JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Xufa He,Kangle Jia,Longfei Yu,Huanling Li,Jinlan Xin,Xiaoshan Zheng,Junhua Ning,Haifu Wu,Linjia Huang,Wu Wen
Pickering emulsions that are stabilized by organic particles that are issued from renewable sources have attracted considerable attention. However, developing green and robust Pickering emulsions of various types via simple methods has always been an important challenge. Herein, a rosin derivative, namely, maleopimaric acid (MPA), which has three carboxylic acid groups, is used to stabilize Pickering emulsions. Various types of gel-like Pickering emulsions can be obtained by adjusting the wettability of rigid MPA by changing the pH, such as water (W) in oil (O), O/W, double, and multiple emulsions. With increasing MPA concentration and volume fraction of the oil phase, phase inversion occurs from W/O to O/W and from O/W to W/O, respectively. The formed gel-like Pickering emulsions have excellent external stimulus and mechanical stabilities and can withstand high temperature (70 °C), freeze-thaw treatment and high centrifugal forces. These outstanding properties are due to the stable interfacial film and the network structure that are formed by the self-assembly of MPA with heterogeneous ionization degrees. This study provides a natural rosin-based solid stabilizer with adjustable wettability and further advances the design of stable Pickering emulsions with various structural features based on practical application needs.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2022
·
IF 7.088
Yi Zhao,Yao Peng,Zhongzhen Yang,Jiaqi Lu,Ru Li,Yuesen Shi,Yaxin Du,Ze Zhao,Li Hai,Yong Wu
To synergistically treat glioma with a combination chemotherapy, we design and prepare novel cascade-targeted liposomes (Lip-TPGS) using glucose and triphenylphosphonium (TPP) as targeting moieties, which could intelligently deliver redox-sensitive doxorubicin (DOX) prodrugs (SDOX) and chemotherapeutic sensitizer lonidamine (LND). The pH-responsive ligand Chol-TPG modified by PEGylated glucose can overcome the blood-brain barrier and reach tumor cells. Combined with the modification of mitochondria targeting ligand (Chol-TPP), Lip-TPGS are endowed with pH-responsive charge regulation function and multi-stage targeting abilities. After triggered by the excessive glutathione in tumor cells, Lip-TPGS could sufficiently release the parent drugs DOX, which would significantly reduce side effects without compromising anti-glioma efficacy. Therefore, Lip-TPGS possess these characteristics: good pharmacokinetic behavior, superior brain targeting ability, specific tumor recognition and internalization capability, and strong endo/lysosome escaping and mitochondria targeting potential. Furthermore, Lip-TPGS exhibit significant advantages on anti-glioma by inhibiting proliferation, promoting apoptosis , inducing mitochondria dysfunction, inhibiting migration and invasion, prolonging the survival time, narrowing tumor areas, limiting lung metastasis , and reducing toxicity to normal organs. In summary, Lip-TPGS, with cascade targeting abilities from tissue/cell to organelle levels and highly controlled drug release properties, would become a promising drug delivery system for glioma treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-9
·
IF 38.104
Cao Changyu,Zhang Tingbo,Yang Nan,Niu Xianghong,Zhou Zhaobo,Wang Jinlan,Yang Dongliang,Chen Peng,Zhong Liping,Dong Xiaochen,Zhao Yongxiang
The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi 2 MoO 6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag + . As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electron-hole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O 2 to ·O 2 − . Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo 5+ /Mo 6+ , further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Xuesong Cai,Xiudi Xiao,Guizhang Sheng,Jieyuan Zheng,Yajie Zhao,Gang Xu
In wet-chemistry processes, pH value is an important parameter that can be used to control the microstructures of the as-grown nanostructures . In this work, W 18 O 49 nanowires with crystalline@amorphous core-shell structures were synthesized by controlling the pH of the precursor solutions in a hydrothermal reaction . Due to surface functionalization by ethylene glycol (EG) groups, the hydrothermally grown W 18 O 49 nanowires could be easily dispersed in aqueous environment, thus enabling the fabrication of electrochromic thin films of W 18 O 49 nanowires by a simple spray-drying process. The optimized W 18 O 49 nanowire films showed a large optical modulation (ΔT) of 81.1% at 633 nm, short response time (coloring/bleaching time τ c /τ b = 7.9 s/3.9 s), good cycle stability (ΔT retention was 84.5% after 1000 cycles), and the excellent memory effect (the color withstood for 36000s after turning off the voltage). Furthermore, the electrochromic device (ECD) (4 × 4 cm 2 ) based on the W 18 O 49 nanowires exhibits a large optical modulation of 56.6%, short response time (τ c = 7.6 s, τ b = 2.7 s), and superior coloration efficiency (CE) of 64 cm 2 C −1 . Finally, by simply amplifying the developed processes, a large-area electrochromic device (10 × 10 cm 2 ) was successfully prepared, which implies the possibility of large-area spraying process for practical applications.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Xinjing Du,Yuanyuan Peng,Chunyue Zhao,Jinfeng Xing
Tumor microenvironment-responsive nanogels loading antitumor drugs can improve the chemotherapy efficiency due to their suitable size, great hydrophilicity , excellent biocompatibility, and sensitivity to specific stimulation. Herein, a simple and effective strategy of one-pot laser-induced emulsion polymerization at 532 nm was developed to prepare carmofur-loaded nanogels based on biocompatible and temperature/pH-sensitive monomers including polyethylene glycol diacrylate (PEGDA), N-vinylcaprolactam (NVCL), and 2-(dimethylamino) ethyl methacrylate (DMAEMA). The nanogels loading carmofur with dual-stimuli responsive drug release properties were rapidly obtained under laser irradiation (beam diameter 2.5 mm, laser power 60 mW) for only 100 s. These nanogels exhibited an average hydrodynamic diameter of 195.9 nm and a low polydispersity index of 0.115. The effect of monomer ratio on the size, morphology, double-bond conversion, and thermo/pH-sensitivity of nanogels was investigated. The cumulative carmofur release from nanogels at pH 5.0 within 48 h was nearly three times that at pH 7.4, while the release amount at 42 °C was twice that at 25 °C, showing the controlled and sustainable release with the change of pH and temperature. The in vitro release kinetics of carmofur was in accord with first-order release model.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Environmental Science-Processes & Impacts
·
2022
·Vol. 24
·期 7
·1071-1081
·
IF 5.334
Qiqi Wei,Qiang Zhang,Yihan Jin,Usman Farooq,Weifeng Chen,Taotao Lu,Deliang Li,Zhichong Qi
To date, there is still very little knowledge about the combined effects of typical inorganic ligands and solution pH values on mobility characteristics of tetracycline (TC) through saturated aquifer media. In this work, three typical inorganic ligands (i.e., phosphate, silicate, and iodate) were employed in the transport experiments. Generally, all the ligands promoted TC mobility over the pH range of 5.0–9.0 owing to the enhanced electrostatic repulsion between sand grains and TC anionic forms (i.e., TC− and TC2−) as well as the competitive deposition between ligands and antibiotic molecules for attachment sites. Furthermore, the transport-enhancement effects of ligands on TC intensively depended on ligand type and followed the sequence of phosphate > silicate > iodate. This phenomenon was ascribed to their different molecular sizes and binding abilities to sand grains. Interestingly, the differences in extents of enhanced effects of various inorganic ligands on TC transport varied with background solution pH due to pH-induced different extents of deposition site competition effects. Moreover, the two-site nonequilibrium model (which accounts for an equilibrium site and a kinetic site) as well as adsorption and kinetic studies were performed to help interpret the controlling mechanisms for the synergistic effects of inorganic ligands and solution pH on TC transport in saturated quartz sand. The findings of our study clearly demonstrate that inorganic ligands may be critical factors in assessing the fate and transport of antibiotics in groundwater systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Yumin Wu,Ying Ma,Yiliang Gao,Yuetao Liu,Chuanhui Gao
A poly (lactic acid) (PLA) -based functional partition composite membrane (PLA/CA) containing chitosan (CS) and alizarin (AL) was designed by solution casting method. The PLA/CA membrane contains the antibacterial zone of the edge part (PLA/CS) and the pH response detection zone of the central part (PLA/AL). At the same time, the environmentally friendly plasticizer tributyl citrate (TBC) was added to make the prepared PLA/CA composite membrane have good flexibility and high transparency. The results of FE-SEM and FTIR showed that CS and AL were uniformly dispersed in PLA matrix and had good compatibility with PLA. The antioxidant activities of PLA/CS and PLA/AL composite films were 43.3 % and 72.8 %, respectively. At the same time, the inhibitory rates of PLA/CS membrane against Escherichia coli and Staphylococcus aureus were as high as 87.91 % and 75.17 %, respectively. PLA/AL films exhibit excellent UV barrier properties. When the environmental pH (ammonia and acetic acid vapor) changed repeatedly, the PLA/AL membrane showed reversible color change of yellow under acidic condition and purple under alkaline condition. During the packaging and storage of chicken breast meat, the freshness of chicken breast meat can be detected by the color change of functional PLA/CA composite membrane.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2022
·
IF 6.51
Tingting Du,Yuchi Wang,Zhiyong Luan,Chaoyue Zhao,Kangjuan Yang
The low immunogenicity and tumor immunosuppressive microenvironment (TIM) are two major obstacles for cancer immunotherapy . Synergistically immunogenic cell death induction and tumor-associated macrophages depletion could perfectly overcome this limitation. Herein, a tumor-associated macrophage (TAMs) membrane-camouflaged pH-responsive doxorubicin (DOX) loaded hyaluronic acid (HA)-g-poly (histidine) polymeric micelles ( [email protected] ) was fabricated for the first time. [email protected] could effectively accumulated into tumor regions via TAMs membrane mediated immune camouflage. In acidic tumor microenvironment , particle size of DHP was enlarged due to decrease hydrophobic interaction of inner core, which caused a “membrane escape effect” to expose inner HA residue. Together high expression of α4β1 integrin , [email protected] could reach CD44/VCAM-1 dual-targetability to facilitate intracellular DOX accumulation for efficient ICD induction. Meanwhile, TAMs membrane could absorb colony stimulating factor 1(CSF1) through high expression of its receptor (CSF1R) on TAMs membrane to deplete TAMs in tumor tissues and relieved TIM. This strategy could efficiently induce cytotoxic T lymphocyte (CTLs) infiltration for antitumor immune response and inhibit tumor progression in 4T1 tumor bearing Balb/c mice. Therefore, [email protected] is suitable for cancer chemotherapy-sensitized immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Xianliang Li,Yuyang Di,Zhihao Chen,Wenzhong Yang
In this study, novel pH-sensitive bimetallic Ce-ZIF-8 nanocontainers are loaded with benzotriazole (BTA) corrosion inhibitors and then decorated with a polydopamine (PDA) shell. The applied PDA layer acts as an acid-responsive gatekeeper, controlling the intelligent release of the encapsulated inhibitors and also preventing their self-leakage. UV–vis and ICP-OES tests indicate that the BTA and cerium inhibitors release slowly in the neutral 3.5 wt% NaCl solution. Afterward, the designed pH-responsive Ce-ZIF-8-BTA-PDA nanocontainers are dispersed uniformly in the epoxy matrix as a novel intelligent filler. EIS results demonstrate that the incorporation of Ce-ZIF-8-BTA-PDA nanocontainers significantly improves the corrosion resistance of epoxy coatings, in which the low-frequency impedance is about three orders of magnitude higher than that of the pure epoxy coating after 60 days of immersion. Furthermore, the low-frequency value of the scratched Epoxy-Ce-ZIF-8-BTA-PDA coating increases from 5.05 × 10 5 Ω cm 2 to 8.83 × 10 5 Ω cm 2 after 8 h of exposure to the 3.5 wt% NaCl solution, confirming their outstanding self-healing performance. The excellent corrosion protection and self-healing ability are due to the incorporation of the Ce-ZIF-8-BTA-PDA nanocontainers, improving the surface compactness and therefore enhancing the physical barrier effect. Moreover, the intelligent release of the encapsulated corrosion inhibitors provides active corrosion protection performance by forming a dense protective film on the Al alloy surface when the coating is damaged. Meanwhile, the highly dispersed nanocontainers lengthen the diffusion path of corrosive ions and therefore extend the service life of the epoxy coatings in aggressive environments. This new type of acid-responsive smart coating based on the bimetallic Ce-ZIF-8 nanocontainers has the potential to broaden the future applications of active corrosion protection of metals.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2021
·
IF 3.383
Jun Xu,Tiantian Hao,Changlin Liu,Jingjing Bi,Jing Sun,Zheng Wen,Zhaosheng Hou,Jinjian Wei
In this paper, we synthesized a new type of pH-responsive block polyurethane (PMCU) through the condensation polymerization of N-methyldiethanolamine (MDEA), poly(ε-caprolactone) and 4,4′-dicyclohexylmethane diisocyanate. The chemical structure of the PMCU were characterized, and the influence of MDEA content on the physicochemical properties of the casted PMCU films were studied detailly. The tensile test demonstrated the good tensile properties of the PMCU films with the breaking strain of 983–425% and the ultimate strength of 11.7–31.2 MPa. The tertiary amine groups and polyester segments endowed the material with pH sensitivity and hydrolytic degradability, respectively. The pH responsiveness of the films was confirmed from the enhanced equilibrium swelling ratio (ESR) with decreasing pH value of the medium, and the ESR in acidic condition (pH 1.5) was much higher than that in neutral (pH 7.0) and basic (pH 12.0) conditions. The studies of drug sustained-release in vitro at different pH indicated a pH-dependent release efficiency, which was closely related with the ESR and almost unaffected by the slow hydrolytic degradation. In addition, the cytotoxicity assay showed that the PMCU had good cytocompatibility to L929 cells. This study showed that pH-responsive promising platform for targeted drug delivery in the biomedical areas.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Wei Chen,Zhiyang Guo,Hao Yu,Qingyun Liu,Min Fu
Glycoproteins play vital roles in living organisms and often serve as biomarkers for some disease. However, due to the low content of glycoprotein in biological fluids, selective detection of glycoproteins is still a challenging issue that needs to be addressed. In this study, molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under physiological pH was proposed. Monodispersed glycoprotein imprinted particles (SiO 2 @PEI/MIPs) was first prepared based on surface imprinting strategy using horseradish peroxidase (HRP) as template, and polyethyleneimine (PEI) was used to increase the number of boronic acid groups. The binding experiment indicated that the SiO 2 @PEI/MIPs hold satisfactory adsorption capacity (1.41 μmol/g), rapid adsorption rate (40 min) and preferable selectivity toward HRP. Then the SiO 2 @PEI/MIPs was assembled into close-packed colloidal array to construct a label free optical sensor (denoted as GICA). Benefiting from the high ordered photonic crystal structure, binding of HRP onto the GICA could be directly readout from the changes in structure color and diffracted wavelength. The structure color of the GICA changed from bright blue to yellow with the diffraction wavelength red shifted 59 nm when the HRP concentration increased from 2.5 to 15 μmol/L. Importantly, the GICA was capable of detecting HRP from human serum samples. All those results indicated the potential of the GICA for naked-eye detection of glycoprotein.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TEXTILE RESEARCH JOURNAL
·
2021
·
IF 1.82
Long Feng,Yimiao Hou,Qingqing Hao,Mingxing Chen,Shuo Wang,Xuemin Hu,Wenxiu Yang
The deterioration of water ecology caused by the discharge of oil spill wastewater, industrial sewage, and municipal sewage has attracted wide attention worldwide. Thus, it is significant to design a simple, environmentally friendly approach to separate oil–water mixtures. In this work, three different fabrics with pH-induced wettability transition were prepared by a dip-coating process for oil and water separation. The dip-coating fabrics had the advantages of oil–water separation, photocatalytic degradation, and recycling. Polyethylene terephthalate/polyamide nonwoven fabric was used as the substrate materials of the fabric. The carboxylic acid-modified TiO2 endowed the fabric with hydrophilicity–hydrophobicity and photocatalytic properties. The Fe3O4 nanoparticles obtained by the coprecipitation method provided magnetism for the fabric, facilitating the recycling of the fabric and improving the hydrophobicity of the fabric. The fabrics coated with dipping solutions were superhydrophobic in a neutral environment and hydrophilic in an alkaline environment. Among the three coated fabrics, the fabric coated with stearic acid/TiO2-Fe3O4 (FST) had the most satisfying oil–water separation performance and durability. Under the neutral condition, the contact angle of the FST was 151° and the separation efficiency was 98%. Under the alkaline condition, the underwater oil contact angle of the FST was 150° and the separation efficiency was 95%. After 15 cycles, the oil–water separation rate of the FST was still higher than 90%. Due to the presence of TiO2, the coated fabric had an exceptional performance in the photodegradation of organic pollutants (69.9%). In addition, the fabrics can be quickly recovered due to magnetism.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）