CURRENT PHARMACEUTICAL DESIGN
·
2024
·Vol. 30
·期 32
·2574-2585
·
IF 2.6
Yuanjian Wang,Ruixun Wang,Huijia Wang,Ran Liu,Kaishun Bi,Qing Li
BackgroundEssential hypertension is a common clinical disease and a risk factor for cardiovascular and cerebrovascular diseases. Olmesartan medoxomil, amlodipine, and hydrochlorothiazide are commonly used antihypertensive drugs. The aim of this study was to establish a robust UPLC-MS/MS method for the simultaneous determination of olmesartan medoxomil, amlodipine, and hydrochlorothiazide in dog plasma. At the same time, the in vivo and in vitro release studies were conducted, and a preliminary in vitro-in vivo correlation (IVIVC) evaluation was performed.MethodsThe bioequivalence experiment was conducted with a double-crossed design. Three major components were extracted and analyzed by UHPLC-MS/MS. With the MRM scan, olmesartan and amlodipine were quantified by fragment conversion (m/z 447.10→190.10) and (m/z 408.95→294.00) under positive ESI mode, while hydrochlorothiazide was quantified with fragment conversion (m/z 295.90→268.90) under negative ESI mode. The in vitro release studies were performed using a USP paddle, and the dissolution medium was chosen from pH 6.0 to pH 6.8 according to the BCS classification of compounds. The IVIVC was calculated using the Wagner-Nelson equation.ResultsThe linear ranges of olmesartan, amlodipine, and hydrochlorothiazide in the plasma were 5.0-2500, 0.1-50, and 3.0-1500 ng/mL, respectively. All accuracies were within 3.8% of the target values, and the findings revealed that intra-day and inter-day accuracies were less than 12.1%. Moreover, the recoveries exceeded 88.3%, the matrix effect tests were positive, and the stability tests were positive. With the establishment of correlation, the distinguishable dissolution condition (pH 6.8) was selected as the predictable condition.ConclusionThe established method was suitable for the preclinical pharmacokinetic study of tripartite drugs with strong specificity and high sensitivity. Through the evaluation of IVIVC, the connection between in vivo and in vitro drug testing was initially established.
研究领域:
药理学
·
分析化学
·
临床医学
✓ 已验证
DOI
PubMed
高影响因子
Natural Product Communications
·
2024
·
IF 1.5
Shen-long Yan,Kai-lin Li,Qing-rui Yang,Kai-quan Yu,Ling Liu,Qing Li,Lin-wen Wen,Cong Huang,Hui Li,Yan-nan Liu
ObjectiveTo further explore the unknown chemical composition and aimed to develop a reliable strategy for characterizing compounds in Rhodobryum roseum (R. roseum).MethodsThis study employed an efficient, high-sensitivity, and high-resolution analysis method. The method utilized UHPLC-Q-Exactive Orbitrap MS, along with trace data acquisition mode (parallel reaction monitoring scanning, PRM), and multiple data processing methods.ResultsA total of 77 chemical substances were identified in R. roseum, including 16 amino acids, 33 organic acids including 6 aromatic acids, 8 phenolics compounds, 2 flavonoid glycosides, 4 flavonoids and 14 other compounds including 4 fatty alcohols by comparing with reference substances, secondary characteristic ion fragments, public databases, and literature. Among these, 74 compounds were found in this plant for the first time.ConclusionThis result significantly expands the knowledge of the chemical constituents of R. roseum and contributes to the understanding of its active constituents for quality control.
研究领域:
植物化学
·
分析化学
·
药用植物学
✓ 已验证
DOI
高影响因子
Minerals
·
2018
·Vol. 8
·期 4
·145
·
IF 1.835
Cheng Wang,Shaozheng Leng,Yuan Xu,Qinyue Tian,Xuemeng Zhang,Liyun Cao,Jianfeng Huang
Amino functionalized hydrophobic zeolite was prepared by modification of natural zeolite with 3-aminopropyltrimethoxysilane. X-ray diffraction, Fourier transform infrared analysis, thermal gravimetric analysis, Brunauer-Emmett-Teller surface areas, and element analysis were employed to investigate the structures of the samples. The water vapor adsorption method was used to determine the hydrophobicity of the samples. The adsorption properties of the samples for chromate and naphthalene were then investigated. The results showed that the silane modification had a negligible effect on the crystalline structure of zeolite while significantly decreasing the specific surface area and increasing the hydrophobicity of the zeolite sample. The functionalized zeolite samples exhibit higher adsorption capacity and removal rate on chromate and naphthalene as compared with the unmodified zeolite sample due to their specific amino functional group and hydrophobicity property.
研究领域:
环境科学
·
材料科学
·
化学工程
·
污染控制
·
吸附分离
✓ 已验证
DOI
高影响因子
Nano Research
·
2022
·Vol. 16
·期 5
·6048-6056
·
IF 10.269
Wu Yining,Tang Lisha,Cao Mengjiao,Li Li,Liu Kai,Kong Demin,Zhao Qingshan,Jin Xu,Liu He,Dai Caili
Zero-dimensional (OD) carbon dots exhibit excellent potential as a new oil-displacing agent for unconventional reservoir development. However, the difficulty in size/surface properties control and unclear mechanism hinder their further applications. In this study, amino-modified carbon dots (am-CDs) for oil displacement were facilely synthesized through the rapid polymerization of D-glucose (D-Glc) and 3-aminopropyltriethoxysilane (APTES). The size of am-CDs could be precisely controlled by the reaction condition and quenching achieved by adjusting the pH value to neutral. The surface amine groups endow am-CDs with excellent hydrophilicity and dispersion stability. The 0.30 wt.% nanofluid based on am-CDs with an average size of 2.6 ± 0.040 nm showed remarkable oil recovery efficiency (54.09%) without the addition of surfactant. The oil recovery efficiency of am-CDs is much higher than those of water flooding (30.25%), nano-SiO 2 flooding (36.45%), and amino-free carbon dots (af-CDs) flooding (37.80%). Experimental and theoretical results reveal that am-CDs can be favorably adsorbed on the core surface to modulate the micro-scale wettability, changing the surface from oil-wet to relatively uniform water-wet. Meanwhile, am-CDs can effectively reduce the adhesion force between alkanes and sandstone surfaces, contributing to oil droplets peeling off and oil displacement. This study provides a new strategy for developing efficient carbon dots-based nanofluids for enhanced oil recovery.
研究领域:
材料科学
·
石油工程
·
纳米技术
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Coatings Technology and Research
·
2024
·Vol. 21
·期 4
·1333-1342
·
IF 2.3
Wei Haoran,Liu Henghui,Li Min,Fu Zhinan,Liu Liqun,Zhang Hanjie,Fan Chuanjie,Xu Jun,Wang Jie
Polydimethylsiloxane (PDMS) has been widely used to improve the antifouling properties of polyurethane (PU) coatings due to its low surface energy. Herein, a novel type of waterborne polyurethane (WPU) coating with good antifouling and self-healing abilities was synthesized by incorporating PDMS and disulfide bonds. The effects of PDMS and the disulfide content on the thermal, mechanical and surface properties of the coatings were investigated. Benefiting from a rational structural design, the obtained WPU coating manifested superior antifouling properties. In addition, the WPU coating exhibited good healing capabilities owing to the collaboration between dynamic disulfide bonds. Interestingly, the self-healing of an experimental crack occurred at a temperature above 60°C, and the coating recovered its mechanical properties to 95%. This finding has great significance for the design of multifunctional smart coatings for diverse applications.
研究领域:
材料科学
·
高分子科学
·
表面工程
·
涂层技术
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2013
·
IF 2.206
Yan-Ling Luo,Li-Li Chen,Yan Miao,Feng Xu
Novel AB4-type polyurethane (PU) micelle-like amphiphilic block copolymers consisting of hydroxyl-functionalized carboxyl-terminated poly(butadiene-co-acrylonitrile) (f-CTBN) as the hydrophobic cores and methoxy poly(ethylene glycol) (MPEG) as the hydrophilic branched blocks were synthesized via esterification, followed by coupling reaction. Their chemical structure and molecular weight were characterized by FTIR, NMR, and SEC measurements. The block copolymers could easily self-assemble to form core–shell micelle nanoparticles in various media. The micelles bear a critical micelle concentration (CMC) in a range from 0.740 to 6.310 mg L–1 and were very stable even in PBS solutions. The TEM and DLS findings revealed that the micelles were almost spherical and narrow-size-distribution, with TEM mean diameters from 13 to 24 nm, and average hydrodynamic diameter about 124–151 nm. All these depended on chain lengths and compositional ratios of hydrophilic MPEG blocks. The drug loading and in vitro release indicated that the self-assembled micelle nanoparticles could effectively load hydrophobic prednisone, with encapsulation capacity of about 27–30%, and the drug release from the nanoparticles was dependent on MPEG chain lengths and the molar ratios of f-CTBN to MPEG. Cytotoxicity assays disclosed that the as-prepared block copolymer micelle nanoparticles exhibit good biocompatibility and could be employed as potential drug controlled release carriers.
研究领域:
生物材料
·
药物递送
·
纳米医学
·
高分子化学
·
药剂学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2015
·Vol. 183
·期 1
·415-421
·
IF 3.741
Liu Xingli,Wang Chun,Wu Qiuhua,Wang Zhi
Magnetic Fe 3 O 4 -doped porous carbon (MPC) was synthesized by using a metal-organic framework as a sacrificial template and iron salts as magnetic precursors. The textural properties of the MPC were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, vibration sample magnetometry, and nitrogen absorption-desorption isotherms. The MPC possesses a high specific surface and is strongly magnetic. It was employed as an adsorbent for magnetic solid-phase extraction of four carbamates. The main parameters that affect extraction efficiency were investigated. The carbamates were analyzed by high performance liquid chromatography with ultraviolet detection at 208 nm. Under optimum conditions, good linearity was achieved for all analytes in the 1–100 ng g −1 concentration range, with correlation coefficients of > 0.9992. The limits of detection (at an S/N ratio of 3) are between 0.1 and 0.2 ng g −1 , and the recoveries of spiked samples ranged from 89.3 to 109.7 %.
A magnetic porous carbon (MPC) was synthesized using metal-organic framework as sacrificial template and Fe salts as magnetic precursor. The MPC showed high specific surface area and good magnetic property. It was employed as magnetic solid-phase extraction adsorbent for the extraction of carbamates from apple sample.
研究领域:
分析化学
·
环境科学
·
食品安全
·
材料科学
·
色谱技术
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2012
·Vol. 28
·期 9
·887-892
·
IF 1.255
Yun ZHANG,Shengdong PAN,Haoyu SHEN,Meiqin HU
An efficient analytical method for the preconcentration and determination of phosphate in water samples at trace levels was proposed. The method was based on sample enrichment using dispersive solid-phase extraction (dSPE) with tetraethylenepentamine (TEPA)-functionalized nano-size composite materials (TEPA-NCMs) as sorbents, which were fully characterized. Various parameters affecting the extraction efficiency were systematically investigated. After extraction, the post-adsorbed TEPA-NCMs were eluted by a NaOH solution for desorption of the phosphate. The resulting eluate containing phosphate was determined by a spectrophotometric method. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.29 and 0.96 μg L−1, respectively. The relative standard deviations (RSDs) were lower than 8.0% with average recoveries ranging from 91 to 118%. The present method was successfully applied to the determination of phosphate at trace levels in real water samples, and it was confirmed that the TEPA-NCMs are highly effective dSPE materials.
研究领域:
环境科学
·
分析化学
·
材料科学
·
水资源管理
·
污染物检测
✓ 已验证
DOI
高影响因子
POLYMER
·
2017
·
IF 3.684
Libang Feng,Zhengyang Yu,Yaohui Bian,Junshan Lu,Xueting Shi,Changsheng Chai
Cracks generated in materials affect comprehensive performance and shorten service life of materials. The problem is expected to be resolved by endowing materials with self-healing property. Herein, a new thermoplastic polyurethane with excellent self-healing performance (PU-DA) has been developed, while the self-healing behavior is investigated by qualitative observation and quantitative measuring comparatively. Results reveal that PU-DA exhibits excellent thermal reversibility due to incorporated Diels-Alder (DA) bonds, and cracks in polyurethane films can be repaired by dual actions of thermo-reversible DA reaction and thermal movement of molecular chains . DA bond and its thermal reversibility contribute much to the recovery of the mechanical property while the thermal movement effect of molecular chains acts as an auxiliary recovering force which accelerates the whole healing process. The self-healing behavior of PU-DAs from diverse soft segments and different -NCO/-OH values further confirms that the excellent self-healing performance is grounded on combined actions indeed. Additionally, the self-healing polyurethane presents outstanding reprocessing performance, and which makes it possible of recycling waste polyurethanes. This study enables the re-demonstration of general points about DA thermal reversibility already known, as well as presentation of link between self-healing capability and thermal reversibility along with thermal movement.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
FERROELECTRICS
·
2020
·
IF 0.669
Jie Liu,Lin Zhang,Meiyu Ci,Shuying Sui,Ping Zhu
The rheological behavior of regenerated cellulose/thermoplastic polyurethane (TPU) blend spinning solutions was investigated by an advanced rotary rheometer. The viscosity decreases with increasing shear rates, exhibiting shear thinning behavior. The storage modulus of G′ and the loss modulus G″ both increase with increasing frequencies, while the complex viscosity decreases gradually. The non-Newtonian index increases while the flow activation energy decreases with increasing TPU content. The composite fibers were characterized by FTIR and XRD, indicating that the addition of TPU into regenerated cellulose matrix destroyed the crystallinity to some extent. The mechanical property tests illustrate that the toughness of the fiber was greatly improved with the incorporation of TPU.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2021
·
IF 4.089
Shuang He,Yu-Yang Gao,Ze-Yong Zhao,Sheng-Chao Huang,Zi-Xun Chen,Cong Deng,Yu-Zhong Wang
Phytic acid and amino acid belonging to the biomass material have a wide range of sources in nature. In this work, three kinds of basic amino acids, which are arginine, lysine, and histidine, were used to prepare different bio-based phytic acid–basic amino acid salts (PaArg, PaLys, and PaHis) via a salt-forming reaction. After the incorporation of PaArg, PaLys, and PaHis into polypropylene (PP), PaArg showed a higher efficiency than PaLys and PaHis in endowing PP with flame retardancy. At 22 wt % PaArg, the limiting oxygen index (LOI) value of functional PP was 26.0%, and its UL-94 rating reached V-0 in the vertical burning test. In the fire hazard test, PaLys showed a higher efficiency than PaArg and PaHis in reducing the fire hazard of PP during burning. The peak value of the heat release rate for PP containing 25 wt % PaLys was decreased by 70.7% compared with that of PP, and its fire growth rate was reduced by 86.9%. Analysis on the fire-safety mechanism revealed that the high char-forming rate and the quality of the residue dominated the superior flame-retardant efficiency of PaArg in UL-94 and LOI tests; high strength of the formed char layer, diluting effect of nonflammable gases, and incomplete combustion action led to the superior efficiency of PaLys in decreasing the fire hazard of PP. This work confirms that fully bio-based phytic acid–basic amino acid salt based on the accurate molecular design may endow PP with fire safety under different burning scenes.
研究领域:
材料科学
·
化学工程
·
燃烧学
✓ 已验证
DOI
高影响因子
ACS Nano
·
2021
·
IF 15.881
Ming Li,Weijun Li,Qingwen Guan,Xiaoli Dai,Jing Lv,Zhenhai Xia,Wee-Jun Ong,Eduardo Saiz,Xu Hou
Dry adhesives that combine strong adhesion, high transparency, and reusability are needed to support developments in emerging fields such as medical electrodes and the bonding of electronic optical devices. However, achieving all of these features in a single material remains challenging. Herein, we propose a pressure-responsive polyurethane (PU) adhesive inspired by the octopus sucker. This adhesive not only showcases reversible adhesion to both solid materials and biological tissues but also exhibits robust stability and high transparency (>90%). As the adhesive strength of the PU adhesive corresponds to the application force, adhesion could be adjusted by the preloading force and/or pressure. The adhesive exhibits high static adhesion (∼120 kPa) and 180° peeling force (∼500 N/m), which is far stronger than those of most existing artificial dry adhesives. Moreover, the adhesion strength is effectively maintained even after 100 bonding–peeling cycles. Because the adhesive tape relies on the combination of negative pressure and intermolecular forces, it overcomes the underlying problems caused by glue residue like that left by traditional glue tapes after removal. In addition, the PU adhesive also shows wet-cleaning performance; the contaminated tape can recover 90–95% of the lost adhesion strength after being cleaned with water. The results show that an adhesive with a microstructure designed to increase the contribution of negative pressure can combine high reversible adhesion and long fatigue life.
研究领域:
材料科学
·
生物医学工程
·
仿生学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）