Journal of Analytical Methods in Chemistry
·
2022
·Vol. 2022
·期 1
·2565494
·
IF 2.594
Qiulong Zhao,Chunxue Wang,Jiaxin Cheng,Hui Yan,Ling Wang,Dawei Qian,Jinao Duan
According to the sixth edition of China’s “New Coronavirus Diagnosis and Treatment Plan (NCDTP),” ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested to take with extreme caution and full reasons. Therefore, we aim to describe the pharmacokinetics of seven active phytochemicals and semiquantification of nine relevant metabolites in ReDuNing injection (RDN) after combining with cefuroxime sodium (CNa) for injection in rat plasma. Male Sprague–Dawley rats were randomly assigned to six groups, and they were intravenously administered, respectively, with different prescriptions of RDN (2 mL/kg) and CNa (225 mg/kg). At different time points (0.03, 0.08, 0.17, 0.24, 0.33, 0.50, 0.67, 1, and 6 h) after administration, the drug concentrations of iridoids glycosides, organic acids, and metabolites in rat plasma were determined using ultrahigh-pressure liquid chromatography coupled with linear ion rap-orbitrap tandem mass spectrometry (UHPLC–LTQ–Orbitrap–MS), and main pharmacokinetic parameters were estimated by noncompartment model. The results showed that there were differences in pharmacokinetic parameters, AUC (0-t) , T 1/2 , C max , CL of iridoids glycosides, and organic acids, after the intravenous administration of the different combinations of RDN and CNa. Moreover, different combinations of the injections also resulted in different curves of relative changes of each metabolite. The obtained results suggested that RDN and CNa existed pharmacokinetic drug–herb interactions in rats. The findings not only lay the foundation for evaluating the safety of RDN injection combined with CNa but also make contributions to clinically applying RDN injection combined with CNa, which works potentially against severe forms of COVID-19.
研究领域:
药理学
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药物代谢
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中药学
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临床药学
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分析化学
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病毒学
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转化医学
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DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 30
·期 9
·2313-2320
·
IF 2.162
Hui Zhao,Si-Qi Zhao,Guo-Hua Hu,Qun-Chao Zhang,Yang Liu,Chong-Xing Huang,Wei Li,Tao Jiang,Shuang-Fei Wang
A facile method was developed to synthesize a new type of polyhedral oligomeric silsesquioxane (POSS). It contained a single amine group and seven aliphatic moieties on its corners. FT-IR, 1 H-NMR, 13 C-NMR, 13 C- 1 H COSY, and 1 H- 1 H COSY confirmed that cages with eight corners were the main part of the product. This new POSS was used to modify the structure of hexamethylene diisocyanate trimer and then copolymerized with hexamethylene diisocyanate and poly (tetramethylene glycol) to get a serious of waterborne polyurethane (WPU)/POSS hybrid materials with low dielectric constants for microelectronics applications. The results showed that POSS particles were uniformly dispersed in the WPU dispersions. The WPU/POSS films did not show any macrophase separation, even when the POSS content was as high as 16%. As the POSS content increased from 0% to 16%, the tensile strength was increased from 2.3 to 7.3 MPa, the dielectric constant was decreased from about 2.9 to 2.0, and the thermal stability of the WPU/POSS was also improved.
研究领域:
高分子科学
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材料化学
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纳米复合材料
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电子封装材料
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功能高分子
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DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Lu Shi,Wei Liu,Yanhu Xue,Mei Hong,Xiangling Ji
Temperature Rising Elution Fractionation (TREF) is effective for separating polyolefin resins according to crystallizability. A relatively low isothermal crystallization temperature is necessary to fractionate poly(1-butene) (PB-1) resin because of its slow crystallization kinetics . This study aims to investigate the influence of isothermal crystallization temperature of TREF on the fractionation and chain microstructure of eluted fractions for one poly(1-butene-co-ethylene) with 5.8 mol% ethylene. The resin is fractionated using P-TREF under four different isothermal crystallization temperatures, i.e. 0 °C, −5 °C, −10 °C, and −30 °C, and then the fractions are characterized by high-temperature gel permeation chromatography (HT-GPC), 13 C nuclear magnetic resonance spectroscopy ( 13 C NMR), and differential scanning calorimetry (DSC) to acquire their chain microstructure information. The isothermal crystallization temperature significantly affects the nucleation and growth of the crystals, which consequently results in differences in the relative content of eluted fractions. With the decrease of isothermal crystallization temperature from 0 °C to −30 °C, the copolymer is fractionated more effectively since fractions are more evenly distributed among elution temperatures rather than concentrated at lower elution temperatures. Furthermore, the isothermal crystallization temperature influences the chain microstructure of fractions obtained at the same elution temperature, which are different in ethylene content, isotacticity, and average sequence length. The distribution of ethylene content and isotacticity becomes broader with the decrease in isothermal crystallization temperature. Lower isothermal crystallization temperature is conducive to effective separation of the fractions with weak crystallizability. These results are of great significance for the selection of fractionation conditions and chain microstructure analysis of poly(1-butene-co-ethylene) resins.
研究领域:
高分子化学
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材料科学
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聚合物表征
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热分析
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核磁共振波谱学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Bin Qin,Yifei Cai,Xiaoqing Si,Chun Li,Jian Cao,Weidong Fei,Junlei Qi
The practical application of lithium-sulfur (Li-S) batteries is impeded by the shuttle effect of intermediate polysulfides and the inherent sluggish kinetics. Herein, Mo 2 C nanocatalysts anchoring on holey graphene scaffold (Mo 2 C@HGr) is explored as a lightweight and ultrathin modified separator to conquer the above issues. The artificially customized holes on holey graphene sheets facilitate ionic transfer and electrolyte penetration, and further enhance the sulfur utilization under lean electrolyte conditions. The experimental results together with theoretic calculation demonstrate the favourable chemical adsorption ability of Mo 2 C sites that blocking the diffusion of LiPSs. Abundant triple-phase interfaces among Mo 2 C nanomediators, holey graphene and electrolyte boost the conversion kinetics of the intercepted LiPSs. As a result, the cell with Mo 2 C@HGr modified separator shows superior rate capability (836 mAh g −1 ) even at 5 C current with a negligible Mo 2 C@HGr loading of 0.08 mg cm −2 . Furthermore, ultrahigh areal capacity of 5.9 mAh cm −2 is still attained with high sulfur loading of 6 mg cm −2 under lean electrolyte operation (E/S = 5.6 µL mg −1 ). This design concept can be extended to other graphene based multifunctional nanocomposite toward the development of more practical Li-S batteries.
研究领域:
电化学
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能源材料
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纳米催化
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电池技术
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功能复合材料
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2017
·
IF 2.726
Tianhua Huang,Dingqiang Lu,Xiuquan Ling,Xinxian Wang,Tongqi Liu,Fangfang Shen,Kefei He
In this paper, we focused on solubility and solution thermodynamics of istradefylline. Herein, we investigated the solubility and solution thermodynamics of istradefylline in binary solvent mixtures by gravimetric method. The solubility of istradefylline in (ethyl acetate + isopropanol), (ethyl acetate + tetrahydrofuran) and (ethyl acetate + acetone) was measured in the temperature range of 278.15 K–333.15 K under atmospheric pressure. In order to correlate the solubility of istradefylline, we employed the modified Apelblat equation, general cosolvency model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation and general cosolvency model have low mean deviation. As calculated by van’t Hoff equation, the values of thermodynamic properties such as Gibbs energy, enthalpy, and entropy proved that the dissolution process is endothermic.
研究领域:
药物化学
·
药剂学
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物理化学
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药物热力学
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分子溶解行为
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药物结晶
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DOI
高影响因子
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2014
·Vol. 52
·期 5
·3072-3078
·
IF 2.024
Song Lianjun,Zhi Junli,Zhang Pingan,Zhao Qiuyan,Li Ning,Qiao Mingwu,Liu Jie
In this study, a new method was developed to produce biodegradable material using soy protein isolate (SPI) as matrix. The blend films were successfully prepared by casting the aqueous dispersions of SPI and polyamic acid salt (PAS) solution. The effects of blending and PAS content on the structure of the resultant films were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) analyses, scanning electron microscopy (SEM). Furthermore, film thickness, water vapor permeability (WVP), water barrier and mechanical properties were measured. The result showed that there exists strong intermolecular interactions between SPI and PAS, which played an important role in forming a homogeneous structure of the blend films. Moreover, the incorporation of PAS enhanced the water barrier and mechanical properties of the films. This is a simple way to prepare biodegradable films compared with other methods and the blend films have the potentiality to be used as food packaging and biomedical materials instead of synthetic polymer.
研究领域:
生物材料学
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高分子科学
·
食品科学
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包装工程
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生物医学工程
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2016
·
IF 2.196
Peizhu Zheng,Dongxing Cai,Jihua Zhao,Weiguo Shen
The mixed surfactants of dodecyltrimethylammonium bromide (DTAB) and 1-dodecyl-3-methylimidazolium bromide (C 12 mimBr) in aqueous solutions were studied by measurement of electrical conductivity and isothermal titration microcalorimetry (ITC). The critical micelle concentrations (cmc) and the degree of dissociations of counter ions were determined for this system at various surfactant compositions, and the thermodynamic properties of micellization were evaluated. A one-parameter Margules equation was used to fit the cmc values to calculate the mole fraction, the activity coefficients of two surfactant components and the excess properties in mixed micelles.
研究领域:
胶体化学
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物理化学
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表面化学
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热力学
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溶液化学
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DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2013
·
IF 2.144
XiaoDan Zeng,Lin Zhu,FuSheng Zhang,LiYun Feng
The interaction of bovine serum with leucomalachite green (LMG) was investigated by spectroscopic methods . LMG was found to quench the intrinsic fluorescence of BSA by dynamic quenching. High quenching constant suggested that LMG can form a complex with BSA. Binding constant and number of binding site were determined. The thermodynamic parameters suggested the main interacting force is hydrophobic forces . The effect of LMG on the conformation of BSA was analyzed by synchronous fluorescence spectroscopy . RLS spectra were also used to reconfirm the formation of complex between BSA and LMG.
研究领域:
生物化学
·
分子生物学
·
光谱学
·
药物代谢
·
蛋白质-配体相互作用
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DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2017
·Vol. 303
·期 2
·1700396
·
IF 2.863
Zhihui Qin,Rui Niu,Chenjue Tang,Jun Xia,Feng Ji,Dianyu Dong,Haitao Zhang,Shuo Zhang,Junjie Li,Fanglian Yao
A novel type of physical hydrogel based on dual-crosslinked strategy is successfully synthesized by micellar copolymerization of stearyl methacrylate, acrylamide, and acrylic acid, and subsequent introduction of Fe 3+ . Strong hydrophobic associations among poly(stearyl methacrylate) blocks form the first crosslinking point and ionic coordination bonds between carboxyl groups and Fe 3+ serve as the second crosslinking point. The mechanical properties of the hydrogel can be tuned in a wide range by controlling the densities of two crosslinks. The optimal hydrogel shows excellent mechanical properties (tensile strength of ≈6.8 MPa, elastic modulus of ≈8.0 MPa, elongation of ≈1000%, toughness of 53 MJ m −3 ) and good self-recovery property. Furthermore, owing to stimuli responsiveness of physical interaction, this hydrogel also shows a triple shape memory effect. The combination of two different physical interactions in a single network provides a general strategy for designing of high-strength hydrogels with functionalities.
研究领域:
高分子材料科学
·
生物医用材料
·
组织工程
·
智能响应材料
·
软物质物理
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Shiyuan Chen,Junheng Zhang,Jiliang Zhou,Daohong Zhang,Aiqing Zhang
A novel hyperbranched polymeric ionic liquid (HBP-AMIM + PF6 − ) was explored via a thiol-ene click reaction using thiol-ended hyperbranched polyesters (THBP) and 1-allyl-3-imethylimidazolium hexafluorophosphate (AMIMPF6). The effects of HBP-AMIM + PF6 − on the curing behavior, mechanical properties and thermal stability of benzoxazine/epoxy thermosets were investigated. The gelation time and differential scanning calorimetry of non-isothermal analysis indicated that the addition of HBP-AMIM + PF6 − significantly decreased the curing temperature of benzoxazine/epoxy thermosets. Simultaneously, the addition of HBP-AMIM + PF6 − also improved the strength, toghness and thermal properties of benzoxazine-epoxy thermosets. The addition of 3 wt% HBP-AMIM + PF6 − -2 could significantly improve the mechanical and thermal performance of thermosets compared with that of cured neat benzoxazine/epoxy resin. The tensile strength, tensile toughness, flexural strength and flexural modulus, impact strength of the thermosets were improved by about 76.6%, 279.3%, 57.8%, 22.3% and 80.4%, respectively, compared with those of cured neat resin. The toughening mechanisms was attributed to the “in situ” reinforcing and toughening mechanism.
研究领域:
高分子材料
·
材料科学
·
热固性树脂
·
复合材料
·
高分子化学
·
功能材料
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DOI
高影响因子
COMBUSTION AND FLAME
·
2021
·
IF 4.185
Zhi-Hao Jin,Jin-Tao Chen,Wang Li,Shu-Bao Song,Jiu-Zhong Yang,Zhen-Yu Tian
Owing to significant advantages over traditional biofuels, 2-methylfuran (MF) has arisen extensive interest as next generation biofuels . Atmospheric pressure pyrolysis of a 1:1 blend of MF with a three-component (3C) surrogate jet fuel was conducted in a flow tube using synchrotronphotoionization and molecular beam mass spectrometry techniques within a temperature range of 898–1223 K. Therein, the 3C surrogate fuel consists of 66.2% n-dodecane (NC 12 H 26 ), 18.0% 1,3,5-trimethylcyclohexane (T135MCH) and 15.8% n-propylbenzene (NPB, A1C 3 H 7 ). The detailed kinetic model including 579 species and 3474 reactions was developed via validating against both measured and literature data with reasonable agreement. MF exhibits no obvious influence on the 3C components pyrolysis . However, 3C mixtures play an important roles in MF decomposition: lower initial temperature and different decomposition pathways. In the meantime, n-propylbenzene (NPB) pyrolysis curve in 3C and 3C+MF significantly transfers to low temperature zone after 1000 K in contrast to pure NPB, while smaller change was found in the decomposition curve of n-dodecane. Compared with 3C pyrolysis, 3C+MF blends have less formation of aromatic species and light hydrocarbons except for vinylacetylene (C 4 H 4 ) and acetylene (C 2 H 2 ). Allyl radical (C 3 H 3 ) has significant roles in benzene ring formation. The combination of allyl radical with propargyl radical producing benzene and H radical (aC 3 H 5 + C 3 H 3 = A1 + 2H) has the highest contribution to the benzene formation in both 3C and 3C+MF. Moreover, most of naphthalene (A2) formation is also related to C 3 H 3 radical via reaction: A1CH 2 + C 3 H 3 = A2 + H, rather than via HACA (hydrogen abstraction carbon addition) reaction. Interaction of fuel blends was mainly presented through the common and important sensitive reactions which are much to do with CH 3 and H radicals. The overview of product distribution was investigated by providing comparisons of carbon conversion rates during the pyrolysis of 3C and 3C+MF. These results will be helpful to better understand the pyrolysis properties of MF/jet fuel surrogate blends and could contribute to developing new generation biofuels for aviation.
研究领域:
燃料化学
·
燃烧动力学
·
生物燃料
·
能源化学
·
反应机理
·
质谱分析
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DOI
高影响因子
Small
·
2022
·Vol. 18
·期 29
·2202622
·
IF 15.153
Hao Zhu,Zixuan Chen,Yun Chen,Jun-Jie Zhu
Quantifying the binding kinetics and affinities of protein–small molecule interactions is critical for biomarker validation, drug discovery, and deep understanding of various biological processes at the molecular-scale. Novel approaches are demanded as most common label-free techniques are mass-sensitive, which are not suitable for the detection of small molecule interactions. Here, an optical imaging platform is developed to measure the binding kinetics of both protein–small molecules and protein–ions based on monolayer MoS 2 , an ultra-thin 2D material whose optical absorption is extremely sensitive to charge. A model is established to calibrate the optical response due to the charged analyte binding and it is applied to quantify the interactions between abl1 kinase and different small-molecule inhibitors. Such a presented method is capable of distinguishing different inhibitors binding to a wild or mutated kinase, which provides guidance for drug evaluation and drug mechanism exploration. The binding kinetics of calcium ions to calmodulin is also measured, further broadening the application field of the method. In addition, the imaging capability allows mapping the local binding kinetics of the molecular interactions with a high resolution, which reveals visible spatial variability and offers a promising tool for studying heterogeneous local interfacial interactions.
研究领域:
分子生物学
·
药物发现
·
生物传感器
·
化学生物学
·
生物物理
·
转化医学
·
纳米生物技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）