ACS Sensors
·
2026
·
IF 10.9
Weizhuo Gao,Chuanyu Zhang,Hongcheng Xu,Xifeng Sun,Xiaoke Lu,Jing Zhang,Wanheng Zhou,Kun Wei,Hao Sun,Weixuan Jing,Zhuangde Jiang,Xueyong Wei
Biomolecular point-of-care monitoring in saliva, urine, and sweat pioneers the real-time and noninvasive biochemical analysis for personalized healthcare and precision disease therapeutics. However, the adoption of these technologies still faces challenges due to the hardly detectable targets with weak redox activity, extremely low analyte concentration, operational instability of sensors, and low scalability of the fabrication process. To address these issues, we proposed a novel core-shell multifunctional particle for the light-enhanced detection of testosterone at the nanomolar level. The particle comprises a ZnIn2S4/SiC core and a targeted molecularly imprinted polymer shell, achieving multifunctions, including visible light sensitivity, testosterone recognition, and redox activity. The printable ability of the multifunctional particle leads to inkjet-printed testosterone sensors with stable (over 50 days), reproducible, and outstanding light-promoted sensing performance (limit of detection 0.01 nM (S/N = 3) and linear range from 0.01 to 1000 nM). The effectiveness of the testosterone sensors was validated in saliva and urine lateral flow electrochemical testing strips and wearable sweat testosterone sensors, achieving testosterone point-of-care testing in multiple human biofluids. These offer great opportunities for the noninvasive biomolecular profiling, further promoting personalized healthcare and precision disease therapeutics.
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MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Xiaoqian Liu,Weitao Fang,Ruijie Zhang,Wuheng Yue,Zhiwei Xiong,Baimin Niu,Huizhen Sun,Jiaxin Chen,Jue Wang,Jiawei Han
Some drugs undergo gelation during the formulation development process, which not only poses significant challenges to the manufacturing process of solid dosage forms but also significantly restricts the drug dissolution and absorption. Could such gelation be utilized by designing the prescription to overcome the adverse effects and water solubility defect of drugs? Herein, this study attempted to design the self-gelation tablets of indomethacin (IND) by introducing small-molecule ligands and to explore the self-gelation mechanism. As a result, the designed tablets occurred to have spontaneous gelation with a typical 3D structure and viscoelasticity upon contact with a small amount of water, accompanied by amorphization transformation. Such a self-gelation behavior was significantly influenced by the composition ratios, storage temperatures, and medium pH values. In comparison to pure IND tablet, the designed IND-ligand tablets performed significantly increased apparent solubility (>200-fold) and intrinsic dissolution rate (>6000-fold) and maintained the long-term supersaturated dissolution with acid–base interactions, which was revealed by nucleation inhibition, fluorescence quenching, and phase solubility tests. Moreover, the self-gelled tablets significantly enhanced the membrane permeability of IND, demonstrating the potential for promoting oral absorption. Thus, this study revealed the self-gelation mechanism of the tablet combination and confirmed such prescription design involving self-gelation as an efficient solubilization strategy.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Peixin Zhang,Luoxing Xiang,Junghye Lee,Zhengkai Chen,Lin Huang,Liang Feng
Developing advanced adsorbents with both high selectivity and low regeneration energy remains a central challenge in realizing energy-efficient CO2 capture technologies. In this work, we report an ultramicroporous metal–organic framework, PCP-IPAN, designed with CO2-philic electrostatic cavities to promote strong yet thermally tunable interactions with CO2 molecules. Notably, the framework exhibits highly temperature-sensitive adsorption profiles, characterized by a sharp reduction in CO2 uptake within a narrow temperature range (273–323 K). This significant thermal sensitivity enables a large working capacity and ensures facile desorption at mild temperatures, which is a key requirement for reducing the energy penalty in pressure- and temperature-swing adsorption (P/TSA) processes. Single-component adsorption measurements reveal that PCP-IPAN-Co achieves high CO2 capacities of 4.60 and 3.32 mmol g–1 at 273 and 298 K (1.0 bar), respectively. Furthermore, it delivers CO2/N2 (15/85) IAST selectivities of 71.6 and 99.3, alongside CO2/CH4 (50/50) IAST selectivities of 39.8 and 19.6 at these temperatures. Dynamic column breakthrough experiments for CO2/N2 and CO2/CH4 binary mixtures confirm the material’s excellent separation selectivity, and vacuum pressure swing adsorption (VPSA) simulations demonstrate its efficient separation energy consumption during cyclic operation. These findings highlight PCP-IPAN as an efficient platform for carbon capture.
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RSC Advances
·
2026
·
IF 6.1
Zhenhua Zeng,Ayang Wu,Haimin Gao,Yanping Zheng,Huicong Yang,Xiaojie Yao,Zhongjie Yang
MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma. This work developed a CRISPR/Cas13a biosensing platform based on near-infrared (NIR) light and glutathione (GSH) dual activation for highly sensitive and specific determination of miRNA-21, miRNA-155, and miRNA-224. The advantages of this platform lie in the introduction of GSH-responsive mesoporous silica carriers and photolytic linkers (pc-linkers), which transform the sensing process from “passive triggering” to “controllable activation”, effectively suppressing nonspecific signals. Specifically, GSH can degrade mSiO 2 with tetrasulfide bonds, thereby degrading the carrier. It will release the CRISPR/Cas13a system loaded on the carrier, thereby achieving specific recognition and cleavage of miRNA-21/155; at the same time, 808 nm NIR light excites upconversion nanoparticles (UCNPs) to generate ultraviolet light, which cleaves the pc-linker to activate the detection of miRNA-224. The detection limits of the developed assay for detecting miRNA-21, miRNA-155, and miRNA-224 were 4.2 pM, 5.7 pM, and 0.205 nM, respectively. The recoveries in the serum spiked experiments were 98.97–109.24%, with a relative standard deviation of less than 4.613%, indicating that the method has good accuracy and reliability. This work proposes a novel and reliable strategy for detecting multiple miRNAs in complex biological samples. MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma.
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ACS Applied Nano Materials
·
2026
·
IF 5.8
Mengting Li,Yiping Liu,Wenxuan Liu,Yuqing Wang,Bo Fu,Meisi Chen,Licheng Li,Fang Guo,Muhua Chen
Graphitic carbon nitride (g-C3N4) is a promising metal-free photocatalyst for solar-driven H2O2 production, yet its activity is intrinsically limited by a narrow visible-light response, rapid charge recombination and low surface area. This work reports a cold plasma engineering strategy using radio frequency (RF), dielectric-barrier-discharge (DBD) and glow-discharge (GD) treatments to simultaneously modulate the morphology, defect chemistry and electronic structure of g-C3N4. Among the three protocols, RF plasma yields a “sponge-like” architecture with a 53% larger specific surface area (43.7 m2 g–1) and introduces nitrogen/oxygen-containing surface species that narrow the bandgap from 2.32 to 2.12 eV while preserving the crystalline framework. As a result, NCN-RF exhibits the highest H2O2 evolution rate among the investigated samples, reaching 1239 μmol g–1 h–1 under visible light irradiation (λ ≥ 420 nm), which is 4.7 times that of pristine NCN, and retains ∼80% activity after three cycles. Radical trapping and in situ EPR spectroscopy reveal a sequential two-electron oxygen-reduction pathway dominated by ·O2– intermediates. The enhanced activity is mainly attributed to the combined contribution of defect-modulated electronic structure, oxygen-containing surface species that may facilitate interfacial charge regulation, and a mesoporous network that improves mass transport. This work demonstrates a simple dry plasma-assisted surface modification strategy based on combined electronic-structure and morphology modulation for designing carbon nitride based photocatalysts for photocatalytic H2O2 production.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 30
·16281-16300
·
IF 3.9
Zhang Xuan,Wang Bo,Hu Zhi,Wang Yue,Feng Ru,Liu Shucheng
Agricultural
waste peanut shells are rich in cis -diol flavonoid
luteolin (LTL). However, conventional separation
materials suffer from insufficient specific sites, binding limitations
only under alkaline environments, and poor anti-interference performance
in complex matrices. Herein, an integrated fabrication strategy combining
in situ polymerization in mesoporous soft confined space and teamed
boronate (TBA)-functional molecular imprinting technology is innovatively
proposed. The hierarchical substrate of GO@MS was covalently assembled
via a thiol–ene click reaction, and a boronate affinity-imprinted
polymer was grown confinedly inside mesoporous channels. The TBA molecular
group as a functional monomer would be used for specific recognition
of LTL under neutral conditions. As a result, the prepared MI-GO@MS@GLYMO-TBA
exhibits high binding capacity (61.78 μmol g –1 ) for LTL at 308 K under physiological pH (7.4), with an equilibrium
time of 360 min. In addition, MI-GO@MS@GLYMO-TBA could be recycled
six times with a slight loss of 8.00% in adsorption. Meanwhile, the
commercially available LTL with 85% purity could be easily enriched
and further extracted with high selectivity (up to 93.67%). Remarkably,
the purified LTL solutions displayed lasting antibacterial performance
against Staphylococcus aureus ( S. aureus ) with an inhibition zone of 12.15 mm. Therefore,
the MI-GO@MS@GLYMO-TBA nanocomposite could be potentially developed
as a feasible and efficient method to achieve the goals of green sustainable
chemistry for precise identification and separation of LTL from complex
samples from agricultural wastes.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Wang Chenxi,Chen Jieyi,Guo Wenhe,Du Jinghua,Dong Xiaoyu,Yang Lei,Jiang Zezhong,Ding Yunsheng
Biobased
polycarbonate diol (BPCDL)-derived polyurethane
adhesives
(PUAs) are promising sustainable materials. Among various properties,
the peel strength is a key indicator for evaluating the adhesion reliability
of adhesives. However, the peel strength is governed by coupled formulation
and processing variables, limiting its accurate prediction and regulation.
To address this issue, a small-data-driven and interpretable machine-learning-assisted
prediction framework was developed to engineer the peel strength of
BPCDL-based PUAs. A full factorial data set covering five formulation
and processing variables, including soft segment ratio (SSR), cross-linking
level (CL), R value, hot-pressing temperature, and hot-pressing time,
was constructed to sample the multidimensional design space. Extremely
Randomized Trees (Extra Trees) and Gaussian Process Regression (GPR)
were benchmarked against advanced statistical baselines under repeated
and structured validation, while analysis of variance, Extra Trees-derived
SHapley Additive exPlanations, and GPR-derived response surfaces were
integrated to distinguish main effects, interactions, and processing
modulation. The results identify R value as the principal formulation
factor, reveal a pronounced interaction between SSR and R value, and highlight hot-pressing temperature as a key processing
modulator. The model indicated that high peel strength could be achieved
through multiple formulation and processing combinations, including
low SSR and low R value, high SSR and high R value, or moderate R value with sufficient
hot-pressing temperature. Increasing CL, however, does not necessarily
enhance the peel strength and may even suppress it. Molecular dynamics
simulations further suggest that increasing temperature weakens cohesive
interactions within the polyurethane while enhancing interfacial interactions
with the substrate, thereby balancing chain mobility, interfacial
adhesion, and bulk cohesion. Beyond forward prediction, a multicriteria
inverse design strategy was proposed by integrating milder hot-pressing
conditions, predictive uncertainty, and target-oriented constraints,
enabling uncertainty-informed screening of promising candidates. This
work provides an interpretable small-data strategy for inverse design
and performance optimization of advanced biobased adhesives.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 31
·23335-23345
·
IF 7.3
Dong Hui,Lv Xiaoyu,Qian Yujia,Chang Aixin,Cheng Menghao,Yang Xue,Ding Jiahui,Yang Zimo,Zhou Yanli,Zhang Yintang,Li Zhaohui,Xu Maotian
Copper ions (Cu 2+ ) are
closely implicated in the pathogenesis
of Alzheimer’s disease (AD) by mediating oxidative stress and
promoting β-amyloid (Aβ) aggregation. Accurate quantification
of labile Cu 2+ in the brain extracellular microenvironment
is critical for elucidating its pathological roles and developing
AD diagnostic tools. Herein, we report a dual-mode sensing platform
integrating “turn-on” fluorescence and ratiometric electrochemistry
for sensitive and selective Cu 2+ quantification, based
on a resorufin-picolinate conjugate (RP) probe and a carbon nanotube-modified
carbon fiber microelectrode (CFME/CNT). Resorufin (Re) acts as both
the fluorescent reporter and electrochemical redox center, while picolinate
serves as the Cu 2+ -specific recognition moiety. Cu 2+ coordinates with picolinate to catalyze the ester hydrolysis
of RP, releasing free Re that triggers a fluorescence enhancement
at 594 nm and a ratiometric electrochemical response, corresponding
to the oxidation currents of free Re and intact RP, respectively.
The RP probe exhibits high selectivity for Cu 2+ over other
metal ions, with limits of detection of 19 nM (fluorescence) and 7.2
nM (electrochemistry). The dual-mode platform was successfully applied
to the accurate quantification of endogenous labile Cu 2+ in cerebral cortex dialysate from AD mice and age-matched wild-type
(WT) mice, and noninvasive in vivo fluorescence imaging further confirmed
the elevated Cu 2+ level in living AD mouse brains. Quantitative
results revealed that the labile Cu 2+ concentration in
AD mouse cerebral cortex dialysate was significantly higher than that
in WT mice. The two detection modes yielded highly consistent results,
validating the reliability of the dual-mode platform in complex biological
matrices. This dual-mode strategy synergizes the merits of fluorescence
and ratiometric electrochemistry, providing a robust and selective
tool for investigating AD pathogenesis related to Cu 2+ dyshomeostasis
and holds great potential for clinical translational applications
in AD diagnosis.
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 31
·23301-23313
·
IF 7.3
Liang Shuang,Chen Dongyao,Ma Liming,Feng Xinyi,Gu Dongxue,Yu Kedi,Chen Zhengbo
The
issue of tetracycline (TC) residues in the environment poses
a serious threat to ecosystems and public health, therefore, there
is an urgent need to develop efficient and convenient detection methods.
This study successfully prepared Ga/Zn NC single-atom (SA) nanozymes
with peroxidase-like catalytic activity. Based on the differential
inhibitory effects of different TCs on the Ga/Zn NC SA nanozymes’
catalytic activity, a three-channel colorimetric sensor array is constructed
by regulating the temperature, resulting in differentiated colorimetric
response signals for TCs. Combined with linear discriminant analysis,
the sensor array successfully achieved qualitative differentiation
and quantitative analysis of seven TCs within the range of 1 nM to
100 μM. Further combining the sensor array with machine learning
algorithms such as random forests, accurate identification and prediction
of TCs in blind samples and various actual environmental samples have
been achieved. The sensor array provides a new method for efficient
differentiation and detection of TCs in complex samples, and has good
application prospects in environmental monitoring and food safety
fields.
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ACS Sensors
·
2026
·
IF 10.9
Yang Ting,Jiao Yang,Ma Yali,Lang Dajun,Cheng Liang,Wang Tingting,Ma Lin
Accurately resolving trace acetone against the highly humid background of exhaled breath remains a central obstacle to non-invasive diabetes diagnosis. Here we develop a metal–organic framework (MOF)-conversion-induced prenucleation strategy for the controlled construction of Fe 2 TiO 5–δ (FTO) solid solutions. During the topological transformation of MIL-125(Ti), Ti-derived oxide nuclei form within the pores of a daughter Fe-based MOF, enabling the generation of FTO enriched with mixed-valence Fe 3+ /Fe 2+ and Ti 4+ /Ti 3+ centres and abundant oxygen vacancies. The optimized FTO-3.49 sensor selectively detects acetone across 30–90% relative humidity, reaches a detection limit of 100 ppb and distinguishes ppb-level acetone concentrations in simulated exhaled breath. This performance is underpinned by mixed-valence centres that limit water-induced hydroxyl accumulation and oxygen vacancies that create additional adsorption sites and strengthen acetone binding, as supported by spectroscopic and computational evidence. This defect–valence synergy enables stable acetone sensing under highly humid conditions and provides a materials-design route towards humidity-resilient metal-oxide sensors for breath-acetone analysis.
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LANGMUIR
·
2026
·Vol. 42
·期 30
·22338-22349
·
IF 4.4
Gao Xing,Xiang Yan,Guo Wenjun,Xu Tao,Wang Zhoujie,Xu Longhua,Sun Wei,Xie Lei
Hetero-aggregation between serpentine and sulfide minerals
represents
a persistent challenge in the efficient recovery of valuable metals
from complex ores, while most existing depressants suffer from limited
selectivity, insufficient suppression efficiency, or environmental
and toxicity concerns, restricting their application in sustainable
mineral processing. Herein, we report for the first time the use of
a phosphorylated nanocellulose biopolymer as a highly selective and
environmentally benign depressant to overcome serpentine-induced interference
in sulfide flotation, and elucidate the selective depression and interfacial
mechanism. Phosphorylated cellulose nanofibers (P-CNF) and phosphorylated
cellulose nanocrystals (P-CNC) were synthesized by introducing phosphate
functional groups, resulting in a marked enhancement in pyrite flotation
performance, with recoveries exceeding 88.0% and reaching 89.6% for
P-CNF. The exceptional separation efficiency arises from the highly
selective adsorption of phosphorylated cellulose on the serpentine
MgOH plane, with a surface coverage of 96.32% on serpentine compared
to only 0.28% on the pyrite surface. This pronounced selectivity induced
a reversal of the serpentine surface charge, thereby transforming
pyrite–serpentine interactions from electrostatic attraction
to strong repulsion. Force-resolved atomic force microscopy measurements
provided direct nanoscale evidence for this transition, revealing
a dramatic reduction in adhesion forces from ∼9.81 mN m –1 to ∼1.25 mN m –1 (P-CNC)
and ∼0.10 mN m –1 (P-CNF). Moreover, phosphorylated
nanocellulose promoted the flocculation of fine serpentine particles
via polymer-bridging effects, leading to the enlarged aggregates and
effective suppression of mechanical entrainment. This work establishes
phosphorylated nanocellulose as a novel green depressant platform
and provides molecular insights into interfacial interactions governing
complex mineral separation, thereby enabling the rational design of
sustainable reagents and advancing resource-efficient environmentally
interfacial responsible mineral processing.
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高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 8
·722
·
IF 3
Song Zhe,Xiao Chunyan,Gao Qixuan,Ma Haoyi,Yue Xiting,Lu Jiatian,Jiang Ming
Peroxymonosulfate (PMS)-assisted photocatalytic degradation represents an efficient advanced oxidation process for water purification. In this study, a novel SrTiO₃/Cu₂SnS₃ heterojunction was synthesized via a hydrothermal method, which was employed for visible-light-driven PMS activation to degrade norfloxacin (NOR). The STO/CTS-2 (n SrTiO₃ /n Cu₂SnS₃ = 2) composite exhibited superior catalytic performance, achieving 92.65% NOR degradation within 60 min, attributed to enhanced charge separation and efficient PMS activation. Comprehensive characterization confirmed the heterostructure formation, optimized band alignment, and improved light absorption. Radical trapping experiments revealed that superoxide radicals (•O₂⁻) dominated the degradation process, with additional contributions from SO 4 •⁻ , •OH, 1 O 2 , and h⁺. A plausible NOR degradation pathway and the underlying PMS activation mechanism were proposed. This study provides new insights into visible-light-driven PMS activation and presents an effective strategy for antibiotic wastewater treatment.
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