Bioactive Materials
·
2023
·
IF 18.9
Qinfeng Yang,Shenghui Su,Shencai Liu,Sheng Yang,Jing Xu,Yixiu Zhong,Yusheng Yang,Liangjie Tian,Zilin Tan,Jian Wang,Zhiqiang Yu,Zhanjun Shi,Fangguo Liang
Over the years, electroconductive hydrogels (ECHs) have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral nerve injury (PNI) with diabetes, given their favorable mechanical and electrical properties identical to endogenous nerve tissue. Nevertheless, PNI causes the loss of locomotor function and inflammatory pain, especially in diabetic patients. It has been established that bone marrow stem cells-derived exosomes (BMSCs-Exos) have analgesic, anti-inflammatory and tissue regeneration properties. Herein, we designed an ECH loaded with BMSCs-Exos (ECH-Exos) electroconductive nerve dressing to treat diabetic PNI to achieve functional recovery and pain relief. Given its potent adhesive and self-healing properties, this laminar dressing is convenient for the treatment of damaged nerve fibers by automatically wrapping around them to form a size-matched tube-like structure, avoiding the cumbersome implantation process. Our in vitro studies showed that ECH-Exos could facilitate the attachment and migration of Schwann cells. Meanwhile, Exos in this system could modulate M2 macrophage polarization via the NF-κB pathway, thereby attenuating inflammatory pain in diabetic PNI. Additionally, ECH-Exos enhanced myelinated axonal regeneration via the MEK/ERK pathway in vitro and in vivo, consequently ameliorating muscle denervation atrophy and further promoting functional restoration. Our findings suggest that the ECH-Exos system has huge prospects for nerve regeneration, functional restoration and pain relief in patients with diabetic PNI.
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高影响因子
npj Quantum Materials
·
2023
·Vol. 8
·期 1
·1-7
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IF 5.7
Xu R. Z.,Du X.,Zhou J. S.,Gu X.,Zhang Q. Q.,Li Y. D.,Zhao W. X.,Zheng F. W.,Arita M.,Shimada K.,Kim T. K.,Cacho C.,Guo Y. F.,Liu Z. K.,Chen Y. L.,Yang L. X.
TaTe 4 , a metallic charge-density wave (CDW) material discovered decades ago, has attracted renewed attention due to its rich interesting properties, such as pressure-induced superconductivity and candidate nontrivial topological phase. Here, using high-resolution angle-resolved photoemission spectroscopy and ab initio calculation, we systematically investigate the electronic structure of TaTe 4 . At 26 K, we observe a CDW gap as large as 290 meV, which persists up to 500 K. The CDW-modulated band structure shows a complex reconstruction that closely correlates with the lattice distortion. Inside the CDW gap, there exist highly dispersive energy bands contributing to the remnant Fermi surface and metallic behavior in the CDW state. Interestingly, our ab initio calculation reveals that the large CDW gap mainly opens in the electronic states with out-of-plane orbital components, while the in-gap metallic states originate from in-plane orbitals, suggesting an orbital texture that couples with the CDW order. Our results shed light on the interplay between electron, lattice, and orbital in quasi-one-dimensional CDW materials.
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ADVANCED FUNCTIONAL MATERIALS
·
2023
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IF 19
Menghui Liu,Yunzhi Wang,Yanlv Chen,Liujun Li,Yang Sun,Yongchao Li,Yajun Yuan,Pan Lu,Wenkai Zhang,Pengfei Pang,Xin Peng,Hong Shan
Endovascular embolization can selectively deploy embolic agents into diseased or injured blood vessels to complete the treatment. However, traditional embolic agents still face challenges, such as poor intravascular diffusivity, non-biodegradable, unstable mechanical properties, radiolucency, and recanalization. Herein, we report a poly (lipoic acid-tannic acid)/tromethamine/Galinstan (PLTTG) dimethyl sulfoxide (DMSO) solution-derived hydrogel liquid embolic agent. By injecting PLTTG DMSO solution into body fluids, a PLTTG hydrogel can be formed in situ owing to the solvent exchange induced intra- and inter-polymer hydrogen bonding and electrostatic interactions. Moreover, the gelation time and injection forces of the solution as well as the mechanical properties and embolic pressure of the obtained hydrogels can be adjusted by changing the concentration of PLTTG. The PLTTG hydrogel can effectively embolize the renal artery and femoral vein without recanalization and displacement in rabbit models. Furthermore, the hydrogel can embolize the ruptured femoral artery to arrest active bleeding. Owing to the advantages of the hydrogel, including adjustable gelation time, mechanical properties, viscosities, injection forces, and embolic pressure, as well as good biocompatibility and biodegradability, radiopacity, excellent embolization performance and intravascular diffusivity, easy usage, low cost, allowing it to be a potential embolic agent to treat multiple vascular diseases in clinic.
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ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Xingzhao Zhang,Ximing Cui,Yuxuan Li,Qinmin Pan
All-solid-state lithium batteries (ASSLBs) have attracted considerable attention because of their excellent safety and high energy density. However, application of ASSLBs is significantly impeded by the lack of solid-state electrolytes with ultra-thinness, high mechanical strength, and high electrochemical stability. Herein, we address this dilemma by designing an ultra-thin agarose-based electrolyte through a high-density anchoring strategy. The high-density anchoring is achieved by the supramolecular interaction between agarose (AG) and tannic acid (TA), which effectively restricts the free rotation of hydroxyl groups on AG backbones and forms Li-ion migration channels between AG chains. These characteristics endow the ultra-thin polymer electrolyte (UTPE) with a high mechanical strength, a wide electrochemical window (4.5 V), and a high lithium-ion transference number of 0.45 at 25 °C. A solid-state LiFePO4||Li battery with a 20 μm UTPE displays outstanding cyclability with a specific capacity of 141 mAh g–1 over 300 cycles at a 0.5 C rate. A LiNi0.5Mn0.2Co0.3O2||Li battery using the UTPE delivers a specific capacity of 93.9 mAh g–1 over 100 cycles at a 0.1 C rate at 2.5–4.2 V, showing a retention rate of 75.0% at room temperature. Furthermore, solid-state LiFePO4||Li pouch cells exhibit remarkable safety even after being folded, cut, and penetrated by the nail. This study offers a promising strategy to address the mechanical strength and electrochemical stability issues of solid polymer electrolytes, which has potential applications in high-energy-density ASSLBs.
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EUROPEAN POLYMER JOURNAL
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2023
·
IF 6
Leqi Wu,Sui Wang,Jie Mao,Zhiyong Guo,Yufang Hu
In this study, a conductive double network cross-linked hydrogel with anti-swelling and shape memory was successfully prepared by [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), polyvinyl alcohol (PVA), and tannic acid (TA). The hydrogel is formed by SBMA radical polymerization to form the first layer of the network and PVA freeze-thawing to form the second layer of the network. The conversion of -SO 3 - on the SBMA structure to -SO3H in the presence of TA and the electrostatic repulsion between -N + (CH 3 ) 3 reduces the osmotic pressure and achieves an anti-swelling effect. The prepared hydrogels have good mechanical properties tensile strength of 1.4 MPa, elongation at break of 287.52 %, and compressive strength of 2.36 MPa at 80 % strain. The structure of SBMA forms ion channels with stable conductivity, simulating the realization of underwater monitoring movements. In addition, the hydrogel can recover its original shape in a few seconds at 60 °C and has a 99 % inactivation rate against E. coli and S. aureus within 24 h, which can provide new ideas for the biomedical field.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Zuwu Tang,Xinxing Lin,Meiqiong Yu,Ajoy Kanti Mondal,Liulian Huang,Lihui Chen,Hui Wu
Hydrogel-based sensors have attracted increasing attention as fascinating materials for various applications in biomedicine and bioelectronics. However, the application of strain sensors underwater remains a great challenge due to the swelling of hydrogels in an aqueous environment. Herein, we report a coacervate conductive polyacrylamide/tannic acid (PAM/TA) composite hydrogel with strong antiswellable properties. The PAM/TA composite hydrogel exhibits a good electrical performance, where the conductivity is found to be 2.7 × 10–4 S/cm, which is stable during recycling, with an excellent stretchability of 1000% at a tensile strength of 1.5 MPa. The composite hydrogel shows excellent biocompatibility and antiswellable behavior and maintains long-term stability underwater to monitor human movements. In addition, the environmentally friendly composite hydrogel can be recycled repeatedly. The PAM/TA composite hydrogel with excellent antiswelling and stability, good electrical performance, and remarkable stretchability has great potential for the applications as underwater wearable sensors.
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BIOMATERIALS
·
2023
·
IF 14
Yu Wang,Ye Wu,Bo Zhang,Cheng Zheng,Cheng Hu,Chuan Guo,Qingquan Kong,Yunbing Wang
Intervertebral disc degeneration (IDD) progresses due to local inflammatory response, gradually unbalanced anabolic/catabolic activity, and progressive functional impairment within the nucleus pulposus. Antagomir-21, a cholesterol-modified miRNA-21 inhibitor, has potential extracellular matrix (ECM) regenerative ability , but its application for IDD is limited by inadequate local delivery systems. An injectable hydrogel gene delivery system encapsulating a modified tannic acid nanoparticles (TA NPs) vector was engineered for on-demand and sustained delivery of antagomir-21 into the nucleus pulposus. After nucleus pulposus cell uptake, antagomir-21 was released from TA NPs and regulated the ECM metabolic balance by inhibiting the MAPK/ERK signaling pathway . TA NPs scavenged intracellular ROS and reduced inflammation by downregulating TNF-α expression. In vivo , synergistic anti-inflammatory effects and ECM regeneration effectively promoted therapeutic efficacy against IDD. This hydrogel gene delivery system represents a creative, promising strategy for IDD repair.
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高影响因子
PEST MANAGEMENT SCIENCE
·
2023
·Vol. 79
·期 10
·3796-3807
·
IF 4.1
Xuan Li,Zhiyuan Zhou,Yuqi Huang,Gang Tang,Yulu Liu,Xi Chen,Guangyao Yan,Huachen Wang,Xiaohong Zhang,Jialu Wang,Yongsong Cao
Background Pesticides are irreplaceable inputs for protecting crops from pests and improving crop yield and quality. Self-assembly nanotechnology is a promising strategy by which to develop novel nano-formulations for pesticides. Nano-formulations improve the effective utilization of pesticides and reduce risks to the environment because of their eco-friendly preparation, high drug loading, and desirable physicochemical properties. Here, to enhance the utilization efficiency of myclobutanil (MYC) and develop a novel nano-formulation, carrier-free co-assembled nanoparticles (MT NPs) based on MYC and tannic acid (TA) were prepared by noncovalent molecular interactions using a green preparation process without any additives. Results The results showed that the prepared spherical nanoparticles had good stability in neutral and acidic aqueous solutions, low surface tension (40.53 mN m −1 ), high rainfastness, and good maximum retention values on plant leaves. Release of active ingredients from MT NPs could be regulated by altering the molar ratio of subassemblies in the co-assembly and the pH of the environment. Antifungal experiments demonstrated that MT NPs had better activities against Alternaria alternata and Fusarium graminearum [half-maximal effective concentration (EC 50 ) = 6.40 and 77.08 mg/L] compared with free MYC (EC 50 = 11.46 and 124.82 mg/L), TA (EC 50 = 251.19 and 503.81 mg/L), and an MYC + TA mixture (EC 50 = 9.62 and 136.21 mg/L). These results suggested that MYC and TA incorporated in the co-assembled nanoparticles had a synergistic antifungal activity. The results of a genotoxicity assessment indicated that MT NPs could reduce the genotoxicity of MYC to plant cells. Conclusion Co-assembled MT NPs with synergistic antifungal activity have outstanding potential for the management of plant diseases. © 2023 Society of Chemical Industry.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Zimu Li,Min Zhu,Fang Li,Zhi Li,Anqi Zhao,Mohammad A. Haghighatbin,Hua Cui
The development of chemiluminescence (CL) sensing strategy with multiple-parameters for discrimination of small molecules remains a great challenge. Herein, a multicolor CL sensing strategy for the discrimination of five antioxidants , including dopamine, catechin, cysteine, glutathione , and thioctic acid was presented. Firstly, multilayer paper chips modified with luminol-Co(II), luminol-fluorescein-Co(II), and luminol-rhodamine B-Co(II) that can produce strong blue, green and purple colored light emission, respectively, via CL and CL resonance energy transfer (CRET) reactions were fabricated. The presence of antioxidants exhibits different inhibition or enhancement effect on the CL reactions, creating unique multicolor CL response pattern to each antioxidant. The red (R), green (G), and blue (B) channel split from the purple, green and blue CL image, respectively, generate cross-reactive sensing parameters for the discrimination of the five antioxidants. The distinct R, G, and B values of the CL images to each antioxidant are created as analytical fingerprints to identify five antioxidants by using principal component analysis and hierarchical cluster analysis. Satisfied results were obtained for discrimination antioxidant mixtures and spiked antioxidants in serum samples. Identification of 10 unknown samples resulted in 100% accuracy. This work presents the first example of multicolor CL sensing strategy for the discrimination of small molecules.
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高影响因子
JOURNAL OF APPLIED PHYSICS
·
2023
·Vol. 133
·期 23
·
IF 3.2
Shen Jibing,Zhang Min,Lin Shuai,Song Wenhai,Liu Huijun,Liu Qiangchun,Zhu Xuebin,Sun Yuping
The application of microwave absorption materials, which can effectively convert electromagnetic energy into thermal energy and/or other forms of energy, can effectively solve the increasingly serious electromagnetic pollution. As a type of promising microwave absorption material, ternary transition metal carbides/nitrides MAX phases possess layered structure and superior conduction loss capability. However, poor impedance matching and single polarization loss type seriously hinder their improvement of microwave absorption performance. High-entropy engineering is expected to be an effective strategy to address the above problems simultaneously. Herein, a series of low-, medium-, and high-entropy MAX phases with Ti 2 AlC structure were successfully synthesized and their structure, composition, and morphology were comprehensively characterized. High-entropy MAX phase (Ti 1/5 Zr 1/5 V 1/5 Nb 1/5 Ta 1/5 ) 2 AlC presents excellent microwave absorption performance with the optimal minimum reflection loss (RL min ) of −47 dB at 11.92 GHz (a thickness of 2.4 mm) and optimal effective absorption bandwidth of 3.92 GHz between 8.48 and 12.4 GHz (a thickness of 2.78 mm), which are better than those of our prepared low-/medium-entropy MAX phases as well as most of the other previously reported MAX phases. Such excellent microwave absorption performance of (Ti 1/5 Zr 1/5 V 1/5 Nb 1/5 Ta 1/5 ) 2 AlC is attributed to high-entropy engineering, which not only optimizes the impedance matching through regulating permittivity but also introduces more polarization loss type and amount. This work reveals that high-entropy engineering is not only a workable method to enhance the microwave absorption performance in MAX phases, but also an effective strategy to tailor the balance between impedance matching and loss capability through compositional design in single-phase systems.
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Materials Today Bio
·
2023
·
IF 8.2
Fangguo Liang,Yusheng Yang,Yuyong Chen,Jiajun Xie,Shencai Liu,Zilin Tan,Liangjie Tian,Zhiqiang Yu,Zhanjun Shi,Peigen Xie,Hong Ding,Qinfeng Yang
In recent years, electroconductive hydrogels (ECHs) have shown great potential in promoting nerve regeneration and motor function recovery following diabetic peripheral nerve injury (PNI), attributed to their similar electrical and mechanical characteristics to innate nervous tissue. It is well-established that PNI causes motor deficits and pain, especially in diabetics. Current evidence suggests that ropivacaine (ROP) encapsulated in poly lactic-co-glycolic acid (PLGA) microspheres (MSs) yield a sustained analgesic effect. In this study, an ECH electroconductive network loaded with MS/ROP (ECH-MS/ROP) was designed as a promising therapeutic approach for diabetic PNI to exert lasting analgesia and functional recovery. This dual delivery system allowed ROP's slow and sequential release, achieving sustained analgesia as demonstrated by our in vivo experiments. Meanwhile, this system was designed like a lamellar dressing, with desirable adhesive and self-curling properties, convenient for treating injured nerve tissues via automatically wrapping tube-like structures, facilitating the process of implantation. Our in vitro assays verified that ECH-MS/ROP was able to enhance the adhesion and motility of Schwann cells. Besides, both in vitro and in vivo studies substantiated that ECH-MS/ROP stimulated myelinated axon regeneration through the MEK/ERK signaling pathway, thereby improving muscular denervation atrophy and facilitating functional recovery. Therefore, this study suggests that the ECH-MS/ROP dressing provides a promising strategy for treating diabetic PNI to facilitate nerve regeneration, functional recovery and pain relief.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Junxiang Zhang,Zeyu Cheng,Xinbo Qin,Xi Gao,Rongping Yun,Xu Xiang
Salt lake brine has become a promising lithium resource, but it remains challenging to separate Li+ ions from the coexisting ions. We designed a membrane electrode having conductive and hydrophilic bifunctionality based on the H2TiO3 ion sieve (HTO). Reduced graphene oxide (RGO) was combined with the ion sieve to improve electrical conductivity, and tannic acid (TA) was polymerized on the surface of ion sieve to enhance hydrophilicity. These bifunctional modification at the microscopic level improved the electrochemical performance of the electrode and facilitated ion migration and adsorption. Poly(vinyl alcohol) (PVA) was used as a binder to further intensify the macroscopic hydrophilicity of the HTO/RGO-TA electrode. Lithium adsorption capacity of the modified electrode in 2 h reached 25.2 mg g–1, more than double that of HTO (12.0 mg g–1). The modified electrode showed excellent selectivity for Na+/Li+ and Mg2+/Li+ separation and good cycling stability. The adsorption mechanism follows ion exchange, which involves H+/Li+ exchange and Li–O bond formation in the [H] layer and [HTi2] layer of HTO.
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危险品化学品经营许可证（带存储）