NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 37
·17384-17397
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IF 3.591
X. Y. Wei,L. Ren,Y. N. Sun,X. Y. Zhang,X. F. Guan,M. Y. Zhang,H. X. Zhang
In this article, glycidyl methacrylate (GMA) was grafted on poly(butylene succinate) (PBS) by virtue of reactive blending in the extrusion process and thermoplastic starch (TPS) was prepared via a melt blend process with anhydroxylitol tripelargonate (AXP) as a bio-based plasticizer and starch as a polymer matrix. A ternary blend of fully biodegradable polymers, namely PBS-g-GMA, thermoplastic starch and poly(butylene adipate-co-terephthalate) (PBAT), was successfully fabricated in an attempt to achieve novel entirely biodegradable composites with good comprehensive properties. The mechanical properties, rheological behavior, thermal behavior, crystallization properties and microscopic morphology of PBS-g-GMA/TPS/PBAT composites were investigated in detail. The incorporation of 30 wt% TPS into the PBS-g-GMA/TPS composite promoted a dramatic increase of 47% in the Izod impact strength of the PBS, which indicated that our work proposed an efficient route to fabricate PBS composites with good properties by a simple, eco-friendly, and low-cost processing methodology. DMA results showed that the loss factor of the composite was dependent on the TPS amount, meanwhile, with the increase of PBAT, the glass transition temperature (Tg) was more affected. The change in storage modulus indicates that the addition of TPS can improve the elasticity and the degradation of elastic properties due to the addition of PBAT. Analysis of the rheological results showed that the storage modulus (G′), loss modulus (G′′) and complex viscosity increased significantly with increasing PBAT and TPS amount which could enhance their processability. SEM indicated that PBAT was compatible with the system, and the appearance of particles at a high TPS amount confirmed the occurrence of phase separation.
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高影响因子
OncoTargets and Therapy
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2021
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IF 4.147
Jian-Hong An,Chun-Yan Li,Chun-Ya Chen,Jian-Bin Wu,Hong Shen
Purpose Cisplatin is one of the most widely used antineoplastic drugs but has limited therapeutic effects due to nephrotoxicity. The aim of this study was to determine the possible renoprotective effect of the antioxidant raloxifene on cisplatin-induced nephrotoxicity in mice. Materials and Methods Cisplatin-induced acute renal injury was established in female C57 mice that were treated with saline (normal control) or raloxifene over a 7-day period. The body weight of the mice was recorded. Histopathological examinations of the kidney tissues were performed using H&E, PAS staining and TEM. The histomorphology of liver and other organs was observed by H&E staining. The serum levels of creatinine, blood urea nitrogen (BUN), alanine transaminase (ALT) and glutamic oxalacetic transaminase (AST) were analyzed by specific kits. Superoxide dismutase (SOD) and glutathione (GSH) activity, and the content of malondialdehyde (MDA) in the kidney, liver homogenates and HK-2 cells were measured by WST-8 and thiobarbituric acid colorimetric methods. Moreover, the mitochondrial structures of HK-2 cells were performed using TEM. The viability and proliferation of HK-2 cells were examined by CCK-8 and EdU incorporation assays. The mitochondrial membrane potential was measured by JC-1 fluorescence. Results Raloxifene significantly reduced the levels of serum creatinine, urea, ALT and AST in the cisplatin-treated mice, and alleviated cisplatin-induced renal and hepatic tissue injury. Furthermore, raloxifene also increased the activity of GSH and SOD in the renal tissues and HK-2 cells, and reduced MDA levels, thereby limiting oxidative stress in the kidney. Conclusion Raloxifene protected against cisplatin-induced nephrotoxicity by activating the antioxidant system, along with alleviating liver damage. It should be considered as a potential adjuvant in cisplatin-based chemotherapeutic protocols.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Wenbo Shen,Bin Du,Haitao Zhuo,Shaojun Chen
In this study, an Epoxy/POSS-liquid crystalline azobenzene-Poly (ethylene-co-vinyl acetate) (Epoxy/POSS-Azo-EVA) composite was prepared via the thermal curing of epoxy monomers and multi-functional thiol-containing Polyhedral oligomeric silsesquioxane (POSS) in an EVA matrix. The EVA matrix afforded the composite with shape memory performance. Epoxy/POSS polymer was uniformly dispersed in the matrix to act as a rigid skeleton, leading to the improvement of the mechanical properties and shape memory performance of the composite. Liquid crystalline azobenzene as the photosensitive component provided the inner stress to render the composite film with photo-induced shape-deformation behavior under UV light . The composite film not only exhibited thermal- and light-responsive programmable shape-memory behavior stimulated by heat and light, but also was recyclable and reprocessable. Moreover, the recycled composite film was processed into different functional devices. A flexible photomechanical device based on the recycled Epoxy/POSS-Azo-EVA composite film was fabricated, and the soft device deformed into a hook-shape under UV light and hooked an object whose weight is larger than that of the device. A smart wire was also prepared via assembling a stretched recycled Epoxy/POSS-Azo-EVA composite film and a copper foil by adhesive. The wire could control the status of a circuit via changing its shape under UV light and maintain the status after the removal of light. The functional devices described in this work only needed a short time of UV irradiation during a work cycle, and the devices still held the temporary shape in the absence of UV irradiation. The recyclable and reprocessable Epoxy/POSS-Azo-EVA composite film in this work could provide a creative approach for the fabrication of novel photomechanical devices and soft robotics with energy-saving, intelligence, recyclability , and sustainability.
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IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
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2021
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IF 2.73
Yang Liu,Hua Fu,Li Zuo
Background Angiogenesis and inflammation exhibit a mutually reinforcing relationship in many human diseases. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic mediators. Conbercept is a novel VEGF inhibitor.Method Type II collagen-induced rat rheumatoid arthritis (CIA) model was established to evaluate the anti-chronic inflammation activities of Conbercept. ELISA was used to measure the concentrations of immune factors in the blood of arthritis rats. The xylene-induced ear edema was conducted to evaluate the effect of Conbercept on acute inflammation.Result and discussion Our results showed that Conbercept significantly reduced the paw edema volume and the arthritis index in CIA rats. Furthermore, we found that Conbercept decreased the serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in CIA rats. Xylene-induced ear edema is a widely used method to study acute inflammation. Conbercept significantly inhibited xylene-induced ear edema.Conclusion All results indicate that Conbercept exhibits significant inhibition of acute and chronic inflammation.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Shaoyun Chen,Yongqiang Luo,Yihao Xu,Yanyu Zheng,Xiaoying Liu,Rui Wang,Bo Qu,Dongxian Zhuo
A novel bio-based prepolymer methacrylate cardan phenolic polycondensate (MCPP) was successfully synthesized via prepolymerization and methacrylation of cardanol. Its chemical structure was determined by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. MCPP-based three-dimensional (3D) printing resins with excellent coating properties were prepared. The MCPP-based 3D printing resins were cured using digital light processing, while some samples also underwent ultraviolet (UV) postprocessing. MCPP-based 3D-printed products exhibit excellent thermal and mechanical properties, including a glass-transition temperature and thermal stability temperature of 80.2 and 313.0 °C, respectively, along with tensile strength, storage modulus, and hardness values of 38.5 MPa, 5371.8 MPa, and 80.3 HD, respectively. The good performance of the MCPP-based 3D printing resins was attributed to the rigidity of their compact cross-linked structures. This study pioneers a method for the production of photoactive acrylates like cardanol-based methacrylate oligomer resins from renewable, low-cost, aromatic biomass for use in photocurable 3D printing.
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高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Tianchi Chen,Jie Guo,Hao Xu,Jialu Zhang,Ningning Hu,Hongtao Liu
Various types of functional materials incorporating superhydrophobic components have been rapidly developed for efficient oil/water separation. The post-processing of these used separated materials remains a challenging problem due to their non-biodegradable characteristics in natural environments, thus easily contributing to secondary contamination. Herein, we report a biodegradable superhydrophobic PLA fabric with hierarchical coral-like micro/nano structures by a one-step spraying method. The as-prepared PLA fabric was found to be both superhydrophobic and superoleophilic with a static water contact angle of 161 ± 2° and an oil contact angle of 0°. In addition, the as-prepared PLA nonwoven fabrics also revealed efficient continuous oil separation efficiency (>97.5%) and tiny water droplet collection efficiency, as well as high oil flux ranging from 2239 L·m −2 ·h −1 to 59,713 L·m −2 ·h −1 . Furthermore, these fabrics retained their inherent wetting property and oil separation ability in a variety of acidic and basic solutions, 3.5 wt% NaCl solution, hot (100 °C), and freezing (0 °C) temperatures. This study provides a novel and environmentally friendly method for preparing biodegradable oil–water separation materials with green post-treatment characteristics when compared to the non-biodegradable separation materials, indicating potential applications in the fields of green water treatment and petroleum refining.
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CHEMOSPHERE
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2021
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IF 7.086
Siyan Che,Sunni Chen,Shiqi Li,Zheng Ruan
Decabromodiphenyl ether (BDE-209) tends to accumulate in lipid-rich tissues and targets the liver since its high lipophilicity. This study aimed to investigate the effects of BDE-209 on mouse liver and reveal the underlying toxicological mechanisms. Here we firstly confirmed that treatment of BDE-209 could lead to an imbalance of redox and promote apoptosis with a mitochondria-dependent manner in mice livers. Next, the transmission electron microscope (TEM) image revealed BDE-209 induced changes in mitochondrial morphology and increased endoplasmic reticulum (ER) - mitochondrial contact. ER stress was involved in the apoptosis process, which was displayed by the enhancive ER stress makers . Finally, from the increased abundance of cellular pivotal Ca 2+ signals transducer CaM, activating Ca 2+ release channel Sig-1R and IP3R1, and the stronger fluorescence density of mitochondria-specifically Ca 2+ labeled probe Rhod-2 in vitro , we summarized that there was overloaded mitochondrial Ca 2+ in hepatocytes of BDE-209 treated mice. In conclusion, these results partly illustrated evidence to reveal a potential mechanism of BDE-209-induced hepatoxicity, where oxidative stress-induced-ER stress led to the over-release of Ca 2+ , followed by the overloaded mitochondrial Ca 2+ , and cell apoptosis initiated. Our findings provided a theoretical basis for further studying.
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PubMed
高影响因子
Bioengineered
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2021
·
IF 3.269
Chuanfeng Lv,Hui Li,Hongxia Cui,Qianyu Bi,Meng Wang
Allergic asthma is one of the most common chronic airway diseases, and there is still a lack of effective drugs for the treatment of allergic asthma. The purpose of this work is to formulate rhynchophylline (Rhy)-solid lipid nanoparticles (SLNs) to improve their therapeutic efficacy in a mice allergic model of asthma. A solvent injection method was employed to prepare the Rhy-SLNs. Physicochemical characterization of Rhy-SLNs was measured, and the release assessment was investigated, followed by the release kinetics. Next, a model of murine experimental asthma was established. Mice were subcutaneously injected with 20 μg ovalbumin mixed with 1 mg aluminum hydroxide on days 0, 14, 28, and 42 and administrated aerosolized 1% ovalbumin (w/v) by inhalation from day 21 to day 42. Mice were intraperitoneally injected with 20 mg/kg Rhy-SLNs or Rhy at one hour before the airway challenge with ovalbumin. The results showed that Rhy-SLNs revealed a mean particle size of 62.06 ± 1.62 nm with a zeta potential value of −6.53 ± 0.04 mV and 82.6 ± 1.8% drug entrapment efficiency. The release curve of Rhy-SLNs was much higher than the drug released in phosphate buffer saline at 0, 1, 1.5, 2, 4, or 6 h. Moreover, Rhy-SLNs exerted better effects on inhibiting ovalbumin-induced airway inflammation, oxidative stress, airway remodeling (including collagen deposition and mucus gland hyperplasia) than Rhy in murine experimental asthma. Subsequently, we found that Rhy-SLNs relieved allergic asthma via the upregulation of the suppressor of cytokine signaling 1 by repressing the p38 signaling pathway.
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高影响因子
WATER ENVIRONMENT RESEARCH
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2021
·Vol. 93
·期 12
·3023-3036
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IF 1.946
Xuecheng Sun,Shuguang Lyu
l -cysteine-modified Fe 3 O 4 nanoparticles ( l -cys@nFe 3 O 4 ) were synthesized successfully and used as catalyst to activate persulfate (PS) for benzene, toluene, ethylbenzene, and xylenes (BTEX) degradation. The composite was fully characterized, and the l -cys@nFe 3 O 4 had more protrusions and l -cys was combined on the surface of nFe 3 O 4 . The removals of BTEX were 78.2%, 85.1%, 85.3%, 81.2%, respectively, in PS/ l -cys@nFe 3 O 4 system, while only 52.7% 57.8%, 60.8%, and 56.3% of BTEX removals reached under the same condition for nFe 3 O 4 chelated with l -cys in 48 h. Four successive cycles of BTEX degradation were completed in PS/ l -cys@nFe 3 O 4 system. The synergistic mechanisms of BTEX degradation in PS/ l -cys@nFe 3 O 4 system were investigated by electron paramagnetic resonance (EPR), benzoic acid (BA) probe and X-ray photoelectron spectroscopy (XPS) tests. S Fe bond in l -cys-Fe complexes promoted the electron transfer between nFe 3 O 4 core and the solution, iron and iron at the interface, thereby promoting the Fe 3+ /Fe 2+ cycle and the catalytic capacity of nFe 3 O 4 . The optimal pH of PS/ l -cys@nFe 3 O 4 system was 3, while HCO 3 − and Cl − exhibited negative influences on BTEX degradation. Only 14.2%, 15.5%, 15.9%, and 15.6% BTEX had been removed in the presence of 0.12-M PS and 8.0 g/L l -cys@nFe 3 O 4 under the actual groundwater condition. However, expanding the dosage of PS and l -cys@nFe 3 O 4 was an effective strategy to overcome the adverse effect. Practitioner Points L-cys@nFe 3 O 4 were synthesized successfully and used as catalyst to activate PS for BTEX degradation. Four successive cycles of BTEX degradation were completed in PS/L-cys@nFe 3 O 4 system. lS―Fe bond in L-cys@nFe 3 O 4 promoted the electron transfer between PS and nFe 3 O 4 core.
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高影响因子
Experimental and Therapeutic Medicine
·
2021
·Vol. 23
·期 1
·1-10
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IF 2.447
Tian Zhang,Tan Wang,Xinxu Chen,Zhenqiang Zhao,Zhibin Chen
The composition of the intestinal flora of patients with Parkinson's disease (PD) can change. However, whether reshaping the gut microbial composition can treat PD remains to be seen. The present study evaluated the effect of intestinal flora in the treatment of PD in a C57BL/6 mouse PD model induced by 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP). Chronic, low‑dose, MPTP‑treated mice exhibited upregulated gene expression levels of TNF‑α and IL‑1β in the substantia nigra (SN) of the mice, and induced intestinal microbial disorders. This indicated that the chronic low‑dose MPTP model could be used to evaluate the progress of early intestinal pathology and intestinal flora imbalance in PD. After transplantation of faecal bacteria to MPTP‑induced PD mice, the level of inflammation in the SN of the mice was reduced, and motor dysfunction was alleviated. Notably, faecal microbiota transplantation (FMT) upregulated the abundance of Blautia but downregulated Anaerostipes, Bifidobacterium, ASF356 and Ruminococcus in the gut of PD mice. In addition, FMT reduced the activation of microglia and astrocytes in the SN and reduced the expression levels of GSK3β, IL‑1β, inducible nitric oxide synthase and phosphorylated PTEN in the SN. Overall, the present study demonstrated that gut microbial dysfunction is associated with the pathogenesis of PD, and that FMT can protect PD mice by inhibiting neuroinflammation.
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高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yu He,Yunxiang Cai,Ling Zhang,Kaige Liu,Gang Liu,Bingxi Xiang,Jianpang Zhai,Ling Bing Kong,Tianshu Zhang,Yin Liu
Al 2 O 3 transparent ceramics have important applications in electronics, solid-state lighting, military and 5G industries. At present, thin and large-size Al 2 O 3 ceramics are urgently required by enterprises. Tape casting method has emerged as a powerful tool in producing transparent ceramics, but the preparation of the slurries is generally very time consuming. In this study, a one-step ball milling process was proposed to fabricate Al 2 O 3 transparent ceramics through non-aqueous tape casting, in which green tapes were obtained with uniform texture and no distortion. Thickness of the Al 2 O 3 transparent ceramics approached 0.1 mm. The effects of dry pressing on single and double-layer tapes were also compared. It was found that dry pressing has essentially no effect on monolayer samples, but contributed to improve the densification and promoted grain growth of the bilayer samples. Our results could be used as reference for the preparation of extremely thin Al 2 O 3 transparent ceramic wafers.
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高影响因子
STARCH-STARKE
·
2021
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IF 2.741
Hui Yang,Rihui Lin,Yanye Fan,Sai Jiang,Yujiao Lin
The rosin acid starch (RAS) is prepared under the catalysis of lipase, by esterification on the starch particles' surface in a two-phase reaction system, using rosin acid and native cassava starch as starting materials. The effects of reaction time, solvent types, substrate ratio, reaction temperature, and lipase dosage on the degree of substitution (DS) of RAS are investigated. Based on the single factor experiments, the reaction conditions are optimized according to the principle of the combination Box-behnken centered design and response surface methodology analysis. The mathematical model of the influence of reaction temperature, material ratio, and enzyme addition amount on DS is established. The optimum synthesis conditions are determined as follows: solvent, trichloromethane; reaction time, 10 h; reaction temperature, 59 °C; substrate ratio (m Rosin acid :m starch) , 4.1; and lipase dosage, 264 µL. Under these conditions, it is found that the DS is 0.0608. The analysis of variance and verification experiments show that the mathematical model has good fit degree and high credibility. Compared with the native cassava starch, RAS has improved contact angle, emulsion capacity, and emulsion stability.
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