanoplatform for promoting SCI repair with multifunction of controlled release of Zn 2+ and regulating ROS microenvironment of mitochondrion. Herein, we propose a protocol of preparing NIR sensitive ZnO quantum dots (QDs) decorated MXene hydrogel for SCI repair. TEM and EDS mapping showed that the ZnO QDs were uniformly distributed on the Mxene nanosheets. Catalase (CAT) analysis showed that the ZnO-Ti 3 C 2 nano enzymes could effectively scavenge ROS. Molecular biology studies showed that ZnO-Ti 3 C 2 @H repaired mitochondrial function by scavenging ROS with a clearance rate of up to 80 %. Neuronal apoptosis was subsequently reduced, and nerves and blood vessels were regenerated. NIR irradiation warmed the injury site to 42.9 °C, which enabled rapid enrichment of Zn 2+ at the lesion site. Footprinting and pathology experiments have shown that it improves functional recovery after injury and results in near-normal BMS scores. These results suggest that this multifunctional type of material incorporating NIR controlled release of Zn 2+ provides a promising strategy for promoting SCI repair.
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Advanced Healthcare Materials
·
2024
·
IF 10
Yixuan Xu,Huiping Dang,Changchang Teng,Dalong Yin,Lifeng Yan
Rapid propagation of tumor cells requires plenty of energy, which is adenosine triphosphate (ATP) dependent. ATP inhibition in tumors not only results in the starvation of tumor cells but also down-regulation of the level of heat shock proteins (HSPs), which usually increase during traditional photothermal therapy (PTT), especially when the temperature is up 50 °C. 2-deoxy-D-glucose (2DG) is an anti-glycolytic reagent and can be used as an efficient agent for ATP inhibition in tumors. Compared with typical PTT, low-temperature mild photothermal therapy (MPTT) is receiving more and more attention because it avoids the high temperatures causing damage to the normal tissue, and the increase of HSPs which decrease PTT. Here, multifunctional polypeptide nanoparticles pDG@Ahx conjugating both a NIR probe Ahx-BDP and 2DG into the side chain of the amphiphilic polypeptide have been prepared. In vitro and in vivo studies reveal that the as-prepared nanoparticles achieve a synergistic effect of starvation/MPTT/PDT (photodynamic therapy), and it provides a new strategy to NIR-I/II fluorescence imaging-guided starvation/MPTT/PDT synergy therapy for tumors.
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Advanced Science
·
2025
·
IF 14.1
Doudou Lei,Lin Liao,Tao Qin,Xiaoxuan Guan,Kunpeng Duan,Zhiwei Gao,Weiqian Jin,Mingjing Yin,Ke Zhang,Yan Liu,Yin Chen,Huyang Gao,Jiaxiao Li,Feifei Huang,Wenjing Liu,Chengde Xia,Bailei Wang,Hualin Huang,Shengqiu Lv,Qiang Zhi,Jiahao Huang,Ming Gao,Junyu Lu
Acute lung injury (ALI) refers to damage to lung related cells, typically caused by an uncontrollable inflammatory response, and over-generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming lung redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, the simple synthesis of ultra-small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities and broad spectrum ROS scavenging, thereby promoting tissue repair for ALI immunotherapy. Mechanistically, through the therapeutic strategy of TP@Pd+NIR, the damaged cells and tissues are ameliorated by decreasing intracellular ROS levels (total ROS, ·OH and ·O 2 − ), downregulating inflammatory cytokines levels (IL-6, TNF-α and IL-1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation of iNOS and CD86, and upregulation of IL-10 and CD206), activating immunoregulation (CD4 + /CD8 + ratio increase), promoting tissue repair factor levels (upregulation of HSP70 and CD31), and suppressing the NF-κB signaling pathway (downregulation of phosphorylated p65 and IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated in lung tissue for 6 h, indicating the promising therapeutic efficacy via this administration route. Notably, the TP@Pd+NIR strategy demonstrated the excellent synergistic effects in alleviating lung inflammation storms, reducing diffuse alveolar damage, and accelerating lung tissue repair. Summarily, this work has designed a novel TP@Pd+NIR strategy for the synergistic enhancement of ALI amelioration, which may serve as a promising therapeutic approach for other ROS related diseases.
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Chemical & Biomedical Imaging
·
2024
·
IF 0
Xing Tian,Jiayi Cheng,Lei Yang,Zhanxian Li,Mingming Yu
Hydrogen peroxide and polarity are closely related to many physiological activities and pathological processes. However, near-infrared fluorescent probes that are sensitive to both H2O2 and polarity are still scarce. Herein, we developed the first dual-channel near-infrared fluorescent probe NBO, with an AIE effect, enabling simultaneous monitoring of H2O2 and polarity. The probe presented high sensitivity, high selectivity, and low detection limit for H2O2. It also had high sensitivity to polarity, independent of pH and viscosity, with large Stokes shifts, good photostability, and low cytotoxicity. Moreover, NBO was able to detect both endogenous and exogenous H2O2 as well as polarity fluctuations in vivo as a method to effectively differentiate between cancer cells and normal cells. Importantly, it also could monitor the therapeutic effects of drugs in inflammation and iron-dead cells and mice. Based on NIR emission, NBO could be used as an imaging tool and a way to evaluate the therapeutic effect of drugs for inflammation and ferroptosis.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Chongqing Yu,Qiqi Lu,Yichun Wang,Zujiang Liu,Sathishkumar Gnanasekar,Ugo D’Amora,En-Tang Kang,Liqun Xu,Jie Xu,Xi Rao
Methicillin-resistant Staphylococcus aureus (MRSA) wound infections remain a significant global challenge and demand new-generation biomaterials to eliminate bacterial infections and promote rapid wound healing. Although the nanozyme is a promising approach, the restricted unimodal bactericidal functionality hinders its efficacy in treating complex wound infections. In this study, copper-tannic acid (Cu-TA) nanozymes (NMs) with multifunctional properties were developed for the treatment of bacterial infections and biofilms via cuproptosis-like cell death. The as-prepared Cu-TA demonstrated peroxidase-like (POD-like) activity, generating substantial amounts of hydroxyl radicals (•OH). In vitro studies revealed that Cu-TA efficiently disrupted bacterial biofilms, while in vivo experiments demonstrated its ability to promote anti-inflammatory responses, angiogenesis, collagen synthesis, and cellular proliferation. Transcriptome sequencing revealed that bacterial reactive oxygen species (ROS) caused damage to the cell membrane and disrupted metabolic processes. Furthermore, copper overload triggered lipid peroxidation (LPO) buildup and interfered with the tricarboxylic acid (TCA) cycle, culminating in cuproptosis-like bacterial death. Overall, this study successfully developed a spindle-shaped, multifunctional nanozyme for combating bacterial infections through cuproptosis-like cell death while promoting infected wound healing. The results validate the clinical potential of Cu-TA NMs for treating MRSA-infected wounds.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Guozhu Ren,Tingyu Pan,Yue Xu,Jingyu Wang,Lingdong Wang,Ruiping Deng,Shihong Zhou,Long Tian,Xiaojie Wu,Liang Zhou
Since the O–H and N–H oscillators of solvent molecules attached to ytterbium ion (Yb3+) and C–H oscillators existing in the inner coordination sphere of Yb3+ would quench the excited energy of Yb(III), which leads to low quantum yields (QYs) of Yb(III) complexes, we aimed to design a ligand that could block solvent molecules and C–H oscillators out of the first coordination sphere of Yb3+. Herein, a series of novel polycyclic aromatic dicarboxylate ligands are designed and synthesized to effectively protect Yb3+ from solvent molecules and efficiently sensitize Yb3+ luminescence, while the cost and sophistication of the synthesis are satisfactory. Therein, [Yb(MO–DPyPDA)2](DIEA) exhibited a considerable QY of 5.20% and a long luminescent lifetime of 102 μs in CD3OD. The single-crystal structure demonstrates that there are no solvent molecules and C–H oscillators existing in the inner coordination sphere of Yb3+, which is conducive to alleviating the quenching effect. Meanwhile, we also carried out experiments to verify that it was thermodynamically feasible for ligands to sensitize the luminescence of center ion through internal redox processes. Moreover, several groups of near-infrared organic light-emitting diodes based on [Yb(DTFM-DPyPDA)2](DIEA) were fabricated based on the solution-processing method, and the highest irradiance of 110,284 μW/m2 was realized by optimizing the device structure.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 45
·7486-7494
·
IF 4.776
Xin Yang,Ying Qian
A NIR fluorescence probe with long emission wavelength at 746 nm and high quantum yield of 0.36 was designed and synthesized to selectively detect GSH over Hcy and Cys in living systems. 2-(1,3,3-Trimethylindolin-2-ylidene)acetaldehyde was attached to rhodamine by Knoevenagel condensation to shift the emission to near infrared region. Then, ethylenediamine was linked to M2 get an important intermediate M3. Finally, target molecule named RhNM was synthesized through combined N-[4-(carbonyl)phenyl] with M3. RhNM shows excellent discrimination in detecting GSH from Hcy/Cys along with an obvious color change. The fluorescence band at 746 nm is rapidly enhanced 106-fold after adding GSH, and the quantum was calculated at 0.36. Titration experiments of GSH showed good linear relationship of intensity vs. GSG concentration, and the detection limit was calculated at 70 nM. The proposed mechanism for identifying GSH based on Michael addition involves reactions of the carbon–carbon double bond and subsequent spirolactam opening. Meanwhile, the probe RhNM can work in a wide range of pH of 4–10. The probe RhNM was used for endogenous and exogenous imaging in HepG2 cells for glutathione. There was an outstanding intracellular red fluorescence occurring upon the addition of GSH incubated with HepG2 cells. It has been successfully applied for the determination of GSH in diluted serum and for bio-imaging of GSH in living cells with low cell toxicity. All results indicated that the probe can be used as an ultra-sensitive, near-infrared fluorescent chemical sensor for selectively detecting GSH in living cell. It has great potential in imaging of live tissues and even, animal imaging.
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ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Sha Liu,Siyu Lu,Shihao Sun,Jun Hai,Genping Meng,Baodui Wang
Quantitative detection of cancer cells using portable devices is promising for the development of simple, fast, and point-of-care cancer diagnostic techniques. However, how to further amplify the detection signal to improve the sensitivity and accuracy of detecting cancer cells by portable devices remains a challenge. To solve the problem, we, for the first time, synthesized folic-acid-conjugated Au nanoframes (FA-Au NFs) with amplification of pressure and temperature signals for highly sensitive and accurate detection of cancer cells by portable pressure meters and thermometers. The resulting Au NFs exhibit excellent near-infrared (NIR) photothermal performance and catalase activity, which can promote the decomposition of NH4HCO3 and H2O2 to generate corresponding gases (CO2, NH3, and O2), thereby synergistically amplifying pressure signals in a closed reaction vessel. At the same time, Au NFs with excellent peroxidase-like activity can catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce TMB oxide (oxTMB) with a strong photothermal effect, thereby cooperating with Au NFs to amplify the photothermal signal. In the presence of cancer cells with overexpressing folate receptors (FRs), the molecular recognition signals between FA and FR can be converted into amplified pressure and temperature signals, which can be easily read by portable pressure meters and thermometers, respectively. The detection limits for cancer cells using pressure meters and thermometers are 6 and 5 cells/mL, respectively, which are better than other reported methods. Moreover, such Au NFs can improve tumor hypoxia by catalyzing the decomposition of H2O2 to produce O2 and perform photothermal therapy of cancer. Together, our work provides new insight into the application of Au NFs to develop a dual-signal sensing platform with amplification of pressure and temperature signals for portable and ultrasensitive detection of cancer cells as well as personalized cancer therapy.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Zongjun Liu,Junhui Shi,You Wang,Yang Gan,Peng Wan
A novel light-responsive nanovalve is facilely prepared on mesoporous silica (mSiO2) coated upconversion nanoparticles (UCNP) through modification of photo-cleavagable pyrenemethyl ester (Py) molecules on its surface. These Py molecules can associate with β -cyclodextrin ( β -CD) molecules as gatekeepers to block the mSiO 2 pore channels and entrap the loaded drugs. Upon NIR light irradiation , NIR light is upconverted to ultraviolet (UV) and visible (Vis) light by UCNP, and the modified Py molecules are cleaved by the upconverted UV light leading to the detachment of β -CD gatekeepers to trigger drug release. For the fabrication of a monitoring system, β -CD is covalently conjugated with the fluorescein isothiocyanate (FITC) as drug release indicator (FITC- β -CD). The luminescence resonance energy transfer (LRET) from UCNP to Py/FITC- β -CD before drug release results in the quenching of Vis emission of UCNP while the detachment of Py/FITC- β -CD nanovalves after drug release diminishes the LRET between UCNP and FITC- β -CD which recovers the luminescence of UCNP, the change in luminescence provides a potential capability for one to quantitatively monitor the drug release process. in vitro study shows a remarkable killing ability on HeLa cancer cell of this system.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Chunyang Zhang,Yifan Wang,Zexiong Wang,Shilong Zhao,Ruoshan Lei,Shiqing Xu
The development of ultrasensitive thermometric phosphors has become an active area of research due to their appealing applications in the contactless temperature detection field. Herein, the scheelite-related compounds—CaGd 2 (WO 4 ) 4 : Nd 3+ , Yb 3+ and CaGd 2 (MoO 4 ) 4 : Nd 3+ , Yb 3+ , which exhibit high sensing capacity—are successfully prepared and systematically characterized. The X-ray diffraction analysis reveals that CaGd 2 (WO 4 ) 4 : Nd 3+ , Yb 3+ exhibits the monoclinic structure, whereas CaGd 2 (MoO 4 ) 4 : Nd 3+ , Yb 3+ is in the tetragonal phase. The maximum phonon cut-off energy of CaGd 2 (WO 4 ) 4 : Nd 3+ , Yb 3+ is 929 cm −1 , slightly larger than that of CaGd 2 (MoO 4 ) 4 : Nd 3+ , Yb 3+ (904 cm −1 ). Irradiated by 980 nm laser, PL spectra consist of the Nd 3+ : 4 F j → 4 I 9/2 (j = 7/2, 5/2, 3/2) and Yb 3+ : 2 F 5/2 → 2 F 7/2 emissions located in the near-infrared (NIR) range. Negative and positive thermal quenching behaviors are observed for the emissions of Nd 3+ (754, 802, and 868 nm) and Yb 3+ (1008 nm), respectively, attributed to the cooperative effects of the phonon-assisted energy transfer process of Yb 3+ → Nd 3+ and excited state absorption process of Nd 3+ . Moreover, the host material can affect the luminescence properties, thermal enhancement factor of the NIR anti-Stokes emission, and thermal sensing performance of the Nd 3+ -Yb 3+ pair. Consequently, CaGd 2 (MoO 4 ) 4 : Nd 3+ , Yb 3+ exhibits higher sensing sensitivity (S r-max = ∼6.00%K −1 ) than CaGd 2 (WO 4 ) 4 : Nd 3+ , Yb 3+ (S r-max = ∼5.56%K −1 ). This study provides useful information for the construction of high-performance ratiometric thermometers based on the inverse thermal dependence of the NIR emissions of Nd 3+ and Yb 3+ ions.
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