ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Hongying Liu,Cairui Zhang,Chenwei Wang,Kai Fan,Yuqing Zhang,Lu Fang,Lihua Li,Chaoxiang Ren,Zheng-Zhi Yin,Zhong Lü
Promethazine (PMZ) is an effective antihistamine that is used as a nerve tranquilizer to treat mental disorders. However, drug abuse causes harm to the human body and also pollutes the environment to a certain extent. Therefore, it is crucial to develop a highly selective and sensitive biosensor for PMZ determination. An acupuncture needle (AN) was used as an electrode in 2015, and further research on the electrode's essence in electrochemistry is needed. In this work, a sensor based on a surface imprinted film coordinated Au/Sn biometal was first fabricated on AN via electrochemistry. The obtained cavities showed complementary and suitable sites for “N atom” electron transfer through the phenyl ring structure in promethazine, which is rigorous for the configuration near the interface. Under the optimal conditions, MIP/Au/Sn/ANE exhibits a good linear relationship in the range of 0.5 μM–500 μM, and the detection limit (LOD) is 0.14 μM (S/N = 3). The sensor exhibits good repeatability, stability, and selectivity and can be successfully used to analyze and detect PMZ in human serum and environmental water. The findings are scientifically significant for AN electrochemistry and the sensors have potential for in vivo medicamentosus monitoring in the future.
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高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Ruoxi Zhang,Shengchen Ke,Wenxiang Lu,Weijian Zhu,Lu Ma,Linling Qin,Shaolong Wu,Xiaofeng Li
Constructing novel heterojunctions has become an effective strategy to improve the performance of photoelectrochemical (PEC) biosensors, but most of the glucose-sensing photoelectrodes involve enzyme modification and disordered or semi-closed surface topography which restricts the working environment and sensing performance. Herein, the dense and burr-like CuO nanospikes (CuONSs) are grown on all over the whole surfaces of the relatively-sparse and ordered Si nanowires (SiNWs) by a combination of magnetron sputtering and hydrothermal growth. The optimized SiNWs-CuONSs heterojunction with a core–shell structure achieves the enzyme-free PEC detection of glucose with a sensitivity of 2324.09 μA mM −1 cm −2 in the concentration range of 0–1.0 mM and a detection limit of 0.74 μM (Signal/Noise = 3). The excellent sensing performance is ascribed to that (1) the SiNWs with a large specific surface area acting as host have open-style surface topography, ensuring the analyte flowability; (2) the CuONSs with a desired glucose-catalytic activity are hierarchical, providing a great number of active sites; and (3) the SiNWs-CuONSs heterojunction has a satisfactory optical absorption and a high efficiency of the photogenerated-hole transfer. This work demonstrates that the enzyme-free and highly-sensitive glucose detection can be realized by morphology-controllable heterojunction, and provides an alternative route to noninvasive sensing.
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高影响因子
Journal of Environmental Sciences
·
2023
·
IF 6.9
Xiang Zhang,Yunpeng Huang,Jikun Wang,Jie Tang,Yang Mei,Nali Zhu,Zhigang Li,Lingxiangyu Li,Yawei Wang
The nanoscale zinc oxide (n-ZnO) was used in food packages due to its superior antibacterial activity, resulting in potential intake of n-ZnO through the digestive system, wherein n-ZnO interacted with saliva. In recent, facet engineering, a technique for controlling the exposed facets, was applied to n-ZnO, whereas risk of n-ZnO with specific exposed facets in saliva was ignored. ZnO nanoflakes (ZnO-0001) and nanoneedles (ZnO-1010) with the primary exposed facets of {0001} and {1010} respectively were prepared in this study, investigating stability and toxicity of ZnO-0001 and ZnO-1010 in synthetic saliva. Both ZnO-0001 and ZnO-1010 partially transformed into amorphous Zn 3 (PO 4 ) 2 within 1 hr in the saliva even containing orgnaic components, forming a ZnO-Zn 3 (PO 4 ) 2 core-shell structure. Nevertheless, ZnO-1010 relative to ZnO-0001 would likely transform into Zn 3 (PO 4 ) 2 , being attributed to superior dissolution of {1010} facet due to its lower vacancy formation energy (1.15 eV) than {0001} facet (3.90 eV). The toxicity of n-ZnO to Caco-2 cells was also dependent on the primary exposed facet; ZnO-0001 caused cell toxicity through oxidative stress, whereas ZnO-1010 resulted in lower cells viability than ZnO-0001 through oxidative stress and membrane damage. Density functional theory calculations illustrated that ·O 2 − was formed and released on {1010} facet, yet O 2 2− instead of ·O 2 − was generated on {0001} facet, leading to low oxidative stress from ZnO-0001. All findings demonstrated that stability and toxicity of n-ZnO were dependent on the primary exposed facet, improving our understanding of health risk of nanomaterials.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 27
·12759-12769
·
IF 3.3
Yuheng Deng,Jie Zhao,Yaoguang Yu,Junhan Gao,Shifan Zhao,Jianying Yuan,Qingze Han,Guofeng Cui
In this study, we report a rapid and efficient strategy by cyclic square wave voltammetry (CSWV), a novel voltammetric technique, to detect dopamine (DA) and epinephrine (EP) separately and simultaneously with an unmodified graphene-based integrated electrode. The CSWV method, with high sensitivity and capability of mechanistic study, is achieved by controlling an inexpensive modified open-source potentiostat (MOSP) that has a superior performance comparable to commercial benchtop electrochemical workstations. Based on the different intramolecular cyclization reaction rates of DA and EP depending on pH, the concentration of DA could be derived from the cathodic peak at +0.12 V, and the concentration of EP could be calculated from the negative cathodic peak at −0.26 V. The CSW voltammogram presented that the linear range of both DA and EP was 5–70 μM, with a detection limit of 2.14 μM and 1.94 μM (S/N = 3) at neutral pH, respectively. In addition, the cathodic currents of CSWV were 12.68 and 10.72 times higher than those of cyclic voltammetry (CV) and 1.53 and 1.24 times higher than those of cathodic square wave voltammetry (cSWV). The proposed method showed a strong anti-interference capability and can be applied to detect DA and EP in the real sample (calf serum sample), with a recovery rate in the range of 100.05–108.25%. The introduced electrochemical determination method can provide a promising application prospect for point-of-care testing (POCT) of neurotransmitters.
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高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Hui Dong,Le Zhao,Tao Wang,Yanan Chen,Wanqing Hao,Ziyi Zhang,Yizhao Hao,Cunliang Zhang,Xiuhua Wei,Yintang Zhang,Yanli Zhou,Maotian Xu
Biomarkers detection in blood with high accuracy is crucial for the diagnosis and treatment of many diseases. In this study, the proof-of-concept fabrication of a dual-mode sensor based on a single probe (Re-BChE) using a dual-signaling electrochemical ratiometric strategy and a “turn-on” fluorescent method is presented. The probe Re-BChE was synthesized in a single step and demonstrated dual mode response toward butyrylcholinesterase (BChE), a promising biomarker of Alzheimer’s disease (AD). Due to the specific hydrolysis reaction, the probe Re-BChE demonstrated a turn-on current response for BChE at −0.28 V, followed by a turn-off current response at −0.18 V, while the fluorescence spectrum demonstrated a turn-on response with an emission wavelength of 600 nm. The developed ratiometric electrochemical sensor and fluorescence detection demonstrated high sensitivity with BChE concentrations with a low detection limit of 0.08 μg mL–1 and 0.05 μg mL–1, respectively. Importantly, the dual-mode sensor presents the following advantages: (1) dual-mode readout can correct the impact of systematic or background error, thereby achieving more accurate results; (2) the responses of dual-mode readout originate from two distinct mechanisms and relatively independent signal transduction, in which there is no interference between two signaling routes. Additionally, compared with the reported single-signal electrochemical assays for BChE, both redox potential signals were detected in the absence of biological interference within a negative potential window. Furthermore, it was discovered that the outcomes of direct dual-mode electrochemical and fluorescence quantifications of the level of BChE in serum were in agreement with those obtained from the use of commercially available assay kits for BChE sensing. This method has the potential to serve as a useful point-of-care tool for the early detection of AD.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Mengyao Liu,Taotao Gao,Hongmei Li,Bo Xie,Chunqiong Hu,Yong Guo,Dan Xiao
Based on the incidence of diabetes, developing glucose sensors of superior performance with low-cost transition metals (TMs) has been the direction of many researchers, amorphous TMs with highly efficient electrocatalytic properties have attracted our interest. On this basis, amorphous nickel–cobalt bimetallic N -doped carbon nanoparticles on carbon cloth (a-Ni 2 /Co 1 -NC/CC) were fabricated from ZIF-8, which was then used to fabricate an enzyme-free glucose sensor. It was found that the a-Ni 2 /Co 1 -NC/CC had the best response to glucose in 0.4 M NaOH at 0.55 V (vs Hg/HgO). As compared to crystal Ni 2 /Co 1 nanoparticle on carbon cloth (c-Ni 2 /Co 1 NPs/CC), cyclic voltammetry (CV) and chronoamperometry studies revealed that the a-Ni 2 /Co 1 -NC/CC showed a significant increase in the efficient of electrochemical oxidation of glucose under optimal conditions, exhibiting a high sensitivity of 2.455 mA mM −1 cm −2 with a low detection limit of 0.15 μM (S/N = 3). Furthermore, the constructed sensor based on a-Ni 2 /Co 1 -NC/CC also has long-term stability and can be used to detect glucose accurately in beverages (pure milk, coffee drinks, tea drinks, and soda water) with reasonable recovery from 95.6 % to 105.6 %. This study provides a simple and feasible method for the construction of a highly sensitive non-enzyme glucose electrochemical sensor based on amorphous TMs.
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高影响因子
Frontiers in Chemistry
·
2023
·
IF 5.5
Huang Liyuan,Su Ruobing,Xi Fengna
Sensitive determination of noradrenaline (NE), the pain-related neurotransmitters and hormone, in complex whole blood is of great significance. In this work, an electrochemical sensor was simply constructed on the pre-activated glassy carbon electrode (p-GCE) modified with vertically-ordered silica nanochannels thin film bearing amine groups (NH2-VMSF) and in-situ deposited Au nanoparticles (AuNPs). The simple and green electrochemical polarization was employed to pre-activate GCE to realize the stable binding of NH2-VMSF on the surface of electrode without the use of any adhesive layer. NH2-VMSF was conveniently and rapidly grown on p-GCE by electrochemically assisted self-assembly (EASA). With amine group as the anchor sites, AuNPs were in-situ electrochemically deposited on the nanochannels to improve the electrochemical signals of NE. Owing to signal amplification from gold nanoparticles, the fabricated AuNPs@NH2-VMSF/p-GCE sensor can achieve electrochemical detection of NE ranged from 50 nM to 2 μM and from 2 μM to 50 μM with a low limit of detection (LOD) of 10 nM. The constructed sensor exhibited high selectivity and can be easily regenerated and reused. Owing to the anti-fouling ability of nanochannel array, direct electroanalysis of NE in human whole blood was also realized.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Fuxin Liu,Lingling Han,Yali Yang,Zhonghua Xue,Xiaoquan Lu,Xiuhui Liu
The increased level of homocysteine (Hcy) becomes an independent risk factor for various diseases. Quantification of Hcy is helpful to the early diagnosis and treatment of related diseases. For this purpose, it is very necessary to explore innovative materials to construct sensitive electrochemical sensors. Herein, we designed and synthesized a novel composite (BSA-AuCNs/MXene) by using two-dimensional (2D) layered MXene as the matrix and supported with gold nanoclusters (BSA-AuCNs). Combining the properties of the above two materials, the composite was endowed with the ideal characteristics of electrochemical sensing materials such as high electrical conductivity, outstanding catalytic activity, large specific surface area, and good thermal stability. The constructed sensor exhibited excellent analytical behavior for Hcy with a super low detection limit (1.76 nM, S/N = 3). It also displayed satisfactory selectivity, reproducibility, and stability. In addition to detect Hcy in human serum, we also realized the electrochemical detection of Hcy in cell lysate for the first time. This work not only opens up a new way to broaden the application of MXene and gold nanoclusters in the sensing field, but also provides a possibility for their future application in the early diagnosis of Hcy-related diseases.
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高影响因子
Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 8
·1624-1632
·
IF 7
Kangkang Wang,Zhexue Chen,Yueqi Li,Yong Zhang
Semiconductor quantum dots (QDs) are of great interest for a wide range of applications. Herein, we report the top-down production of CdSe QDs with a super small size (about 3 nm) and high yield (14%). The as-produced QDs exhibit different optical properties from those of colloidal QDs. This is probably due to the generation of numerous bare edges during the process of silica-assisted ball-milling. The CdSe QD-based substrate could serve as a surface-enhanced Raman scattering (SERS) substrate for the ultrasensitive recognition of probe molecules at trace levels, which are mainly attributed to the special edge–edge interactions and charge transfer (CT) enhancement mechanism. The substrate exhibits good reproducibility, uniformity, and high enhancement factor (5.05 × 106) with an expansion of the ultra-low limit of detection (LOD) to 10−10 M. It has also been successfully used in the reliable, quantitative, and label-free detection of uric acid (UA) at a low concentration (1 μM), which facilitates the early prevention of gout disease. This QD-based platform not only confirms the feasibility of SERS analysis but also provides ideas for the early detection of residues.
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RSC Advances
·
2022
·Vol. 12
·期 54
·35199-35205
·
IF 4.036
Jiaojiao Jiang,Zhixuan Zhang,Chong Yang,Rui Wang,Zhouling Wu
In this work, urchin-like NiCo2O4 microspheres were prepared via a facile ionic liquid-assisted hydrothermal synthesis and used as non-enzymatic H2O2 sensors for the first time. The porous structure and high surface area of the NiCo2O4 microspheres provide plentiful active sites for electrocatalytic H2O2 oxidation. When adapted into an electrochemical sensor for H2O2, the microsensors showed fast response of 4 s, a high sensitivity of 392.5 μA·mM−1 cm−2, and a wide linear range towards H2O2 (0–14 mM). The detection limit was as low as 0.05 μM, significantly lower than other published high performance NiCo2O4-based H2O2 sensors. Furthermore, this non-enzymatic sensor exhibits good selectivity for H2O2. These results suggest that NiCo2O4 microspheres could be a promising material for trace H2O2 detection.
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高影响因子
MOLECULES
·
2022
·Vol. 27
·期 24
·8640
·
IF 4.927
Ning Lv,Xun Qiu,Qianqian Han,Fengna Xi,Yina Wang,Jun Chen
A disposable and portable electrochemical sensor was fabricated by integrating vertically-ordered silica mesoporous films (VMSF) and electrochemically reduced graphene (ErGO) on a screen-printed carbon electrode (SPCE). Such VMSF/ErGO/SPCEs could be prepared by a simple and controllable electrochemical method. Stable growth of VMSF on SPCE could be accomplished by the introduction of an adhesive ErGO nanolayer owing to its oxygen-containing groups and two-dimensional (2D) planar structure. An outer VMSF layer acting as a protective coating is able to prevent the leakage of the inner ErGO layer from the SPCE surface. Thanks to the electrostatic permselectivity and anti-fouling capacity of VMSF and to the good electroactive activity of ErGO, binary nanocomposites of VMSF and ErGO endow the SPCE with excellent analytical performance, which could be used to quantitatively detect doxorubicin (DOX) in biological samples (human serum and urine) with high sensitivity, good long-term stability, and low sample amounts.Keywords:silica nanochannel array;electrochemically reduced graphene oxide;screen-printed carbon electrode;doxorubicin;electrochemical sensor
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高影响因子
Sensors and Actuators Reports
·
2022
·
IF 0
Yiqun Liu,Wei Yue,Yue Cui
The development of simple sensing platforms for evaluating the oral conditions has attracted great attentions for healthcare. Saliva or toothpaste contains various analytes that can indicate health conditions. A salivary glucose sensing platform can provide a convenient and non-invasive alternative detection approach for diabetic patients. Toothbrush is used every day, and it has an easy access to saliva biomarker and toothpaste residues. Here, we demonstrate for the first time an amperometric biosensor on a toothbrush, using glucose as a typical analyte. The carbon graphite ink and the Ag/AgCl ink are painted on a toothbrush as the sensing electrodes, followed by the enzyme immobilization. The sensor shows an excellent detection performance for glucose with a concentration ranging from 0.18 mM to 5.22 mM and a short detection time of less than 5 min. The sensor is promising for the non-invasive monitoring of salivary glucose levels in diabetic patients when they brush their teeth. We anticipate that these results would open up exciting opportunities for developing new toothbrush sensors, as well as advance related healthcare applications.
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