JOURNAL OF APPLIED PHYSICS
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2024
·Vol. 136
·期 7
·
IF 2.7
Zha Jielin,Yang Yulong,Liu Jiaxun,Lu Xiaomei,Hu Xueli,Yan Shuo,Wu Zijing,Zhou Min,Huang Fengzhen,Ying Xuenong,Zhu Jinsong
Although K 0.5 Na 0.5 NbO 3 (KNN) possesses large maximum polarization and relatively high breakdown strength, the large remnant polarization constrains their practical applications as energy storage materials. In this work, through multi-element doping, (K 0.5−0.5 x Na 0.5−0.5 x Bi x )(Nb 1− x Sn 0.2 x Zn 0.6 x Ta 0.2 x )O 3 relaxor ferroelectrics were prepared. As the superparaelectric states (SPE) were adjusted to room temperature, orthorhombic, tetragonal, and cubic phases coexisted, accompanied by the highly dynamic polar nanoregions (PNRs). In particular, a high recoverable energy storage density of 4.5 J/cm 3 and an energy storage efficiency of 83% were achieved for the x = 0.125 ceramic, with the variations less than 11% and 4%, respectively, in the wide temperature range of 20–180 °C. These results demonstrate that the multiphase PNRs in the SPE state is an effective strategy for improving the energy storage performance of KNN-based ceramics.
研究领域:
材料科学
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能源存储
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2013
·Vol. 18
·期 4
·4158-4169
·
IF 2.428
Luhui Ren,Xue Du,Mengnan Hu,Chaoqun Yan,Taigang Liang,Qingshan Li
An asymmetric synthesis of a series of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives3a–ois reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR and MS. Their cytotoxic activity was evaluated by the MTT assay against three selected human cancer cell lines: HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), LS174T (human colon carcinoma). Some compounds showed high inhibitory activity against these human cancer cell lines. Among them, compound3aexhibited strong cytotoxicity, with IC50values ranging from 8.51 to 29.65 μM. The results showed that 4-methyl-cis-khellactone derivatives withS,Sconfiguration could be a potential antitumor agents.Keywords:4-methyl-(3'S,4'S)-cis-khellactone derivatives;asymmetric synthesis;antitumor activity
研究领域:
药物化学
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肿瘤学
·
有机合成化学
✓ 已验证
DOI
PubMed
高影响因子
PHARMAZIE
·
2014
·Vol. 69
·期 4
·281-286
·
IF 1.003
Sun Xiaoyi,Chen Jinliang,Gu Xiaohui,Liang Wenquan,Wang Junbo
The polycation transfection agent, polyethylenimine (PEI) was introduced into cisplatin (CDDP)-encapsulated liposomes by modification with amphiphilic PEI-cholesterol (PEI-Chol) to evaluate its potential application in chemotherapeutic drug delivery. Compared with unmodified neutral
liposomes (CDDP-NL), the remarkable features of PEI-modified cationic liposomes (CDDP-CL) increased cytotoxicity attributed to enhanced cellular uptake and extended cellular retention resulting from endosome escape in vitro. In a H22 hepatoma-bearing mouse model, CDDP-CL reduced the
nephrotoxicity associated with CDDP and had an antitumor activity similar to free drug, without inducing obvious system toxicity. These results confirm that the cationic modification of liposomes with PEI is efficient and safe for antitumor drug delivery.
研究领域:
药学
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肿瘤学
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生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xiao Sun,Mingzhu Zhang,Ruohong Du,Xiaojia Zheng,Caiguo Tang,Yiqun Wu,Jiacai He,Wei Huang,Yuanyin Wang,Zhiyuan Zhang,Xiaolan Han,Junchao Qian,Kai Zhong,Xiaohe Tian,Lifang Wu,Guilong Zhang,Zhengyan Wu,Duohong Zou
Multimode bioimaging probes with complementary advantages of imaging sensitivity and spatial resolution in a single drug delivery system have significant potential applications for clinical cancer diagnosis and chemotherapy. In this work, a polyethyleneimine-driven self-assembled lanthanide-doped CaF 2 nanocluster was synthesized and used for fluorescence/MR imaging guided cancer chemotherapy. This nanocluster has an ordered pore structure and good cisplatin loading capacity. The release of cisplatin from this nanoplatform was triggered by acidic pH. In addition, this nanoplatform showed a high relaxation rate (4.91 mM −1 s −1 ) and fluorescence signal. The cell assay results indicated that the nanoplatform was effectively internalized by HeLa cells and showed a good fluorescence/MR imaging ability and cell inhibition effect. In vivo experiment, the nanoplatform displayed excellent fluorescence/MR imaging and anticancer activity. In addition, the side effects of cisplatin on vital organs were significantly mitigated. Thus, this multifunctional nanoplatform is an excellent candidate for fluorescence/MR imaging guided cancer chemotherapy.
研究领域:
生物医学工程
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肿瘤学
·
分子影像学
✓ 已验证
DOI
高影响因子
Soft Matter
·
2018
·Vol. 14
·期 10
·1917-1924
·
IF 3.709
Guangshuo Wang,Yingying Ma,Guohua Cui,Nannan Li,Xufeng Dong
Superparamagnetic Fe3O4 nanoparticles were successfully deposited on the surface of MoS2 nanosheets (Fe3O4/MoS2) by a sonochemical method and the obtained Fe3O4/MoS2 nanocomposites were used as a promising candidate for a magnetorheological (MR) fluid. This MR fluid was prepared from the Fe3O4/MoS2 nanocomposites and its corresponding MR performances were examined using a rotational rheometer. The MR fluid based on Fe3O4/MoS2 showed typical MR effects with increasing viscosity, shear stress, yield stress and dynamic shear modulus depending on the applied magnetic fields. Compared with commercial carbonyl iron (CI) particles, the sedimentation stability of the Fe3O4/MoS2–MR fluid was greatly improved because of its unique two-dimensional structure and the reduced fluid–particle density mismatch. Therefore, the prepared Fe3O4/MoS2-based MR fluid with typical MR effects and good sedimentation stability would have great potential in practical applications.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 24
·12329-12338
·
IF 5.968
Tianbin Ren,Qiuming Liu,Hang Lu,Hongmei Liu,Xin Zhang,Jianzhong Du
Presented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the membrane. Superparamagnetic iron oxide nanoparticles (SPIONs) were generated in situ within the membrane of the polymer vesicles by nanoprecipitation. 1H NMR, GPC, DLS, TGA, VSM and TEM were employed to characterize the structure and properties of the block copolymer, polymer vesicles and Fe3O4-decorated magnetic polymer vesicles. The water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T2 relaxivity, demonstrating ultra-sensitivity for magnetic resonance imaging and promising potential applications in nanomedicine.
研究领域:
材料科学
·
生物医学工程
·
影像学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Zhi-Bin Zhou,Xue Bai,Zhi-Yong Zhou,Zi-Yue Lin,Bing Liao,Fei Gong,Mei-Qun Wang,Xu-Bo Chen,Yue-hui Liu,Hong-Ping Chen,Kai Xu
Hearing loss represents a common adverse effect following platinum-based chemotherapy regimens. The therapeutic management of inner ear diseases is significantly constrained by the blood-labyrinth barrier, which restricts the penetration of drug molecules into the endolymphatic, thereby limiting their therapeutic efficacy. Local drug delivery has emerged as a safe and effective method for the treatment of inner ear diseases. Nevertheless, the suboptimal retention duration of therapeutic agents within the middle ear substantially compromises drug delivery efficiency. To overcome this limitation, we designed and synthesized a methacrylate-gelatin microsphere (GH) conjugate polydopamine (PDA) layer (GH@PDA) with excellent adhesion ability. This engineered platform demonstrates rapid loading kinetics for bioactive molecules, enabling precise localized delivery of therapeutic payloads. Based on our findings that calcium overload and ROS accumulation are important mechanisms for cisplatin-induced hearing loss, we functionalized GH@PDA with both the nitric oxide (NO) precursor L-arginine and calmodulin-dependent kinase II inhibitor KN93 to construct the multifunctional composite GH@PDA@LK. In vivo imaging analyses revealed that the GH@PDA can prolong the retention of the middle ear and significantly increase the drug uptake concentration of the inner ear. Notably, intratympanic administration of GH@PDA@LK conferred robust protection against cisplatin-induced auditory threshold shifts and reduced outer hair cell loss in rat models. These findings collectively demonstrate that injectable GH@PDA microspheres constitute a clinically translatable platform for inner ear drug delivery. More importantly, our work establishes a novel mechanistically grounded therapeutic paradigm for preventing chemotherapy-induced ototoxicity through dual-pathway modulation of calcium signaling and oxidative stress.
研究领域:
药理学
·
耳科学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 11
·2400
·
IF 4.6
Ming Yuan,Huai Wang,Mingjun Yu,Sen Yao,Risheng Yao
Cisplatin (CIS) is a widely used chemotherapeutic agent that is highly effective against various cancers. However, its clinical application is frequently limited by its substantial nephrotoxic side effects. The gastrin-releasing peptide receptor (GRPR), a critical regulator in inflammatory diseases, has been identified as a promising therapeutic target. Our previous studies have demonstrated that the GRPR antagonists PD176252 and RH-1402 can mitigate CIS-induced nephrotoxicity through anti-inflammatory mechanisms. Based on these findings, we designed and synthesized a series of 2-arylpropanoic acid-L-tryptophan derivatives to enhance the therapeutic effects. Among these compounds,3mexhibited superior renal protection by significantly improving mouse renal tubular epithelial cell (mRTEC) viability from 50.2 ± 2.6% to 80.5 ± 3.9%, surpassing PD176252 (70.8 ± 1.4%) and RH-1402 (73.9 ± 3.7%). Moreover, compound3mmarkedly reduced the expression of kidney injury molecule-1 (KIM-1) and inflammatory cytokines [Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), Monocyte Chemoattractant Protein-1 (MCP-1)]. Finally, molecular docking results revealed that3mexhibited a high binding affinity for GRPR. Computational predictions using SwissADME further indicated that3mpossesses favorable drug-like properties, thereby supporting its potential as a promising candidate for mitigating CIS-induced nephrotoxicity.
研究领域:
药理学
·
肿瘤学
·
毒理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Li Xu,Suyun Jie,Zhiyang Bu,Bo-Geng Li
As a telechelic polymer, the primary amine-terminated cis -polybutadiene (AmTPB) has a wide application prospect due to its active hydrogens in both end groups and high cis 1,4-chain structure. In this work, the AmTPB with high cis -1,4 content (>96%) was prepared for the first time by taking cis -polybutadiene as a starting material. Firstly, the aldehyde-terminated polybutadiene (ATPB) in a molecular weight range of 600–8000 g/mol was successfully synthesized by oxidative degradation of epoxidized polybutadiene prepared by reaction-controlled phase-transfer catalysis. After a simple post-processing, the AmTPB was prepared via two steps, i.e. the efficient synthesis of oxime-terminated polybutadiene (OTPB) from ATPB and the subsequent selective reduction of OTPB. The results showed that the high cis 1,4-chain structure of polybutadiene did not change in all the reactions.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Yameng Wan,Haixia He,Pengshuai Zhang,Zibo Huang,Rui Zhao,Jiao Sha,Tao Li,Baozeng Ren
Solubility of cis-5-norbornene-endo-2,3-dicarboxylic anhydride (carbic anhydride) in fourteen pure solvents including methyl acetate (MAC), ethyl acetate (EAC), n-propyl acetate (NPAC), isopropyl acetate (IPAC), n-butyl acetate (NBAC), n-amyl acetate (NAAC), isoamyl acetate (IAAC), hexyl acetate (HAC), octyl acetate (OAC), ethanol (EtOH), 1,4-dioxane, 1-methyl-2-pyrrolidinone (NMP), acetone, N , N -dimethylformamide (DMF) and three binary solvents of (DMF + EtOH), (1,4-dioxane + EtOH) and (EtAC + EtOH) with various mass fractions was experimentally studied at various temperatures under 0.1 MPa. The results showed that solubility of carbic anhydride increased with the increasing temperature in all pure/binary solvents and decreased with the increasing mass fractions of ethanol in binary solvents. The Hansen solubility parameter was used for explaining the solubility order of carbic anhydride in selected solvents. Solubility of carbic anhydride in pure solvents was correlated by van't Hoff equation, modified Apelblat equation, and λh equation. Experimental solubility of carbic anhydride in binary solvents was correlated by Jouyban-Acree model, Jouyban-Acree-modified Apelblat model, Jouyban-Acree-van't Hoff model, Sun model and Ma model. Moreover, thermodynamic properties of solutions were calculated by the van't Hoff analysis. The dissolution process was always endothermal and entropy-driven.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2015
·Vol. 29
·期 8
·1133-1136
·
IF 1.723
Li Zhang,Chaozhan Wang,Yinmao Wei
Boronate affinity has attracted much attention in recent years. It has been broadly used for selective isolation and enrichment of cis -diol-containing molecules. Conventionally, the cis -diols are adsorbed in mild alkaline aqueous solutions. In this work, for the first time, we found that boronate affinity adsorption could also be performed in nonaqueous solvent at nonbasic pH. Cis -diol-containing compounds present in herbal medicines were used for the adsorption test. The results indicated that all compounds obtained higher recoveries in the organic solvents (methanol, acetonitrile, ethyl acetate) compared with alkaline buffer. The adsorption of vicinal cis -diol-containing molecules in organic solvents could be accomplished rapidly, with high selectivity and high recoveries (>80%). These results shed light on the possibility of boronate affinity adsorption in nonaqueous solvents. The results are very important for the isolation and enrichment of cis -diols, which have poor solubility in water, especially for those in herbal medicines. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
生物化学
·
药物化学
✓ 已验证
DOI
高影响因子
Journal of Biomedical Research
·
2024
·Vol. 39
·期 1
·87
·
IF 2.2
Chunming Tang,Yanling Wang,Min Wu,Zhiji Wang,Yupeng Zhou,Ya Lin,Yijun Wang,Huae Xu
Glioblastoma multiforme (GBM) is a highly aggressive and lethal brain tumor with limited treatment options. To improve therapeutic efficacy, we developed a novel multifunctional nanoplatform, GM@P(T/S), comprised of polymeric nanoparticles coated with GBM cell membranes as well as co-loaded with temozolomide (TMZ) and superparamagnetic iron oxide (SPIO) nanoparticles. The successful preparation was confirmed in terms of particle size, morphology, stability, the in vitro drug release, and cellular uptake assays. We demonstrated that GM@P(T/S) exhibited the enhanced homotypic targeting, the prolonged blood circulation, and efficient blood-brain barrier penetration in both in vitro and in vivo studies. The combination of TMZ and SPIO nanoparticles within GM@P(T/S) synergistically improved chemo-radiation therapy, leading to a reduced tumor growth, an increased survival, and minimal systemic toxicity in the orthotopic GBM mouse models. Our findings suggest that GM@P(T/S) holds a great promise as a targeted and efficient therapeutic strategy for GBM.
研究领域:
肿瘤学
·
纳米医学
·
神经科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）