JOURNAL OF SURFACTANTS AND DETERGENTS
·
2024
·
IF 1.6
Jiadong Chen,Weikang Tang,Mengqi Han,Qinfei Chen,Hong Zhou,Yongkui Zhang,Wenbin Liu
Amino acid surfactants are widely used in areas of life and industry. Biomimetic synthesis of a new type of amino acid surfactant was based on the melanogenesis using the natural substances ethyl protocatechuate. Ethyl protocatechuate was oxidized to o-benzoquinone using silver oxide. The amino group of amino acids, including arginine, cysteine, glutamic acid, histidine, leucine, and threonine, was conjugated with o-benzoquinone to synthesize melanin-like amino acid surfactants. o-Benzoquinone moiety behaved as hydrophobic part while amino acid residue served as hydrophilic head group. The critical micelle concentration of cysteine product was 1.18 mM. The melanin-like amino acid surfactant showed excellent foamability, wettability, emulsification, solubilization, and dispersibility properties. Arginine product showed the longest foam half lifetime of 18 min; the wetting time of threonine product was 23 s; the emulsion delamination time of cysteine product was 1034 and 1940 s for liquid paraffin and soybean oil, respectively; threonine product had the most solubilization capacity of 9430 mL mol −1 of benzene; glutamic acid product showed the highest lime soap dispersing power value of 45.58%. It was the first invention for biomimetic synthesis of amino acid surfactant from aspect of both structure and route. Melanin-like amino acid surfactant had promising potential in both fundamental research and industrial application.
研究领域:
化学
·
生物学
·
材料科学
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DOI
高影响因子
Bioresources and Bioprocessing
·
2023
·Vol. 10
·期 1
·1-12
·
IF 4.6
Dai Mohan,Xu Binpeng,Guo Qing,Wan Junfen,Cao Xuejun
Ursodeoxycholic acid (UDCA) is not only safer than chenodeoxycholic acid in the treatment of hepatobiliary diseases, but also has a wide range of applications in Acute Kidney Injury and Parkinson’s Disease. The purpose of this experiment is to improve the conversion rate of 7-ketocholic acid (7K-LCA) and the yield of ursodeoxycholic acid in aprotic solvents during electrochemical reduction process. Three aprotic solvents were investigated as electrolytes. 1,3-Dimethyl-2-imidazolidinone (DMI) has a stable five-membered ring structure, and 7K-LCA has undergone two nucleophilic reactions and “Walden” inversion, the 7K-LCK was stereoselectively reduced to UDCA. Hexamethylphosphoramide (HMPA) and 1,3-methyl-3,4,5,6-Tetrahydro-2(1 H )-pyrimidinone (DMPU) can be attacked by chloride ions to produce by-products. Molecular orbital theory-based simulations were conducted to study the reducibility of three aprotic solvents [hexamethylphosphoramide (HMPA), 1,3-methyl-3,4,5,6-Tetrahydro-2(1 H )-pyrimidinone (DMPU), and 1,3-Dimethyl-2-imidazolidinone (DMI)] in combination with experiments. Choose the best solvent based on the simulation results, the electrolysis reaction can be carried out by applying current and voltage when lithium chloride is used as electrolytes. Calculations using Materials Studio showed that Cu, Pb, Hg–Cu, and Ni exhibited the highest binding energies to the substrate in this system. Using Cu as the electrode when the solvent is a 1:1 mix of DMI and HMPA, the conversion rate of 7-ketocholic acid (could reach 98%, the yield of ursodeoxycholic acid was up to 80%. Under the same conditions, linear voltammetry was performed on the electrochemical workstation to study the electrolysis behavior, and the obtained results were consistent with the experiment. Graphical Abstract
研究领域:
药理学
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有机化学
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生物化学
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DOI
高影响因子
ENERGY & FUELS
·
2013
·
IF 2.853
Shufeng Shen,Xiaoxia Feng,Shaofeng Ren
Preliminary screening experiments of carbon dioxide (CO2) absorption into aqueous 35 wt % equivalent potassium carbonate (K2CO3) solution with different additives were performed in a wetted-wall column at 322 K. Arginine was found as an effective promoter to enhance the absorption rate in aqueous K2CO3 solution. The effect of arginine concentration and CO2 loading on the absorption rate into carbonate solutions is discussed. The vapor–liquid equilibrium of 35 wt % equivalent K2CO3 with 0–5 wt % arginine was obtained in the temperature range from 323 to 343 K using inert-gas stripping method. Desorption curves of the unpromoted and arginine-promoted carbonate solutions are also discussed.
研究领域:
化学工程
·
环境科学
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能源技术
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气体吸收
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热力学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 181
·期 5
·589-595
·
IF 3.719
Tian Li,Zhang Boxun,Sun Ding,Chen Ruizhan,Wang Binbin,Li Tianjiao
We have fabricated, in a single step, carbon ceramic electrodes modified with a poly(acridine orange) film containing reduced graphene oxide. They display electrocatalytic activity to ascorbic acid (AA) and uric acid (UA) at pH 4.5. The anodic peak potentials of AA and UA are separated by 276 mV so that they can be well resolved in cyclic voltammetry. UA and AA were simultaneously determined in a mixture at working potentials of 170 and 400 mV, respectively. Under optimized conditions, the calibration curves for AA and UA cover the 0.8–5,000 μM and 0.6–900 μM concentration range, respectively, while detection limits are 0.3 μM and 0.2 μM. The electrode was applied to determine AA and UA in urine samples.
DPV curves of RGO–PAO/CCE in the phosphate buffer solution (pH 4.5) containing 5.0 × 10 −5 mol L −1 AA with different concentration of UA (a → f: 0, 1, 3, 5, 7, 9 × 10 −6 mol L −1 )
研究领域:
分析化学
·
电化学
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生物传感器
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临床检验诊断学
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纳米材料
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DOI
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 17
·期 5
·1168-1172
·
IF 3.858
Shaojuan Luo,Jiyun Feng,Ka Ming Ng
Indium–tin carboxylate precursors were successfully synthesized by a direct reaction of indium and tin metals with a molten fatty acid under a nitrogen atmosphere at 260 °C. A linear relationship between the reaction initiation temperature and the number of carbon atoms of the fatty acids ranging from capric acid to stearic acid was observed. There was a 7 °C increase in the reaction initiation temperature for an increase of one carbon atom in the fatty acid. Nearly monodisperse 7–9 nm ITO nanocrystals without agglomeration were synthesized by direct pyrolysis of the as-synthesized precursors without using additional organic solvents. The fatty acid had a minor effect on the decomposition temperature and the mean ITO particle size, but affected the particle size distribution. TOF-SIMS data confirmed that the residue fatty acids on the surface of the indium tin oxide (ITO) nanoparticles served as a built-in surfactant leading to excellent dispersity of the ITO nanocrystals in non-polar solvents.
研究领域:
材料科学
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纳米技术
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化学合成
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表面化学
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DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Meimei Guo,Zhihua Zhou,Wenjuan Liu,Tianlong Huang,Wei Wu,Jianglong Duan,Meiling Yi,Chao Zhang,Xiao He,Jinxing Chen,Jiaming Gu,Jianjun Fang
Polymer/bioceramic composite scaffolds have gained importance in treating bone defects. In this paper we described a novel degradable scaffold material for bone tissue repairing prepared by combining poly(lactide-co-glycolide-co-ε-caprolactone) (PLLGC) and 1,4-butanediamine-modified poly(lactide-co-glycolide) (BMPLGA) with nano-biaoactive glass (NBAG) and nano β-tricalcium phosphate (β-TCP). The composite scaffolds were characterized by using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The FTIR results indicated that the inorganic fillers of NBAG and β-TCP were successfully incorporated into the PLLGC/BMPLGA matrix. The influences of the inorganic filler content and freezing temperature on the porosity and compressive strength of the composite scaffolds were studied. The composite scaffolds showed an interconnected pore structure with the pore size ranging from 20 to 100 μm depending on the freezing temperature and the inorganic fillers. The compressive strength was enhanced with increasing content of the inorganic fillers and the freezing temperature; however, the porosity decreased. We suggest the PLLGC-BMPLGA/NBAG-β-TCP composite scaffolds have great potential for application in bone tissue regeneration.
研究领域:
生物材料
·
组织工程
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高分子科学
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生物医学工程
·
材料表征
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DOI
高影响因子
ANALYST
·
2012
·Vol. 137
·期 18
·4235-4240
·
IF 4.23
Xiaoyu Mu,Li Qi,Ying Shen,Haizhi Zhang,Juan Qiao,Huimin Ma
A novel amino acid ionic liquid (AAIL) with L-ornithine (L-Orn) as anion was successfully synthesized, and subsequently applied as an available chiral ligand coordinated with Zn(II) in a chiral ligand exchange capillary electrophoresis (CLE-CE) system for the enantioseparation of dansyl amino acids (Dns-D,L-AAs). The influence of key parameters, such as buffer pH, concentration ratio of Zn(II) to ligand and complex concentration, was investigated in detail. Eleven pairs of Dns-D,L-AAs enantiomers were baseline separated and three pairs were partly separated under the optimum conditions. For exploring its potential application, the quantitative features of this proposed method were studied. Good linearity (r2 = 0.999) and favorable repeatability (RSD ≤ 3.4%) were obtained by using Dns-D,L-Met as the test analyte. Finally, this method was employed to investigate the inhibition efficiency of D-amino acid oxidase (DAAO) inhibitors, which may pave a new way for the high-throughput screening of enzyme inhibitors and relevant drug discovery.
研究领域:
分析化学
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药物分析
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酶学
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手性分离
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药物发现
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代谢酶
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DOI
高影响因子
ENERGY & FUELS
·
2020
·
IF 3.421
Jiatao Xiang,Zhen Zhang,Luning Tian,Qinghua Zhao,Haiping Yang,Xiong Zhang,Jingai Shao,Shihong Zhang,Hanping Chen
In order to enhance wet flue gas desulfurization efficiency and reduce cost, the effects of different series of additives (typical organic acids, organic salts, inorganic salts, organic amines, and their mixture) on the desulfurization properties, including pH buffering characteristics of slurry, dissolution characteristics of CaCO3, oxidation characteristics of CaSO3, desulfurization efficiency, and economic cost were investigated in this work. The results show that the pH buffering capacity is sodium benzoate ≈ Na2SO4 > adipic acid > double oxazine. The dissolution promoting effect of CaCO3 is acetic acid > double oxazine ≈ sodium acetate > MgSO4. The additives that can significantly promote the oxidation of CaSO3 are adipic acid, citric acid, acetic acid, MgSO4, and Na2SO4. Without an additive, the desulfurization efficiency of CaCO3 slurry decreased to 85.87% after 4 h. After the addition of the composite additive (CA-3), the desulfurization efficiency of CaCO3 slurry remained 96.53% for 4 h, increasing by 10.66%. The main reasons for the enhancement in the desulfurization process may be a collection of three factors: the reversible hydrolysis reactions of acetic acid and sodium acetate, the formation of an acid–base conjugate system by sodium benzoate, and the formation of a neutral ion pair MgSO3 by MgSO4 in the slurry. In addition, the composite additive has been used in the Dabie mountain power plant of China. The economic benefit analysis shows that the desulfurization unit of 4 × 640 MW coal-fired power plant can save 1.26 million dollars per year by composite additive.
研究领域:
环境科学
·
化学工程
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DOI
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2021
·
IF 3.133
Ya-Wen Zhang,Ling-Lan Tu,Zhan Tang,Qiao Wang,Gao-Li Zheng,Li-Na Yin
Oral absorption of peptides/proteins is usually compromised by various gastrointestinal tract barriers. To improve delivery efficiency, chitosan-conjugated deoxycholic acid (CS-DCA) coupled with sodium alginate (ALG) was prepared to load insulin into pH-sensitive nanoparticles. The insulin-loaded chitosan-deoxycholic acid/alginate nanoparticles (CDA NPs) were characterized by size (143.3 ± 10.8 nm), zeta potential (19.5 ± 1.6 mV), entrapment efficiency (61.14 ± 1.67%), and insulin drug loading (3.36 ± 0.09%). The CDA NPs exhibited pH-triggered release characteristics in vitro and protected the wrapped insulin from gastric degradation. Stability of the CDA NPs in enzyme-containing simulated gastrointestinal fluids suggested that the NPs could partially protect the wrapped insulin from enzymatic degradation. Additionally, CS-DCA-modified NPs promoted the permeability of Caco-2 cells and enhanced intracellular absorption of FITC-labeled insulin by 9.4 and 1.2-folds, when compared to insulin solution and unmodified NPs, respectively. The positively charged NPs increased intestinal villi adhesion and enhanced insulin absorption in the intestines of diabetic rat models. Furthermore, the hypoglycemic test showed that CDA NPs prolonged insulin release in vivo and exerted a remarkable hypoglycemic effect on diabetic rats with an oral bioavailability of 15%. In conclusion, CDA NPs is a potential oral insulin delivery system.
研究领域:
药剂学
·
生物医学工程
·
糖尿病治疗
✓ 已验证
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Feng Zhang,Dongyi Zhang,Tong Chang,Hongyan Li,Jiali Cui,Jianguo Cui
In this study, an electrochemically activated persulfate (EAP) process using boron-doped diamond (BDD) as the anode was adopted for the activation of peroxydisulfate (PDS) to treat bromide-containing water. In this EAP process, the activation of PDS to generate SO 4 •- is mainly caused by direct electron transfer at the cathode. The synergetic oxidation by the free radical oxidants, including OH• electrogenerated on the BDD anode and SO 4 •- produced on the cathode, is the major driving force to oxidize bromide to bromate through the continuous stepwise reaction. The cathodic reduction of high-valent bromine compounds coexisting in the EAP process could also affect the distribution of bromine by-products. The bromate formed in the EAP process decreased when humic acid coexisted in the bromide-containing water because the active bromine (Br• and HOBr) could react with organic matter to form brominated by-products. Bromate formation was increased with increasing PDS dosage, initial bromide concentration and current density. An acidic environment is beneficial for inhibiting the formation of bromate, but it might also increase the risk of formation of brominated by-products.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2012
·
IF 5.602
Na Zhang,Fei Qu,Hong Qun Luo,Nian Bing Li
In this work, we present a label-free biosensor for the sensing of biothiols such as cysteine, homocysteine , and glutathione . This biosensor is based on the fluorescent probe , polyethyleneimine-capped silver nanoclusters . The selective binding of silver nanoclusters to biothiols promotes the silver nanoclusters agglomeration to yield larger non-fluorescent silver nanoparticles . And the fluorescence intensity of silver nanoclusters was quenched efficiently with increasing concentration of biothiols. The other amino acids introduced to the silver nanoclusters probe solution did not quench the fluorescence of the probe as they do not have thiol group which has strong affinity to the silver nanoclusters. Thus, this biosensor allowed selectively investigation of biothiols. The as-proposed biosensor was sensitive for the detection of biothiols. The linear ranges for cysteine, homocysteine, and glutathione were 0.1–10 μΜ ( R 2 =0.9930), 0.1–10 μΜ ( R 2 =0.9924), and 0.5–6 μΜ ( R 2 =0.9900), respectively. The detection limits for cysteine, homocysteine, glutathione were 42, 47, and 380 nΜ, respectively. The silver nanoclusters-based fluorescent biosensor provides a simple, cost-effective, and sensitive platform for the detection of biothiols.
研究领域:
生物化学
·
分析化学
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DOI
高影响因子
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
·
2024
·Vol. 129
·期 3
·e2023JD040017
·
IF 3.8
Yangyang Liu,Tao Wang,Qiuyue Ge,Wenbo You,Kejian Li,Wei Wang,Lifang Xie,Longqian Wang,Xiaozhong Fang,Xuejun Ruan,Le Yang,Runbo Wang,Liwu Zhang
Carbonate radical anion ( C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ ) is generally overlooked in atmospheric chemistry. Our recent work emphasizes the important role of carbonate radicals produced on mineral dust surfaces in fast sulfate production under solar irradiation in the presence of CO 2 at specifically low RH and light intensity. Yet so far how C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ involves and affects secondary sulfate production under diverse RH, light intensity, and complex constituent matrix remains unknown, which essentially limits our comprehensive knowledge of C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ initiated SO 2 oxidation scheme in the atmosphere. Herein, we explored the heterogeneous SO 2 oxidation over both model and authentic dust and clays in the presence of CO 2 at atmospheric relevant RHs and light intensities. Interestingly, we observe that CO 2 promotes sulfate yield over authentic dust and clays at atmospheric-relevant RH and light intensity. This observation relates to the favorable kinetic between SO 2 oxidation and C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ while auto-quenching of these radical ions is largely minimized due to the sufficient sites of crustal constituents. Furthermore, employing a suite of authentic dust and machine learning strategies, we evaluated the relative importance of each constituent within airborne minerals or clays as well as environmental conditions including relative humidity, light intensity, and CO 2 concentration in affecting SO 2 uptake capability. On this basis, sulfate formation mediated by dust-driven pathway, accounting for nearly ∼20.9% of overall contribution by the end of this century during some pollution episodes, even higher than gas-phase · OH $\cdot \text{OH}$ (∼16.9%), will be increased by 163% if CO 2 -initiated SO 2 oxidation scheme is incorporated. Key Points Carbonate radical-initiated SO 2 heterogeneous oxidation is sensitive to RH, CO 2 concentration, light intensity, and dust constituents Carbonate radicals promote atmospheric sulfate production on authentic dust and clay particles at haze-relevant conditions This previously unrecognized scheme will account for ∼20.9% of overall atmospheric sulfate formation by the end of this century Plain Language Summary How carbonate radical ions involve and affect sulfate formation under different RHs, light intensities, and complex component matrices remains an open question. Secondary sulfate production is facilitated by C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ over authentic dust particles in atmospheric relevant RH and light intensity. More importantly, this research emphasizes that CO 2 is not an inert greenhouse gas that rarely participates in atmospheric chemistry but a strong oxidant precursor that will produce C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ and subsequently trigger quick SO 2 oxidation via chain reactions. This dust-driven reaction channel mediated by C O 3 . − ${\mathrm{C}{\mathrm{O}}_{3}}^{.-}$ potentially contributes to nearly ∼1/5 of secondary sulfate production during some pollution hours if the growing intensive anthropogenic activities continue.
研究领域:
大气化学
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）