RSC Advances
·
2021
·Vol. 11
·期 63
·39758-39767
·
IF 3.361
Cheng Shi,Qiugang Huang,Ruirui Zhang,Xingtang Liang,Feng Wang,Zijie Liu,Min Liu,Huayu Hu,Yanzhen Yin
The preparation of antioxidant starch with the activity of glutathione peroxidase (GPx) for scavenging free radicals can not only enrich the types of modified starch but also alternate native GPx to overcome its drawbacks. In this work, an antioxidant cassava starch (AO-ca-starch) was prepared by the sequential esterification and selenylation of cassava starch. The process was optimized based on the selenium content. Various characterizations for the AO-ca-starch indicated that the catalytic center of GPx, the selenium, was anchored on the starch. The catalytic activity of AO-ca-starch, a starch-based biomimetic GPx, was about 4.95 × 105 times higher than that of the typical artificial selenoenzyme (diphenyl diselenide, PhSeSePh), and it exhibited a typical saturation kinetic catalytic behavior. The surface changes of the starch during the modification were conducive to the formation of hydrophobic microenvironments, which played an important role in the catalytic reaction of biomimetic GPx due to the binding of the hydrophobic substrates. The match of the catalytic center and the hydrophobic microenvironments was the key factor for maintaining the high catalytic activity of AO-ca-starch. Without cytotoxicity, AO-ca-starch exemplified a new and promising modified starch as a selenium-enriched functional food and antioxidant drug.
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RSC Advances
·
2021
·Vol. 11
·期 62
·39291-39305
·
IF 3.361
Rui Li,Haoran Xu,Yuhang Zhang,Lijing Chang,Yang Ma,Yanjun Hou,Shoulei Miao,Cheng Wang
Pyrene is composed of four benzene rings and has a unique planar melting ring structure. Pyrene is the smallest condensed polycyclic aromatic hydrocarbon, and its unique structural properties have been extensively studied. Pyrene has excellent properties such as thermal stability, high fluorescence quantum efficiency and high carrier mobility. This paper mainly used thiophene, EDOT and triphenylamine groups to enhance the pyrene based π-conjugated system and control the molecular accumulation of organic semiconductors, and improve their charge transport performances. Five kinds of polymer were synthesized and correspondingly characterized. The five kinds of pyrene conductive polymer had outstanding properties in terms of solubility, fluorescence intensity and thermal stability, good film-forming properties, stable electrochromic properties and high coloring efficiency. The coloration efficiency (CE) of PPYTP was as high as 277 cm2 C−1, and the switching response time was short. The coloring time of PPYEDOT was 1.3 s and the bleaching time was 3.2 s. The lower impedance will also provide the possibility of such polymers being incorporated into electrochromic devices in the future. In short, the synthesized new pyrene conductive polymers will have wide application prospects in the field of electrochromic materials.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 17
·24612-24622
·
IF 4.223
Li Zhansheng,Zhao Hongxia,Li Xintong,Bekele Tadiyose Girma
Environmentally persistent free radicals (EPFRs) are an emerging class of environmental hazardous contaminants that extensively, stably exist in airborne particulate matter and pose harmful effects on human health. However, there was little research about the sources of EPFRs in actual atmospheric conditions. This study reported the occurrence, characteristics, and sources of EPFRs and polycyclic aromatic hydrocarbons (PAHs) in PM 2.5 collected in Dalian, China. The concentrations of PM 2.5 -bound EPFRs ranged from 1.13 × 10 13 to 8.97 × 10 15 spins/m 3 (mean value: 1.14 × 10 15 spins/m 3 ). Carbon-centered radicals and carbon-centered radicals with adjacent oxygen atoms were detected. The concentration of ∑PAHs ranged from 1.09 to 76.24 ng/m 3 , and PAHs with high molecular weight (HMW) were predominant species in PM 2.5 . Correlation of EPFRs with SO 2 , NO 2 , O 3 , and 12 kinds of PAHs indicated that both fuel (coal and biomass) combustion and photoreaction in atmosphere influenced the concentrations of EPFR. The positive matrix factorization (PMF) model results have shown that the primary sources contributed most of the EPFRs and those of secondary sources had a little proportion. Coal combustion (52.4%) was the primary contributor of EPFRs, followed by traffic emission (22.6%), industrial sources (9.6%), and secondary sources (9.2%) during the heating period, whereas industrial emission (39.2%) was the primary contributor, followed by coal combustion (38.1%), vehicular exhaust (23.5%), and secondary sources (9.6%) during the non-heating period. The finding of the present study provides an important evidence for further study on the formation mechanism of EPFRs in actual atmospheric to control the air pollution.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Yu Chen,Han Han,Mengqiuzi Yin,Xiao Wang,Xiaoman He,Qiwu Zhang
Soil contaminated by polycyclic aromatic hydrocarbons (PAHs) is a common problem in the world. Mechanochemical treatment is a promising technology for remediation of PAH-contaminated soil. This study investigated the feasibility of pyrene degradation with silica by mechanochemical remediation. The effects of ball milling time and rotation speed on the removal efficiency of pyrene in soil were also studied. When the milling time was 3 h and the rotation speed was 500 rpm, the removal efficiency of pyrene in soil was over 98%. The intermediate products detected by gas chromatography–mass spectrometry proved that the hydrogenation reaction and the destruction of benzene rings occurred in the milling process. Both graphite and amorphous carbon were detected by Raman spectra. The main degradation pathway and mechanism of pyrene by mechanochemical treatment should be the destruction of benzene rings caused by free radicals and further carbonization.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 9
·1-10
·
IF 5.705
Zhou Xiu-Jie,Zhang Li-Shun,Song Wen-Fang,Huang Yan-Ping,Liu Zhao-Sheng
An inorganic-organic hybrid monolith incorporated with stellated mesoporous silica nanoparticles (SMSNs) was prepared. Using binary solvents, deep eutectic solvents and room temperature ionic liquids, an SMSN-incorporated poly(butyl methacrylate- co -ethylene glycol dimethacrylate) monolith demonstrated uniform structure with good column permeability. A systematic investigation of preparation parameter was performed, including SMSN content, crosslinking monomer content, and the component of binary solvent. The optimized monoliths were characterized by field emission scanning electron microscopy, transmission electron microscopy, area scanning energy dispersive spectrometry, and nitrogen adsorption. Column performance was tested by separating four groups of analytes (alkylbenzenes, anilines, naphthalenes and phenols) by capillary electrochromatography (CEC). Baseline separation of all analytes was obtained with column efficiencies of up to 266,000 plates m −1 . The performance of the resulting monolith was further investigated in detail by separating mixtures of polycyclic aromatic hydrocarbons (PAHs), nonsteroidal antiinflammatory drugs (NSAIDs), and hydroxybenzoic acid isomers. Compared with the corresponding SMSN-free monolith, the CEC performance was improved by about six times. Successful extraction of PAHs and quinolones (QNs) were also performed using this capillary. Improved extraction efficiency (20.2%) for complex samples, lake water, was also found when the material was applied to solid phase microextraction of fluoranthene.
A poly(butyl methacrylate-co-ethylene glycol dimethacrylate) monolith incorporated with stellated mesoporous silica nanoparticles was prepared. It demonstrated column efficiency up to 266,000 plates m −1 in capillary electrochromatography and ability as solid phase microextraction for organic small molecules with good column permeability.
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Advanced Healthcare Materials
·
2026
·
IF 11
Yixuan Gao,Haonan Wu,Jian Yang,Junyu Meng,Junhua Zhang,Han Zhang,Jian Yang
Acute lung injury (ALI) features vascular endothelial damage, impaired barrier function, and excessive ROS accumulation, which depletes endogenous peroxidases and disrupts redox homeostasis. Transcriptomic comparison between control and ALI model groups verified marked dysregulation of genes linked to oxidative stress, inflammation, and endothelial barrier dysfunction. To date, exogenous enzyme supplementation represents a necessary strategy for treating ALI, yet very few options are available to halt excessive ROS accumulation within the critical therapeutic time window. Here, we developed a nanozyme system (SCP@CD) capable of solving this problem by encapsulating autofluorescent Mn/S-co-doped carbon dots (CDs) into polymer micelles self-assembled via a Schiff base formed by sialic acid-modified chitosan oligosaccharide and protocatechualdehyde. As a targeting ligand, sialic acid enables active targeting of E-selectin on inflamed endothelium, realizing enhanced fluorescence for noninvasive in vivo tracking. Chitosan oligosaccharide linked to sialic acid reduces systemic toxicity, while the Schiff base formed by chitosan oligosaccharide and protocatechualdehyde mediates pH-responsive release via cleavage in acidic inflammatory microenvironments. SCP@CD functions as an exogenous enzyme supplementation via the multi-nanozyme activities of CDs and achieves synergistic anti-inflammatory and endothelial barrier-repairing effects by regulating inflammatory mediators and junctional proteins. This platform offers a novel precision nanomedicine strategy for ALI.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·
IF 4.3
Hu Xingru,Pang Long,Wu Mingkai,Wang Chaohai,Li Jiansheng
Metal–organic framework-derived carbon materials have shown extensive application in the sensitive extraction of polycyclic aromatic hydrocarbons (PAHs), but more active sites for its adsorption were still a tireless pursuit. In this study, ZIF-nanoleaf-derived carbon (NLCs) was synthesized and developed as a solid-phase microextraction (SPME) fiber (NLCs-F). The extraction performance was compared with ZIF-dodecahedron-derived carbon (DHCs) coated fiber (DHCs-F), which was prepared by only changing the ratio of the reactants. The unique morphology of NLCs provided abundant adsorption active sites for the selected PAHs, while the large average aperture facilitated selective extraction of high molecular weight analytes. Additionally, the high carbon content enhanced the strong enrichment capability for hydrophobic PAHs. Hence, the prepared NLCs-F coupled with GC–MS showed a good correlation coefficient (0.9975) in a wide linear range, low limits of detection (0.3–1.8 ng L −1 ), satisfactory repeatability, and reproducibility, which made it apply in the enrichment of PAHs in actual tea and coffee samples. Graphical abstract
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ANALYTICAL LETTERS
·
2023
·
IF 2
Qian Gao,Yang Li,Xinyi Li,Huiqing Wang,Lin Tian,Hao Gong,Cuiping Ma,Chao Shi
A highly ultrafast and sensitive electrochemical sensor based on electrical potential-assisted hybridization was developed for the determination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The electrode was modified with multi-walled carbon nanotubes (MWCNTs) and Au nanoparticles (AuNPs) for excellent electrochemical performance. The constant electric field was applied to rapidly and efficiently enrich the capture probes to the electrode surface in 60 s. Meanwhile, pyrene as the backfill reagent resulted in a significant reduction of nonspecific adsorption. The electrochemical properties of the modified electrode were investigated via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The analytical response was measured by differential pulse voltammetry (DPV). The sensor achieved the ultrafast hybridization of nucleic acids at the electrode interface within 90 s, substantially reducing the reaction time from hours to minutes. Under optimal conditions, the sensor exhibited a superior detection limit of 60 fM and showed satisfactory specificity toward single-base mismatch. Additionally, the proposed sensor realized sensitive determination of SARS-CoV-2 in throat swabs. The enzyme-free and non-amplification sensing strategy showed promising potential for application in point-of-care testing (POCT).
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LANGMUIR
·
2023
·
IF 3.9
Fang Chen,Li Yin,Teng He,Tao Chen,Hangbo Yue,Chufen Yang
To enhance the stability of the polymeric micelles and optimize their drug-controlled release ability, three disulfide-linked polyethylene glycol methyl ether methacrylate–disulfide–poly(ε-caprolactone-co-γ-amine−ε-caprolactone) (PPEGMA-SS-P(CL-co-ACL)) polymers were synthesized and characterized by 1H NMR, GPC, and FT-IR successfully, and their dual pH/reduction-responsive cross-linked polymeric micelles were prepared for paclitaxel (PTX) delivery by using 2,3-dimethylmaleic anhydride (DMMA) as the cross-linking agent. The PTX loading capacity (LC) and encapsulation efficiency (EE) values of the cross-linked micelles formed by PPEGMA8-SS-P(CL47-co-ACL15) achieved were 23.96% and 71.58%, slightly higher than those of un-cross-linked micelles. Both particle sizes of blank micelles and in vitro drug release of PTX-loaded micelles confirmed that compared with those un-cross-linked micelles, the cross-linked micelles were more stable at pH 7.4 + 0 mM DTT, with a PTX cumulative release of 13% at 120 h, while the PTX cumulative release of the cross-linked micelles at pH 5.0 + 10 mM DTT were close to that of un-cross-linked micelles after 60 h, indicating the successful reversible cross-linking and smooth drug release of the cross-linked micelles. The cytotoxicity assay showed that PPEGMA8-SS-P(CL47-co-ACL15) and its cross-linked micelles had low cell cytotoxicity, and both PTX-loaded micelles revealed a certain inhibitory effect on HepG2 cells. These results revealed that the dual pH/reduction-responsive cross-linked polymeric micelles prepared from PPEGMA8-SS-P(CL47-co-DCL15) were a promising candidate for PTX delivery.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2023
·
IF 5
Yanan Bu,Hongcai Wang,Ting Wu,Xiuqiong Chen,Siyuan Zhao,Huiqiong Yan,Qiang Lin
Nowadays, self-assembled polymeric micelles from amphiphilic polymer conjugates are urgently needed to enhance drug targeting and release efficiency. On account of the excellent properties of alginate and the redox-responsiveness of disulfide bonds , a redox-sensitive alginate–SS–ibuprofen derivative (LSA–SS–IBU) based anti-tumor target drug delivery system was created by attaching the hydrophobic ibuprofen (IBU) onto the hydrophilic alginate molecular skeleton through disulfide linkages for glutathione (GSH) triggered delivery of doxorubicin hydrochloride (DOX). The structure and self-assembly behavior of the synthesized LSA–SS–IBU was systematically evaluated by FT-IR spectrometer, 1 H NMR spectrometer, fluorescence spectrophotometer (FM), transmission electron microscope (TEM) and dynamic light scattering (DLS). Furthermore, the in vitro release of drugs from the LSA–SS–IBU micelles loaded with DOX was examined, along with the assessment of their cytotoxicity to HeLa cells. The resultant LSA–SS–IBU had a critical micelle concentration (CMC) value of 0.19 mg/mL that was able to self-assemble into the spherical micelles with the particle size and zeta potential of 148.2 ± 4.3 nm (PDI = 0.25) and −47.2 ± 0.4 mV, respectively. At a mass ratio of 3:10 for DOX/LSA–SS–IBU, the LSA–SS–IBU micelles achieved drug loading ratio (DLR) and encapsulation efficiency (EE) values of 12.2 % and 46.3 %, respectively. Furthermore, the in vitro drug release study indicated that the total drug release percentage of the drug-encapsulated LSA–SS–IBU micelles in PBS with the presence of 10 mmol/L GSH for 12 h exceeded 67.0 %, demonstrating a substantial increase compared to that in GSH-free PBS. The in vitro cytotoxicity findings indicated that LSA–SS–IBU had good biocompatibility , while the IC 50 value and the cell viability of DOX-loaded LSA–SS–IBU micelles cultured with HeLa cells for 48 h was 2.2 μg/mL and less than 20.1 %, respectively, which could significantly inhibit the growth of HeLa cells. Therefore, redox-responsive LSA–SS–IBU micelles had potential applications in cancer therapy for hydrophobic anti-tumor drug delivery.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Wenzhang Tian,Jun Yang,Wen-Qing Xu,Lin Lian,Xia-Wen Qiu,Xiao Liang,Chen-Chou Wu,Xiangjun Gong,Guangzhao Zhang,Lian-Jun Bao,Eddy Y. Zeng
Chemical transfer across the air–water interface is one of the most important geochemical processes of global significance. Quantifying such a process has remained extremely challenging due to the lack of suitable technologies to measure chemical diffusion across the air–water microlayer. Herein, we present a fluorescence optical system capable of visualizing the formation of the air–water microlayer with a spatial resolution of 10 μm and quantifying air–water diffusion fluxes using pyrene as a target chemical. We show for the first time that the air–water microlayer is composed of the surface microlayer in water (∼290 ± 40 μm) and a diffusion layer in air (∼350 ± 40 μm) with 1 μg L–1 of pyrene. The diffusion flux of pyrene across the air–water interface is derived from its high-resolution concentration profile without any pre-emptive assumption, which is 2 orders of magnitude lower than those from the conventional method. This system can be expanded to visualize diffusion dynamics of other fluorescent chemicals across the air–water interface and provides a powerful tool for furthering our understanding of air–water mass transfer of organic chemicals related to their global cycling.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Shishi Shao,Jiaqiang Zhao,Wei Wang,Hanbing Nie,Yan Jie Li,Xuepeng Zhang,Cheng Zhi Huang,Peng Fei Gao
Host-guest doping room-temperature phosphorescence (RTP) materials have showed excellent potential for ultra-sensitive detection due to its bright luminescence in presence of trace guests. However, the inherent signal fluctuation of solid-state sensors restricts their widespread applications. Herein we constructed a simple internal standard method to overcome the signal fluctuation problem in RTP spectral analysis. Ultralong organic RTP can be obtained by using 1,4-dichlorobenzene (DCB) as a host and trace gaseous NL as a guest through the host-guest doping strategy. In this study, a dual-emission ratiometric phosphorescent probe pyrene (Py)/pentachloropyridine (PCP)-DCB was constructed by using the Py/PCP system fabricated via melt-casting as the reference afterglow and using the DCB as the stimuli-responsive unit of gaseous NL. This probe can be used for visual identification and content detection of NL in commercial mothballs. The ratio of phosphorescence intensity (I485/I595) was linearly related to the mass of added NL (mNL) within the range of 0.05–1.45 mg in this ratiometric RTP platform, and had a low detection limit of 0.012 mg. Furthermore, the NL content of five commercially available mothballs with different NL content was detected by this Py/PCP-DCB platform, and it had good performance compared to the gas chromatography (GC) analysis results.
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